Superfund Research Program

Nuclear Receptors and Gonadal Toxicity of Xenochemicals

Project Leader: David J. Waxman
Grant Number: P42ES007381
Funding Period: 2005-2012

Project-Specific Links

Publications

2011

• Bagchi G, Stanley KA, Zhang Y, Waxman DJ. 2011. Complex modulation of androgen responsive gene expression by methoxyacetic acid. Reprod Biol Endocrinol 9:doi:10.1186/1477-7827-9-42 PMID:21453523 PMCID:PMC3083340

2010

• Arany I, Baliga R, Tian N, Waxman DJ. 2010. Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells. Kidney International 78:182-190. doi:10.1038/ki.2010.100 PMID:20407477 PMCID:PMC3053138
• Bagchi G, Zhang Y, Waxman DJ. 2010. Impact of methoxyacetic acid on mouse Leydig cell gene expression. Reprod Biol Endocrinol 8:65. doi:10.1186/1477-7827-8-65 PMID:20565877 PMCID:PMC2909983
• Ling G, Sugathan A, Mazor T, Fraenkel E, Waxman DJ. 2010. Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Mol Cell Biol 30(23):5531-5544. doi:10.1128/MCB.00601-10 PMID:20876297 PMCID:PMC2976433
• Liu H, Tian N, Arany I, Bigler S, Waxman DJ, Shah S, Baliga R. 2010. Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy. J Biol Chem 285:40901-10. doi:10.1074/jbc.M110.165498 PMID:20947506 PMCID:PMC3003390

2009

• Bagchi G, Hurst CH, Waxman DJ. 2009. Interactions of methoxyacetic acid with androgen receptor. Toxicol Appl Pharmacol 238(2):101-110. doi:10.1016/j.taap.2008.03.015 PMID:18486176 PMCID:PMC2742301

2008

• Bagchi G, Waxman DJ. 2008. Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. Int J Androl 31(2):269-274. doi:10.1111/j.1365-2605.2007.00846.x PMID:18179559 PMCID:PMC3286123
• Johnston TP, Waxman DJ. 2008. Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice. Can J Physiol Pharmacol 86(9):643-649. doi:10.1139/y08-070 PMID:18758514 PMCID:PMC2615679
• Johnston TP, Waxman DJ. 2008. Peroxisome proiiferator-actlvated receptor (PPAR) agonists: using a mouse model of atherogenic dyslipidemia to better understand the PPAR-LXR-ABCA1 signaling pathway for accelerating cholesterol elimination. In: 22nd Ann Mtg Amer Assoc Pharm Sci.
• Johnston TP, Waxman DJ. 2008. The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha. J Pharm Pharmacol 60(6):753-759. doi:10.1211/jpp.60.6.0011 PMID:18498712 PMCID:PMC2496925
• Waxman DJ, Chang TK. 2008. Nuclear receptor regulation of hepatic cytochrome P450 enzymes. In: Encyclopedia of Molecular Pharmacology (2nd ed.). Springer, pp.889-893.

2007

• Clodfelter KH, Miles GD, Wauthier V, Holloway MG, Zhang X, Hodor P, Ray WJ, Waxman DJ. 2007. Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiol Genomics 31:63-74. PMID:17536022
• Ma X, Idle JR, Malfatti MA, Krausz KW, Nebert DW, Chen C, Felton JS, Waxman DJ, Gonzalez FJ. 2007. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 28(3):732-737. doi:10.1093/carcin/bgl184 PMID:17052995 PMCID:PMC1829392
• Sun L, Chen C, Waxman DJ, Liu H, Halpert JR, Kumar S. 2007. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Arch Biochem Biophys 458(2):167-174. doi:10.1016/j.abb.2006.12.021 PMID:17254539 PMCID:PMC1805465

2006

• Chang TK, Crespi CL, Waxman DJ. 2006. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.127-131.
• Chang TK, Waxman DJ. 2006. Catalytic assays for human cytochrome P450. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.73-83.
• Chang TK, Waxman DJ. 2006. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2 and CYP1B1 with 7-ethoxyresorufin as substrate. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.85-90.
• Chang TK, Waxman DJ. 2006. Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). J Mol Biol 38(1-2):51-73. PMID:16684648
• Clodfelter KH, Waxman DJ, Vajda S. 2006. Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450. Biochemistry 45(31):9393-407. PMID:16878974
• Crespi CL, Chang TK, Waxman DJ. 2006. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.121-125.
• Kaya T, Mohr SC, Waxman DJ, Vajda S. 2006. Computational screening of phthalate monoesters for binding to PPARgamma. Chem Res Toxicol 19(8):999-1009. doi:10.1021/tx050301s PMID:16918238
• Shipley JM, Waxman DJ. 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene. Toxicol Appl Pharmacol 213(2):87-97. PMID:16257430
• Waxman DJ, Chang TK. 2006. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2 and CYP3 families. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.153-156.

2005

• Hurst CH, Waxman DJ. 2005. Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR. Toxicol Sci 87:299-311.

2004

• Clodfelter KH, Waxman DJ. 2004. Computational solvent mapping reveals major differences in substrate binding between bacterial and mammalian cytochrome. In: Proceedings of the New England Member Enzyme Conference.
• Schlezinger JJ, Howard G, Hurst CH, Emberley JK, Waxman DJ, Webster TF, Sherr DH. 2004. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: Interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-Deoxy-Delta(12,14)-prostaglandin J(2). J Immunol 173(5):3165-3177. PMID:15322177