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Your Environment. Your Health.

Project Publications: Boston University: PPAR, Hormones, and Xenobiotics

Superfund Research Program

PPAR, Hormones, and Xenobiotics

Project Leader: David J. Waxman
Grant Number: P42ES007381
Funding Period: 2000 - 2005

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page Visit the grantee's Twitter page View the grantee's Factsheet(377KB)




  • Ahluwalia A, Clodfelter KH, Waxman DJ. 2004. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. Mol Endocrinol 18(3):747-760. PMID:14684848
  • Hurst CH, Waxman DJ. 2004. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol Appl Pharmacol 199(3):266-274. PMID:15364542
  • Shipley JM, Waxman DJ. 2004. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol 199(3):275-284. PMID:15364543
  • Su T, Waxman DJ. 2004. Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes. Arch Biochem Biophys 424(2):226-234. doi:10.1016/ PMID:15047195


  • Hurst CH, Waxman DJ. 2003. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74(2):297-308. doi:10.1093/toxsci/kfg145 PMID:12805656
  • Shipley JM, Waxman DJ. 2003. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma. Mol Pharmacol 64(2):355-364. PMID:12869640
  • Su T, Waxman DJ. 2003. Impact of dimethyl sulphoxide on expression of nuclear receptors and drug-inducible cytochromes P450 (CYPs) in primary rat hepatocytes. FASEB J 17(4):A240-A240Part1Suppl..
  • Waxman DJ. 2003. Nuclear receptor regulation of drug-metzbolizing P450 enzymes. In: Encyclopedia Reference of Molecular Pharmacology. Springer-Verlag Press,


  • Ahluwalia A, Waxman DJ. 2002. Global gene expression profiling in rat liver using oligonucleotide microarrays: evaluation of the regulatory role of hormones and xenobiotics. In: New England Drug Metabolism Discussion Group Summer Symposium. Worcester, MA.
  • Goss KA, Clodfelter KH, Waxman DJ. 2002. Understanding P450 structure-function relationships using DNA shuffling mutagenesis. In: Boston University-Humboldt University Bioinformatics Workshop, Boston, MA.
  • Zhou Y, Davey HW, McLachlan MJ, Xie T, Waxman DJ. 2002. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicol Appl Pharmacol 182(1):1-10. PMID:12127257


  • Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98(6):3375-3380. PMID:11248086


  • Waxman DJ. 2000. Receptor-mediated signaling events in cytochrome P450 gene regulation. In: Proceedings of the Early Toxicity Screening in Drug Discovery Conference.


  • Maloney EK, Waxman DJ. 1999. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 161(2):209-218. PMID:10581215


  • Chang TK, Waxman DJ. 1998. Catalytic assays for human cytochrome P450. Methods Mol Biol 107:95-102. PMID:14577216
  • Chang TK, Waxman DJ. 1998. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol 107:103-109. PMID:14577217
  • Crespi CL, Chang TK, Waxman DJ. 1998. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high-performance liquid chromatography with fluorescence detection. Methods Mol Biol 107:141-145. PMID:14577223
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