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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of California-Berkeley: Biomarkers of Carcinogenesis

Superfund Research Program

Biomarkers of Carcinogenesis

Project Leader: Martyn T. Smith
Grant Number: P42ES004705
Funding Period: 1995 - 2006

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Publications

2008

  • Chang JS, Yeh R, Wiencke JK, Wiemels JL, Smirnov I, Pico AR, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR. 2008. Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. Cancer Epidemiol Biomarkers Prev 17(6):1368-1373. doi:10.1158/1055-9965.EPI-07-2830 PMID:18559551
  • Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res 68(23):9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307

2005

  • Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245. PMID:15967214
  • Wiencke JK, Aldape K, McMillan A, Wiemels JL, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, Wrensch MR. 2005. Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomarkers Prev 14(7):1774-1783. doi:10.1158/1055-9965.EPI-05-0089 PMID:16030116

2004

  • Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M, Rappaport SM, Shen M, Alter BP, Wu Y, Kopp W, Waidyanatha S, Rabkin CS, Guo W, Chanock SJ, Hayes RB, Linet MS, Kim S, Yin S, Rothman N, Smith MT. 2004. Hematotoxicity in workers exposed to low levels of benzene. Science 306(5702):1774-1776. doi:10.1126/science.1102443 PMID:15576619 PMCID:PMC1256034
  • McHale CM, Smith MT. 2004. Prenatal origin of chromosomal translocations in acute childhood leukemia: Implications and future directions. Am J Hematol 75(4):254-257. PMID:15054823
  • Toraason M, Albertini R, Baynard S, Bigbee W, Blair AE, Boffetta P, Bonassi S, Chanock SJ, Christiani DC, Eastmond DA, Hanash S, Henry C, Kadlubar FF, Mirer F, Nebert DW, Rappaport SM, Rest K, Rothman N, Ruder AM, Savage R, Schulte PA, Siemiatycki J, Shields P, Smith MT, Tolbert PE, Vermeulen R, Vineis P, Wacholder S, Ward EM, Waters M. 2004. Applying new biotechnologies to the study of occupational cancer - A workshop summary. Environ Health Perspect 112(4):413-416. PMID:15033588
  • Vermeulen R, Li G, Lan Q, Dosemeci M, Rappaport SM, Bohong X, Smith MT, Zhang L, Hayes RB, Linet MS, Mu R, Wang L, Xu J, Yin S, Rothman N. 2004. Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China. Ann Occup Hyg 48(2):105-116. PMID:14990432
  • Waidyanatha S, Rothman N, Li G, Smith MT, Yin S, Rappaport SM. 2004. Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects. Anal Biochem 327(2):184-199. PMID:15051535
  • Zhang L, Hayes RB, Guo W, McHale CM, Yin S, Wiencke JK, O'Neill JP, Rothman N, Li G, Smith MT. 2004. Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes. Mutat Res 558(1-2):63-74. PMID:15036120
  • Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. 2004. Hypermethylation of the 5 ' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res 64(6):2000-2006. PMID:15026336

2003

  • Albertini R, Clewell H, Himmelstein MW, Morinello EJ, Olin S, Preston J, Scarano L, Smith MT, Swenberg JA, Tice RR, Travis C. 2003. The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene. Regul Toxicol Pharmacol 37(1):105-132. PMID:12662914
  • Curry JD, Smith MT. 2003. Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR. Leuk Res 27(7):575-582. PMID:12681356
  • Escobar PA, Zhang L, Smith MT. 2003. Chemically induced damage to specific regions of DNA detected by cometfish. Environ Mol Mutagen 41(3):174.
  • Holland NT, Smith MT, Eskenazi B, Bastaki M. 2003. Biological sample collection and processing for molecular epidemiological studies. Mutat Res Rev Mutat Res 543(3):217-234. PMID:12787814
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Feusner J, Matthay KK, Dahl GV, Smith MT. 2003. Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood 101(11):4640-4641. PMID:12756163
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. 2003. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes, Chromosomes and Cancer 37(1):36-43. PMID:12661004
  • Smith MT, Wiencke JK, Wiemels JL, Zhang L, Ma X, McHale CM, Buffler PA. 2003. Molecular epidemiology of childhood leukemia. Environ Mol Mutagen 41(3):206.
  • Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.
  • Zhang L, Zheng S, Ma X, Wiemels JL, Buffler PA, Smith MT, Wiencke JK. 2003. Molecular cytogenetic characterization of childhood acute lymphoblastic leukemia and its relation to FHIT gene methylation. Environ Mol Mutagen 41(3):215.
  • Zheng S, Ma X, Wiemels JL, Zhang L, Gunn L, Smith MT, Buffler PA, Wiencke JK. 2003. Hypermethylation of the 5'CpG island of the FHIT gene is associated with hyperdiploid and translocation negative subtypes of pediatric leukemia. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

2002

  • Allan JM, Wild CP, Rollinson S, Roddam PL, Dring AM, Dasgupta R, Sibley K, Worrilow L, Willet EV, Law GR, Roman E, Dovey GJ, Cartwright RA, Holowaty E, Kohler B, Wiklund, Pukkala E, Smith MT, Travis LB, Morgan GJ. 2002. Genetic polymophisms in DNA repair and cell cycle regulatory genes are associated with susceptibility to therapy-related acute myeloid leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4213.
  • Curry JD, McHale CM, Smith MT. 2002. Low efficiency of the Moloney murine leukemia virus reverse transcriptase during reverse transcription of rare t(8;21) fusion gene transcripts. Biotechniques 32(4):768-775. PMID:11962598
  • Damm CJ, Lucas D, Sawyer RF, Koshland CP. 2002. Characterization Of Diesel Particulate Matter With Excimer Laser Fragmentation Fluorescence Spectroscopy. In: Proceedings of the 29th International Symposium on Combustion. Sapporo, Japan.
  • Guo W, Zhang L, Yang W, Smith MT. 2002. Chromosomal aneuploidy detected at different stages of cervical cancer using interphase cytongenetics. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3698.
  • Holland NT, Duramad P, Rothman N, Figgs LW, Blair AE, Hubbard AE, Smith MT. 2002. Micronucleus frequency and proliferation in human lymphocytes after exposure to herbicide 2,4-dichlorophenoxyacetic acid in vitro and in vivo. Mutat Res 521(1-2):165-78. PMID:12438013
  • Ma X, Buffler PA, Gunier RB, Dahl GV, Smith MT, Reinier K, Reynolds P. 2002. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect 110(9):955-960. PMID:12204832
  • Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P. 2002. Daycare attendance and the risk of childhood acute lymphoblastic leukemia. Br J Cancer 86(9):1419-1424.
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Smith MT. 2002. Prenatal origin of TEL-AML positive acute lymphoblastic leukemia in children born in California. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4566.
  • Morgan GJ, Smith MT. 2002. Metabolic enzyme polymorphisms and susceptibility to acute leukemia in adults. Am J Pharmacogenomics 2(2):79-92. PMID:12083944
  • Rollinson S, Allan JM, Law GR, Roddam PL, Smith AG, Higuchi R, Germer S, Roman E, Smith MT, Morgan GJ. 2002. Polymorphic variants of DNA repair and cell cycle genes associated with acute myeloid leukemia identified by genotyping DNA pools. In: COMPSTAT 2002, Proceedings in Computational Staistics. Heidelberg: Physica-Verlag, Berlin, Germany. pp.5048.
  • Skibola CF, Smith MT, Hubbard AE, Shane B, Roberts AC, Law GR, Rollinson S, Roman E, Cartwright RA, Morgan GJ. 2002. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes increase the risk of adult acute leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3807.
  • Smith MT, Linet MS, Morgan GJ. 2002. Causative agents in the etiology of myelodysplastic syndromes and the acute myeloid leukemias. Chapter 3 in: The Myelodysplastic Syndromes: Pathobiology and Clinical Management. Dekker Press, New York, NY. pp.29.
  • Smith MT, Wang Y, Skibola CF, Slater DJ, Nigro LL, Nowell PC, Lange BJ, Felix CA. 2002. Low NAD(P)H: quinone oxidoreductase (NQO1) activity is associated with increased risk of leukemia with MLL translocations in infants and children. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3805.
  • Stipe CB, Higgins D, Lucas D, Sawyer RF, Koshland CP. 2002. Detection Using Excimer Laser Fragmentation Fluorescence Spectroscopy. In: Proceedings of the 29th International Symposium on Combustion. Sapporo, Japan.
  • Urayama KY, Wiencke JK, Buffler PA, Wiemels JL. 2002. #21-S the role of MDR-1 gene polymorphisms in the genetic susceptibility to childhood leukemia. Ann Epidemiol 12(7):497.
  • Urayama KY, Wiencke JK, Buffler PA, Wiemels JL. 2002. The role of MDR-1 gene polymorphisms in the genetic susceptibility to childhood leukemia. In: The proceedings of the American College of Epidemiology Annual Scientific Session, September 22-24. Albuquerque, NM.
  • Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. 2002. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 99(23):15101-15106. PMID:12415113
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 99(10):3801-3805. PMID:11986239
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4567.
  • Yang W, Zhang L, Hubbard AE, Wang Y, Smith MT. 2002. Non-random chromosome damage may be important in chemical carinogenesis. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3451.
  • Zhang L, Eastmond DA, Smith MT. 2002. The nature of chromosomal aberrations detected in humans exposed to benzene. Crit Rev Toxicol 32(1):1-42. PMID:11846214
  • Zhang L, Guo W, Rothman N, Lan Q, Yang W, Lo C, Li G, Turakulov RI, Yin S, Smith MT. 2002. Application of OctoChrome FISH device to detect leukemia and lymphoma specific chromosome aberrations in molecular epidemiology and toxicology. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3810.
  • Zhang L, Yang W, Hubbard AE, Wang Y, Smith MT. 2002. Is chromosomal aneuploidy induced by benzene metabolites random or selective?. Environ Mol Mutagen 39(Suppl33):230.

2001

  • Curry JD, Glaser MC, Smith MT. 2001. Real-time RT-PCR detection and quantification of t(1;19)(E2A-PBX1) fusion genes associated with leukaemia. British Journal of Haematology 115(4):826-830. PMID:11843816
  • Hirao T, Nelson HH, Devi-Ashok T, Wain JC, Mark EJ, Christiani DC, Wiencke JK, Kelsey KT. 2001. Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer. Cancer Res 61(2):612-615. PMID:11212258
  • Smith MT. 2001. Chromosome damage from biological reactive intermediates of benzene and 1,3-butadiene in leukemia. Advances in Experimental Medicine and Biology 500:279-287. PMID:11764955
  • Xiao Z, Greaves MF, Buffler PA, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL. 2001. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia 15:1906-1913. PMID:11753612

2000

  • Hayes RB, Yin S, Rothman N, Dosemeci M, Li G, Travis LB, Smith MT, Linet MS. 2000. Benzene and lymphohematopoietic malignancies in China. J Toxicol Environ Health A 61(5-6):419-432. PMID:11086948
  • Smith MT, Rothman N. 2000. Biomarkers in the molecular epidemiology of benzene-exposed workers. J Toxicol Environ Health A 61(5-6):439-445. PMID:11086950
  • Smith MT, Zhang L, Jeng M, Wang Y, Guo W, Duramad P, Hubbard AE, Hofstadler G, Holland NT. 2000. Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells. Carcinogenesis 21(8):1485-1490. PMID:10910948
  • Zhang L, Rothman N, Wang Y, Guo W, Hayes RB, Li G, Yin S, Smith MT. 2000. Spectrum of chromosomal changes detected by fluorescence in situ hybridization in workers exposed to benzene. Proc Am Assoc Cancer Res 41:Abstract2777.

1999

  • Liu Y, Jeng M, Lubin B, Smith MT. 1999. Large quantitative variation in V(D)J recombination error among children. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.477.
  • Rothman N, Campleman S, Hayes RB, Hoener B, Yin S, Dosemeci M, Meyer KB, Li G, Zhang L, Smith MT. 1999. High CYP2E1 activity is a risk factor for benzene poisoning. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.282.
  • Rothman N, Traver RD, Smith MT, Hayes RB, Li G, Campleman S, Dosemeci M, Zhang L, Linet MS, Wacholder S, Yin S, Ross D. 1999. Lack of NAD(P)H:quinone oxidoreductase activity (NQ01) is associated with increased risk of benzene hematotoxicity. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.258.
  • Smith MT. 1999. Benzene, NQO1, and genetic susceptibility to cancer. Proc Natl Acad Sci U S A 96(14):7624-7626. PMID:10393869
  • Smith MT, Zhang L, Wang Y, Li G, Hayes RB, Kolachana P, Dosemeci M, Holland NT, Xi L, Yin S, Rothman N. 1999. Translocations between chromosome 8 and 21 in workers exposed to benzene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Traver RD, Rothman N, Smith MT, Yin S, Hayes RB, Li G, Franklin WF, Ross D. 1999. Incidence of a polymorphism in NAD(P)H: Quinone Oxidoreductase (NQO1). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.278.
  • Xi L, Zhang L, Wang Y, Smith MT. 1999. Induction of chromosome-specific aneusomy and micronuclei in human lymphocytes by metabolites of 1, 3-butadiene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Yeowell-O'Connell K, Rothman N, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1999. Hemoglobin adducts of benzene oxide in workers exposed to high levels of benzene in China. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.251.
  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1999. Albumin adducts of benzene oxide, 1, 2- and 1, 4 benzoquinones in benzene exposed workers. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.477.
  • Zhang L, Rothman N, Li G, Wang Y, Hayes RB, Guo W, Lu W, Zhang D, Yin S, Smith MT. 1999. Molecular cytogenetics of humans exposed to benzene and 1,3-butadiene. In: Proceedings of the 1999 HEI (The Health Effects Institute ) Annual Conference. San Diego, CA.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1999. Benzene exposure is associated with increased aneusomy and long arm deletion of chromosomes 5 and 7 in Chinese workers. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.628.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Li G, Smith MT. 1999. Aneuploidy of chromosomes 7, 8 and 9 detected by fluorescence in situ hybridization in workers exposed to benzene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.112.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Wang Y, Kolachana P, Lu W, Xi L, Li G, Smith MT. 1999. Benzene increases aneuploidy in the lymphocytes of exposed workers: A comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells. Environ Mol Mutagen 34:260-268. PMID:10618174
  • Zhang L, Wang Y, Shang N, Smith MT. 1999. Differential chromosome sensitivity to aneuploidy induced by benzene and its metabolites. Proc Am Assoc Cancer Res Abstract3365.

1998

  • Holland NT, Jacob RA, Shang N, Balaraman A, Smith MT. 1998. Micronuclei in lymphocytes and exfoliated buccal cells of postmenopausal women with dietary changes in folate. Mutat Res 417(2-3):101-114. PMID:9733936
  • Jeng M, Holland NT, Smith MT. 1998. A comparison of cytogenetic damage in human hematopoietic CD34+ progenitor cells and peripheral blood lymphocytes. Blood 92(10,supp.1):
  • Liu Y, Jeng M, Lubin B, Smith MT. 1998. Large quantitative variation in V(D)J recombination error among children. Chapter 39in: Proceedings of the Eighty Nineth Annual Meeting of the (AACR) American Association for Cancer Research, March 28th-April 1st, 1998. New Oreleans, LA. pp.477Abstract.
  • Rothman N, Bechtold WE, Yin S, Dosemeci M, Li G, Wang Y, Griffith WC, Smith MT, Hayes RB. 1998. Urinary excretion of phenol, catechol, hydroquinone, and muconic acid by workers occupationally exposed to benzene. Occup Environ Med 55(10):705-711. PMID:9930093
  • Smith MT. 1998. Genetic susceptibility and risk factors for leukemia. J Biomol Struct Dyn 16:149-187.
  • Smith MT, Rothman N. 1998. Biomarkers of leukemia risk from benzene. In: Biomarkers: Medical and Workplace Applications. Joseph Henry Press, Washington, DC. pp.355-374.
  • Smith MT, Rothman N, Yin S. 1998. Biomarkers in the molecular epidemiology of benzene exposed workers. Environ Mol Mutagen 31(29):24.
  • Smith MT, Zhang L. 1998. Biomarkers of leukemia risk: benzene as a model. Environ Health Perspect 106(4):937-946. PMID:9703476
  • Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels JL, Dosemeci M, Holland NT, Xi L, Kolachana P, Yin S, Rothman N. 1998. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res 58(10):2176-2181. PMID:9605763
  • Titenko-Holland N, Ahlborn T, Lowe X, Shang N, Smith MT, Wyrobek AJ. 1998. Micronucleal and developmental abnormalities in 4-day mouse embryos after paternal treatment with acrylamide. Environ Mol Mutagen 31(3):206-217. PMID:9585259
  • Titenko-Holland N, Shao J, Zhang L, Xi L, Ngo H, Shang N, Smith MT. 1998. Studies on the genotoxicity of molybdenum salts in human cells in vitro and in mice in vivo. Environ Mol Mutagen 32(3):251-259. PMID:9814440
  • Titenko-Holland N, Zhang L, Smith MT. 1998. Biomarkers of genetic damage in humans. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, Honolulu, Hawaii, 22-24 April, 1998. Honolulu, HI. pp.141-143.
  • Yeowell-O'Connell K, Rothman N, Smith MT, Hayes RB, Li G, Waidyanatha S, Dosemeci M, Zhang L, Yin S, Titenko-Holland N, Rappaport SM. 1998. Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene. Carcinogenesis 19(9):1565-1571. PMID:9771926
  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1998. Albumin adducts of benzene oxide, 1, 2-and 1, 4 benzoquinones in benzene exposed workers. Chapter 39in: Proceedings of the Eighty Nineth Annual Meeting of the (AACR) American Association for Cancer Research, March 28th-April 1st, 1998. New Oreleans, LA. pp.477.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1998. Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis 19(11):1955-1961. PMID:9855009
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Titenko-Holland N, Yin S, Shang N, Smith MT. 1998. The loss and long arm deletions of chromosomes 5 and 7 in human lymphocytes treated with benzene metabolites and in workers exposed to benzene. Environ Mol Mutagen 31(29):72.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Kolachana P, Xi L, Li G, Smith MT. 1998. A comparison of interphase and metaphase FISH analysis of aneusomy in benzene-exposed workers. Environ Mol Mutagen 31(29):72.
  • Zhang L, Wang L, Shang N, Smith MT. 1998. Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes. Leuk Res 22(2):105-113. PMID:9593466

1997

  • Biggs ML, Kalman DA, Moore LE, Hopenhayn-Rich C, Smith MT, Smith AH. 1997. Relationship of urinary arsenic to intake estimates and a biomarker of effect, bladder cell micronuclei. Mutat Res Rev Mutat Res 386:185-195. PMID:9219557
  • Fanning EW, Bois FY, Rothman N, Bechtold WE, Li G, Hayes RB, Smith MT. 1997. Population toxicokinetics of benzene and its metabolites. In: Proceedings of the 36th Society of Toxicology (SOT) Annual Meeting, March 9-13, 1997. Cincinnati, OH.
  • Holland NT, Shao J, Zhang L, Ngo H, Shang N, Smith MT. 1997. Molybdenum salts are genotoxic. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. 1997. Decrease in bladder cell micronucleus prevalance after intervention to lower the concentration of arsenic in drinking water. Cancer Epidemiol Biomarkers Prev 6(12):1051-1056. PMID:9419402
  • Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. 1997. Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water. Cancer Epidemiol Biomarkers Prev 6(1):31-36. PMID:8993795
  • Rothman N, Smith MT, Hayes RB, Traver RD, Hoener B, Campleman S, Li G, Dosemeci M, Linet MS, Zhang L, Xi L, Wacholder S, Lu W, Meyer KB, Titenko-Holland N, Stewart JT, Yin S, Ross D. 1997. Benzene poisoning, a risk factor for hematologic malignancy, is associated with the NQ01 609C->T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res 57(14):2839-2842. PMID:9230185
  • Smith MT, Fanning EW. 1997. Mechanism Based Risk Assessment for Benzene-induced Leukemia. In: Proceedings of the 36th Society of Toxicology (SOT) Annual Meeting, March 9-13, 1997. Cincinnati, OH.
  • Smith MT, Fanning EW. 1997. Report on the workshop entitled: modeling chemically-induced leukemia - implications for benzene risk assessment. Leuk Res 21(5):361-374. PMID:9225061
  • Smith MT, Rothman N, Yin S, Zhang L, Dosemeci M, Wang Y, Li G, Hayes RB. 1997. Benzene exposure and risk of MDS/AML. Leuk Res Supp.1:S3.
  • Subrahmanyam VV, Smith MT. 1997. Free radical mediated hematopoietic toxicity by drugs, environmental pollutants and ionizing radiation. In: Free Radical Toxicology. Taylor and Francis, pp.249-278.
  • Xi L, Zhang L, Wang Y, Smith MT. 1997. Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene. Carcinogenesis 18(9):1687-1693. PMID:9328162
  • Xi L, Zhang L, Wang Y, Smith MT. 1997. Induction of chromosome-specific aneusomy and micronuclei in human lymphocytes by metabolites of 1, 3-butadiene. Chapter 38in: Proceedings of the Eighty Eightieth Annual Meeting of the (AACR) American Association for Cancer Research, 1997.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1997. Benzene exposure is associated with increased aneusomy and long arm deletion of chromosomes 5 and 7 in Chinese workers. Chapter 38in: Proceedings of the Eighty Eightieth Annual Meeting of the (AACR) American Association for Cancer Research, 1997. pp.628.

1996

  • Bois FY, Jackson ET, Pekari K, Smith MT. 1996. Population toxicokinetics of benzene. Environ Health Perspect 104(Suppl.6):1405-1411. PMID:9118927
  • Buffler PA, Reynolds P, Smith MT, Lea CS, Wood S. 1996. The molecular epidemiology of childhood leukemia with emphasis on chemical exposures. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, November 4-8, 1996, Kuala Lumpur, Malaysia. East-West Center, Kuala Lumpur, Malaysia.
  • Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Warner M, Kalman DA, Smith MT. 1996. Increased micronuclei found in two populations environmentally exposed to arsenic. Clin Chem 41(12):1915-1917.
  • Moore LE, Warner M, Smith AH, Kalman DA, Smith MT. 1996. Use of the fluorescent micronucleus assay to detect the clastogenic effects of radiation and arsenic in human exfoliated epithelial cells. Environ Mol Mutagen 27:176-184. PMID:8625953
  • Rothman N, Li G, Dosemeci M, Bechtold WE, Marti GE, Wang Y, Linet MS, Xi L, Lu W, Smith MT, Titenko-Holland N, Zhang L, Blot W, Yin S, Hayes RB. 1996. Hematotoxicity among Chinese workers heavily exposed to benzene. Am J Ind Med 29:236-246. PMID:8833776
  • Rothman N, Smith MT, Hayes RB, Li G, Irons RD, Dosemeci M, Haas R, Stillman WS, Linet MS, Xi L, Bechtold WE, Wiemels JL, Campleman S, Zhang L, Quintana PJ, Titenko-Holland N, Wang Y, Lu W, Kolachana P, Meyer KB, Yin S. 1996. An epidemiologic study of early biologic effects of benzene in Chinese workers. Environ Health Perspect 104(6):1365-1370. PMID:9118921
  • Rothman N, Traver RD, Smith MT, Hayes RB, Li G, Campleman S, Dosemeci M, Zhang L, Linet MS, Wacholder S, Yin S, Ross D. 1996. Lack of NAD(P)H:quinone oxidoreductase activity (NQ01) is associated with increased risk of benzene hematotoxicity. Chapter 37in: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.258.
  • Shao J, Zhang L, Semenza JC, Beach B, Smith MT. 1996. Tetrasomy 8 detected by interphase cytogenetics in a child with acute lymphocytic leukemia. Cancer Genet Cytogenet 92:135-140. PMID:8976370
  • Smith MT. 1996. Mechanistic studies of benzene toxicity: implications for risk assessment. In: Biological Reactive Intermediates V: Basic Mechanistic Research in Toxicology and Human Risk Assessment. Plenum Publishing, New York, NY. pp.259-266.
  • Smith MT. 1996. Overview of benzene-induced aplastic anaemia. Eur J Haematol 60:107-110. PMID:8987251
  • Smith MT. 1996. The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia. Environ Health Perspect 104(6):1219-1225. PMID:9118896
  • Smith MT, Rothman N. 1996. Diet and risk of human leukemia. In: Proceedings of the Meeting on Modulation of Chemical Toxicity and Risk Assessment. Tucson, AZ.
  • Smith MT, Rothman N, Zhang L, Wang Y, Hayes RB, Yin S. 1996. Molecular cytogenetics of humans exposed to benzene. Environ Health Perspect 30(1,part2):911.
  • Smith MT, Zhang L, Wang Y, Li G, Hayes RB, Kolachana P, Dosemeci M, Titenko-Holland N, Xi L, Yin S, Rothman N. 1996. Translocations between chromosome 8 and 21 in workers exposed to benzene. In: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996.
  • Traver RD, Rothman N, Smith MT, Yin S, Hayes RB, Li G, Franklin WF, Ross D. 1996. Incidence of a polymorphism in HAD(P)H: Quinone Oxidoreductase (NQO1). Chapter 37in: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.278.
  • Yeowell-O'Connell K, Rothman N, Wang Y, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1996. Hemoglobin adducts of benzene oxide in workers exposed to high levels of benzene in China. Chapter 37in: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.251.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Bechtold WE, Venkatesh P, Yin S, Wang Y, Dosemeci M, Li G, Lu W, Smith MT. 1996. Interphase cytogenetics of workers exposed to benzene. Environ Health Perspect 104Suppl6:1325-1329. PMID:9118914 PMCID:PMC1469718

1995

  • Chenna A, Hang B, Rydberg B, Kim E, Pongcracz K, Bodell WJ, Singer B. 1995. The benzene metabolite p-benzeoquinone forms adducts with DNA bases that are excised by repair activity from human cells that differs from an ethenoadenine glycosylase. Proc Natl Acad Sci U S A 92(13):5890-5894. PMID:7597048
  • Rothman N, Campleman S, Hayes RB, Hoener B, Yin S, Dosemeci M, Meyer KB, Li G, Zhang L, Smith MT. 1995. High CYP2E1 activity is a risk factor for benzene poisoning. Chapter 36in: Proceedings of the Eighty Sixth Annual Meeting of the (AACR) American Association of Cancer Research, March, 1995. Ontario, Canada. pp.282.
  • Rothman N, Haas R, Hayes RB, Li G, Wiemels JL, Campleman S, Quintana PJ, Xi L, Dosemeci M, Titenko-Holland N, Meyer KB, Lu W, Zhang L, Bechtold WE, Wang Y, Kolachana P, Yin S, Blot W, Smith MT. 1995. Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans. Proc Natl Acad Sci U S A 92(9):4069-4073. PMID:7732033
  • Salmon AG, Kizer KW, Zeise L, Jackson RJ, Smith MT. 1995. Potential carcinogenicity of chloral hydrate - a review. Journal of Toxicology and Clinical Toxicology 33(2):115-121. PMID:7897749
  • Schindler PA, Settineri CA, Collet X, Fielding CJ, Burlingame AL. 1995. Site specific detection and structural characterization of the glycosylation of human plasma proteins lecithin: Cholesterol acyltransferase (LCAT) and apolipoprotein D using HPLC-electrospray mass spectrometry and sequential glycosidase digestion. Protein Sci 4:791-803. PMID:7613477
  • Smith MT, Lea CS, Buffler PA. 1995. Human population changes caused by hazardous waste. Eur J Public Health 2(3):77-79. PMID:7655408
  • Titenko-Holland N, Turteltaub KW, Wyrobek AJ, Smith MT. 1995. Acrylamide induces DNA adducts in male germ cells and causes preimplantation abnormalities and dominant lethal mutations in mice. Environ Health Perspect 15(1):167.
  • Xi L, Zhang L, Smith MT. 1995. Butadiene metabolites induce micronuclei and aneuploidy in human lymphocytes. In: Proceedings of the International symposium on evaluation of butadiene & isoprene health risks. Blaine, WA.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Li G, Smith MT. 1995. Aneuploidy of chromosomes 7, 8 and 9 detected by fluorescence in situ hybridization in workers exposed to benzene. Chapter 36in: Proceedings of the Eighty Sixth Annual Meeting of the (AACR) American Association of Cancer Research, March, 1995. Ontario, Canada. pp.112.
  • Zhang L, Smith MT, Bandy B, Tamaki SJ, Davison AJ. 1995. Role of quinones, active oxygen species and metals in the genotoxicity of 1,2,4-benzenetriol, a metabolite of benzene. In: Free radicals in the Environment, and Toxicology. Richelieu Press, London, United Kingdom. pp.521-562.
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