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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of California-Berkeley: Biomarkers of Exposure Using Accelerator Mass Spectrometry

Superfund Research Program

Biomarkers of Exposure Using Accelerator Mass Spectrometry

Project Leader: Kenneth W. Turteltaub (Lawrence Livermore National Laboratory)
Grant Number: P42ES004705
Funding Period: 1995 - 2006

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Publications

2005

2004

  • Chepanoske CL, Brown K, Turteltaub KW, Dingley KH. 2004. Characterization of a peptide adduct formed by N-acetoxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a reactive intermediate of the food carcinogen PhIP. Food Chem Toxicol 42(8):1367-1372. doi:10.1016/j.fct.2003.11.012 PMID:15207388
  • Chiarappa-Zucca ML, Finkel RC, Martinelli RE, McAninch JE, Nelson DO, Turteltaub KW. 2004. Measurement of beryllium in biological samples by accelerator mass spectrometry: applications for studying chronic beryllium disease. Chem Res Toxicol 17(12):1614-20. PMID:15606137
  • Cupid BC, Lightfoot TJ, Russell D, Gant SJ, Turner PC, Dingley KH, Curtis KD, Leveson SH, Turteltaub KW, Garner RC. 2004. The formation of AFB(1)-macromolecular adducts in rats and humans at dietary levels of exposure. Food Chem Toxicol 42(4):559-569. PMID:15019179
  • Li YW, Shawgo RS, Tyler B, Henderson PT, Vogel JS, Rosenberg A, Storm PB, Langer R, Brem H, Cima MJ. 2004. In vivo release from a drug delivery MEMS device. Journal of Controlled Release 100(2):211-219. PMID:15544869
  • Neeley WL, Delaney JC, Henderson PT, Essigmann JM. 2004. In vivo bypass efficiencies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole. J Biol Chem 279(42):43568-43573. doi:10.1074/jbc.M407117200 PMID:15299010
  • Neeley WL, Henderson PT, Essigmann JM. 2004. Efficient synthesis of DNA containing the guanine oxidation-nitration product 5-guanidino-4-nitroimidazole: generation by a postsynthetic substitution reaction. Org Lett 6(2):245-248. PMID:14723539
  • Sandhu P, Vogel JS, Rose MJ, Ubick EA, Brunner JE, Wallace MA, Adelsberger JK, Baker MP, Henderson PT, Pearson PG, Baillie TA. 2004. Evaluation of microdosing strategies for studies in preclinical drug development: Demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range. Drug Metab Dispos 32(11):1254-1259. PMID:15286054

2003

  • Brown K, Harvey CA, Turteltaub KW, Shields SJ. 2003. Structural characterization of carcinogen-modified oligodeoxynucleotide adducts using matrix-assisted laser desorption/ionization mass spectrometry. J Mass Spectrom 38(1):68-79. PMID:12526008
  • Martin EA, Brown K, Gaskell M, Al-Azzawi F, Garner RC, Boocock DJ, Mattock E, Pring DW, Dingley KH, Turteltaub KW, Smith LL, White IN. 2003. Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry. Cancer Res 63(23):8461-8465. PMID:14679010
  • Turesky RJ, Richoz J, Constable A, Curtis KD, Dingley KH, Turteltaub KW. 2003. The effects of coffee on enzymes involved in metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine in rats. Chem Biol Interact 145(3):251-265. PMID:12732453
  • Turteltaub KW, Mani C. 2003. Benzene metabolism in rodents at doses relevant to human exposure from urban air. Res Rep Health Eff Inst (113):1-26;discussion27-35. PMID:12675491

2002

  • Brown K, Dingley KH, Vogel JS, Turteltaub KW. 2002. Accelerator Mass Spectrometry for Biomedical Research. In: Encyclopedia of Mass Spectrometry, Volume 1.

2001

  • Brown K, Guenther EA, Dingley KH, Cosman M, Harvey CA, Shields SJ, Turteltaub KW. 2001. Synthesis and spectroscopic characterization of site-specific 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine oligodeoxyribonucleotide adducts. Nucleic Acids Res 29:1951-1959. PMID:11328879

2000

  • Phillips DH, Farmer PB, Beland FA, Nath RG, Poirier MC, Reddy MV, Turteltaub KW. 2000. Methods of DNA adduct determination and their application to testing compounds for genotoxicity. Environ Mol Mutagen 35(3):222-233. PMID:10737957

1999

  • Holland NT, Ahlborn T, Turteltaub KW, Markee C, Moore DH, Wyrobek AJ, Smith MT. 1999. Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reprod Toxicol 13(3):167-178. PMID:10378466
  • Mauthe RJ, Dingley KH, Leveson SH, Freeman SP, Turesky RJ, Garner RC, Turteltaub KW. 1999. MeIQx-DNA adduct formation in rodent and human colon at low dose. Int J Cancer 4:539-545.
  • Turteltaub KW, Dingley KH, Curtis KD, Malfatti MA, Turesky RJ, Garner RC, Felton JS, Lang NP. 1999. Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses. Cancer Lett 143(2):149-155. PMID:10503895

1998

  • Dingley KH, Roberts ML, Velsko CA, Turteltaub KW. 1998. Attomole detection of 3H in biological samples using accelerator mass spectrometry: application in low-dose, dual-isotope tracer studies in conjunction with 14C accelerator mass spectrometry. Chem Res Toxicol 11(10):1217-1222. PMID:9778319
  • Mauthe RJ, Sideras-Haddad E, Turteltaub KW, Bench G. 1998. Quantitative imaging microscopy for the sensitive detection of administered metal containing drugs in single cells and tissue slices - a demonstration using platinum based chemotherapeutic agents. J Pharm Biomed Anal 17(4-5):651-663. PMID:9682148
  • Turteltaub KW, Mani C, Dingley KH, Bench G, Mauthe RJ. 1998. DNA Adducts Using Accelerator Mass Spectrometry. In: Biomarkers: Medical and Workplace Applications. Joseph Henry Press, Washington, DC. pp.99-114.
  • Vogel JS, Turteltaub KW. 1998. Accelerator mass spectrometry as a bioanalytical tool for nutritional research. Advances in Experimental Medicine and Biology 445:397-410. PMID:9781403

1997

  • Creek MR, Mani C, Vogel JS, Turteltaub KW. 1997. Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice. Carcinogenesis 18(12):2421-2427. PMID:9450490
  • Kautiainen A, Vogel JS, Turteltaub KW. 1997. Dose-dependent binding of trichloroethylene to hepatic DNA and protein at low doses in mice. Chem Biol Interact 106(2):109-121. PMID:9366897

1995

  • Frantz CE, Bangerter C, Fultz E, Mayer KM, Vogel JS, Turteltaub KW. 1995. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. Carcinogenesis 16(2):367-373. PMID:7859370
  • Macgregor JT, Farr S, Tucker JD, Heddle JA, Tice RR, Turteltaub KW. 1995. New molecular endpoints and methods for routine toxicity testing. Fundam Appl Toxicol 26(2):156-173. PMID:7589905
  • Pathak DN, Levay G, Bodell WJ. 1995. DNA adduct formation in the bone marrow of B6C3F1 mice treated with benzene. Carcinogenesis 16(8):1803-1808. PMID:7634407
  • Sadinski WJ, Levay G, Wilson MC, Hoffman JR, Bodell WJ, Anderson SL. 1995. Relationships among DNA adducts, micronuclei, and fitness parameters in Xenopus laevis exposed to benzo[a]pyrene. Aquat Toxicol 32(4):333-352.
  • Vogel JS, Turteltaub KW, Finkel R, Nelson DE. 1995. Accelerator mass spectrometry: isotope identification at attomole sensitivity. Anal Chem 67(11):353A-359A.
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