Skip Navigation

Project Publications: University of Washington: Effects Related Biomarkers of Toxic Exposures

Superfund Research Program

Effects Related Biomarkers of Toxic Exposures

Project Leader: Terrance J. Kavanagh
Grant Number: P42ES004696
Funding Period: 1995 - 2006

Project-Specific Links

Connect with the Grant Recipients

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page Visit the grantee's Facebook page Visit the grantee's Video page





  • Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol 219(2-3):181-189. PMID:17084875


  • Botta D, Franklin CC, White CC, Krejsa CM, Dabrowski MJ, Pierce RH, Fausto N, Kavanagh TJ. 2004. Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis. Free Radic Biol Med 37(5):632-642. PMID:15288121
  • Diaz D, Krejsa CM, White CC, Charleston JS, Kavanagh TJ. 2004. Effect of methylmercury on glutamate-cysteine ligase expression in the placenta and yolk sac during mouse development. Reprod Toxicol 19(1):117-129. PMID:15336720
  • Kevil CG, Pruitt HM, Kavanagh TJ, Wilkerson J, Farin FM, Moellering D, Darley-Usmar VM, Bullard DC, Patel RP. 2004. Regulation of endothelial glutathione by ICAM-1: implications for inflammation. FASEB J 18(11):1321-3. PMID:15180961
  • Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu R, Kavanagh TJ, Forman HJ. 2004. Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys 423(1):116-125. PMID:14871475
  • Tran PT, Parker SM, LeRoy E, Franklin CC, Kavanagh TJ, Zhang T, Zhou H, Vliet PA, Oseid E, Harmon JS, Robertson RP. 2004. Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. J Biol Chem 279(52):53988-53993. PMID:15485876


  • Bea F, Hudson FN, Chait A, Kavanagh TJ, Rosenfeld ME. 2003. Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements. Circ Res 92(4):386-393. PMID:12600891
  • Franklin CC, Rosenfeld-Franklin ME, White CC, Kavanagh TJ, Fausto N. 2003. TGF beta 1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent posttranslational and caspase-independent transcriptional regulatory mechanisms. FASEB J 17(11):1535-1537. PMID:12824300
  • Garry MR, Sidhu JS, Kavanagh TJ, Faustman EM. 2003. Differential modulation of stress and ubiquitination signaling pathways by cadmium, H202, and serum withdrawal in cultured mouse fibroblasts. Society of Toxicology 42nd annual Meeting in Salt Lake City, Utah, March 2003. Toxicol Sci 72(1):311Suppl.S.
  • Luderer U, Diaz D, Faustman EM, Kavanagh TJ. 2003. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Mol Reprod Dev 65(3):254-261. PMID:12784246
  • Shi S, Hendsch MB, Ogburn CE, Rabinovitch PS, Martin GM, Kavanagh TJ. 2003. Female mice transgenic for mitochondrial directed catalase have altered glutathione redox cycle enzyme activities coincident with tissue specific catalase expression. Toxicol Sci 72(1):394Suppl.S.
  • White CC, Viernes HA, Krejsa CM, Botta D, Kavanagh TJ. 2003. Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity. Anal Biochem 318(2):175-180. PMID:12814619


  • Cobb GP, Houlis PD, Bargar TA. 2002. Polychlorinated biphenyl occurrence in American alligators (Alligator mississippiensis) from Louisiana and South Carolina. Environ Pollut 118:1-4. PMID:11996374
  • Diaz D, Krejsa CM, Kavanagh TJ. 2002. Expression of glutamate-cysteine ligase during mouse development. Mol Reprod Dev 62:83-91. PMID:11933164
  • Faustman EM, Ponce RA, Ou YC, Mendoza MC, Lewandowski TA, Kavanagh TJ. 2002. Investigations of methylmercury-induced alterations in neurogenesis. Environ Health Perspect 110(Supp5):859-864. PMID:12426147
  • Franklin CC, Krejsa CM, Pierce RH, White CC, Fausto N, Kavanagh TJ. 2002. Caspase-3-dependent cleavage of the glutamate-L-cysteine ligase catalytic subunit during apoptotic cell death. Am J Pathol 160(5):1887-1894. PMID:12000740


  • Adams ML, Pierce RH, Vail ME, White CC, Tonge RP, Kavanagh TJ, Fausto N, Nelson SD, Bruschi SA. 2001. Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2. Mol Pharmacol 60(5):907-915. PMID:11641418
  • Diaz D, Krejsa CM, Kavanagh TJ. 2001. Localization of glutamate-cysteine ligase mRNA and protein in mouse kidney and induction with methylmercury. Toxicol Lett 123(1):33-41. PMID:11514103
  • Diaz D, Krejsa CM, White CC, Keener CL, Farin FM, Kavanagh TJ. 2001. Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury. Toxicol Lett 122(2):119-129. PMID:11439218
  • Luderer U, Kavanagh TJ, White CC, Faustman EM. 2001. Gonadotropin regulation of glutathione synthesis in the rat ovary. Reprod Toxicol 15:495-504. PMID:11780957
  • Rosato MT, Jabbour AJ, Ponce RA, Kavanagh TJ, Takaro TK, Hill JP, Poot M, Rabinovitch PS, Faustman EM. 2001. Simultaneous analysis of surface marker expression and cell cycle progression in human peripheral blood mononuclear cells. J Immunol Methods 256(1-2):35-46. PMID:11516753


  • Hudson FN, Kavanagh TJ. 2000. Cloning and characterization of the proximal promoter region of the mouse glutamate-L-cysteine ligase regulatory subunit gene. Biochim Biophys Acta 1492:447-451. PMID:10899580
  • Jarvinen K, Pietarinen-Runtti P, Linnainmaa K, Raivio KO, Krejsa CM, Kavanagh TJ, Kinnula VL. 2000. Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells. Am J Physiol 278(4):L696-702. PMID:10749746
  • Kirlin WG, Cai J, Thompson SA, Diaz D, Kavanagh TJ, Jones DP. 2000. Glutathione redox potential in response to differentiation and enzyme inducers. Free Radic Biol Med 27(11-12):1208-1218. PMID:10641713
  • Pierce RH, Campbell JS, Stephenson AB, Franklin CC, Chaisson M, Poot M, Kavanagh TJ, Rabinovitch PS, Fausto N. 2000. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. Am J Pathol 157(1):221-36. PMID:10880392
  • Thompson SA, White CC, Krejsa CM, Eaton DL, Kavanagh TJ. 2000. Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development. Toxicol Sci 57:141-6. PMID:10966520


  • Nelson KC, Carlson JL, Newman ML, Sternberg P, Jones DP, Kavanagh TJ, Diaz D, Cai J, Wu M. 1999. Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 40(9):1927-1935. PMID:10440245
  • Ou YC, Thompson SA, Ponce RA, Schroeder JI, Kavanagh TJ, Faustman EM. 1999. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicol Appl Pharmacol 157:203-212. PMID:10373404
  • Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM. 1999. The Role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology 20:784-793. PMID:10591515
  • Siitonen T, Alaruikka P, Mantymaa P, Savolainen ER, Kavanagh TJ, Krejsa CM, Franklin CC, Kinnula VL, Koistinen P. 1999. Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress. Annals of Oncology 10(11):1361-1367. PMID:10631466
  • Thompson SA, White CC, Krejsa CM, Diaz D, Woods JS, Kavanagh TJ. 1999. Induction of glutamate-cysteine ligase in the brains of adult female mice sub-chronically exposed to methylmercury. Toxicol Lett 110:1-10. PMID:10593589


  • Broudy VC, Lin NL, Buhring H, Komatsu N, Kavanagh TJ. 1998. Analysis of c-Kit receptor dimerization by fluorescence resonance energy transfer. Blood 91:898-906. PMID:9446650
  • Calverley DC, Kavanagh TJ, Roth GJ. 1998. Human signaling protein 14-3-3 zeta interacts with platelet glycoprotein Ib subunits Ib alpha and Ib beta. Blood 91(4):1295-1303. PMID:9454760
  • Ponce RA, Bartell SM, Kavanagh TJ, Woods JS, Lee RC, Takaro TK, Faustman EM. 1998. Uncertainty analysis methods for comparing predictive models and biomarkers: A case study of dietary methylmercury exposures. Regul Toxicol Pharmacol 28(2):96-105.
  • Thompson SA, Roellich KL, Grossmann A, Gilbert SG, Kavanagh TJ. 1998. Alterations in immune parameters associated with low level methylmercury exposure in mice. Immunopharmacol Immunotoxicol 20(2):299-314. PMID:9653674


  • Krejsa CM, Nadler SG, Esselstyn JM, Kavanagh TJ, Ledbetter JA, Schieven GL. 1997. Role of oxidative stress in the action of vanadium phosphotyrosine phosphotase inhibitors: Redox independent activation of NF-ÇB. J Biol Chem 272(17):11541-11549.
  • Ou YC, Thompson SA, Kirchner SC, Kavanagh TJ, Faustman EM. 1997. Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicol Appl Pharmacol 147:31-38. PMID:9356304
  • Potter AJ, Grossmann A, Rabinovitch PS, Eaton DL, Kavanagh TJ. 1997. The effect of in vitro phorone exposure on glutathione content and T-cell antigen receptor stimulated calcium mobilization in murine splenic T lymphocytes. In Vitr Mol Toxicol 11(4):355-363. PMID:20654322
  • Reid LL, Botta D, Lu Y, Gallagher EP, Kavanagh TJ. 1997. Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase. Biochim Biophys Acta 1352(3):233-237. PMID:9224945
  • Reid LL, Botta D, Shao J, Hudson FN, Kavanagh TJ. 1997. Molecular cloning and sequencing of the cDNA encoding mouse glutamate-cysteine ligase regulatory subunit. Biochim Biophys Acta 1353(2):107-110. PMID:9294003


  • Gallagher EP, Stapleton PL, Slone DH, Schlenk D, Eaton DL. 1996. Channel catfish glutathione S-transferase isoenzyme activity toward (+)-anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide. Aquat Toxicol 34(2):135-150.
  • Krejsa CM, Nadler SG, Esselstyn JM, Kavanagh TJ, Ledbetter JA, Schieven GL. 1996. The differenetial role of oxidative stress in the activation of protein tyrosine kinases, MAP kinase, and NF-χB by vanadium phosphotyrosine phosphatase inhibitors. FASEB J 10(6):P10.
  • Li S, Thompson SA, Kavanagh TJ, Woods JS. 1996. Localization by in situ hybridizatioin of glutamylcysteine synthetase mRNA expression in rat kidney following acute methylmercury treatment. Toxicol Appl Pharmacol 141:59-67. PMID:8917676
  • Li S, Thompson SA, Woods JS. 1996. Localization of glutamylcysteine synthetase mRNA expression in mouse brain following methylmercury treatment using reverse transcription in situ PCR amplification. Toxicol Appl Pharmacol 140:180-187. PMID:8806884
  • Poot M, Hudson FN, Grossmann A, Rabinovitch PS, Kavanagh TJ. 1996. Probenicid inhibition of fluorescence extrusion after MCB-staining of rat-1 fibroblasts. Cytometry Part A 23(1):78-81. PMID:14650445


  • Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DL. 1995. Induction of phase I and phase II drug metabolizing enzyme mRNA, protein and activity by BHA, ethoxyquin and oltipraz. Toxicol Appl Pharmacol 135(1):45-57. PMID:7482539
  • Eaton DL, Hill J. 1995. Human Effects of Hazardous Materials. In: Handbook of Hazardous Materials, Vol. 1. Prentice Hall, Columbus, OH. pp.81-118.
  • Gallagher EP, Buetler TM, Wang C, Stapleton PL, Stahl DL, Eaton DL. 1995. The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. Toxicol Appl Pharmacol 134(1):81-91. PMID:7676460
  • Gallagher EP, Eaton DL. 1995. In vitro biotransformation of aflatoxin B1 in channel catfish liver. Toxicol Appl Pharmacol 132:82-90. PMID:7747288
  • Grossmann A, Rabinovitch PS, Kavanagh TJ, Jinneman JC, Gilliland LK, Ledbetter JA, Kanner SB. 1995. Activation of murine T-cells via phospholipase-Cg1-associated protein tyrosine phosphorylation is reduced with aging. J Gerontol 50(4):B205-B212. PMID:7614232
  • Krejsa CM, Ledbetter JA, Kavanagh TJ. 1995. Oxidant induced changes in red autofluorescence in lymphocytes and lymphoblastoid cell lines correlates with decreased glutathione. Environ Health Perspect 15:158a.
  • Poot M, Teubert H, Rabinovitch PS, Kavanagh TJ. 1995. De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. Journal of Cellular Physiology 163(3):555-560. PMID:7539813
  • Reid LL, Kavanagh TJ. 1995. Cloning and sequencing of the mouse cDNAs encoding the light and heavy subunits of g-glutamylcysteine synthetase. Environ Health Perspect 15:1613a.
  • Thompson SA, Grossmann A, White CC, Eaton DL, Gilbert SG, Kavanagh TJ. 1995. Strain specific effects of sub-chronic, low level methylmercury exposure on GSH levels in mice. Environ Health Perspect 15:1616a.
to Top