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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of California-San Diego: Glutathione Conjugation of Environmental Toxins

Superfund Research Program

Glutathione Conjugation of Environmental Toxins

Project Leader: Michael J. Kelner
Grant Number: P42ES010337
Funding Period: 2000-2010

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Publications

2004

  • Kelner MJ, Bagnell RD, Morgenstern R. 2004. Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression. Biochim Biophys Acta 1678(2-3):163-169. doi:10.1016/j.bbaexp.2004.03.001 PMID:15157743
  • Khetani SR, Szulgit G, Del Rio JA, Barlow C, Bhatia SN. 2004. Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Hepatology 40(3):545-554. doi:10.1002/hep.20351 PMID:15349892
  • Lin P, Chan WC, Badylak S, Bhatia SN. 2004. Assessing porcine liver-derived biomatrix for hepatic tissue engineering. Tissue Engineering Part A 10(7-8):1046-53. PMID:15363162

2003

  • Allen JW, Bhatia SN. 2003. Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol Bioeng 82(3):253-262. doi:10.1002/bit.10569 PMID:12599251
  • Ekstrom L, Lyrenas L, Jakobsson PJ, Morgenstern R, Kelner MJ. 2003. Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3. Biochim Biophys Acta 1627(2-3):79-84. PMID:12818425
  • Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. 2003. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng 81(5):578-587. PMID:12514807
  • Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ. 2003. Polymer replicas of photonic porous silicon for sensing and drug delivery applications. Science 299(5615):2045-2047. PMID:12663921
  • Ozkan M, Pisanic T, Scheel J, Barlow C, Esener S, Bhatia SN. 2003. Electro-optical platform for the manipulation of live cells. Langmuir 19(5):1532-1538.
  • Vozzi G, Flaim C, Ahluwalia A, Bhatia SN. 2003. Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials 24(14):2533-2540. PMID:12695080

2002

  • Cunin F, Schmedake T, Link JR, Li YY, Koh J, Bhatia SN, Sailor MJ. 2002. Biomolecular screening with encoded porous-silicon photonic crystals. Nat Mater 1(1):39-41. doi:10.1038/nmat702 PMID:12618846
  • Liu VA, Bhatia SN. 2002. Three-dimensional photopatterning of hydrogels containing living cells. Biomed Microdevices 4(4):257-66.
  • Liu VA, Jastromb WE, Bhatia SN. 2002. Engineering protein and cell adhesivity using PEO-terminated triblock polymers. J Biomed Mater Res 60(1):126-134. doi:10.1002/jbm.10005 PMID:11835168

2001

  • Allen JW, Hassanein T, Bhatia SN. 2001. Advances in bioartificial liver devices. Hepatology 34(3):447-455. PMID:11526528
  • Chin V, Collins BE, Sailor MJ, Bhatia SN. 2001. Compatibility of primary hepatocytes on nanoporous silicon. Advanced Materials 13(24):1877-1880.

2000

  • Behnia K, Bhatia SN, Jastromb N, Balis U, Sullivan S, Yarmush M, Toner M. 2000. Xenobiotic metabolism by cultured primary porcine hepatocytes. Tissue Engineering Part A 6(5):467-479. PMID:11074934
  • Kelner MJ, Bagnell RD, Montoya MA, Estes LA, Forsberg L, Morgenstern R. 2000. Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p131-132 Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. J Biol Chem 275(17):13000-13006. PMID:10777602

1999

  • Balis U, Behnia K, Dwarakanath B, Bhatia SN, Sullivan S, Yarmush M, Toner M. 1999. Oxygen consumption characteristics of porcine hepatocytes. Metab Eng 1(1):49-62. PMID:10935754
  • Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Effect of cell-cell interactions in preservation of cellular phenotype: co-cultivation of hepatocytes and non-parenchymal cells. FASEB J 13(14):1883-1900. PMID:10544172
  • Bhatia SN, Chen CS. 1999. Tissue engineering at the micro-scale. Biomed Microdevices 2(2):131-144.
  • Ledezma GA, Folch A, Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes. J Biomech Eng 121(1):58-64. PMID:10080090

1998

  • Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions. Biotechnol Prog 14(3):378-387. PMID:9622518
  • Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. Journal of Biomaterials Science, Polymer Edition 9(11):1137-1160. PMID:9860177

1997

  • Bhatia SN, Yarmush M, Toner M. 1997. Controling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts. J Biomed Mater Res 34(2):189-199. PMID:9029299

1996

  • Bhatia SN, Toner M, Foy BD, Rotem A, Tompkins R, Yarmush M. 1996. Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes. Journal of Cellular Engineering 1:125-135.
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