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Project Publications: Texas A&M University: Chemical Intervention Strategies

Superfund Research Program

Chemical Intervention Strategies

Project Leader: Timothy D. Phillips
Grant Number: P42ES004917
Funding Period: 2000-2008

Project-Specific Links



  • Phillips TD, Richardson MB, Cheng YL, He L, McDonald TJ, Cizmas LH, Safe SH, Donnelly KC, Wang F, Moorthy B, Zhou GD. 2015. Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89(6):967-977. doi:10.1007/s00204-014-1285-8 PMID:24888377 PMCID:PMC4254891


  • Taylor JF, Robinson A, Mitchell NJ, Marroquin-Cardona A, Johnson N, Elmore SE, Romoser AA, Phillips TD. 2013. In vivo efficacy of ferrihydrite as an enterosorbent for arsenic: Short-term evaluation in rodents. J Toxicol Environ Health A 76:167-175. doi:10.1080/15287394.2013.752322 PMID:23356646



  • Phillips TD, Afriyie-Gyawu E, Williams J, Huebner HJ, Ankrah N, Ofori-Adjei D, Jolly PE, Johnson N, Taylor JF, Marroquin-Cardona A, Xu L, Tang LS, Wang J. 2008. Reducing human exposure to aflatoxin through the use of clay: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25(2):134-145. doi:10.1080/02652030701567467 PMID:18286403


  • Dash B, Afriyie-Gyawu E, Huebner HJ, Porter WW, Wang J, Jolly PE, Phillips TD. 2007. Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. J Toxicol Environ Health A 70(1):58-66. doi:10.1080/15287390600748880 PMID:17162498
  • Dash B, Metz RP, Huebner HJ, Porter WW, Phillips TD. 2007. Molecular characterization of two superoxide dismutases from Hydra vulgaris. Gene 387(1-2):93-108. PMID:17150313


  • Dash B, Afriyie-Gyawu E, Huebner HJ, Porter WW, Wang J, Jolly PE, Phillips TD. 2006. Noninvasive identification of interindividual variation in xenobiotic-metabolizing enzymes: implications for cancer epidemiology and biomarker studies. J Toxicol Environ Health A 69(13):1203-1216. PMID:16754536
  • Jolly PE, Jiang Y, Ellis W, Awuah R, Nnedu O, Phillips TD, Wang J, Afriyie-Gyawu E, Tang L, Person S, Williams J, Jolly CM. 2006. Determinants of aflatoxin levels in Ghanaians: Sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. Int J Hyg Environ Health 209(4):345-358. PMID:16644281


  • Afriyie-Gyawu E, Mackie J, Dash B, Wiles MC, Taylor JF, Huebner HJ, Tang L, Guan H, Wang J, Phillips TD. 2005. Chronic toxicological evaluation of dietary NovaSil clay in Sprague-Dawley rats. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 22(3):259-169. PMID:16019794
  • Afriyie-Gyawu E, Wiles MC, Richardson MB, Fickey C, Phillips TD. 2005. Prevention of zearalenone-induced hyperestrogenism in prepubertal mice. J Toxicol Environ Health A 68(5):353-368. PMID:15799627
  • Wang J, Luo H, Billam M, Wang Z, Guan H, Tang L, Goldston T, Afriyie-Gyawu E, Lovett C, Griswold J, Brattin B, Taylor RJ, Huebner HJ, Phillips TD. 2005. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 22(3):270-279. PMID:16019795
  • Wiles MC, Huebner HJ, McDonald TJ, Donnelly KC, Phillips TD. 2005. Matrix-immobilized organoclay for the sorption of polycyclic aromatic hydrocarbons and pentachlorophenol from groundwater. Chemosphere 59(10):1455-1464. PMID:15876388


  • Herrera P, Burghardt RC, Huebner HJ, Phillips TD. 2004. The efficacy of sand-immobilized organoclays as filtration bed materials for bacteria. Food Microbiol 21(1):1-10.
  • Pimpukdee K, Kubena LF, Bailey CA, Huebner HJ, Afriyie-Gyawu E, Phillips TD. 2004. Aflatoxin-induced toxicity and depletion of hepatic vitamin A in young broiler chicks: protection of chicks in the presence of low levels of NovaSil PLUS in the diet. Poultry Science 83(5):737-744. PMID:15141830
  • Wiles MC, Huebner HJ, Afriyie-Gyawu E, Taylor RJ, Bratton GR, Phillips TD. 2004. Toxicological evaluation and metal bioavailability in pregnant rats following exposure to clay minerals in the diet. J Toxicol Environ Health A 67(11):863-874. doi:10.1080/15287390490425777 PMID:15205041


  • Ake CL, Wiles MC, Huebner HJ, McDonald TJ, Cosgriff D, Richardson MB, Donnelly KC, Phillips TD. 2003. Porous organoclay composite for the sorption of polycyclic aromatic hydrocarbons and pentachlorophenol from groundwater. Chemosphere 51(9):835-844. doi:10.1016/S0045-6535(03)00040-7 PMID:12697173
  • Bingham AK, Phillips TD, Bauer JE. 2003. Potential for dietary protection against the effects of aflatoxins in animals. J Am Vet Med Assoc 222(5):591-596. doi:10.2460/javma.2003.222.591 PMID:12619837
  • Huebner HJ, Phillips TD. 2003. Clay-based affinity probes for selective cleanup and determination of aflatoxin B1 using nanostructured montmorillonite on quartz. J AOAC Int 86(3):534-539. PMID:12852572
  • Lum KT, Huebner HJ, Li Y, Phillips TD, Raushel FM. 2003. Organophosphate nerve agent toxicity in Hydra attenuata. Chem Res Toxicol 16(8):953-957. PMID:12924922
  • Meek IB, Peplow AW, Ake CL, Phillips TD, Beremand MN. 2003. Tri1 encodes the cytochrome P450 monooxygenase for C-8 hydroxylation during trichothecene biosynthesis in Fusarium sporotrichioides and resides upstream of another new Tri gene. Appl Environ Microbiol 69(3):1607-1613. PMID:12620849
  • Peplow AW, Meek IB, Wiles MC, Phillips TD, Beremand MN. 2003. Tri16 is required for esterification of position C-8 during trichothecene mycotoxin production by Fusarium sporotrichioides. Appl Environ Microbiol 69(10):5935-5940. PMID:14532047
  • Phillips TD, Lemke SL, Grant PG. 2003. Characterization of clay-based enterosorbents for the prevention of aflatoxicosis. In: Advances in Experimental Medicine and Biology. Kluwer Academic/Plenum Publishers, NY. pp.157-173.


  • Ake CL, Mayura K, Huebner HJ, Bratton GR, Phillips TD. 2001. Development of porous clay-based composites for the sorption of lead from water. J Toxicol Environ Health A 63(6):459-475. PMID:11482800
  • Lemke SL, Mayura K, Reeves WR, Wang N, Fickey C, Phillips TD. 2001. Investigation of organophilic montmorillonite clay inclusion in zearalenone-contaminated diets using the mouse uterine weight bioassay. J Toxicol Environ Health A 62(4):243-258. doi:10.1080/009841001459405 PMID:11245394
  • Lemke SL, Ottinger SE, Ake CL, Mayura K, Phillips TD. 2001. Deamination of fumonisin B1 and biological assessment of reaction product toxicity. Chem Res Toxicol 14(1):11-15. PMID:11170503
  • Lemke SL, Ottinger SE, Mayura K, Ake CL, Pimpukdee K, Wang N, Phillips TD. 2001. Development of a multi-tiered approach to the in vitro prescreening of clay-based enterosorbents. Animal Feed Science and Technology 93(1-2):17-29. doi:10.1016/S0377-8401(01)00272-3
  • Reeves WR, Barhoumi R, Burghardt RC, Lemke SL, Mayura K, McDonald TJ, Phillips TD, Donnelly KC. 2001. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environ Sci Technol 35(8):1630-1636. doi:10.1021/es001689a PMID:11329713


  • Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. PMID:10696774
  • Herrera P, Burghardt RC, Phillips TD. 2000. Adsorption of Salmonella enteritidis by cetyl pyridinium exchanged montmorillonite clays. Vet Microbiol 74:259-272. PMID:10808094
  • Huebner HJ, Mayura K, Pallaroni L, Ake CL, Lemke SL, Phillips TD. 2000. Development and characterization of a carbon-based composite for reducing patulin levels in apple juice. J Food Prot 63(1):106-110. PMID:10643778
  • Tag A, Hicks J, Garifullina G, Ake CL, Phillips TD, Beremand MN, Keller NP. 2000. G-protein signaling mediates differential production of toxic secondary metabolites. EMBO J 38(3):658-665. PMID:11069688


  • Huebner HJ, Lemke SL, Mayura K, Phillips TD, Ottinger SE. 1999. Molecular characterization of high affinity, high capacity clays for the equilibrium sorption of ergotamine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 16(4):159-171. doi:10.1080/026520399284118 PMID:10560569
  • Lemke SL, Mayura K, Ottinger SE, McKenzie KS, Wang N, Fickey C, Kubena LF, Phillips TD. 1999. Assessment of the estrogenic effects of zearalenone after treatment with ozone utilizing the mouse uterine weight bioassay. J Toxicol Environ Health A 56(4):283-295. doi:10.1080/009841099158114 PMID:10706245
  • Mayura K, Huebner HJ, Dwyer MR, McKenzie KS, Donnelly KC, Kubena LF, Phillips TD. 1999. Multi-bioassay approach for assessing the potency of complex mixtures of polycyclic aromatic hydrocarbons. Chemosphere 38(8):1721-1732. PMID:10101844
  • Ottinger SE, Mayura K, Lemke SL, McKenzie KS, Wang N, Kubena LF, Phillips TD. 1999. Utilization of electrochemically generated ozone in the degradation and detoxification of benzo[a]pyrene. J Toxicol Environ Health A 56(8):565-583. doi:10.1080/009841099157511 PMID:10515574
  • Phillips TD. 1999. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol Sci 52:118-126. PMID:10630600
  • Springman KR, Mayura K, McDonald TJ, Donnelly KC, Kubena LF, Phillips TD. 1999. Organoclay adsorption of wood-preserving waste from groundwater. Environ Toxicol Chem 71(1-2):247-259.


  • Clark KJ, Grant PG, Sarr AB, Belakere JR, Swaggerty CL, Phillips TD, Woode GN. 1998. An in vitro study of theaflavins extracted from black tea to neutralize bovine rotavirus and bovine coronavirus infections. Vet Microbiol 63(2-4):147-157. doi:10.1016/S0378-1135(98)00242-9 PMID:9850995
  • Clark KJ, Sarr AB, Grant PG, Phillips TD, Woode GN. 1998. In vitro studies on the use of clay, clay minerals and charcoal to adsorb bovine rotavirus and bovine coronavirus. Vet Microbiol 63:137-146. PMID:9850994
  • Lopez Y, Keller NP, Sarr AB, Phillips TD, Cuero RG, Smith OD. 1998. Visual estimation of aflatoxin production in peanut with Aspergillus norsolorinic acid mutants. Peanut Science 25:92-99.
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