Superfund Research Program

Multiscale Imaging and Proteomics Core

Project Leader: Mark H. Ellisman
Co-Investigators: Elizabeth A. Komives, Roger Y. Tsien
Grant Number: P42ES010337
Funding Period: 2005-2017

Project-Specific Links

Publications

2016

• Zhang Z, Xie Q, Jobe TO, Kau AR, Wang C, Li Y, Qiu B, Wang Q, Mendoza-Cozatl DG, Schroeder JI. 2016. Identification of AtOPT4 as a plant glutathione transporter. Mol Plant 9(3):481-484. doi:10.1016/j.molp.2015.07.013 PMID:26283048 PMCID:PMC5139274
• Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins GA, Ali S, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. 2016. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164(5):896-910. doi:10.1016/j.cell.2015.12.057 PMID:26919428 PMCID:PMC4769378

2015

• Antonucci L, Fagman JB, Kim J, Todoric J, Gukovsky I, Mackey MR, Ellisman MH, Karin M. 2015. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A 112(45):E6166-E6174. doi:10.1073/pnas.1519384112 PMID:26512112 PMCID:PMC4653219

2014

• Dowding JM, Song W, Bossy K, Karakoti A, Kumar A, Kim AH, Bossy B, Seal S, Ellisman MH, Perkins GA, Self WT, Bossy-Wetzel E. 2014. Cerium oxide nanoparticles protect against A beta -induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ 21(10):1622-1632. doi:10.1038/cdd.2014.72 PMID:24902900 PMCID:PMC4158687
• Engineer C, Ghassemian M, Anderson JC, Peck SC, Hu H, Schroeder JI. 2014. Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development. Nature 513(7517):246-250. doi:10.1038/nature13452 PMID:25043023 PMCID:PMC4274335
• Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. 2014. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124(8):3566-3578. doi:10.1172/JCI74068 PMID:24983318 PMCID:PMC4109552
• Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. 2014. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell 26(3):331-343. doi:10.1016/j.ccr.2014.07.001 PMID:25132496 PMCID:PMC4165611

2012

• Perkins GA, Scott RT, Perez A, Ellisman MH, Johnson JE, Fox DA. 2012. Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: Electron microscopy, tomography and oxygen consumption. Mol Vis 18:3029-3048. PMID:23288995 PMCID:PMC3534145

2010

• Suhr ST, Chang E, Tjong J, Alcasid N, Perkins GA, Goissis M, Ellisman MH, Perez GI, Cibelli J. 2010. Mitochondrial rejuvenation after induced pluripotency. PLoS One 5:e14095:doi:10.1371/journal.pone.0014095 PMID:21124794 PMCID:PMC2991355

2009

• Perkins GA, Bossy-Wetzel E, Ellisman MH. 2009. New insights into mitochondrial structure during cell death. Experimental Neurology 218(2):183-92. doi:10.1016/j.expneurol.2009.05.021 PMID:19464290 PMCID:PMC2712651
• Perkins GA, Sun M, Frey TG. 2009. Chapter 2 Correlated light and electron microscopy/electron tomography of mitochondria in situ. Methods Enzymol 456:29-52. doi:10.1016/S0076-6879(08)04402-9 PMID:19348881 PMCID:PMC2730195
• Yamaguchi R, Perkins GA. 2009. Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochim Biophys Acta 1787(8):963-972. doi:10.1016/j.bbabio.2009.02.005 PMID:19245786 PMCID:PMC2773558

2008

• Knott AB, Perkins GA, Schwarzenbacher R, Bossy-Wetzel E. 2008. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9(7):505-518. doi:10.1038/nrn2417 PMID:18568013 PMCID:PMC2711514
• Yamaguchi R, Lartigue L, Perkins GA, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. 2008. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell 31(4):557-569. doi:10.1016/j.molcel.2008.07.010 PMID:18691924 PMCID:PMC2636708

2007

• Bencheikh-Latmani R, Obraztsova AY, Mackey MR, Ellisman MH, Tebo BM. 2007. Toxicity of Cr(III) to Shewanella sp. strain MR-4 during Cr(VI) reduction. Environ Sci Technol 41(1):214-220. PMID:17265950

2006

• Nguyen V, Schroeder JI. 2006. The role of reactive oxygen species in hormonal responses. Plant Physiol 141(2):323-329. PMID:16760482
• Schroeder JI, Kuhn JM. 2006. Plant biology: abscisic acid in bloom. Nature 439(7074):277-278. doi:10.1038/439277a PMID:16421556
• Schroeder JI, Nambara E. 2006. A quick release mechanism for abscisic acid. Cell 126(6):1023-1025. PMID:16990126

2005

• Coggan JS, Bartol TM, Esquenazi E, Stiles JR, Lamont S, Martone ME, Berg DK, Ellisman MH, Sejnowski TJ. 2005. Evidence for ectopic neurotransmission at a neuronal synapse. Science 309:446-451. PMID:16020730
• Giepmans BN, Deerinck TJ, Smarr BL, Jones YZ, Ellisman MH. 2005. Correlated light and electron microscopic imaging of multiple endogenous proteins using Quantum dots. Nat Methods 2(10):743-749. PMID:16179920
• Sosinsky GE, Deerinck TJ, Greco R, Buitenhuys CH, Bartol TM, Ellisman MH. 2005. Development of a model for microphysiological simulations: small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography. Neuroinformatics 3(2):133-162. doi:10.1385/NI:3:2:133 PMID:15988042

2004

• Martone ME, Gupta A, Ellisman MH. 2004. e-Neuroscience: challenges and triumphs in integrating distributed data from molecules to brains. Nat Neurosci 7:467-472. PMID:15114360

2003

• Martone ME, Zhang S, Gupta A, Qian X, He H, Price DL, Wong M, Santini S, Ellisman MH. 2003. The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy. Neuroinformatics 1(4):379-396. PMID:15043222