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Project Publications: University of Albany - SUNY: Neurochemical, Neurobehavioral, And Endocrine Effects of Developmental Exposure of Rats to Individual PCB Congeners

Superfund Research Program

Neurochemical, Neurobehavioral, And Endocrine Effects of Developmental Exposure of Rats to Individual PCB Congeners

Project Leader: Richard Seegal
Grant Number: P42ES004913
Funding Period: 1995 - 2000

Project-Specific Links



  • Bemis JC, Seegal R. 2000. Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells. Neurotoxicology 21(6):1123-1134. PMID:11233759
  • Seegal R. 2000. Coplanar PCB congeners are uterotropic in prepubertal rats. Society of Toxicology
  • Seegal R. 2000. Mechanisms of PCB-induced neurotoxicity. In: Proceedings of the 1st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY.
  • Seegal R, Okoniewski RJ, Bemis JC. 2000. Aroclor 1254 alters extra-cellular dopamine concentrations in adult rat striatum. In: Proceedings of the DIOXIN 2000 International Meeting. Monterey, CA.


  • Arcaro KF, Yi L, Seegal R, Vakharia D, Yang Y, Spink DC, Brosch KO, Gierthy JF. 1999. 2,2',6,6'-tetrachlorobiphenyl is estrogenic in vitro and in vivo. J Cell Biochem 72(1):94-102. PMID:10025670
  • Bemis JC, Seegal R. 1999. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environ Health Perspect 107:879-885. PMID:10544155
  • Casey AC, Berger D, Lombardo JP, Hunt A, Quimby FW. 1999. Aroclor 1242 inhalation and ingestion by Sprague-Dawley rats. J Toxicol Environ Health A 56(5):311-342. PMID:10094245
  • Seegal R. 1999. Polychlorinated biphenyls and methylmercury synergistically alter dopamine and intracellular calcium in vitro. In: Proceedings of the 17th International Neurotoxicology Conference. Little Rock, AR.
  • Seegal R, Brosch KO. 1999. The uterotropic actions of 3,4,5,3',4'-PCB are mediated by the estrogen receptor. In: Proceedings of the 38th Annual Meeting of the Society of Toxicology (SOT), March, 1999. New Orleans, LA.


  • Kodavanti PR, Ward TR, Derr-Yellin EC, Mundy WR, Casey AC, Bush B, Tilson HA. 1998. Congener-specific distribution of polychlorinated biphenyls in brain regions, blood, liver, and fat of adult rats following repeated exposure to Aroclor 1254. Toxicol Appl Pharmacol 153:199-210. PMID:9878591
  • Seegal R. 1998. Neurochemical effects of co-planar and non-coplanar polychlorinated biphenyls. In: Neurobehavioral Teratology Society Meeting. San Diego, CA.
  • Seegal R, Bemis JC, Okoniewski RJ. 1998. Polychlorinated biphenyls interact with other Great Lakes fish-borne contaminants to alter dopamine function in vitro. In: Proceedings of the DIOXIN 1998 International Meeting. Stockholm, Sweden.
  • Seegal R, Gierthy JF, Arcaro KF, Brosch KO. 1998. Neurochemical and neuroendocrine effects of non-coplanar and coplanar PCBs. Fundam Appl Toxicol 41:49-61.
  • Seegal R, Pappas BA, Park GA. 1998. Neurochemical effects of consumption of Great Lakes salmon by rats. Regul Toxicol Pharmacol 27:S68-S75. PMID:9618335


  • Seegal R, Brosch KO, Okoniewski RJ. 1997. Effects of in utero and lactational exposure of the laboratory rat to 2,4,2',4'- and 3,4,3',4'-tetrachlorobiphenyl on dopamine function. Toxicol Appl Pharmacol 146:95-103. PMID:9299601


  • Carpenter DO, Stoner CT, Lawrence DA, Niemi WD, Shain W, Seegal R. 1996. Multiple mechanisms of PCB neurotoxicity. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, November 4-8, 1996, Kuala Lumpur, Malaysia. East-West Center, Kuala Lumpur, Malaysia. pp.404-418.
  • Chishti MA, Fisher JP, Seegal R. 1996. Aroclors 1254 and 1260 reduce dopamine concentrations in rat striatal slices. Neurotoxicology 17:653-660. PMID:9086486
  • Seegal R. 1996. Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit Rev Toxicol 26:709-737. PMID:8958469
  • Seegal R. 1996. Neurochemical effects of PCBs: limitations in extrapolation of in vitro effects to whole animals. Organohalogen Compounds 29:137-142.
  • Seegal R, Chishti MA, Gierthy JF. 1996. Uterotropic and neurochemical effects of 2,2',6,6'-tetrachlorobiphenyl in the prepubertal rat. Environ Health Perspect 30:227.


  • Hansen LG, Li MH, Saeed A, Bush B. 1995. Environmental polychlorinated biphenyls: acute toxicity of landfill soil extract to female prepubertal rats. Arch Environ Contam Toxicol 29(3):334-343. PMID:7487157
  • Seegal R. 1995. Dopaminergic bases of polychlorinated biphenyl-neurotoxicity. In: Neurotoxicology: Approaches and Methods. Academic Press, NY. pp.347-357.
  • Seegal R. 1995. Neurochemical effects of PCBs are structure and recipient age-dependent. Organohalogen Compounds 25:425-430.
  • Seegal R, Chishti MA. 1995. Polychlorinated biphenyls reduce dopamine content in striatal slices from immature and adult rats. Environ Health Perspect 15:146.
  • Seegal R, Chishti MA, Battaglioli G. 1995. Polychlorinated biphenyls decrease dopamine and elevate GABA content in striatal slices from adult rats. In: Proceedings of the 5th International Neurotoxicology Association Conference. Port Ludlow, WA. pp.18.
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