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Project Publications: Boston University: Training Core

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Superfund Research Program

Training Core

Project Leader: Michael D. McClean
Co-Investigator: Jean van Seventer (Boston University School of Public Health)
Grant Number: P42ES007381
Funding Period: 2017-2021

Project-Specific Links



  • Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Hahn ME, Nacci DE, Schlezinger JJ. 2020. Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARy. Aquat Toxicol 218:105334. doi:10.1016/j.aquatox.2019.105334 PMID:31743820 PMCID:PMC6935467


  • Butler L, Gallagher L, Winter MR, Fabian MP, Wesselink AK, Aschengrau A. 2019. Residential proximity to roadways and placental-associated stillbirth: a case-control study. Int J Environ Health Res 31:465-474. doi:10.1080/09603123.2019.1673882 PMID:31587563 PMCID:PMC7131873
  • Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Claus Henn B, Griffith KN, Howes BL, Schlezinger DR, Hahn ME, Nacci DE, Schlezinger JJ. 2019. Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. Aquat Toxicol 210:30-43. doi:10.1016/j.aquatox.2019.02.011 PMID:30822701 PMCID:PMC6544361
  • Crawford KA, Schlezinger DR, Craffey P, Heiger-Bernays WJ. 2019. Spatiotemporal trends in polychlorinated biphenyl concentrations in seafood based on long-term monitoring and remediation in New Bedford Harbor, Massachusetts. bioRxivorg doi:10.1101/675355
  • Edwards L, Watt J, Webster TF, Schlezinger JJ. 2019. Assessment of total, ligand-induced peroxisome proliferator activated receptor gamma ligand activity in serum. Environ Health 18(45):doi:10.1186/s12940-019-0486-2 PMID:31072366 PMCID:PMC6506953
  • Federico A, Karagiannis T, Karri K, Kishore D, Koga Y, Campbell J, Monti S. 2019. Pipeliner: a nextflow-based framework for the definition of sequencing data processing pipelines. Front Genet 10:614. doi:10.3389/fgene.2019.00614 PMID:31316552 PMCID:PMC6609566
  • Federico A, Monti S. 2019. hypeR: An R Package for Geneset Enrichment Workflows. Bioinformatics PMID:31498385 (in press)
  • Kartha V, Sebastiani P, Kern J, Zang L, Varelas X, Monti S. 2019. CaDrA: A computational framework for performing candidate driver analyses using genomic features. Front Genet 10:121. doi:10.3389/fgene.2019.00121 PMID:30838036 PMCID:PMC6390206
  • Li A, Lu X, Natoli T, Bittker J, Sipes N, Subramanian A, Auerbach SS, Sherr DH, Monti S. 2019. The Carcinogenome Project: in vitro gene expression profiling of chemical perturbations to predict long-term carcinogenicity. Environ Health Perspect 127:47002. doi:10.1289/EHP3986 PMID:30964323 PMCID:PMC6785232
  • Reed E, Moses E, Xiao X, Liu G, Campbell J, Perdomo C, Monti S. 2019. Assessment of a highly multiplexed RNA sequencing platform and comparison to existing high-throughput gene expression profiling techniques. Front Genet 10:150. doi:10.3389/fgene.2019.00150 PMID:30891063 PMCID:PMC6411637


  • Aschengrau A, Gallagher L, Winter MR, Butler L, Patricia FM, Vieira VM. 2018. Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths. Environ Health 17:58. doi:10.1186/s12940-018-0402-1 PMID:29970097 PMCID:PMC6029409
  • Aschengrau A, Gallagher LG, Winter MR, Butler L, Fabian MP, Vieira VM. 2018. Modeled exposure to tetrachloroethylene-contaminated drinking water and the occurrence of birth defects: a case-control study from Massachusetts and Rhode Island. Environ Health 17(1):75. doi:10.1186/s12940-018-0419-5 PMID:30400949 PMCID:PMC6219161
  • Basra K, Fabian MP, Scammell MK. 2018. Consumption of contaminated seafood in an environmental justice community: A qualitative and spatial analysis of fishing controls. Environ Justice 11(1):doi:10.1089/env.2017.0010 PMID:30828408 PMCID:PMC5830855 (ahead of print)
  • Basra K, Scammell MK, Benson EB, Heiger-Bernays WJ. 2018. Ambient air exposure to PCBs: Regulation and monitoring at five contaminated sites in EPA Regions 1, 2, 4, and 5. New Solut 28(2):262-282. doi:10.1177/1048291118763620 PMID:29558851
  • Glazer L, Kido Soule MC, Longnecker K, Kujawinski EB, Aluru N. 2018. Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 205:114-122. doi:10.1016/j.aquatox.2018.10.007 PMID:30368057 PMCID:PMC6246827
  • Kim S, Li A, Monti S, Schlezinger JJ. 2018. Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 1-16. doi:10.1007/s00204-018-2268-y PMID:30027469
  • Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees F, Hahn ME, Stegeman JJ. 2018. Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta 1866:155-165. doi:10.1016/j.bbapap.2017.06.026 PMID:28694077 PMCID:PMC5693637
  • Narasimhan S, Zulick ES, Novikov O, Parks A, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. 2018. Towards resolving the pro- and anti-tumor effects of the aryl hydrocarbon receptor. Int J Mol Sci 19:24. doi:10.3390/ijms19051388 PMID:29735912 PMCID:PMC5983651
  • Tomsho KS, Basra K, Rubin SM, Miller CB, Juang R, Broude S, Martinez A, Hornbuckle KC, Heiger-Bernays WJ, Scammell MK. 2018. Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environ Sci Pollut Res Int 25(17):16389-16400. doi:10.1007/s11356-017-0286-6 PMID:29079973 PMCID:PMC6015112
  • Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. 2018. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. Journal of Cellular Physiology 233:7007-7021. doi:10.1002/jcp.26495 PMID:29380368
  • Wesselink AK, Hatch EE, Wise L, Rothman KJ, Vieira VM, Aschengrau A. 2018. Exposure to tetrachloroethylene-contaminated drinking water and time to pregnancy. Environ Res 167:136-143. doi:10.1016/j.envres.2018.07.012 PMID:30014895


  • Butler L, Scammell MK, Benson EB. 2016. The Flint, Michigan water crisis: a case study in regulatory failure and environmental injustice. Environ Justice 9:93-97. doi:10.1089/env.2016.0014
  • Carignan C, Fang M, Stapleton HM, Heiger-Bernays WJ, McClean MD, Webster TF. 2016. Urinary biomarkers of flame retardant exposure among collegiate US gymnasts. Environ Int 94:362-368. doi:10.1016/j.envint.2016.06.030 PMID:27395335 PMCID:PMC4980234
  • Carwile JL, Butler L, Janulewicz PA, Winter MR, Aschengrau A. 2016. Childhood fish consumption and learning and behavioral disorders. Int J Environ Res Public Health 13(11):doi:10.3390/ijerph13111069 PMID:27827868 PMCID:PMC5129279
  • Chapuy B, Cheng H, Watahiki A, Ducar M, Tan Y, Chen L, Roemer M, Ouyang J, Christie A, Zhang L, Gusenleitner D, Abo R, Farinha P, von Bonin F, Thorner A, Sun H, Gascoyne R, Pinkus G, van Hummelen P, Wulf G, Aster J, Weinstock D, Monti S, Rodig S, Wang Y, Shipp M. 2016. Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease. Blood 127(18):2203-2213. doi:10.1182/blood-2015-09-672352 PMID:26773040 PMCID:PMC4859195
  • Girguis M, Strickland M, Hu X, Liu Y, Bartell SM, Vieira VM. 2016. Maternal exposure to traffic-related air pollution and birth defects in Massachusetts. Environ Res 146:1-9. doi:10.1016/j.envres.2015.12.010 PMID:26705853 PMCID:PMC4761511
  • Hewlett MM, Chow E, Aschengrau A, Mahalingaiah S. 2016. Prenatal exposure to endocrine disruptors: a developmental etiology for polycystic ovary syndrome. Reprod Sci 24(1):19-27. doi:10.1177/1933719116654992 PMID:27342273
  • Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ. 2016. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol 296:73-84. doi:10.1016/j.taap.2016.02.001 PMID:26853319 PMCID:PMC4807407
  • Mahalingaiah S, Winter MR, Aschengrau A. 2016. Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study. Reprod Toxicol 65:87-94. doi:10.1016/j.reprotox.2016.07.005 PMID:27412368 PMCID:PMC5091798
  • Padilla CM, Kihal-Talantikite W, Vieira VM, Deguen S. 2016. City-specific spatiotemporal infant and neonatal mortality clusters: links with socioeconomic and air pollution spatial patterns in France. Int J Environ Res Public Health 13(6):doi:10.3390/ijerph13060624 PMID:27338439 PMCID:PMC4924081
  • Pennell KG, Scammell MK, McClean MD, Suuberg EM, Moradi A, Moradi A, Roghani M, Ames J, Friguglietti L, Indeglia PA, Shen R, Yao Y, Heiger-Bernays WJ. 2016. Field data and numerical modeling: a multiple lines of evidence approach for assessing vapor intrusion exposure risks. Sci Total Environ 556:291-301. doi:10.1016/j.scitotenv.2016.02.185 PMID:26977535 PMCID:PMC4844003
  • Smith BW, Stanford EA, Sherr DH, Murphy GJ. 2016. Genome editing of the CYP1A1 locus in iPSCs as a platform to map AHR expression throughout human development. Stem Cells Int 2016:2574152. doi:10.1155/2016/2574152 PMID:27148368 PMCID:PMC4842384
  • Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH. 2016. Role for the aryl hydrocarbon receptor and diverse ligands in oral squamous cell carcinoma migration and tumorigenesis. Mol Cancer Res 14(8):696-706. doi:10.1158/1541-7786.MCR-16-0069 PMID:27130942 PMCID:PMC4987205
  • Stawski L, Kartha V, Han R, Haines P, Gallagher G, Noonan V, Kukuruzinska M, Monti S, Trojanowska M. 2016. PDGFRβ is a novel marker of stromal activation in oral squamous cell carcinomas. PLoS One 11(4):e0154645. doi:10.1371/journal.pone.0154645 PMID:27128408 PMCID:PMC4851360
  • Voena C, Varesio L, Zhang L, Menotti M, Poggio T, Panizza E, Wang Q, Minero V, Fagoonee S, Compagno M, Altruda F, Monti S, Chiarle R. 2016. Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1. Oncotarget 7(22):33316-33330. doi:10.18632/oncotarget.8955 PMID:27119231 PMCID:PMC5078097
  • Watt J, Webster TF, Schlezinger JJ. 2016. Generalized concentration addition modeling predicts mixture effects of environmental PPARγ agonists. Toxicol Sci 153(1):18-27. doi:10.1093/toxsci/kfw100 PMID:27255385 PMCID:PMC5013877
  • Wincent E, Kubota A, Timme-Laragy A, Jonsson ME, Hahn ME, Stegeman JJ. 2016. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol 110-111:117-129. doi:10.1016/j.bcp.2016.04.012 PMID:27112072 PMCID:PMC4887394


  • Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. 2015. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol 28(6):1156-1166. doi:10.1021/tx500433r PMID:25932594 PMCID:PMC4737589
  • Watt J, Schlezinger JJ. 2015. Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology 331:66-77. doi:10.1016/j.tox.2015.03.006 PMID:25777084 PMCID:PMC4406869


  • Parks A, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. 2014. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86(5):593-608. doi:10.1124/mol.114.093369 PMID:25159092 PMCID:PMC4201140





  • Webster TF. 2000. Bias in ecologic and semi-individual studies. D.Sc. Thesis. Boston University.
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