Superfund Research Program

PCB Effects on Uterine Muscle

Project Leader: Rita Loch-Caruso (University of Michigan)
Grant Number: P42ES004911
Funding Period: 1995 - 2006

Project-Specific Links

Publications

2006

• Brant KA, Loch-Caruso R. 2006. PCB 50 stimulates release of arachidonic acid and prostaglandins from late gestation rat amnion fibroblast cells. Reprod Toxicol 22(4):591-8. PMID:16713698

2004

• Brant KA, Loch-Caruso R. 2004. Gestational increases and activation of rat uterine phospholipase A2 enzyme expression mediates PCB 50 - induced stimulation of uterine function. In: Proceedings of the 43^rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
• Chung D, Loch-Caruso R. 2004. Role of gap junctions in the modification on rat uterine contraction by 2,2'-dichlorobiphenyl. In: Proceedings of the 43^rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
• Loch-Caruso R, Galvez MM, Brant KA, Chung D. 2004. Cell and toxicant specific phosphorylation of conexin43: effects of lindane and TPA on rat myometrial and WB-F344 liver cell gap junctions. Cell Biol Toxicol 20(3):147-169. doi:10.1023/B:CBTO.0000029465.74815.62 PMID:15250540
• Loch-Caruso R, Tsuneta T, Hanna M, Grindatti C, Quensen JF. 2004. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. In: Proceedings of the 43^rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.

2003

• Brant KA, Loch-Caruso R. 2003. iPLA2 contributes to the gestation day sensitivity to 2,2',4,6 tetrachlorobiphenyl-induced stimulation of contraction frequency in rat uterus. Biol Reprod 68:382Suppl.1.
• Chung D, Loch-Caruso R. 2003. Role of oxidative stress in the modification on rat uterine contraction by 2,2 '-dichlorobiphenyl. Toxicol Sci 72(1):376.
• Nasser F, Chung D, Loch-Caruso R. 2003. Roles of endocannabinoids in rat uterine contractions. Biol Reprod 68:390Suppl.1.

2002

• Loch-Caruso R. 2002. Uterine muscle as a potential target of polychlorinated biphenyls during pregnancy. Int J Hyg Environ Health 205:121-130. PMID:12018005

1999

• Bae J, Peters-Golden M, Loch-Caruso R. 1999. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture Aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. J Pharmacol Exp Ther 289:1112-1120. PMID:10215694
• Bae J, Stuenkel E, Loch-Caruso R. 1999. Stimulation of oscillatory uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca2+]i through voltage-operated calcium channels. Toxicol Appl Pharmacol 155(3):261-272. PMID:10079212

1997

• Tsai M, Webb RC, Loch-Caruso R. 1997. The increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor-mediated. Biol Reprod 56(2):341-347. PMID:9116132

1996

• Bae J, Loch-Caruso R. 1996. Stimulation of rat uterine oscillatory contraction by a polychlorinated biphenyl mixture, Aroclor 1242, and its sustained effect after removal of the compound. Biol Reprod 54(supp.):182.
• Loch-Caruso R, Tsai M. 1996. Possible involvement of gap junctions in the development of spontaneous oscillatory contractions in uteri. Biol Reprod 54(supp.):118.
• Tsai M, Webb RC, Loch-Caruso R. 1996. Congener-specific effects of PCBs on contractions of pregnant rat uteri. Reprod Toxicol 10(1):21-28. PMID:8998381

1995

• Criswell KA, Loch-Caruso R. 1995. Lindane-induced elimination of gap junctional communication in rat uterine myocytes is mediated by an arachidonic acid-sensitive cAMP-independent mechanism. Toxicol Appl Pharmacol 135(1):127-138. PMID:7482532
• Criswell KA, Loch-Caruso R, Stuenkel E. 1995. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messenger. Toxicol Appl Pharmacol 130:280-293. PMID:7532876