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Your Environment. Your Health.

Project Publications: University of Kentucky: Mechanisms of Hepatic Tumor Promotion by PCBs

Superfund Research Program

Mechanisms of Hepatic Tumor Promotion by PCBs

Project Leader: Howard P. Glauert
Grant Number: P42ES007380
Funding Period: 1997 - 2005

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Publications

2007

  • Strathmann J, Paal K, Ittrich C, Appel KE, Glauert HP, Buchmann A, Schwarz M, Krause E. 2007. Proteome analysis of chemically induced mouse liver tumors with different genotype. Proteomics 7(18):3318-31. PMID:17722141

2005

  • Bunaciu RP, Spear BT, Glauert HP. 2005. The effect of Kupffer cell inhibition on hepatocyte cell proliferation in rats administered PCB-77 or PCB-153. FASEB J 17:A1165:
  • Espandiari P, Robertson LW, Srinivasan C, Glauert HP. 2005. Comparison of different initiation protocols in the resistant hepatocyte model. Toxicology 206(3):373-381. PMID:15588927
  • Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S, Tharappel JC, Stemm DN, Lehmler H, Lee EY, Robertson LW, Spear BT. 2005. Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats. J Nutr 135(2):283-286. PMID:15671227
  • Hennig B, Toborek M, Ramadass P, Ludewig G, Robertson LW, Arif JM. 2005. Polychlorinated biphenyls, oxidative stress and diet. Chapter Vol. 3 in: Reviews in Food and Nutrition Toxicity. CRC Press, Inc., Boca Raton, DE. pp.93-128.

2004

  • Lu Z, Lee EY, Robertson LW, Glauert HP, Spear BT. 2004. Effect of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) on Hepatocyte Proliferation and Apoptosis in Mice Deficient in the p50 Subunit of the Transcription Factor NF-B. Toxicol Sci 81(1):35-42.
  • Stemm DN, Robertson LW, Tharappel JC, Glauert HP. 2004. Effects of 3,3',4,4'-tetrachlorobiphenyl (PCB 77) on the distribution and metabolism of selenium in rats. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Toborek M, Hennig B. 2004. Fatty acid-induced activation of vascular endothelial cells. In: Biochemistry of Lipids in Vascular Function. Trivandrum, Kerala, India. pp.111.

2003

  • Bunaciu RP, Robertson LW, Spear BT, Glauert HP. 2003. Effect of inhibition of Kupffer cell activation by dietary glycine on hepatic cell proliferation in rats. FASEB J 17(5):A1165Part2Suppl.S.
  • Espandiari P, Lehmler H, Stemm DN, Glauert HP, Robertson LW. 2003. PCB metabolites as initiating agents in hepatocarcinogenesis. Toxicol Sci 72(S-1):1145.
  • Fadhel ZA, Bunaciu RP, Glauert HP, Robertson LW, Ludewig G. 2003. Lipid peroxidation and antioxidant enzymes in testes of rats treated with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and effects of corn oil, medium-chain triglyceride (MCT) oil and olive oil. Toxicol Sci 72(1):1771Suppl.S.
  • Harp C, Stafine N, Bunaciu RP, Lu Z, Tharappel JC, Robertson LW, Spear BT, Glauert HP. 2003. Influence of purified diets on the induction of cell proliferation by the hepatic tumor promoters 2,2',4,4'5,5'-hexachlorobiphenyl (PCB-153) and the peroxisome proliferator ciprofibrate. FASEB J 17(5):A1155Suppl.S.
  • Lu Z, Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. 2003. Effect of a single dose of polychlorinated biphenyls on hepatic cell proliferation and the DNA binding activity of NF-kappaB and AP-1 in rats. Mol Carcinog 37(4):171-180. doi:10.1002/mc.10135 PMID:12891626
  • Tharappel JC, Glauert HP, Spear BT. 2003. The effect of phenobarbital on cell proliferation in mice deficient in the p50 subunit of NF-kappa B. Toxicol Sci 72(S-1):1160.

2002

  • Espandiari P, Glauert HP, Robertson LW. 2002. Replacement of partial hepatectomy with fasting/refeeding or the use of neonatal animals in the resistant hepatocyte model. Toxicol Sci 66:310.
  • Fadhel ZA, Lu Z, Robertson LW, Glauert HP. 2002. Effect of 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl on the induction of hepatic lipid peroxidation and cytochrome P-450 associated enzyme activities in rats. Toxicology 175(1-3):15-25. PMID:12049832
  • Fadhel ZA, Stafine N, Glauert HP, Robertson LW, Ludewig G. 2002. The effects of purified vs. unrefined diets on lipid peroxidation and antioxidant enzymes in tests of PCB-153 treated rats. Toxicol Sci 66:349.
  • Hennig B, Viswanathan S, Daugherty A, Toborek M. 2002. Fatty acid-induced endothelial cell activation. In: Atherosclerosis: Risk Factors, Diagnosis, and Treatment. Monduzzi Editore, Bologna, Italy. pp.37-40.
  • Hennig B, Viswanathan S, Toborek M. 2002. Fatty acid-induced endothelial cell activation. Atherosclerosis Supplements 3(2):123.
  • Lu Z, Robertson LW, Spear BT, Glauert HP. 2002. Effect of 2,2', 4,4', 5,5' -hexachlorobiphenyl (PCB153) on gene expression in mice deficient in the P50 subunit of NF-kappa B. In: Proceedings of the Superfund Basic Research Program Annual Meeting, November 3-6, 2002. Tucson, AZ.
  • Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. 2002. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by Polychlorinated Biphenyls. Toxicol Appl Pharmacol 179(3):172-184. PMID:11906247
  • Kostner GM, Kostner KM, eds. 2002. Atherosclerosis: Risk Factors, Diagnosis, and Treatment Monduzzi Editore, Bologna, Italy.

2001

  • Glauert HP, Silberhorn EM, Robertson LW. 2001. PCBs and tumor promotion. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.355-371.
  • Lu Z, Lee EY, Robertson LW, Spear BT, Glauert HP. 2001. Effect of dietary vitamin E on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl (PCB-77) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in rats initiated with diethylnitrosamine. Toxicol Sci 60:161.
  • Lu Z, Spear BT, Lee EY, Robertson LW, Glauert HP. 2001. Activation of Rat Hepatic Transcription Factor NF-kB by PCBs. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.419-420.
  • Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 2001. Effect Of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) And 3,3',4,4'-Tetrachlorobiphenyl (PCB-77) On NF-kB And AP-1 Activation, Altered Hepatic Foci Formation, Cell Proliferation, And Apoptosis In Rats. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.417-418.
  • Twaroski TP, O'Brien ML, Larmonier N, Glauert HP, Robertson LW. 2001. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E and oxidative stress in the rat liver. Toxicol Appl Pharmacol 171(2):85-93. PMID:11222084

2000

  • Calfee-Mason K, Spear BT, Glauert HP. 2000. Effect of dietary vitamin E on other cellular antioxidant defense systems in phenobarbital-treated rats. Toxicol Sci 54(1):946.
  • Fadhel ZA, Lu Z, Robertson LW, Glauert HP. 2000. Role of cytochrome P-450 induction and lipid peroxidation in 3,3',4,4'-tetrachlorobiphenyl (PCB-77)- and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153)-induced toxicity in liver of male rats. Toxicol Sci 54:78.
  • Glauert HP, Tharappel JC, Lee EY, Robertson LW, Spear BT. 2000. Effect of PCBs on the activation of the transcription factors AP-1 and NF-kB. Cent Eur J Public Health 8Suppl::17-18. PMID:10943439
  • Lu Z, Spear BT, Robertson LW, Glauert HP. 2000. Activation of hepatic hepatic NF-kB by polychlorinated biphenyls (PCBs) in vivo and in cultured rat hepatocytes. Toxicol Sci 54:254.
  • Robertson LW, Espandiari P, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Ludewig G, Glauert HP, Arif JM, Gupta RC. 2000. Metabolism and activation of polychlorinated biphenyls (PCBs). Cent Eur J Public Health 8Suppl:14-15. PMID:10943437
  • Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 2000. Effect of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 3,3',4,4'-tetrachlorobiphenyl (PCB-77) on NF-kB and AP-1 activation, altered hepatic foci formation, cell proliferation, and apoptosis in rats. Toxicol Sci 54:271.
  • Twaroski TP, Larmonier N, O'Brien ML, Glauert HP, Robertson LW. 2000. PCB-induced effects on cytochrome P-450 1A1, DT-diaphorase, AP-1 binding and oxidative stress in the rat liver. Chapter 41in: Proceedings of the 91st Annual Meeting of American Association for Cancer Research Annual Meeting, 2000. San Diego, CA. pp.507.

1998

  • Boissonneault GA, Hardwick TA, Bogardus SL, Chan WK, Tatum V, Glauert HP, Chow CK, Decker EA. 1998. Interactions between carnosine and vitamin E in mammary cancer risk determination. Nutr Res 18:723-733.
  • Glauert HP, Li Y, Nilakantan V, Tharappel JC, Calfee KG, Lu Z, Robertson LW, Spear BT. 1998. Role of NF-ÇB in the promotion of hepatocarcinogenesis. Pol J Pharmacol 50:80-81.
  • Leung LK, Glauert HP. 1998. Effect of the peroxisome proliferator ciprofibrate on hepatic cyclooxygenase and phospholipase A2 in rats. Toxicology 126(1):65-73. PMID:9585093
  • Nilakantan V, Spear BT, Glauert HP. 1998. Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity. Free Radic Biol Med 24:1430-1436. PMID:9641260
  • Nilakantan V, Spear BT, Glauert HP. 1998. Liver-specific catalase expression in transgenic mice inhibits NF-χB Activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate. Carcinogenesis 19:631-637.

1995

  • Berberian I, Chen L, Robinson FR, Glauert HP, Chow CK, Robertson LW. 1995. Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl in rats initiated with diethylnitrosamine. Carcinogenesis 16(2):393-398. PMID:7859372
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