Superfund Research Program
Determinants for Chromosomally Defective Human Sperm
Project Leaders: Andrew J. Wyrobek (Lawrence Livermore National Laboratory), Brenda Eskenazi
Grant Number: P42ES004705
Funding Period: 2000 - 2006
Project-Specific Links
- Project Summary
Publications
2020
- Frias S, van Hummelen P, Meistrich ML, Wyrobek AJ. 2020. Meiotic susceptibility for induction of sperm with chromosomal aberrations in patients receiving combination chemotherapy for Hodgkin lymphoma. PLoS One 15:e0242218. doi:10.1371/journal.pone.0242218 PMID:33370316 PMCID:PMC7769287
2013
- Schmid TE, Grant PG, Marchetti F, Weldon RH, Eskenazi B, Wyrobek AJ. 2013. Elemental composition of human semen is associated with motility and genomic sperm defects among older men. Hum Reprod 28:274-282. doi:10.1093/humrep/des321 PMID:23042799 PMCID:PMC3619967
2012
- Schmid TE, Eskenazi B, Marchetti F, Young SS, Weldon RH, Baumgartner A, Anderson D, Wyrobek AJ. 2012. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril 98:1130-1137. doi:10.1016/j.fertnstert.2012.07.1126 PMID:22935557
2008
- Young SS, Eskenazi B, Marchetti F, Block G, Wyrobek AJ. 2008. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Hum Reprod 23(5):1014-1022. doi:10.1093/humrep/den036 PMID:18353905
2006
- Sloter E, Schmid TE, Marchetti F, Eskenazi B, Nath J, Eskenazi AJ. 2006. Quantitative effects of male age on sperm motion. Hum Reprod 21(11):2868-75. PMID:16793993
2005
- Eskenazi B, Kidd SA, Marks AR, Sloter E, Block G, Wyrobek AJ. 2005. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 20(4):1006-1012. PMID:15665024
- Wyrobek AJ, Schmid TE, Marchetti F. 2005. Cross-species sperm-FISH assays for chemical testing and assessing paternal risk for chromosomally abnormal pregnancies. Environ Mol Mutagen 45(2-3):271-283. PMID:15754381
- Wyrobek AJ, Schmid TE, Marchetti F. 2005. Relative susceptibilities of male germ cells to genetic defects induced by cancer chemotherapies. J Natl Cancer Inst (34):31-35. doi:10.1093/jncimonographs/lgi001 PMID:15784819
2004
- Sloter E, Nath J, Eskenazi B, Wyrobek AJ. 2004. Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents. Fertil Steril 81(4):925-943. PMID:15066442
2003
- Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Young SS, Moore DH. 2003. The association of age and semen quality in healthy men. Hum Reprod 18(2):447-454. PMID:12571189
- Glaser RL, Broman KW, Schulman RL, Eskenazi B, Wyrobek AJ, Jabs EW. 2003. The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet 73(4):939-947. PMID:12900791
2002
- Eskenazi B, Wyrobek AJ, Kidd SA, Lowe X, Moore DH, Weisiger K, Aylstock M. 2002. Sperm aneuploidy in fathers of children with paternally and maternally inherited Klinefelter syndrome. Hum Reprod 17(3):576-583. PMID:11870106
- Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore LE, Young SS, Moore DH, Nath J. 2002. Semen quality and chromosomal integrity of sperm decreases with age among healthy men. Environ Mol Mutagen 39(Supp33):59.
- Rubes J, Vozdova M, Robbins WA, Rezacova O, Perreault SD, Wyrobek AJ. 2002. Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy. Am J Hum Genet 70(6):1507-1519. PMID:11992257
- Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N. 2002. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A 99(23):14952-14957. PMID:12397172
- Velazquez-Wong AC, Sloter E, Tomascik-Cheeseman LM, Araujo-Solis MA, Wyrobek AJ, Salamanca-Gomez F. 2002. Structural and numerical chromosomal abnormalities in sperm following accidental occupational exposure to 192Iridium. Environ Mol Mutagen 39(Supp33):65.
2001
- Kidd SA, Eskenazi B, Wyrobek AJ. 2001. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 75(2):237-248. PMID:11172821
- Lowe X, Eskenazi B, Nelson DO, Kidd SA, Alme A, Wyrobek AJ. 2001. Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome. Am J Hum Genet 69(5):1046-1054. PMID:11582569
- Marchetti F, Sloter E, Wyrobek AJ. 2001. Advances in understanding paternally transmitted chromosomal abnormalities. In: Impact of air pollution on human health. Academia Press, Prague, Czech Republic. pp.193-205.
- Sloter E, Eskenazi B, Kidd SA, Moore DH, Hill F, Nath J, Wyrobek AJ. 2001. Effects of age on structural chromosomal abnormalities in sperm from healthy men. Environ Mol Mutagen 37(32):70.
1997
- Wyrobek AJ, Eskenazi B, Chuu Y, Kidd SA, Lowe X, Weisiger K, Aylstock M, Sloter E, Moore DH, Katz D. 1997. Genetic biomarkers in human sperm: Applications in reproductive epidemiology. In: Proceedings of the Superfund Basic Research Program: A decade of improving health through multi-disciplinary research, Chapel Hill, NC, February 23-26, 1997. Chapel Hill, NC.