Superfund Research Program

The role of HMGCR in Modulating TCDD-induced, AHR-mediated NAFLD

Project Leader: Timothy R. Zacharewski
Grant Number: P42ES004911
Funding Period: 2022-2027

Project-Specific Links

Publications

2025

• Yuan K, Nault R. 2025. Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations. Environ Epidemiol doi:10.1093/toxsci/kfaf065 PMID:40445920

2024

• Cholico G, Nault R, Zacharewski T. 2024. Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure. BMC Genomics 25(1):809. doi:10.1186/s12864-024-10730-3 PMID:39198768

2023

• Cholico G, Fling RR, Sink WJ, Nault R, Zacharewski T. 2023. Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice. J Biol Chem 300(1):105500. doi:10.1016/j.jbc.2023.105500 PMID:38013089 PMCID:10731612
• Cholico G, Orlowska K, Fling RR, Sink WJ, Zacharewski N, Fader KA, Nault R, Zacharewski TR. 2023. Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver. Sci Rep 13(1):4138. doi:10.1038/s41598-023-31087-9 PMID:36914879 PMCID:PMC1001158
• Jurgelewicz A, Nault R, Harkema JR, Zacharewski TR, LaPres JJ. 2023. Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity. Sci Rep 13(1):16598. doi:10.1038/s41598-023-42972-8 PMID:37789023 PMCID:PMC10547718
• Kana O, Nault R, Filipovic D, Marri D, Zacharewski T, Bhattacharya S. 2023. Generative modeling of single-cell gene expression for dose-dependent chemical perturbations. Patterns 4(8):100817. doi:10.1016/j.patter.2023.100817 PMID:37602218 PMCID:10436058
• Nault R, Cave MC, Ludewig G, Moseley HN, Pennell KG, Zacharewski TR. 2023. A case for accelerating standards to achieve the FAIR principles of environmental health research experimental data. Environ Health Perspect 131(6):65001. PMID:37352010 PMCID:PMC10289218
• Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR. 2023. Cystine/glutamate Xc- antiprorter induction compensates for transsulfuration pathway repression by 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) to ensure cysteine for heptic glutathione biosynthesis. Chem Res Toxicol 36(6):900-915. doi:10.1021/acs.chemrestox.3c00017 PMID:37184393 PMCID:PMC10284067
• Rance N. 2023. How single-cell transcriptomics provides insight on hepatic responses to TCDD. Curr Opin Toxicol 36:100441. doi:10.1016/j.cotox.2023.100441 PMID:37981901 PMCID:PMC10653208

2022

• Liu R, Zacharewski TR, Conolly RB, Zhang Q. 2022. A physiologically based pharmacokinetic (PBPK) modeling framework for mixtures of dioxin-like compounds. Toxics 10(11):700. doi:10.3390/toxics10110700 PMID:36422908 PMCID:PMC9698634
• Nault R, Saha S, Bhattacharya S, Sinha S, Maiti T, Zacharewski TR. 2022. Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice. Toxicol Sci doi:10.1093/toxsci/kfac109 PMID:36222588