Skip Navigation

Project Publications: Texas A&M University: Detection, Prioritization and Detoxification of Developmental Toxicants Associated with Chemical Wastes

Superfund Research Program

Detection, Prioritization and Detoxification of Developmental Toxicants Associated with Chemical Wastes

Project Leader: Timothy D. Phillips
Grant Number: P42ES004917
Funding Period: 1995 - 2000
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Project-Specific Links



  • Alejandro NF, Parrish AR, Bowes RC, Burghardt RC, Ramos KS. 2000. Phenotypic profiles of cultured glomerular cells following repeated cycles of hydrocarbon injury. Kidney International 57:1571-1580. PMID:10760092
  • Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. PMID:10696774


  • Huebner HJ, Lemke SL, Mayura K, Phillips TD, Ottinger SE. 1999. Molecular characterization of high affinity, high capacity clays for the equilibrium sorption of ergotamine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 16(4):159-171. doi:10.1080/026520399284118 PMID:10560569
  • Lemke SL, Mayura K, Ottinger SE, McKenzie KS, Wang N, Fickey C, Kubena LF, Phillips TD. 1999. Assessment of the estrogenic effects of zearalenone after treatment with ozone utilizing the mouse uterine weight bioassay. J Toxicol Environ Health A 56(4):283-295. doi:10.1080/009841099158114 PMID:10706245
  • Mayura K, Huebner HJ, Dwyer MR, McKenzie KS, Donnelly KC, Kubena LF, Phillips TD. 1999. Multi-bioassay approach for assessing the potency of complex mixtures of polycyclic aromatic hydrocarbons. Chemosphere 38(8):1721-1732. PMID:10101844
  • Ottinger SE, Mayura K, Lemke SL, McKenzie KS, Wang N, Kubena LF, Phillips TD. 1999. Utilization of electrochemically generated ozone in the degradation and detoxification of benzo[a]pyrene. J Toxicol Environ Health A 56(8):565-583. doi:10.1080/009841099157511 PMID:10515574
  • Phillips TD. 1999. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol Sci 52:118-126. PMID:10630600
  • Springman KR, Mayura K, McDonald TJ, Donnelly KC, Kubena LF, Phillips TD. 1999. Organoclay adsorption of wood-preserving waste from groundwater. Environ Toxicol Chem 71(1-2):247-259.


  • Burghardt RC, Barhoumi R, Sanborn BM, Andersen J. 1998. Oxytocin-induced Ca2+ responses in human myometrial cells. Biol Reprod 60:777-782. PMID:10084948
  • Grant PG, Lemke SL, Dwyer MR, Phillips TD. 1998. Modified Langmuir equation for S-shaped and multi-site isotherm plots. Langmuir 14:4292-4299.
  • Grant PG, Phillips TD. 1998. Isothermal adsorption of aflatoxin B1 on HSCAS clay. J Agric Food Chem 46:599-605. PMID:10554284
  • Hutchinson RW, Barhoumi R, Miles J, Burghardt RC. 1998. Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. Toxicol Appl Pharmacol 151:311-318. PMID:9707507
  • Hutchinson RW, Ing NH, Burghardt RC. 1998. Induction of c-fos and cytochrome C oxidase subunits I and II by gossypol acetic acid in rat liver cells. Cell Biol Toxicol 14(6):391-399. PMID:9879931
  • Legare ME, Barhoumi R, Hebert E, Bratton GR, Burghardt RC, Tiffany-Castiglioni E. 1998. Analysis of Pb2+ entry into cultured astroglia. Toxicol Sci 46(1):90-100. doi:10.1006/toxs.1998.2492 PMID:9928672
  • Lemke SL, Grant PG, Phillips TD. 1998. Adsorption of zearalenone by organophilic montmorillonite clay. J Agric Food Chem 46:3789-3796.
  • Mayura K, Abdel-Wahhab MA, McKenzie KS, Sarr AB, Edwards JF, Naguib K, Phillips TD. 1998. Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: Potential for hidden risks. Toxicol Sci 41:175-182. PMID:9520353
  • McKenzie KS, Kubena LF, Denvir AJ, Rogers TD, Hitchens GD, Bailey RH, Harvey RB, Buckley SG, Phillips TD. 1998. Aflatoxicosis in turkey poults is prevented by treatment of naturally-contaminated corn with ozone generated by electrolysis. Poultry Science 77:1094-1102. PMID:9706072
  • Parrish AR, Fisher RL, Bral CM, Burghardt RC, Gandolfi A, Brendel K, Ramos KS. 1998. Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver slices. Toxicol Appl Pharmacol 152:302-308. PMID:9852999
  • Thompson DC, Barhoumi R, Burghardt RC. 1998. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol 149:55-63. PMID:9512727


  • Burghardt RC, Barhoumi R. 1997. Analysis of mechanisms of cellular injury on the micrometer scale. Microscopy and Microanalysis 3(2):37-38.
  • Dwyer MR, Kubena LF, Harvey RB, Mayura K, Sarr AB, Buckley SG, Bailey RH, Phillips TD. 1997. Effects of inorganic adsorbents and cyclopiazonic acid in broiler chickens. Poultry Science 76:1141-1149. PMID:9251144
  • Legare ME, Hanneman WH, Barhoumi R, Tiffany-Castiglioni E. 1997. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in primary astroglia: identification of biochemical and cellular targets. Neurotoxicology 18:515-524. PMID:9291499
  • McKenzie KS, Sarr AB, Mayura K, Bailey RH, Miller DR, Rogers TD, Norred WP, Voss KA, Plattner RD, Kubena LF, Phillips TD. 1997. Oxidative degradation and detoxification of mycotoxins using a novel source of ozone. Food Chem Toxicol 35(8):807-820. doi:10.1016/S0278-6915(97)00052-5 PMID:9350226
  • Meola S, Meola R, Barhoumi R, Miles J, Burghardt RC. 1997. Laser cytometric analysis of permethrin toxicity in insect and mammalian cells. Toxic Subst Mech 16:237-250.
  • Zhao F, Mayura K, Kocurek N, Edwards JF, Kubena LF, Safe SH, Phillips TD. 1997. Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl. Fundam Appl Toxicol 35:1-8. PMID:9024668
  • Zhao F, Mayura K, Safe SH, Phillips TD, Harper N. 1997. Inhibition of 3,3',4,4',5-Pentachlorobiphenyl induced fetal cleft palate and immunotoxicity in C57BL/6 mice by 2,2',4,4',5,5'-Hexacholorobiphenyl. Chemosphere 34(5-7):1605-1613. doi:10.1016/S0045-6535(97)00456-6 PMID:9134691
  • Zoran DL, Barhoumi R, Burghardt RC, Chapkin RS, Lupton JR. 1997. Diet and carcinogen alter luminal butyrate concentration and intracellular pH in isolated rat colonocytes. Nutr Cancer 27:222-230. PMID:9101550


  • Barhoumi R, Burghardt RC. 1996. Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. Fundam Appl Toxicol 30:290-297. PMID:8812278


  • Barhoumi R, Bailey RH, Burghardt RC. 1995. Kinetic analysis of glutathione in anchored cells with monochlorobimane. Cytometry Part A 19:226-234. PMID:7736868
  • Barhoumi R, Bailey RH, Hutchinson RW, Bowen JA, Burghardt RC. 1995. Enhancement of melphalan toxicity by octanol in ovarian adenocarcinoma cell lines: effects of altered cell-cell communication, glutathione levels and plasma membrane fluidity. Fundam Appl Toxicol 25:70-79. PMID:7601329
  • Hutchinson RW, Barhoumi R, Burghardt RC. 1995. Laser cytometric analysis of gossypol-induced cytotoxicity. Toxic Subst Mech 14:169-184.
  • Washburn KS, Phillips TD. 1995. Development of a field-practical assay for water-solvated chlorophenols. J Hazard Mater 41:371-381.
  • Zhao F, Mayura K, Hutchinson RW, Lewis RP, Burghardt RC, Phillips TD. 1995. Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells. Toxicol Lett 78(1):35-42. doi:10.1016/0378-4274(95)99684-A PMID:7604397
to Top