Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Project Publications: Michigan State University: PCB Effects on Uterine Muscle

Superfund Research Program

PCB Effects on Uterine Muscle

Project Leader: Rita Loch-Caruso (University of Michigan)
Grant Number: P42ES004911
Funding Period: 1995 - 2006

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page

Publications

2006

  • Brant KA, Loch-Caruso R. 2006. PCB 50 stimulates release of arachidonic acid and prostaglandins from late gestation rat amnion fibroblast cells. Reprod Toxicol 22(4):591-8. PMID:16713698

2004

  • Brant KA, Loch-Caruso R. 2004. Gestational increases and activation of rat uterine phospholipase A2 enzyme expression mediates PCB 50 - induced stimulation of uterine function. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Chung D, Loch-Caruso R. 2004. Role of gap junctions in the modification on rat uterine contraction by 2,2'-dichlorobiphenyl. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Loch-Caruso R, Galvez MM, Brant KA, Chung D. 2004. Cell and toxicant specific phosphorylation of conexin43: effects of lindane and TPA on rat myometrial and WB-F344 liver cell gap junctions. Cell Biol Toxicol 20(3):147-169. doi:10.1023/B:CBTO.0000029465.74815.62 PMID:15250540
  • Loch-Caruso R, Tsuneta T, Hanna M, Grindatti C, Quensen JF. 2004. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.

2003

  • Brant KA, Loch-Caruso R. 2003. iPLA2 contributes to the gestation day sensitivity to 2,2',4,6 tetrachlorobiphenyl-induced stimulation of contraction frequency in rat uterus. Biol Reprod 68:382Suppl.1.
  • Chung D, Loch-Caruso R. 2003. Role of oxidative stress in the modification on rat uterine contraction by 2,2 '-dichlorobiphenyl. Toxicol Sci 72(1):376.
  • Nasser F, Chung D, Loch-Caruso R. 2003. Roles of endocannabinoids in rat uterine contractions. Biol Reprod 68:390Suppl.1.

2002

  • Loch-Caruso R. 2002. Uterine muscle as a potential target of polychlorinated biphenyls during pregnancy. Int J Hyg Environ Health 205:121-130. PMID:12018005

1999

  • Bae J, Peters-Golden M, Loch-Caruso R. 1999. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture Aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. J Pharmacol Exp Ther 289:1112-1120. PMID:10215694
  • Bae J, Stuenkel E, Loch-Caruso R. 1999. Stimulation of oscillatory uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca2+]i through voltage-operated calcium channels. Toxicol Appl Pharmacol 155(3):261-272. PMID:10079212

1997

  • Tsai M, Webb RC, Loch-Caruso R. 1997. The increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor-mediated. Biol Reprod 56(2):341-347. PMID:9116132

1996

  • Bae J, Loch-Caruso R. 1996. Stimulation of rat uterine oscillatory contraction by a polychlorinated biphenyl mixture, Aroclor 1242, and its sustained effect after removal of the compound. Biol Reprod 54(supp.):182.
  • Loch-Caruso R, Tsai M. 1996. Possible involvement of gap junctions in the development of spontaneous oscillatory contractions in uteri. Biol Reprod 54(supp.):118.
  • Tsai M, Webb RC, Loch-Caruso R. 1996. Congener-specific effects of PCBs on contractions of pregnant rat uteri. Reprod Toxicol 10(1):21-28. PMID:8998381

1995

  • Criswell KA, Loch-Caruso R. 1995. Lindane-induced elimination of gap junctional communication in rat uterine myocytes is mediated by an arachidonic acid-sensitive cAMP-independent mechanism. Toxicol Appl Pharmacol 135(1):127-138. PMID:7482532
  • Criswell KA, Loch-Caruso R, Stuenkel E. 1995. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messenger. Toxicol Appl Pharmacol 130:280-293. PMID:7532876
Back
to Top