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Your Environment. Your Health.

Project Publications: Texas A&M University: Image Analysis and Bioassays Core

Superfund Research Program

Image Analysis and Bioassays Core

Project Leader: Robert C. Burghardt
Grant Number: P42ES004917
Funding Period: 2000-2008






  • Jiang J, Dean D, Burghardt RC, Parrish AR. 2004. Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity. Toxicol Sci 80(1):170-182. PMID:15084754


  • Cizmas LH, Barhoumi R, Burghardt RC, Reeves WR, He L, McDonald TJ, Donnelly KC. 2003. A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysis. J Toxicol Environ Health A 66(14):1351-1370. PMID:12851116
  • Falahatpisheh MH, Ramos KS. 2003. Ligand-activated Ahr signaling leads to disruption of nephrogenesis and altered Wilms' tumor suppressor mRNA splicing. Oncogene 22(14):2160-2171. PMID:12687018
  • Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E. 2003. Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol Appl Pharmacol 186(2):110-118. PMID:12639502
  • Qin C, Burghardt RC, Smith RL, Wormke M, Stewart J, Safe SH. 2003. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Res 63(5):958-964. PMID:12615709
  • Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt RC, Safe SH. 2003. The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Mol Cell Biol 23(6):1842-1855. PMID:12612060


  • Abdelrahim M, Samudio I, Smith, III R, Burghardt RC, Safe SH. 2002. Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. J Biol Chem 277(32):28815-28822. PMID:12052832
  • Barhoumi R, Mouneimne Y, Awooda I, Safe SH, Donnelly KC, Burghardt RC. 2002. Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells. Toxicol Sci 68(2):444-450. PMID:12151640
  • Mealey KL, Barhoumi R, Burghardt RC, Safe SH, Kochevar DT. 2002. Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells. Antimicrobial Agents and Chemotherapy 46(3):755-761. PMID:11850258
  • Qin C, Nguyen T, Stewart J, Burghardt RC, Safe SH. 2002. Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated, by calmodulin kinase IV-dependent activation of a nuclear factor kappa B/CCAAT-binding transcription factor-1 complex. Mol Endocrinol 16(8):1793-1809. PMID:12145335
  • Stoner M, Saville B, Wormke M, Dean D, Burghardt RC, Safe SH. 2002. Hypoxia induces proteasome-dependent degradation of estrogen receptor a in ZR-75 breast cancer cells. Mol Endocrinol 16(10):2231-2242. PMID:12351689


  • Duan R, Xie W, Burghardt RC, Safe SH. 2001. Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. J Biol Chem 276(15):11590-11598. doi:10.1074/jbc.M005492200 PMID:11145955
  • Falahatpisheh MH, Donnelly KC, Ramos KS. 2001. Antagonistic interactions among nephrotoxic polycyclic aromatic hydrocarbons. J Toxicol Environ Health A 62(7):543-560. PMID:11289703
  • Randerath K, Zhou GD, Somers RL, Robbins JH, Brooks PJ. 2001. A 32P-postlabeling assay for the oxidative DNA lesion 8,5'-cyclo-2'-deoxyadenosine in mammalian tissues: evidence that four type II I-compounds are dinucleotides containing the lesion in the 3' nucleotide. J Biol Chem 276(38):36051-36057. doi:10.1074/jbc.M105472200 PMID:11454870
  • Reeves WR, Barhoumi R, Burghardt RC, Lemke SL, Mayura K, McDonald TJ, Phillips TD, Donnelly KC. 2001. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environ Sci Technol 35(8):1630-1636. doi:10.1021/es001689a PMID:11329713
  • Samudio I, Vyhlidal C, Wang F, Stoner M, Chen I, Kiadde M, Barhoumi R, Burghardt RC, Safe SH. 2001. Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17 beta-estradiol. Endocrinology 142(3):1000-1008. PMID:11181512
  • Washburn KS, Donnelly KC, Huebner HJ, Burghardt RC, Sewall TC, Claxton LD. 2001. A study of 2,4,6-trinitrotoluene inhibition of benzo[a]pyrene uptake and activation in a microbial mutagenicity assay. Chemosphere 44(8):1703-1709. PMID:11534902


  • Alejandro NF, Parrish AR, Bowes RC, Burghardt RC, Ramos KS. 2000. Phenotypic profiles of cultured glomerular cells following repeated cycles of hydrocarbon injury. Kidney International 57:1571-1580. PMID:10760092
  • Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. PMID:10696774
  • Herrera P, Burghardt RC, Phillips TD. 2000. Adsorption of Salmonella enteritidis by cetyl pyridinium exchanged montmorillonite clays. Vet Microbiol 74:259-272. PMID:10808094
  • Legare ME, Hanneman WH, Barhoumi R, Burghardt RC, Tiffany-Castiglioni E. 2000. 2,3,7,8-tetrachlorodibenzo-p-dioxin alters hippocampal astroglia-neuronal gap junctional communication. Neurotoxicology 21(6):1109-1116. PMID:11233757
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