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Project Publications: University of North Carolina-Chapel Hill: Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene

Superfund Research Program

Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene

Project Leader: Ivan Rusyn (Texas A&M University)
Grant Number: P42ES005948
Funding Period: 2006-2017
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2018

  • Cichocki JA, Luo Y, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2018. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol Sci 167(1):126-137. doi:10.1093/toxsci/kfy223 PMID:30202895 PMCID:PMC6317418
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2018. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152. doi:10.1016/j.taap.2018.05.033 PMID:29857080 PMCID:PMC6051410
  • Luo Y, Furuya S, Chiu WA, Rusyn I. 2018. Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A 81:37-52. doi:10.1080/15287394.2017.1408512 PMID:29190187
  • Luo Y, Furuya S, Soldatov VY, Kosyk O, Yoo HS, Fukushima H, Lewis L, Iwata Y, Rusyn I. 2018. Metabolism and toxicity of trichloroethylene and tetrachloroethylene in cytochrome P450 2E1 knockout and humanized transgenic mice. Toxicol Sci doi:10.1093/toxsci/kfy099 PMID:29897530
  • Luo Y, Hsieh N, Soldatow VY, Chiu WA, Rusyn I. 2018. Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43. doi:10.1016/j.tox.2018.07.012 PMID:30053492 PMCID:PMC6186498

2017

  • Cichocki JA, Furuya S, Konganti K, Luo Y, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2017. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice. J Pharmacol Exp Ther 361(1):17-28. doi:10.1124/jpet.116.238790 PMID:28148637 PMCID:PMC5363767
  • Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344
  • Grimm FA, Russell WK, Luo Y, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. 2017. Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. Environ Sci Technol 51:7197-7207. doi:10.1021/acs.est.6b06413 PMID:28502166 PMCID:PMC5627358
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
  • Zhang G, Roell K, Truong L, Tanguay RL, Reif DM. 2017. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol Appl Pharmacol 314:109-117. doi:10.1016/j.taap.2016.11.010 PMID:27884602 PMCID:PMC5224523

2016

  • Chappell G, Silva GO, Uehara T, Pogribny IP, Rusyn I. 2016. Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease. Cancer Med 5(3):574-585. doi:10.1002/cam4.606 PMID:26778414 PMCID:PMC4799957
  • Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. 2016. Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps. J Pharmacol Exp Ther 359(1):110-123. doi:10.1124/jpet.116.232629 PMID:27511820 PMCID:PMC5034707
  • Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton K, DeVito MJ, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper SC, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect 124(11):1671-1682. doi:10.1289/ehp233 PMID:27091369 PMCID:PMC5089888
  • Grimm FA, Iwata Y, Sirenko O, Chappell G, Wright FA, Reif DM, Braisted JA, Gerhold D, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde A, Rusyn I. 2016. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chem 18(16):4407-4419. doi:10.1039/c6gc01147k PMID:28035192 PMCID:PMC5179981
  • Marrone AK, Shpyleva S, Chappell G, Tryndyak VP, Uehara T, Beland FA, Rusyn I, Pogribny IP. 2016. Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice. Mol Carcinog 55(5):808-817. doi:10.1002/mc.22323 PMID:25865624
  • Rusyn I, Knap A. 2016. Environmental exposures due to natural disasters. Rev Environ Health 31(1):89-92. doi:10.1515/reveh-2016-0010 PMID:26982607 PMCID:PMC4913349

2015

  • Abdo N, Wetmore BA, Chappell G, Shea D, Wright FA, Rusyn I. 2015. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environ Int 85:147-155. doi:10.1016/j.envint.2015.09.012 PMID:26386728 PMCID:PMC4773193
  • Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou Y, Jack J, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif A, Austin CP, Tice RR, Rusyn I, Wright FA. 2015. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect 123(5):458-466. doi:10.1289/ehp.1408775 PMID:25622337 PMCID:PMC4421772
  • Eduati F, Mangravite LM, Wang T, Tang H, Bare J, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y. 2015. Prediction of human population responses to toxic compounds by a collaborative competition. Nat Biotechnol 33(9):933-940. PMID:26258538
  • Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I. 2015. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Assay Drug Dev Technol 13(9):529-546. doi:10.1089/adt.2015.659 PMID:26539751 PMCID:PMC4652224
  • Pearce N, Blair AE, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli A, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, Mannetje A, McMichael AJ, McLaughlin J, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer F, Monson RR, Nordby K, Olshan A, Parent M, Perera F, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart P, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger DD, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123(6):507-514. doi:10.1289/ehp.1409149 PMID:25712798 PMCID:PMC4455595
  • Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J Toxicol Environ Health A 78(1):15-31. doi:10.1080/15287394.2015.958417 PMID:25424544 PMCID:PMC4281929
  • Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A 78(1):32-49. doi:10.1080/15287394.2015.958418 PMID:25424545 PMCID:PMC4281933
  • Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar WM, Sweet S, Knap A, Wade TL, Campbell J, Clewell H, Melnyk SB, Chiu WA, Rusyn I. 2015. The contribution of peroxisome proliferator-activated receptor alpha to the relationship between toxicokinetics and toxicodynamics of trichloroethylene. Toxicol Sci 147(2):339-349. doi:10.1093/toxsci/kfv134 PMID:26136231 PMCID:PMC4598794

2014

2013

  • Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I. 2013. A systematic approach for identifying, evaluating, and presenting mechanistic evidence in human health assessments. Regul Toxicol Pharmacol 67(2):266-277. doi:10.1016/j.yrtph.2013.08.005 PMID:23959061 PMCID:PMC3818152
  • Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B, Moser M, Karasik E, Gillard B, Ramsey K, Sullivan S, Bridge J, Magazine H, Syron J, Fleming J, Siminoff L, Traino H, Mosavel M, Barker L, Jewell S, Rohrer D, Maxim D, Filkins D, Harbach P, Cortadillo E, Berghuis B, Turner L, Hudson E, Feenstra K, Sobin L, Robb J, Branton P, Korzeniewski G, Shive C, Tabor D, Qi L, Groch K, Nampally S, Buia S, Zimmerman A, Smith A, Burges R, Robinson K, Valentino K, Bradbury D, Cosentino M, Diaz-Mayoral N, Kennedy M, Engel T, Williams P, Erickson K, Ardlie K, Winckler W, Getz G, DeLuca D, MacArthur D, Kellis M, Thomson A, Young T, Gelfand E, Donovan M, Meng Y, Grant G, Mash D, Marcus Y, Basile M, Liu J, Zhu J, Tu Z, Cox NJ, Nicolae DL, Gamazon ER, Im HK, Konkashbaev A, Pritchard J, Stevens M, Flutre T, Wen X, Dermitzakis ET, Lappalainen T, Guigo R, Monlong J, Sammeth M, Koller D, Battle A, Mostafavi S, McCarthy M, Rivas M, Maller J, Rusyn I, Nobel AB, Wright FA, Shabalin AA, Feolo M, Sharopova N, Sturcke A, Paschal J, Anderson JM, Wilder EL, Derr LK, Green ED, Struewing JP, Temple G, Volpi S, Boyer JT, Thomson EJ, Guyer MS, Ng C, Abdallah A, Colantuoni D, Insel TR, Koester SE, Little A, Bender PK, Lehner T, Yao Y, Compton CC, Vaught JB, Sawyer S, Lockhart NC, Demchok J, Moore HF. 2013. The Genotype-Tissue Expression (GTEx) project. Nat Genet 45:580-585. doi:10.1038/ng.2653 PMID:23715323 PMCID:PMC4010069
  • Pogribny IP, Rusyn I. 2013. Environmental toxicants, epigenetics, and cancer. Advances in Experimental Medicine and Biology 754:215-232. doi:10.1007/978-1-4419-9967-2_11 PMID:22956504 PMCID:PMC4281087
  • Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I. 2013. ToxPi GUI: An interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics 29(3):402-403. doi:10.1093/bioinformatics/bts686 PMID:23202747 PMCID:PMC3988461
  • Rusyn I, Lemon SM. 2013. Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?. Cancer Lett doi:10.1016/j.canlet.2013.06.028 PMID:23871966 PMCID:PMC3844040
  • Soldatow VY, LeCluyse EL, Griffith LG, Rusyn I. 2013. In vitro models for liver toxicity testing. Toxicol Res (Camb) 2:23-39. doi:10.1039/C2TX20051A PMID:23495363 PMCID:PMC3593300
  • Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymoniak S, Bradford BU, Boorman GA, Bataller R, Rusyn I. 2013. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol Sci 132(1):53-63. doi:10.1093/toxsci/kfs342 PMID:23288052 PMCID:PMC3576012
  • Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. 2013. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol 266(2):224-232. doi:10.1016/j.taap.2012.11.019 PMID:23200774 PMCID:PMC3534780
  • Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ. 2013. Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect 121:23-31. doi:10.1289/ehp.1205687 PMID:23086705 PMCID:PMC3553440

2012

  • Campbell J, Clewell RA, Gentry PR, Andersen ME, Clewell H. 2012. Physiologically based pharmacokinetic/toxicokinetic modeling. Chapter 18 in: Computational Toxicology: Methods in Molecular Biology. Humana Press, New York, NY. pp.439-499.
  • Guha N, Loomis D, Grosse Y, Secretan-Lauby B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Baan R, Mattock H, Straif K. 2012. Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites. Lancet Oncol 13(12):1192-1193. doi:10.1016/S1470-2045(12)70485-0 PMID:23323277
  • Jeannot E, Boorman GA, Bradford BU, Shymoniak S, Tumurbaatar B, Weinman SA, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I, Kosyk O. 2012. Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice. Int J Cancer 130(6):1347-1356. doi:10.1002/ijc.26140 PMID:21500192 PMCID:PMC3161148
  • Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou Y, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. 2012. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci 126(2):578-588. doi:10.1093/toxsci/kfs023 PMID:22268004 PMCID:PMC3307611
  • Wright FA, Shabalin AA, Rusyn I. 2012. Computational tools for discovery and interpretation of expression quantitative trait loci. Pharmacogenomics 13(3):343-352. doi:10.2217/pgs.11.185 PMID:22304583 PMCID:PMC3295835

2011

  • Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone MC, Threadgill DW, Tryndyak VP, Pogribny IP, Bleyle L, Koop DR, Rusyn I. 2011. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci 120(1):206-217. doi:10.1093/toxsci/kfq362 PMID:21135412 PMCID:PMC3044200
  • Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I. 2011. MicroRNA expression in the livers of inbred mice. Mutat Res 714:126-133. doi:10.1016/j.mrfmmm.2011.05.007 PMID:21616085 PMCID:PMC3166582
  • Grosse Y, Baan R, Secretan-Lauby B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Islami F, Galichet L, Straif K. 2011. Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts. Lancet Oncol 12(4):328-329. doi:10.1016/S1470-2045(11)70088-2 PMID:21598447
  • Jeannot E, Pogribny IP, Beland FA, Rusyn I. 2011. Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. Cancer Lett 301:161-167. doi:10.1016/j.canlet.2010.11.010 PMID:21168264 PMCID:PMC3035933
  • Koturbash I, Scherhag A, Sexton K, Bodnar WM, Tryndyak VP, Swenberg JA, Beland FA, Pogribny IP, Rusyn I, Latendresse JR. 2011. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-Butadiene. Environ Health Perspect 119:635-640. doi:10.1289/ehp.1002910 PMID:21147608 PMCID:PMC3094413
  • Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A. 2011. Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. Environ Health Perspect 119(3):364-370. doi:10.1289/ehp.1002476 PMID:20980217 PMCID:PMC3060000
  • Tan Y, Clewell H, Campbell J, Andersen ME. 2011. Evaluating pharmacokinetic and pharmacodynamic interactions with computational models in supporting cumulative risk assessment. Int J Environ Res Public Health 8(5):1613-1630. doi:10.3390/ijerph8051613 PMID:21655141 PMCID:PMC3108131

2010

2009

  • Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I. 2009. Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mamm Genome 20(7):437-446. doi:10.1007/s00335-009-9199-0 PMID:19609828 PMCID:PMC2745627
  • Gatti DM, Shabalin AA, Lam T, Wright FA, Rusyn I, Nobel AB. 2009. FastMap: fast eQTL mapping in homozygous populations. Bioinformatics 25(4):482-489. doi:10.1093/bioinformatics/btn648 PMID:19091771 PMCID:PMC2642639
  • Gatti DM, Sypa M, Rusyn I, Wright FA, Barry WT. 2009. SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy. Bioinformatics 25(4):541-542. doi:10.1093/bioinformatics/btn655 PMID:19098030 PMCID:PMC2642635
  • Kim S, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I, Collins LB. 2009. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology 262(3):230-238. doi:10.1016/j.tox.2009.06.013 PMID:19549554 PMCID:PMC2765814
  • Kim S, Kim D, Pollack GM, Collins LB, Rusyn I. 2009. Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicol Appl Pharmacol 238(1):90-99. doi:10.1016/j.taap.2009.04.019 PMID:19409406 PMCID:PMC2737827
  • Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, Cunningham ML, Rusyn I. 2009. Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. Toxicol Appl Pharmacol 235(2):199-207. doi:10.1016/j.taap.2008.12.011 PMID:19136022 PMCID:PMC2654411
  • Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A. 2009. A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environ Health Perspect 117(8):1257-64. PMID:19672406

2008

  • Pogribny IP, Tryndyak VP, Boureiko A, Melnyk SB, Bagnyukova TV, Montgomery B, Rusyn I. 2008. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res 644(1-2):17-23. doi:10.1016/j.mrfmmm.2008.06.009 PMID:18639561 PMCID:PMC2571982
  • Rusyn I, Harrill AH. 2008. Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opin Drug Metab Toxicol 4(11):1379-1389. doi:10.1517/17425255.4.11.1379 PMID:18950280
  • Zhu H, Rusyn I, Richard A, Tropsha A. 2008. Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environ Health Perspect 116(4):506-13. PMID:18414635

2007

  • Woods CG, Burns AM, Maki A, Bradford BU, Cunningham ML, Connor HD, Kadiiska MB, Mason RP, Peters JM, Rusyn I. 2007. Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase. Free Radic Biol Med 42(3):335-342. PMID:17210446

2006

  • DeSimone MC, Harbourt D, Boysen G, Collins LB, Bradford BU, Han J, Swenberg JA, Threadgill DW, Rusyn I. 2006. Multi-strain study of trichoroethylene toxicity in mice. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Han J, Harbourt D, Danell RM, Borchers CH, Rusyn I. 2006. High throughput metabolite profiling of serum from trichloroethylene-exposed mice by direct infusion FTICR-MS. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
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