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Project Publications: University of California-Berkeley: Using Adductomic Signatures to Evaluate Risks of Superfund Chemicals

Superfund Research Program

Using Adductomic Signatures to Evaluate Risks of Superfund Chemicals

Project Leader: Stephen M. Rappaport
Co-Investigator: Luoping Zhang
Grant Number: P42ES004705
Funding Period: 2017-2022

Project-Specific Links



  • Grigoryan H, Imani P, Sacerdote C, Masala G, Grioni S, Tumino R, Chiodini P, Dudoit S, Vineis P, Rappaport SM. 2023. HSA adductomics reveals sex differences in NHL incidence and possible involvement of microbial translocation. Cancer Epidemiol Biomarkers Prev 32(9):1217-1226. doi:10.1158/1055-9965.EPI-23-0231 PMID:37409972
  • Rahman ML, Bassig BA, Grigoryan H, Hu W, Hosgood H, Huang W, Wong JY, Strickland P, Rappaport SM, Lan Q, Rothman N. 2023. A nested case-control study of untargeted albumin adductomics and acute myeloid leukemia. Int J Cancer doi:10.1002/ijc.34550 PMID:37138425


  • Phillips RV, Wei L, Cardenas A, Hubbard AE, McHale CM, Vermeulen R, Wei H, Smith MT, Zhang L, Lan Q, Rothman N. 2022. Epigenome-wide association studies of occupational exposure to benzene and formaldehyde. Epigenetics 1-19. doi:10.1080/15592294.2022.2115604 PMID:36017556


  • Chung MK, Rappaport SM, Wheelock CE, Nguyen VK, van der Meer TP, Miller G, Vermeulen R, Patel CJ. 2021. Utilizing a biology-driven approach to map the exposome in health and disease: An essential investment to drive the next generation of environmental discovery. Environ Health Perspect 129(8):85001. doi:10.1289/EHP8327 PMID:34435882 PMCID:PMC8388254
  • Rana I, Dahlberg S, Steinmaus CM, Zhang L. 2021. Benzene exposure and non-Hodgkin lymphoma: A systematic review and meta-analysis of human studies. Lancet Planet Health 5(9):e633-e643. doi:10.1016/S2542-5196(21)00149-2 PMID:34450064
  • Rana I, Rieswijk L, Steinmaus CM, Zhang L. 2021. Formaldehyde and brain disorders: A meta-analysis and bioinformatics approach. Neurotox Res 39(3):doi:10.1007/s12640-020-00320-y PMID:33400181 (ahead of print)
  • Rothman N, Vermeulen R, Zhang L, Hu W, Yin S, Rappaport SM, Smith MT, Jones DP, Rahman M, Lan Q, Walker DI. 2021. Metabolome-wide association study of occupational exposure to benzene. Carcinogenesis 42(11):doi:10.1093/carcin/bgab089 PMID:34606590 (ahead of print)
  • Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick L, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. 2021. Cytokine levels at birth in children who developed acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 30(8):1526-1535. doi:10.1158/1055-9965.EPI-20-1704 PMID:34078642 PMCID:PMC8338848
  • Zhang P, Carlsten C, Chaleckis R, Hanhineva K, Huang M, Isobe T, Koistinen VM, Meister I, Papazian S, Sdougkou K, Xie H, Martin JW, Rappaport SM, Tsugawa H, Walker DI, Woodruff TJ, Wright RO, Wheelock CE. 2021. Defining the scope of exposome studies and research needs from a multidisciplinary perspective. Environ Sci Technol Lett 8(10):839-852. doi:10.1021/acs.estlett.1c00648 PMID:34660833 PMCID:PMC8515788
  • Zhao Y, Magana L, Cui H, Huang J, McHale CM, Yang X, Looney MR, Li R, Zhang L. 2021. Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose. Arch Toxicol 95(2):693-701. doi:10.1007/s00204-020-02932-x PMID:33084937 PMCID:PMC7878325
  • Zhao Y, Wei L, Tagmount A, Loguinov AV, Sobh A, Hubbard AE, McHale CM, Chang C, Vulpe CD, Zhang L. 2021. Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity. Chemosphere 269:128701. doi:10.1016/j.chemosphere.2020.128701 PMID:33189395 PMCID:PMC7904579


  • Guo H, Ahn S, Zhang L. 2020. Benzene-associated immunosuppression and chronic inflammation in humans: a systematic review. Occup Environ Med doi:10.1136/oemed-2020-106517 PMID:32938756
  • Schildroth S, Osborne G, Smith A, Yip C, Collins C, Smith MT, Sandy MS, Zhang L. 2020. Occupational exposure to antimony trioxide: A risk assessment. Occup Environ Med doi:10.1136/oemed-2020-106980 PMID:33243757 PMCID:PMC8149478 (ahead of print)
  • Sille FC, Karakitsios S, Kleensang A, Koehler K, Maertens A, Miller G, Prasse C, Quiros-Alcala L, Ramachandran G, Rappaport SM, Rule A, Sarigiannis D, Smirova L, Hartung T. 2020. The exposome: A new approach for risk assessment. ALTEX 37:3-23. doi:10.14573/altex.2001051 PMID:31960937
  • Smith MT, Guyton KZ, Kleinstreuer N, Borrell A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson III WH, Houck K, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden MR. 2020. The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiol Biomarkers Prev 29(10):doi:10.1158/1055-9965.EPI-19-1346 PMID:32152214 PMCID:PMC7483401
  • Wheelock CE, Rappaport SM. 2020. The role of gene environment interactions in lung disease: The urgent need for the exposome. European Respiratory Journal 55:6. doi:10.1183/13993003.02064-2019 PMID:32029645
  • Yano Y, Schiffman C, Grigoryan H, Hayes J, Edmands WM, Petrick L, Whitehead TP, Metayer C, Dudoit S, Rappaport SM. 2020. Untargeted adductomics of newborn dried blood spots identifies modifications to human serum albumin associated with childhood leukemia. Leuk Res 88:106268. doi:10.1016/j.leukres.2019.106268 PMID:31760269 PMCID:PMC6937378
  • Zhang L, Guo H. 2020. Biomarkers of COVID-19 and technologies to combat SARS-CoV-2. Adv Biomark Sci Technol 2:1-23. doi:10.1016/j.abst.2020.08.001 PMID:33511330 PMCID:PMC7435336


  • Carlsson H, Rappaport SM, Tornqvist M. 2019. Protein Adductomics: Methodologies for Untargeted Screening of Adducts to Serum Albumin and Hemoglobin in Human Blood Samples. High Throughput 8(1):6. doi:10.3390/ht8010006 PMID:30857166 PMCID:PMC6473736
  • Grigoryan H, Schiffman C, Gunter MJ, Naccarati A, Polidoro S, Dagnino S, Dudoit S, Vineis P, Rappaport SM. 2019. Cys34 adductomics links colorectal cancer with the gut microbiota and redox biology. Cancer Res 79(23):6024-6031. doi:10.1158/0008-5472.CAN-19-1529 PMID:31641032 PMCID:PMC6891211
  • Lee KM, Zhang L, Vermeulen R, Hu W, Bassig BA, Wong JJ, Qiu C, Purdue MP, Wen C, Walker DI, Jones DP, Li L, Huang Y, Rothman N, Smith MT, Lan Q. 2019. Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards. Occup Environ Med 76(6):376-381. doi:10.1136/oemed-2018-105583 PMID:30971425 PMCID:PMC6953904
  • Schiffman C, Petrick L, Perttula K, Yano Y, Carlsson H, Whitehead TP, Metayer C, Hayes J, Rappaport SM, Dudoit S. 2019. Filtering procedures for untargeted LC-MS metabolomics data. BMC Bioinformatics 20(1):334. doi:10.1186/s12859-019-2871-9 PMID:31200644 PMCID:PMC6570933



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