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Project Publications: University of North Carolina-Chapel Hill: Biostatistics Core

Superfund Research Program

Biostatistics Core

Project Leader: Fred A. Wright (North Carolina State University)
Grant Number: P42ES005948
Funding Period: 2011-2018
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Li G, Jima DD, Wright FA, Nobel AB. 2018. HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues. BMC Bioinformatics 19:95. doi:10.1186/s12859-018-2088-3 PMID:29523079


  • Tilley SK, Reif DM, Fry RC. 2017. Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina. Environ Int 101:19-26. doi:10.1016/j.envint.2016.10.006 PMID:28153528 PMCID:PMC5351294
  • Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274


  • Singleton D, Dickey AN, Scholl EH, Wright FA, Aitken MD. 2016. Complete genome sequence of a bacterium representing a deep uncultivated lineage within the gammaproteobacteria associated with the degradation of polycyclic aromatic hydrocarbons. Genome Announc 4(5):e01086-e01116. doi:10.1128/genomeA.01086-16 PMID:27795254 PMCID:PMC5054325
  • Tian X, Patel K, Ridpath JR, Chen Y, Zhou Y, Neo D, Clement JM, Takata M, Takeda S, Sale J, Wright FA, Swenberg JA, Nakamura J. 2016. Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium. PLoS One 11(12):e0167503. doi:10.1371/journal.pone.0167503 PMID:27907204 PMCID:PMC5132242


  • Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou Y, Jack J, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif A, Austin CP, Tice RR, Rusyn I, Wright FA. 2015. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect 123(5):458-466. doi:10.1289/ehp.1408775 PMID:25622337 PMCID:PMC4421772
  • Singleton D, Dickey AN, Scholl EH, Wright FA, Aitken MD. 2015. Complete genome sequence of a novel bacterium within the family Rhodocyclaceae that degrades polycyclic aromatic hydrocarbons. Genome Announc 3(2):doi:10.1128/genomeA.00251-15 PMID:25858839 PMCID:PMC4392151
  • Zhou Y, Wright FA. 2015. Hypothesis testing at the extremes: fast and robust association for high-throughput data. Biostatistics 16(3):611-625. doi:10.1093/biostatistics/kxv007 PMID:25792622 PMCID:PMC4804120


  • Wright FA, Sullivan PF, Brooks AI, Zou F, Sun W, Xia K, Madar V, Jansen R, Chung W, Zhou Y, Abdellaoui A, Batista S, Butler C, Chen G, Chen T, D'Ambrosio D, Gallins P, Ha MJ, Hottenga JJ, Huang S, Kattenberg M, Kochar J, Middeldorp CM, Qu A, Shabalin AA, Tischfield JA, Todd L, Tzeng J, van Grootheest G, Vink JM, Wang Q, Wang W, Wang W, Willemsen G, Smit JH, de Geus EJ, Yin Z, Penninx BW, Boomsma DI. 2014. Heritability and genomics of gene expression in peripheral blood. Nat Genet 46(5):430-437. doi:10.1038/ng.2951 PMID:24728292 PMCID:PMC4012342



  • Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou Y, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. 2012. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci 126(2):578-588. doi:10.1093/toxsci/kfs023 PMID:22268004 PMCID:PMC3307611
  • Wright FA, Shabalin AA, Rusyn I. 2012. Computational tools for discovery and interpretation of expression quantitative trait loci. Pharmacogenomics 13(3):343-352. doi:10.2217/pgs.11.185 PMID:22304583 PMCID:PMC3295835


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