Superfund Research Program

Metal-Metal Interactions in the Kidney

Project Leader: A. Jay Gandolfi
Grant Number: P42ES004940
Funding Period: 1995 - 2000

Project-Specific Links

Publications

1999

• Zheng XH, Parrish AR, Turney KD, Younis HS, Gandolfi A. 1999. Arsenite [AS(III)] and arsenate [AS(V)] enhance DNA binding of the AP-1 and elk-1 transcription factors and c-jun and c-fos gene expression in precision-cut renal slices. Toxicol Sci 48:351.

1998

• Gandolfi A, Parrish AR, Turney KD, Zheng XH. 1998. Molecular alteration in renal tissue following in vitro exposure to nanomolar levels of Hg(II), As(III) or As(V). In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA.
• Keith RL, McIntyre LC, Ashbaugh MD, Fernando Q, Gandolfi A. 1998. Characterization of heavy metal deposition in rabbit renal tissue using micro-proton induced x-ray emission. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
• Qiu L, Lott JR, Fernando Q, Ashbaugh MD, McIntyre LC, Keith RL, Wei H, Gandolfi A. 1998. The PIXE and micro-PIXE facility at the University of Arizona. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
• Turney KD, Parrish AR, Gandolfi A. 1998. Increased AP-1 and c-jun in renal slices following exposure to Hg(II). In: Proceedings of the Symposium on Risk Considerations for Environmental Health and Safety. The University of Arizona, Tucson, AZ.
• Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, Gandolfi A. 1998. Accumulation of HgCl₂ and three synthesized Hg-S-conjugates in isolated rabbit renal proximal tubule suspensions. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
• Wijeweera JB, Gandolfi A, Zheng XH. 1998. Interactive toxicity and stress protein expression by vinylidene chloride and monochloroacetate in precision-cut liver slices. Environ Health Perspect 106(Suppl.6):1319-1323. PMID:9860887
• Zheng XH, Younis HS, Turney KD, Parrish AR, Gandolfi A. 1998. Molecular alterations in renal cortical slices following exposure to sub-toxic levels of arsenic. Toxicol Sci 42:323.
• Zheng XH, Younis HS, Turney KD, Parrish AR, Gandolfi A. 1998. Molecular alterations in renal slices following arsenite exposure. In: Proceedings of the Symposium on Risk Considerations for Environmental Health and Safety. The University of Arizona, Tucson, AZ.

1997

• Keith RL, Gandolfi A, McIntyre LC, Ashbaugh MD, Fernando Q. 1997. Use of the nuclear microprobe at the University of Arizona for the study of heavy metal deposition in rabbit renal tissue. Nucl Instrum Methods Phys Res A 130:358-361.
• Keith RL, McIntyre LC, Ashbaugh MD, Fernando Q, Gandolfi A. 1997. Characterization of heavy metal deposition in rabbit renal tissue using micro-proton induced x-ray emission. Environ Health Perspect 36:185.
• Keith RL, Setiarahardjo I, Fernando Q, Aposhian HV, Gandolfi A. 1997. Utilization of renal slices to evaluate the efficacy of chelators to remove mercury from the kidney. Toxicology 116:67-75. PMID:9020508
• McIntyre LC, Leavitt JA, Ashbaugh MD, Borgardt J, Keith RL, Gandolfi A, Qiu L, Lott JR, Fernando Q. 1997. The nuclear microprobe at the University of Arizona. Nucl Instrum Methods Phys Res A 130(1-4):45-50. doi:10.1016/S0168-583X(97)00177-8
• Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, Gandolfi A. 1997. Accumulation of HgCl2 and three synthesized Hg-S-conjugates in isolated rabbit renal proximal tubule suspensions. Environ Health Perspect 36:185.
• Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, Gandolfi A. 1997. Accumulation of HgCl₂ and three synthesized Hg-S-conjugates in isolated rabbit renal proximal tubule suspensions. In: Proceedings of the TCE Symposium, The University of Arizona, Tucson, AZ.
• Wijeweera JB, Zheng XH, Gandolfi A. 1997. Interactive toxicity of MCA and VDC in precision-cut rat livers slices. In: Proceedings of the Current Issues in Chemical Mixtures Conference. Colorado State University, Ft. Collins, CO.

1996

• Gandolfi A, Brendel K, Fernando Q. 1996. Preparation and use of precision-cut renal cortical slices in renal toxicology. In: Methods of Renal Toxicology. CRC Press, Inc., Boca Raton, FL. pp.109-122.
• Keith RL, Gandolfi A, McIntyre LC, Ashbaugh MD, Qiu L, Lott JR, Fernando Q. 1996. Use of the nuclear microprobe at the University of Arizona for the study of heavy metal deposition in rabbit renal tissue. In: Proceedings of the International Conference on Nuclear Microprobe Technology and Applications. Sante Fe, NM.
• Keith RL, Leavitt JA, McIntyre LC, Fernando Q, Gandolfi A. 1996. Assessment of heavy metal accumulation in renal tissue using micro-proton induced x-ray emission (mu-PIXE). Environ Health Perspect 30:258.
• Wei H, Divine KK, Gandolfi A. 1996. Uptake and toxicity of HgCl2 and synthesized Hg(SG)2 and Hg(CYS)2 in isolated rabbit renal proximal tubule suspensions. Environ Health Perspect 30:129.

1995

• Burton CA, Hatlelid K, Divine KK, Carter DE, Fernando Q, Brendel K, Gandolfi A. 1995. Glutathione effects on toxicity and uptake of mercuric chloride and sodium arsenite in rabbit renal cortical slices. Environ Health Perspect 103(Suppl.1):81-84. PMID:7621807
• Gandolfi A, Brendel K, Fisher RL, Michaud J. 1995. Use of tissue slices in chemical mixture toxicology and interspecies investigations. Toxicology 105(2-3):285-290. PMID:8571365
• Keith RL, McGuinness SJ, Gandolfi A, Lowe TP, Chen Q, Fernando Q. 1995. Interaction of metals during their uptake and accumulation in rabbit renal cortical slices. Environ Health Perspect 103(Suppl.1):77-80. PMID:7621806
• Wijeweera JB, Thomas CM, Gandolfi A, Brendel K. 1995. Sodium arsenite and heat shock induce stress proteins in precision-cut liver slices. Toxicology 104:35-45. PMID:8560500