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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of Cincinnati: Molecular Mechanisms of Complex Mixture Toxicity

Superfund Research Program

Molecular Mechanisms of Complex Mixture Toxicity

Project Leader: Alvaro Puga
Grant Number: P42ES004908
Funding Period: 2001 - 2006

Project-Specific Links

Publications

2009

  • Chen L, Ovesen JL, Puga A, Xia Y. 2009. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environ Health Perspect 117(7):1124-30. PMID:19654923

2007

  • Reichard JF, Schnekenburger M, Puga A. 2007. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem Biophys Res Commun 352(1):188-92. PMID:17107663
  • Schnekenburger M, Talaska G, Puga A. 2007. Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol Cell Biol 27(20):7089-101. PMID:17682057

2005

  • Kann S, Estes C, Reichard JF, Huang M, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A. 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci 87(2):365-384. PMID:16014739
  • Kann S, Huang M, Estes C, Reichard JF, Sartor MA, Xia Y, Puga A. 2005. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Mol Pharmacol 68(2):336-346. doi:10.1124/mol.105.011841 PMID:15894712
  • Marlowe JL, Puga A. 2005. Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. J Cell Biochem 96(6):1174-1184. doi:10.1002/jcb.20656 PMID:16211578
  • Puga A, Tomlinson CR, Xia Y. 2005. Ah receptor signals cross-talk with multiple developmental pathways. Biochem Pharmacol 69(2):199-207. PMID:15627472

2004

  • Tan Z, Huang M, Puga A, Xia Y. 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicol Sci 82(1):80-87. doi:10.1093/toxsci/kfh228 PMID:15272135
  • Vonderheide AP, Meija J, Tepperman K, Puga A, Pinhas AR, States JC, Caruso JA. 2004. Retention of Cr(III) by high-performance chelation ion chromatography interfaced to inductively-coupled plasma mass spectrometric detection with collision cell. J Chromatogr A 1024(1-2):129-137. PMID:14753715
  • Wei Y, Tepperman K, Huang M, Sartor MA, Puga A. 2004. Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J Biol Chem 279(6):4110-4119. PMID:14625279

2002

  • Maier A, Schumann BL, Chang X, Talaska G, Puga A. 2002. Arsenic coexposure potentiates benzo[a]pyrene genotoxicity. Mutat Res 517(1-2):101-111. PMID:12034312
  • Tan Z, Chang X, Puga A, Xia Y. 2002. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochem Pharmacol 64(5-6):771-780. PMID:12213569

2000

  • Maier A, Dalton TP, Puga A. 2000. Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic. Mol Carcinog 28:225-235. PMID:10972992
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