Superfund Research Program

Urinary Protein Biomarkers for Assessing the Potential Toxicity of Naphthalene in Humans

Project Leader: Alan R. Buckpitt
Grant Number: P42ES004699
Funding Period: 2010-2015

Project-Specific Links

Publications

2016

• Carratt SA, Morin D, Buckpitt AR, Edwards PC, Van Winkle LS. 2016. Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. Toxicol Lett 246:35-41. doi:10.1016/j.toxlet.2016.01.019 PMID:26840748 PMCID:PMC4774530

2015

• Kültz D, Li J, Sacchi R, Morin D, Buckpitt AR, Van Winkle LS. 2015. Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. Proteomics 15(15):2655-2668. doi:10.1002/pmic.201400445 PMID:25825134 PMCID:PMC4772669

2014

• Schebb N, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. 2014. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos 42(7):1098-1102. doi:10.1124/dmd.114.058206 PMID:24733789 PMCID:PMC4170114

2013

• Chan JK, Charrier JG, Kodani SD, Vogel CF, Kado SY, Anderson DS, Anastasio C, Van Winkle LS. 2013. Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs. Part Fibre Toxicol 10:34. doi:10.1186/1743-8977-10-34 PMID:23902943 PMCID:PMC3735485
• Chan JK, Vogel CF, Baek J, Kodani SD, Uppal RS, Bein KJ, Anderson DS, Van Winkle LS. 2013. Combustion derived ultrafine particles induce cytochrome P-450 expression in specific lung compartments in the developing neonatal and adult rat. Am J Physiol 304(10):L665-L677. doi:10.1152/ajplung.00370.2012 PMID:23502512 PMCID:PMC3652057

2011

• Chan JK, Fanucchi MV, Anderson DS, Abid AD, Wallis C, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle LS. 2011. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicol Sci 124(2):472-486. doi:10.1093/toxsci/kfr233 PMID:21914721 PMCID:PMC3216412
• Inceoglu B, Wagner KM, Schebb N, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose TE, Hammock BD, Brosnan R. 2011. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A 108(12):5093-5097. doi:10.1073/pnas.1101073108 PMID:21383170 PMCID:PMC3064364

2010

• Buchholz BA, Haack KW, Sporty JL, Buckpitt AR, Morin D. 2010. Free flow electrophoresis separation and AMS quantitation of 14C-naphthalene-protein adducts. Nucl Instrum Methods Phys Res B 268(7-8):1324-1327. doi:10.1016/j.nimb.2009.10.164 PMID:20454606 PMCID:PMC2864045
• DeStefano-Shields C, Morin D, Buckpitt AR. 2010. Formation of covalently bound protein adducts from the cytotoxicant naphthalene in nasal epithelium: species comparisons. Environ Health Perspect 118(5):647-652. doi:10.1289/ehp.0901333 PMID:20435546 PMCID:PMC2866680
• Spiess PC, Morin D, Williams CR, Buckpitt AR. 2010. Protein thiol oxidation in murine airway epithelial cells in response to naphthalene or diethyl maleate. Am J Respir Cell Mol Biol 43:316-325. doi:10.1165/rcmb.2009-0135OC PMID:19843705 PMCID:PMC2933547

2009

• Lin C, Wheelock AM, Morin D, Baldwin RM, Lee MG, Taff A, Plopper CG, Buckpitt AR, Rohde A. 2009. Toxicity and metabolism of methylnaphthalenes: Comparison with naphthalene and 1-nitronaphthalene. Toxicology 260(1-3):16-27. doi:10.1016/j.tox.2009.03.002 PMID:19464565 PMCID:PMC2687406