Superfund Research Program

Proteome Response to Toxic Perturbation

Project Leader: Dietmar Kültz
Co-Investigators: Alan R. Buckpitt, William T. Jewell
Grant Number: P42ES004699
Funding Period: 2010-2015

Project-Specific Links

Publications

2016

• Rice RH, Durbin-Johnson BP, Ishitsuka Y, Salemi MR, Phinney BS, Rocke DM, Roop DR. 2016. Proteomic analysis of loricrin knockout mouse epidermis. J Proteome Res 15(8):2560-2566. doi:10.1021/acs.jproteome.6b00108 PMID:27418529

2015

• Kültz D, Li J, Sacchi R, Morin D, Buckpitt AR, Van Winkle LS. 2015. Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. Proteomics 15(15):2655-2668. doi:10.1002/pmic.201400445 PMID:25825134 PMCID:PMC4772669
• Villarreal F, Kultz D. 2015. Direct ionic regulation of the activity of myo-inositol biosynthesis enzymes in Mozambique tilapia. PLoS One 10(6):e0123212. doi:10.1371/journal.pone.0123212 PMID:26066044 PMCID:PMC4466255

2014

• Gardell AM, Qin Q, Rice RH, Li J, Kültz D. 2014. Derivation and osmotolerance characterization of three immortalized tilapia (Oreochromis mossambicus) cell lines. PLoS One 9(5):e95919. doi:10.1371/journal.pone.0095919 PMID:24797371 PMCID:PMC4010420
• Villarreal F, Das GK, Abid AD, Kennedy IM, Kültz D. 2014. Sublethal effects of CuO nanoparticles on Mozambique tilapia (Oreochromis mossambicus) are modulated by environmental salinity. PLoS One 9(2):e88723. doi:10.1371/journal.pone.0088723 PMID:24520417 PMCID:PMC3919801

2013

• Gardell AM, Yang J, Sacchi R, Fangue NA, Hammock BD, Kültz D. 2013. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J Exp Biol 216(24):4615-4625. doi:10.1242/jeb.088906 PMID:24072790 PMCID:PMC3851147
• Kültz D, Li J, Gardell AM, Sacchi R. 2013. Quantitative molecular phenotyping of gill remodeling in a cichlid fish responding to salinity stress. Mol Cell Proteomics 12(12):3962-3975. doi:10.1074/mcp.M113.029827 PMID:24065692 PMCID:PMC3861737
• Sacchi R, Li J, Villarreal F, Gardell AM, Kültz D. 2013. Salinity-induced regulation of the myo-inositol biosynthesis pathway in tilapia gill epithelium. J Exp Biol 13(Pt24):4626-4638. doi:10.1242/jeb.093823 PMID:24072791 PMCID:PMC3851148

2012

• Kemp CJ, Kültz D. 2012. Controlling proteome degradation in Daphnia pulex. J Exp Zool 317(10):645-651. doi:10.1002/jez.1766 PMID:23027649 PMCID:PMC3536481

2011

• Gabert BJ, Kültz D. 2011. Osmoprotective proteome adjustments in mouse kidney papilla. Biochim Biophys Acta 1814(3):435-448. doi:10.1016/j.bbapap.2011.01.003 PMID:21236367 PMCID:PMC3045564
• Pfrender ME, Gilbert D, Thomas W, Tucker A, Oakley TH, Tokishita S, Aerts A, Arnold GJ, Basu MK, Bauer DJ, Caceres CE, Carmel L, Casola C, Choi J, Detter JC, Dong Q, Dusheyko S, Eads BD, Frohlich T, Geiler-Samerotte KA, Gerlach D, Hatcher P, Jogdeo S, Krijgsveld J, Kriventseva EV, Kültz D, Laforsch C, Lindquist E, Lopez J, Manak J, Muller J, Pangilinan J, Patwardhan RP, Pitluck S, Pritham EJ, Rechtsteiner A, Rho M, Rogozin IB, Sakarya O, Salamov A, Schaack S, Shapiro H, Shiga Y, Skalitzky C, Smith Z, Souvorov A, Sung W, Tsuchiya D, Tu H, Vos H, Wang M, Wolf YI, Yamagata H, Yamada T, Ye Y, Shaw JR, Andrews J, Crease TJ, Tang H, Lucas SM, Robertson HM, Bork P, Koonin EV, Zdobnov EM, Grigoriev IV, Lynch M, Boore JL, Colbourne JK. 2011. The ecoresponsive genome of Daphnia pulex. Science 331(6017):555-561. doi:10.1126/science.1197761 PMID:21292972 PMCID:PMC3529199

2010

• Buchholz BA, Haack KW, Sporty JL, Buckpitt AR, Morin D. 2010. Free flow electrophoresis separation and AMS quantitation of 14C-naphthalene-protein adducts. Nucl Instrum Methods Phys Res B 268(7-8):1324-1327. doi:10.1016/j.nimb.2009.10.164 PMID:20454606 PMCID:PMC2864045
• DeStefano-Shields C, Morin D, Buckpitt AR. 2010. Formation of covalently bound protein adducts from the cytotoxicant naphthalene in nasal epithelium: species comparisons. Environ Health Perspect 118(5):647-652. doi:10.1289/ehp.0901333 PMID:20435546 PMCID:PMC2866680
• Dowd W, Renshaw G, Cech JJ, Kültz D. 2010. Compensatory proteome adjustments imply tissue-specific structural and metabolic reorganization following episodic hypoxia or anoxia in the epaulette shark (Hemiscyllium ocellatum). Physiol Genomics 42(1):93-114. doi:10.1152/physiolgenomics.00176.2009 PMID:20371547 PMCID:PMC2888556
• Feng W, Cherednichenko G, Ward C, Padilla I, Cabrales E, Lopez JR, Eltit JM, Allen PD, Pessah IN. 2010. Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1). Biochem Pharmacol 80(4):512-521. doi:10.1016/j.bcp.2010.05.004 PMID:20471964 PMCID:PMC2907350
• Kültz D, Gabert BJ. 2010. Proteomic analysis of the renal inner medulla and collecting ducts. Chapter 4 in: Renal and Urinary Proteomics: Methods and Protocols. Wiley-VCH, pp.39-51.
• Silvestre F, Linares-Casenave J, Doroshov SI, Kültz D. 2010. A proteomic analysis of green and white sturgeon larvae exposed to heat stress and selenium. Sci Total Environ 408(16):3176-3188. doi:10.1016/j.scitotenv.2010.04.005 PMID:20435339 PMCID:PMC3478132

2009

• Lin C, Wheelock AM, Morin D, Baldwin RM, Lee MG, Taff A, Plopper CG, Buckpitt AR, Rohde A. 2009. Toxicity and metabolism of methylnaphthalenes: Comparison with naphthalene and 1-nitronaphthalene. Toxicology 260(1-3):16-27. doi:10.1016/j.tox.2009.03.002 PMID:19464565 PMCID:PMC2687406