Superfund Research Program

Pathogenesis of Toxicity of Vanadium Compounds

Project Leader: John Godleski
Grant Number: P42ES005947
Funding Period: 1995 - 2000

Project-Specific Links

Publications

2000

• Al-Mutairi E, Godleski J, Koziel H, Bullock BP, Paulauskis JD. 2000. Genetic response of human alveolar macrophages to residual oil fly ash particles. FASEB J 14(4):A171.
• Chong I, Lin S, Hwang J, Huang M, Wang T, Tsai M, Hou J, Paulauskis JD. 2000. Expression and regulation of macrophage inflammatory protein-2 gene by vanadium in mouse macrophages. Inflammation 24(2):127-139. doi:10.1023/A:1007098508014 PMID:10718115
• Rice T, Clarke RW, Hauser R, Antonini JM, Godleski J, Paulauskis JD. 2000. Differential ability of transition metals to induce pulmonary inflammation. Toxicol Sci 54(1):36. PMID:11708899
• Stearns R, Clarke RW, Rice T, Al-Mutairi E, Oakberg K, Paulauskis JD, Godleski J. 2000. Compositional heterogeneity influences induction of lung inflammation by residual oil fly-ash. FASEB J 14(4):173.
• Wu MT, Demple B, Bennett RA, Christiani DC, Fan R, Hu H. 2000. Individual variability in the zinc inducibility of metallothionein-IIA mRNA in human lymphocytes. J Toxicol Environ Health A 61(7):553-567. PMID:11127411

1999

• Chong I, Shi MM, Love JA, Christiani DC, Paulauskis JD. 1999. Regulation of chemokine mRNA expression in vanadium-induced lung inflammation. Am J Respir Crit Care Med 159(3):A511.
• Clarke RW, Al-Mutairi E, Love JA, Rice T, Antonini JM, Paulauskis JD, Godleski J. 1999. Residual oil ashes with differing composition elicit pro-inflammatory chemokines in the lung and heart. Toxicol Sci 48(15):259.
• Clarke RW, Catalano PJ, Koutrakis P, Krishna-Murthy GG, Sioutas C, Paulauskis JD, Coull BA, Ferguson S, Godleski J. 1999. Urban air particulate inhalation alters pulmonary function and induces pulmonary inflammation in a rodent model of chronic bronchitis. Inhal Toxicol 11(8):637-656. doi:10.1080/089583799196781 PMID:10477440
• Godleski J, Clarke RE. 1999. Systemic responses to inhaled ambient particles: Pathophysiologic Mechanisms of Cardiopulmonary Effects. In: Inhaled Particles (Lung Biology in Health and Disease Series). Marcel Dekker, Inc., pp.577-601.
• Grabowski GM, Paulauskis JD, Godleski J. 1999. Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Toxicol Appl Pharmacol 156:170-178. PMID:10222309
• Paulauskis JD, Danaee H, Antonini JM, Al-Mutairi E, Rice T, Godleski J, Clarke RW. 1999. Instilled soluble vanadium evokes pulmonary inflammation but does not elicit pro-inflammatory chemokine mRNA in the heart. Toxicol Sci 48(15):52.
• Shi MM, Chong I, Godleski J, Paulauskis JD. 1999. Regulation of macrophage inflammatory protein-2 gene expression by oxidative stress in rat alveolar macrophages. Immunology 97(2):309-315. PMID:10447747
• Shi MM, Godleski J, Paulauskis JD. 1999. Transcriptional and posttranscriptional regulation of macrophage inflammatory protein-1. In: Proceedings of the Oxygen Society Meeting.

1998

• Shahan TA, Sorenson WG, Paulauskis JD, Morey R, Lewis DM. 1998. Concentration- and time-dependent upregulation and release of the cytokines MIP-2, KC, TNF, and MIP-1alpha in rat alveolar macrophages by fungal spores implicated in airway inflammation. Am J Respir Cell Mol Biol 18:435-440. PMID:9490662
• Shi MM, Chong I, Long NC, Love JA, Godleski J, Paulauskis JD. 1998. Functional characterization of recombinant rat macrophage inflammatory protein-1α and mRNA expression in pulmonary inflammation. Inflammation 22:29-43. PMID:9484648

1997

• Alessandrini F, Shi MM, Godleski J, Paulauskis JD. 1997. Comparative antioxidant capabilities of lazaroid U-83836E and N-acetylcysteine in lung macrophages. Am J Respir Crit Care Med 155:A188.
• Grabowski GM, Paulauskis JD, Godleski J. 1997. Role of phosphotyrosine phosphatase, PTP.1C in the initiation of the vanadium-induced respiratory burst in lung macrophages. In: Proceedings of EMBO-FMI Workshop "Europhosphatase 1996".
• Killingsworth CR, Alessandrini F, Krishna-Murthy GG, Catalano PJ, Paulauskis JD, Godleski J. 1997. Inflammation, chemokine expression, and death in monocrotaline-treated rats following fuel oil ash inhalation. Inhal Toxicol 9(6):541-565.
• Killingsworth CR, Shore SA, Alessandrini F, Dey RD, Paulauskis JD. 1997. Rat alveolar macrophages express preprotachykinin gene-I mRNA-encoding tachykinins. Am J Physiol 273(5Pt1):L1073-L1081. PMID:9374737
• Shi MM, Chong I, Chen AX, Godleski J, Paulauskis JD. 1997. Budesonide inhibits macrophage inflammatory protein -2 mRNA increase in response to bacterial lipopolysaccharide. Pharm Res 14:S-387.
• Shi MM, Chong I, Paulauskis JD, Godleski J. 1997. Regulation of chemokine gene expression by oxidative stress in alveolar macrophages. FASEB J 11:1330.
• Tsai CS, Shi MM, Chong I, Godleski J, Paulauskis JD. 1997. Vanadium-induced expression of macrophage inflammatory protein (MIP)-1α and MIP-2 mRNA in lung macrophages is dependent on macrophage:epithelial interaction. Am J Respir Crit Care Med 155:A960.

1996

• Alessandrini F, Shi MM, Godleski J, Paulauskis JD. 1996. The lazaroid U-83836E protects alveolar macrophages from oxidative stress. Am J Respir Crit Care Med 153:A811.
• Cernadas M, DeSanctis GT, Krinzman SJ, Hikutani H, Christiani DC, Perkins DL, Finn PW. 1996. Anti-CD23 inhibits airway reactivity and augments lymphocyte activation in a murine asthma model. Am J Respir Crit Care Med 153:A811.
• Grabowski GM, Tsai CS, Paulauskis JD, Godleski J. 1996. Signal transduction in the metal-induced respiratory burst of lung macrophages. Am J Respir Crit Care Med 153:A544.
• Killingsworth CR, Alessandrini F, Krishna-Murthy GG, Catalano PJ, Paulauskis JD, Godleski J. 1996. Death from inhalation of fuel oil fly ash particles in rats with pre-existing pulmonary inflammation. In: Proceedings of the Second Colloquium on Particulate Air Pollution and Health. pp.238-244.
• Nearing BD, Verrier RL, Skornick WA, Gazula G, Killingsworth CR, Oakberg K, Godleski J. 1996. Inhaled fly ash results in alteration in cardiac electrophysiologic function. Am J Respir Crit Care Med 153:A543.
• Pierce LM, Alessandrini F, Godleski J, Paulauskis JD. 1996. Vanadium-induced chemokine mRNA expression and pulmonary inflammation. Toxicol Appl Pharmacol 138(1):1-11. doi:10.1006/taap.1996.9999 PMID:8658498
• Shi MM, Godleski J, Paulauskis JD. 1996. An oxidative stress increases macrophage inflammatory protein-1α mRNA levels by increasing transcription of the gene and by transcript stabilization. FASEB J 10:156.
• Shi MM, Godleski J, Paulauskis JD. 1996. Elevation of KC (cytokine-induced neutrophil chemoattractant) mRNA in alveolar macrophages by quinone-induced oxidative stress. Am J Respir Crit Care Med 153:A30.
• Shi MM, Godleski J, Paulauskis JD. 1996. Regulation of macrophage inflammatory protein-1α mRNA by oxidative stress. J Biol Chem 271:5878-5883. PMID:8621460
• Tsai CS, Shi MM, Godleski J, Paulauskis JD. 1996. Manganese-induced pulmonary inflammation and increased expression of pro-inflammatory cytokine mRNA in rat lung cells. Am J Respir Crit Care Med 153:A614.

1995

• Grabowski GM, Paulauskis JD, Godleski J. 1995. Tyrosine phosphorylation events in the respiratory burst of rat lung macrophages induced by vanadium. FASEB J 9(4):947.
• Shi MM, Godleski J, Paulauskis JD. 1995. Effect of oxidative stress on inflammatory cytokine mRNA expression in rat alveolar macrophages. FASEB J 9(4):346.
• Shi MM, Godleski J, Paulauskis JD. 1995. Molecular cloning and posttranscriptional regulation of macrophage inflammatory protein-1 alpha in alveolar macrophages. Biochem Biophys Res Commun 211(1):289-295. doi:10.1006/bbrc.1995.1809 PMID:7779098
• Sweeney TD, Skornick WA, Brain JD, Hatch V, Godleski J. 1995. Chronic bronchitis alters the pattern of aerosol deposition in the lung. Am J Respir Crit Care Med 151:482-488. PMID:7842210