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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of California-Berkeley: Biomarkers of Cancer Susceptibility in Human Populations

Superfund Research Program

Biomarkers of Cancer Susceptibility in Human Populations

Project Leader: John K. Wiencke (University of California-San Francisco)
Grant Number: P42ES004705
Funding Period: 1995 - 2000

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Publications

2001

  • Wiencke JK, Kelsey KT, Zuo Z, Weinberg A, Wrensch MR. 2001. Genetic resistance factor for HIV-1 and immune response to varicella tester virus. Lancet 357(9253):360-361. PMID:11211001

2000

  • Duell EJ, Wiencke JK, Cheng T, Varkonyi A, Zuo Z, Devi-Ashok T, Mark EJ, Wain JC, Christiani DC, Kelsey KT. 2000. Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. Carcinogenesis 21(5):965-971. PMID:10783319
  • Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke JK, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels JL, Dosemeci M, Li G, Smith MT. 2000. Genotoxic markers among butadiene-polymer workers in China. Carcinogenesis 21(1):55-62. PMID:10607734
  • Platz EA, Wiencke JK, Kelsey KT, Janower ML, Schottenfeld D, Travis LB, Goldman MB. 2000. Chromosomal aberrations and hprt mutant frequencies in long-term US Thorotrast survivors. Int J Radiat Biol 76(7):955-961. PMID:10923619
  • Thurston SW, Wand MP, Wiencke JK. 2000. Negative binomial additive models. Biometrics 56(1):139-144. PMID:10783788

1999

  • Holland NT, Zhang L, Smith MT. 1999. Cytogenetic biomarkers and air pollution. In: Proceedings of the 7th International Inhalation Symposium, 1999. Hanover, Germany.
  • Ishibe N, Wiencke JK, Zuo Z, McMillan A, Spitz MR, Kelsey KT. 1999. Cytochrome P450 1A1 polymorphisms and lung cancer susceptibility in Mexican-Hispanic and African-American minority populations. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Nelson HH, Christiani DC, Mark EJ, Wiencke JK, Wain JC, Kelsey KT. 1999. Implications and prognostic value of K-ras mutation for early-stage lung cancer in women. J Natl Cancer Inst 91(23):2032-2038. PMID:10580029
  • Nelson HH, Christiani DC, Wiencke JK, Mark EJ, Wain JC, Kelsey KT. 1999. K-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. Cancer Res 59:4570-4573. PMID:10493509
  • Spitz MR, Wu X, Jiang HH, Kelsey KT, Wiencke JK, Hsu TC. 1999. Glutathione S-transferase (GSTM1 & GSTT1) genotypes, mutagen sensitivity, cigarette smoking and lung cancer risk. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Wang X, Christiani DC, Mark EJ, Nelson HH, Wiencke JK, Gunn L, Wain JC, Kelsey KT. 1999. Carcinogen exposure, p53 alteration and K-ras mutation in synchronous multiple primary lung carcinoma. Cancer 85(8):1734-1739. PMID:10223567
  • Wiemels JL, Wiencke JK, Varkonyi A, Smith MT. 1999. Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol 12(6):467-475. doi:10.1021/tx9800811 PMID:10368308
  • Wiencke JK, Thurston SW, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC. 1999. Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. J Natl Cancer Inst 91(7):614-619. PMID:10451453
  • Wiencke JK, Varkonyi A, Kelsey KT, Wain JC, Mark EJ, Christiani DC. 1999. Polyphenol-related DNA adducts in blood mononuclear cells are increased in newly diagnosed patients with lung cancer. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Wiencke JK, Varkonyi A, Semey K, Levay G, Wain JC, Mark EJ, Kelsey KT, Christiani DC. 1999. Detection of benzene-related DNA adducts in human tissues and evidence of co-activation with polyaromatic hydrocarbons (PAHs). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.135.
  • Wiencke JK, Varkonyi A, Semey K, Levay G, Wain JC, Mark EJ, Kelsey KT, Christiani DC. 1999. Validation of blood mononuclear cell DNA-adducts as a marker of DNA damage in human lung. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.283.
  • Wiencke JK, Zheng S, Lafuente A, Lafuente MJ, Grudzen C, Wrensch MR, Miike R, Ballesta A, Trias M. 1999. Aberrant methylation of p16(INK4a) in anatomic and gender specific subtypes of sporadic colorectal cancer. Cancer Epidemiol Biomarkers Prev 8(6):501-506. PMID:10385139

1998

  • Kelsey KT, Wiencke JK. 1998. Growing pains for the environmental genetics of breast cancer: observations on a study of the glutathione s-transferases. J Natl Cancer Inst 90:484-485. PMID:9539238
  • Lee BW, Wain JC, Kelsey KT, Wiencke JK, Christiani DC. 1998. Association of cigarette smoking and asbestos exposure with location and histology of lung cancer. Am J Respir Crit Care Med 157:748-755. PMID:9517586
  • Nelson HH, Wiencke JK, Gunn L, Wain JC, Christiani DC, Kelsey KT. 1998. Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res 58(9):1804-1807. PMID:9581816
  • Wiencke JK, Mustacchi P. 1998. Styrene and Butadiene. In: Environmental and Occupational Medicine. Lippincott-Raven, Philadelphia, PA. pp.1129-1144.
  • Xu X, Wiencke JK, Niu T, Wang M, Watanabe H, Kelsey KT, Christiani DC. 1998. Benzene exposure, glutathione S-transferase theta homozygous deletion and sister chromatid exchanges. Am J Ind Med 33(2):157-163. PMID:9438048

1997

  • Ishibe N, Wiencke JK, Zuo Z, McMillan A, Spitz MR, Kelsey KT. 1997. Susceptibility to lung cancer in light smokers associated with Cyp1A1 polymorphisms and lung cancer in Mexican- and African-Americans. Cancer Epidemiol Biomarkers Prev 6(12):1075-1080. PMID:9419406
  • Kelsey KT, Ross D, Traver RD, Christiani DC, Zuo Z, Spitz MR, Wang M, Xu X, Lee BK, Schwartz BS, Wiencke JK. 1997. Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. Br J Cancer 76(7):852-854. doi:10.1038/bjc.1997.474 PMID:9328142
  • Kelsey KT, Spitz MR, Zuo Z, Wiencke JK. 1997. Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States). Cancer Causes Control 8(4):554-559. PMID:9242470
  • Wiencke JK, Spitz MR, McMillan A, Kelsey KT. 1997. Lung cancer in Mexican-Americans and African-Americans is associated with the wildtype genotype of the NAD(P)H:quinone oxidoreductase polymorphism. Cancer Epidemiol Biomarkers Prev 6(2):87-92. PMID:9037558
  • Wiencke JK, Wrensch MR, Miike R, Zuo Z, Kelsey KT. 1997. Population-based study of glutathione S-transferase mu gene deletion in adult glioma cases and controls. Carcinogenesis 18(7):1431-1433. PMID:9230293
  • Wiencke JK, Yager JW, Varkonyi A, Hultner M, Lutze LH. 1997. Study of arsenic mutagenesis using the plasmid shuttle vector pZ189 propagated in DNA repair proficient human cells. Mutat Res Rev Mutat Res 386:335-344. PMID:9219570
  • Yager JW, Wiencke JK. 1997. Inhibition of poly(ADP-ribose) polymerase by arsenite. Mutat Res Rev Mutat Res 386:345-351. PMID:9219571

1996

  • Wiencke JK, Spitz MR, McMillan A, Kelsey KT. 1996. Lung cancer in Mexican-American and African-Americans is associated with the wildtype genotype of the NAD(P)H:quinone oxidoreductase polymorphism. Am J Hum Genet 59:A294.

1995

  • Kelsey KT, Wiencke JK, Ward J, Bechtold WE, Fajen J. 1995. Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. Mutat Res 335(3):267-273. PMID:8524342
  • Nelson HH, Wiencke JK, Christiani DC, Cheng T, Zuo Z, Schwartz BS, Lee B, Spitz MR, Wang M, Xu X, Kelsey KT. 1995. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis 16(5):1243-1246. PMID:7767992
  • Wiencke JK, Kelsey KT, Varkonyi A, Semey K, Wain JC, Mark EJ, Christiani DC. 1995. Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung. Cancer Res 55(21):4910-4914. PMID:7585529
  • Wiencke JK, Pemble S, Ketterer B, Kelsey KT. 1995. Gene deletion in glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol Biomarkers Prev 4(3):253-259. PMID:7606200
  • Wiencke JK, Wiemels JL. 1995. Genotoxicity of 1,3,-bis(2-chloroethyl)-1- nitrosourea (BCNU). Mutat Res 339(2):91-119. PMID:7791804
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