Superfund Research Program

Detection and Models of Toxicant Exposure

Center Director: Robert H. Tukey
Grant Number: P42ES010337
Funding Period: 2000-2023

Program Links

Publications

2024

• Hsu CL, Loomba R. 2024. From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research. Nat Metab doi:10.1038/s42255-024-00985-1 PMID:38383845
• Koh J, Ng CH, Nah B, Tan D, Loomba R, Huang DQ. 2024. NASH is the leading cause of hepatocellular carcinoma in liver transplant candidates. Clin Gastroenterol Hepatol 22(1):197-199. doi:10.1016/j.cgh.2023.05.019 PMID:37245718
• Rabin B, Cain KL, Ayers LO, Lomeli A, Escoto AA, Burola M, Aguilar M, Tinoco-Calvillo S, Reyes B, Salgin L, Tukey RH, Laurent LC, Stadnick NA. 2024. Adaptation of the brainwriting premortem technique to inform the co-creation of COVID-19 testing strategies in underserved communities in South San Diego. BM Health Serv Res 24(1):12. doi:10.1186/s12913-023-10341-w PMID:38172787 PMCID:PMC10765849
• Tan P, Ostertag T, Rosenthal SB, Chilin-Fuentes D, Aidnik H, Linker S, Murphy K, Miner J, Brenner DA. 2024. Role of hepatic stellate and liver sinusoidal endothelial cells in a human primary cell three-dimensional model of nonalcoholic steatohepatitis. Am J Pathol 194(3):353-368. doi:10.1016/j.ajpath.2023.12.005 PMID:38158078 PMCID:10913759

2023

• Amangurbanova M, Huang DQ, Loomba R. 2023. Review article: the role of HSD17B13 on global epidemiology, natural history, pathogenesis and treatment of NAFLD. Aliment Pharmacol Ther 57(1):37-51. doi:10.1111/apt.17292 PMID:36349732 PMCID:PMC10047549
• Antal CE, Oh TG, Aigner S, Luo E, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. 2023. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun 14(1):5195. doi:10.1038/s41467-023-40798-6 PMID:37673892 PMCID:PMC10482938
• Billon C, Situala S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. 2023. Synthetic ERRalpha/beta/gamma agonist induces an ERRalpha- dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol 18(4):756-771. doi:10.1021/acschembio.2c00720 PMID:36988910
• Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest AR, Tirnitz-Parker JE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. 2023. Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC. Sci Adv 9(37):eadh0831. doi:10.1126/sciadv.adh0831 PMID:37703359 PMCID:PMC10499313
• Cassin J, Stamou MI, Keefe KW, Sung K, Bojo C, Tonsfeldt KJ, Rojas RA, Lopes VF, Plummer L, Salnikov KB, Keefe DL, Ozata M, Genel M, Georgopoulos NA, Hall JE, Crowley WF, Seminara SB, Mellon PL, Balasubramanian R. 2023. Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms. JCI Insight e164324. doi:10.1172/jci.insight.164324 PMID:36602867 PMCID:PMC9977424
• Giustini AB, Loannou GN, Sirlin C, Loomba R. 2023. Review article: available modalities for screening and imaging diagnosis of hepatocellular carcinoma-Current gaps and challenges. Aliment Pharmacol Ther doi:10.1111/apt.17506 PMID:37038283
• He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M. 2023. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol 79(2):362-377. doi:10.1016/j.jhep.2023.03.016 PMID:36996941
• Huang DQ, Ajmera VH, Tomaszewski C, LaFree A, Bettencourt R, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Insel PA, Leachman S, Jung J, Collier S, Richards L, Woods K, Amangurbanova M, Bhatt A, Zhang X, Penciu OM, Zarich S, Retta T, Harkins MS, Teixeira JP, Chinnock B, Utay NS, Lake JE, Loomba R. 2023. Ramipril for the treatment of COVID-19: RAMIC, a randomized, double-blind, placebo-controlled clinical trial. Adv Ther 40(11):4805-4816. doi:10.1007/s12325-023-02618-7 PMID:37615850 PMCID:PMC10709987
• Huang DQ, Chan KE, Tan C, Zeng RW, Koh B, Ong EY, Ong CC, Ong CE, Tan DJ, Lim WH, Cho E, Tan EX, Teng ML, Ng CH, Nah B, Lim MC, Muthiah M, Clark VC, Loomba R. 2023. Meta-analysis: prevalence of significant or advanced fibrosis in adults with alpha-1-antitrypsin deficiency. Aliment Pharmacol Ther doi:10.1111/apt.17516 PMID:37089038
• Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R. 2023. Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors. Nat Rev Gastroenterol Hepatol 20(1):37-49. doi:10.1038/s41575-022-00688-6 PMID:36258033 PMCID:PMC9579565
• Huang DQ, Noureddin N, Ajmera VH, Amangurbanova M, Bettencourt R, Truong E, Gidener T, Siddiqi H, Majzoub AM, Nayfeh T, Tamaki N, Izumi N, Yoneda M, Nakajima A, Idilman R, Gumussoy M, Oz DK, Erden A, Allen AM, Noureddin M, Loomba R. 2023. Type 2 diabetes, hepatic decompensation, and hepatocellular carcinoma in patients with non-alcoholic fatty liver disease: an individual participant-level data meta-analysis. Lancet Gastroenterol Hepatol 8(9):829-836. doi:10.1016/S2468-1253(23)00157-7 PMID:37419133
• Huang DQ, Tan DJ, Ng CH, Amangurbanova M, Sutter N, Tay PW, Lim WH, Yong JN, Tang A, Syn N, Muthiah M, Tan EX, Dave S, Tay B, Majzoub AM, Gerberi D, Kim BK, Loomba R. 2023. Hepatocellular carcinoma incidence in alcohol-associated cirrhosis: systematic review and meta-analysis. Clin Gastroenterol Hepatol 21(5):1169-1177. doi:10.1016/j.cgh.2022.06.032 PMID:35940513
• Huang DQ, Wilson LA, Behling C, Kleiner D, Kowdley KV, Dasarathy S, Amangurbanova M, Terrault N, Diehl AM, Chalasani N, Neuschwander-Tetri BA, Sanyal AJ, Tonascia J, Loomba R, Allende D, Bellar A, Dasarathy J, Guy C, Kopping M, Piercy D, Suzuki A, Tawadrou N, Cruz M, Cummings OW, Garrison L, Gawrieh S, Samala N, Vuppalanchi R, Carpenter D, Cattoor T, Freebersyser J, Angkanaworakul P, Berihun A, Buysse A, Dorrian T, Gulati B, Liu K, Misic S, Sohal A, Vuong J, Ajmera VH, Madamba E, Middleton MS, Richards L, Singh S, Sirlin C, Gill R, Hameed B, Awe R, Olvera D, Yuan L, Yeh M, Albhaisi S, Asgharpour A, Boyett S, Contos MJ, Luketic VA, Schlosser J, Siddiqui MS, Adamo P, Belt P, Clark JM, DeSanto JM, Meinert J, Miriel L, Mitchell EP, Shade C, Smith J, Smith M, Sternberg A, Natta ML, Wagoner A, Woreta T, Yates KP. 2023. Fibrosis progression rate in biopsy-proven nonalcoholic fatty liver disease among people with diabetes versus people without diabetes: a multicenter study. Gastroenterology 165(2):463-472. doi:10.1053/j.gastro.2023.04.025 PMID:37127100
• Kim HY, Sakane S, Eguileor A, Weber RC, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T. 2023. The origin and fate of liver myofibroblasts. Cell Mol Gastroenterol Hepatol 17(1):93-106. doi:10.1016/j.jcmgh.2023.09.008 PMID:37743012 PMCID:PMC10665929
• Kushwaha P, Tran A, Quintero D, Song M, Yu Q, Yu RT, Downes M, Evans RM, Babst-Kostecka AA, Schroeder JI, Maier RM. 2023. Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome. Sci Total Environ 899:165667. doi:10.1016/j.scitotenv.2023.165667 PMID:37478925
• Liu X, Lam K, Zhao H, Sakane S, Kim HY, Eguileor A, Diggle K, Wu S, Weber RC, Soroosh P, Hosseini M, Mekeel K, Brenner DA, Kisseleva T. 2023. Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers. STAR Protoc 4(3):102391. doi:10.1016/j.xpro.2023.102391 PMID:37405925 PMCID:PMC10345194
• Loomba R, Huang DQ, Sanyal AJ, Anstee QM, Trauner M, Lawitz EJ, Ding D, Ma L, Jia C, Billin A, Huss RS, Chung C, Goodman Z, Wong VW, Okanoue T, Romero-Gomez M, Abdelmalek MF, Muir A, Afdhal N, Bosch J, Harrison SA, Younossi Z, Myers RP. 2023. Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis. Gut 72(3):581-589. doi:10.1136/gutjnl-2022-327777 PMID:36750244 PMCID:PMC9905707
• Rabin B, Cain KL, Salgin L, Watson P, Oswald W, Kaiser BN, Ayers LO, Yi C, Alegre A, Ni J, Reyes A, Yu KE, Broyles SL, Tukey RH, Laurent LC, Stadnick NA. 2023. Using ethnographic approaches to document, evaluate, and facilitate virtual community-engaged implementation research. BMC Public Health 23(1):409. doi:10.1186/s12889-023-15299-2 PMID:36855118 PMCID:PMC9974043
• Salgin L, Ayers LO, Burola M, Engler A, Osuna A, Gay L, Cain KL, Stadnick NA, Rabin AB, Zaslavsky I, Laurent LC, Tukey RH, Seifert M. 2023. Perceived COVID-19 risk and testing experiences in the San Ysidro U.S./Mexico border region. Transl Behav Med doi:10.1093/tbm/ibac120 PMID:36999822 PMCID:PMC10314726
• Sharpton S, Shan K, Bettencourt R, Lee M, McCormick JB, Fisher-Hoch SP, Loomba R. 2023. Original Article: prevalence and factors associated with liver fibrosis among first-degree relatives of Mexican Americans with hepatocellular carcinoma. Aliment Pharmacol Ther doi:10.1111/apt.17384 PMID:36628455
• Torosian K, Lal E, Kavanaugh A, Loomba R, Ajmera VH, Guma M. 2023. Psoriatic disease and non-alcoholic fatty liver disease shared pathogenesis review. Semin Arthritis Rheum 59:152165. doi:10.1016/j.semarthrit.2023.152165 PMID:36716599 PMCID:PMC9992353
• Van Loh B, Yaw AM, Breuer JA, Jackson B, Nguyen D, Jang K, Ramos F, Ho EV, Cui L, Gillette D, Sempere LF, Gorman MR, Tonsfeldt KJ, Mellon PL, Hoffmann HM. 2023. The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice. Front. Endocrinol 14:doi:10.3389/fendo.2023.1269672 PMID:38205198 PMCID:10777845
• Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JY, Chang M, Benner CW, Tukey RH, Chen S. 2023. Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem 299(3):102955. doi:10.1016/j.jbc.2023.102955 PMID:36720308 PMCID:PMC9996368
• Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts P, Tukey RH, Chen S. 2023. Effects of early life oral arsenic exposure on intestinal tract development and lipid homeostasis in neonatal mice: Implications for NAFLD development. Environ Health Perspect 131(9):doi:10.1289/ehp12381 PMID:37668303 PMCID:10478510
• Zeng RW, Yong JN, Tan DJ, Fu CE, Lim WH, Xiao J, Chan KE, Tan C, Goh XL, Chee D, Syn N, Tan EX, Muthiah M, Ng CH, Tamaki N, Lee SW, Kim BK, Nguyen MH, Loomba R, Huang DQ. 2023. Meta-analysis: chemoprevention of hepatocellular carcinoma with statins, aspirin and metformin. Aliment Pharmacol Ther 57(6):600-609. doi:10.1111/apt.17371 PMID:36625733
• Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, Wang Y, Ma S, Huang WJ, Lee J, Lee SM, Carvalho-Gontijo R, Zhang V, Hoffmann JP, Kolls J, Raz E, Brenner DA, Kisseleva T, LeibundGut-Landmann S, Bacher P, Starkel P, Schnabl B. 2023. Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. Cell Host Microbe 31(3):389-404. doi:10.1016/j.chom.2023.02.001 PMID:36893735 PMCID:PMC1003970

2022

• Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang L, Vogel I, Zhou C, Nguyen V, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Alexander LE, Suh J, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee I, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. 2022. Obesity alters pathology and treatment response in inflammatory disease. Nature 604:337-342. doi:10.1038/s41586-022-04536-0 PMID:35355021
• Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. 2022. Metabolic injury of hepatocytes promotes progression of NAFLD and AALD. Semin Liver Dis 42(3):233-249. doi:10.1055/s-0042-1755316 PMID:36001995
• Danis N, Weeks SR, Kim A, Baghdadi A, Ghadimi M, Kamel IR, Saberi B, Woreta T, Garonzik-Wang J, Philosophe B, Gurakar A, Loomba R. 2022. Noninvasive risk stratification for nonalcoholic fatty liver disease among living liver donor candidates: A proposed algorithm. Liver Transpl 28(4):670-677. doi:10.1002/lt.26365 PMID:34753223
• Evans RM, Wei Z. 2022. Interorgan crosstalk in pancreatic islet function and pathology. FEBS Lett 13:doi:10.1002/1873-3468.14282 PMID:35014695
• Fu T, Li Y, Oh TG, Cayabyab F, He N, Tang Q, Coulter S, Truitt ML, Medina P, He M, Yu RT, Atkins AR, Zheng Y, Liddle C, Downes M, Evans RM. 2022. FXR mediates ILC-intrinsic responses to intestinal inflammation. Proc Natl Acad Sci U S A 119(51):e2213041119. doi:10.1073/pnas.2213041119 PMID:36508655
• Gao H, Jin Z, Bandyopadhyay G, Rocha KC, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky J. 2022. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab 34(7):978-990. doi:10.1016/j.cmet.2022.05.008 PMID:35700738 PMCID:PMC9262870
• Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KC, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. 2022. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab 34(8):1201-1213. doi:10.1016/j.cmet.2022.07.006 PMID:35921818 PMCID:PMC9365100
• Huang D, Fowler KJ, Liau J, Cunha GM, Louie AL, An JY, Bettencourt R, Jung J, Gitto Z, Hernandez C, Lopez S, Gupta H, Sirlin CB, Marks RM, Loomba R. 2022. Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study. Aliment Pharmacol Ther 55(7):820-827. doi:10.1111/apt.16844 PMID:35229334
• Huang DQ, Downes M, Evans RM, Witzum JL, Glass CK, Loomba R. 2022. Shared mechanisms between cardiovascular disease and NAFLD. Semin Liver Dis 42(4):455-464. doi:10.1055/a-1930-6658 PMID:36008083 PMCID:PMC9828940
• Huang DQ, Singal AG, Kono Y, Tan DJ, El-Serag HB, Loomba R. 2022. Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer. Cell Metab 34(7):969-977. doi:10.1016/j.cmet.2022.05.003 PMID:35793659
• Kim J, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. 2022. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab 34(10):1548-1560. doi:10.1016/j.cmet.2022.08.005 PMID:36041455 PMCID:PMC9547947
• Lavalle SN, Chou T, Hernandez J, Naing NP, He MY, Tonsfeldt KJ, Mellon PL. 2022. Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice. Mol Cell Endocrinol 546:111577. doi:10.1016/j.mce.2022.111577 PMID:35121076 PMCID:PMC8934285
• Liu Y, Meric G, Havulinna AS, Teo SM, Aberg F, Ruuskanen MO, Sanders JG, Zhu Q, Tripathi A, Verspoor K, Cheng S, Jain M, Jousilahti P, Vazquez-Baeza Y, Loomba R, Lahti L, Niiranen TJ, Salomaa VV, Knight R, Inouye M. 2022. Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting. Cell Metab 34(5):719-730. doi:10.1016/j.cmet.2022.03.002 PMID:35354069 PMCID:PMC9097589
• Meadows JD, Breuer JA, Lavalle SN, Hirschenberger MR, Patel MM, Nguyen D, Kim A, Cassin J, Gorman MR, Welsh DK, Mellon PL, Hoffmann HM. 2022. Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice. Mol Metab 57:doi:10.1016/j.molmet.2021.101431 PMID:34974160 PMCID:PMC8810556
• Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH. 2022. Intestinal UDP-glucuronosyltransferase 1A1 and protection against irinotecan-induced toxicity in a novel UDP-glucuronosyltransferase 1A1 tissue-specific humanized mouse model. Drug Metab Dispos 50:33-42. doi:10.1124/dmd.121.000644 PMID:34697081
• Nishio T, Koyama Y, Fuji H, Ischizuka K, Iwaisako K, Taura K, Hatano E, Brenner DA, Kisseleva T. 2022. The role of mesothelin in activation of portal fibroblasts in cholestatic liver injury. Biology (Basel) 11(11):1589. doi:10.3390/biology11111589 PMID:36358290
• Qin Y, Havulinna AS, Liu Y, Jousilahti P, Ritchie SC, Tokolyi A, Sanders JG, Valsta LM, Brozynska M, Zhu Q, Tripathi A, Vazquez-Baeza Y, Loomba R, Cheng S, Jain M, Niiranen TJ, Lahti L, Knight R, Salomaa VV, Inouye M, Meric G. 2022. Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort. Nat Genet 54:PMID:35115689
• Rowe IA, Wong VW, Loomba R. 2022. Treatment candidacy for pharmacologic therapies for NASH. Clin Gastroenterol Hepatol 20:P1209-1217. doi:10.1016/j.cgh.2021.03.005 PMID:33711479 PMCID:PMC8908435
• Sancar G, Liu S, Gasser E, Alvarez JG, Moutos CP, Kim K, van Zutphen T, Wang Y, Huddy T, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM. 2022. FGF1 and insulin control lipolysis by convergent pathways. Cell Metab 34(1):171-183. doi:10.1016/j.cmet.2021.12.004 PMID:34986332 PMCID:PMC886306
• Sharpton S, Oh TG, Madamba E, Wang C, Yu RT, Atkins AR, Huan T, Downes M, Evans RM, Loomba R. 2022. Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. Aliment Pharmacol Ther doi:10.1111/apt.17236 PMID:36164267
• Sinakos E, Liava C, Loomba R. 2022. Emerging advances in the pharmacologic treatment of nonalcoholic steatohepatitis and related cirrhosis. Ann Gastroenterol 35(3):213-225. doi:10.20524/aog.2022.0704 PMID:35599922 PMCID:PMC9062842
• Stadnick NA, Cain KL, Oswald W, Watson P, Ibarra M, Lagoc R, Ayers LO, Salgin L, Broyles SL, Laurent LC, Pezzoli K, Rabin B. 2022. Co-creating a Theory of Change to advance COVID-19 testing and vaccine uptake in underserved communities. Health Serv Res doi:10.1111/1475-6773.13910 PMID:35243622
• Stadnick NA, Cain KL, Watson P, Oswald W, Ibarra M, Lagoc R, Pezzoli K, Laurent LC, Tukey RH, Rabin AB. 2022. Engaging underserved communities in COVID-19 health equity implementation research: an analysis of community engagement resource needs and costs. Front Health Serv 2:850427. doi:10.3389/frhs.2022.850427 PMID:36258685 PMCID:PMC9574473
• Tamaki N, Ajmera VH, Loomba R. 2022. Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD. Nat Rev Endocrinol 18:doi:10.1038/s41574-021-00584-0 PMID:34815553 PMCID:PMC9012520
• Tamaki N, Higuchi M, Kurosaki M, Loomba R, Izumi N. 2022. Risk difference of liver-related and cardiovascular events by liver fibrosis status in nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 20:1171-1173. doi:10.1016/j.cgh.2021.07.021 PMID:34280550 PMCID:PMC8761224
• Tamaki N, Munaganuru N, Jung J, Yonan AQ, Loomba RR, Bettencourt R, Ajmera V, Valasek MA, Behling C, Sirlin CB and Loomba R. 2022. Clinical utility of 30% relative decline in MRI-PDFF in predicting fibrosis regression in non-alcoholic fatty liver disease. Gut 71:983-990. doi:10.1136/gutjnl-2021-324264 PMID:33883248 PMCID:PMC8594562
• Tapper EB, Ufere NN, Huang DQ, Loomba R. 2022. Review article: current and emerging therapies for the management of cirrhosis and its complications. Aliment Pharmacol Ther 55(9):doi:10.1111/apt.16831 PMID:35235219
• Tonsfeldt KJ, Cui L, Lee J, Walbeek TJ, Brusman LE, Jin Y, Mieda M, Gorman MR, Mellon PL. 2022. Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front. Endocrinol 13:doi:10.3389/fendo.2022.956169 PMID:35992114 PMCID:PMC9389073
• Tonsfeldt KJ, Mellon PL, Hoffmann HM. 2022. Circadian rhythms in the neuronal network timing the luteinizing hormone surge. Endocrinology 163(2):doi:10.1210/endocr/bqab268 PMID:34967900 PMCID:PMC8782605
• Waadt R, Seller CA, Hsu P, Takahashi Y, Munemasa S, Schroeder JI. 2022. Plant hormone regulation of abiotic stress responses. Nat Rev Mol Cell Biol doi:10.1038/s41580-022-00479-6 PMID:35513717
• Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. 2022. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun 13(1):4346. doi:10.1038/s41467-022-31947-4 PMID:35896521 PMCID:PMC9329322

2021

• Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. 2021. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep 35:109331. doi:10.1016/j.celrep.2021.109331 PMID:34192547
• Ajmera VH, Cachay ER, Ramers CB, Bassirian S, Singh S, Bettencourt R, Richards L, Hamilton G, Middleton MS, Fowler K, Sirlin C, Loomba R. 2021. Optimal threshold of controlled attenuation parameter for detection of HIV-associated NAFLD with magnetic resonance imaging as the reference standard. Clin Infect Dis 72(12):doi:10.1093/cid/ciaa429 PMID:32975278 PMCID:PMC8204791
• Ajmera VH, Liu A, Bettencourt R, Dhar D, Richards L, Loomba R. 2021. The impact of genetic risk on liver fibrosis in non-alcoholic fatty liver disease as assessed by magnetic resonance elastography. Aliment Pharmacol Ther 54(1):doi:10.1111/apt.16392 PMID:33975381 (ahead of print)
• Ajmera VH, Loomba R. 2021. Imaging biomarkers of NAFLD, NASH, and fibrosis. Mol Metab 50:doi:10.1016/j.molmet.2021.101167 PMID:33460786 PMCID:PMC8324681
• Ajmera VH, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Sriram K, Insel PA, Collier S, Richards L, Loomba R. 2021. RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19. Contemp Clin Trials 103:doi:10.1016/j.cct.2021.106330 PMID:33631357 PMCID:PMC7899027
• Bohaczuk SC, Cassin J, Slaiwa TI, Thackray VG, Mellon PL. 2021. Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB. Endocrinology 162:doi:10.1210/endocr/bqab069 PMID:33824966 PMCID:PMC8157479
• Bohaczuk SC, Thackray VG, Shen J, Skowronska-Krawczyk D, Mellon PL. 2021. FSHB transcription is regulated by a novel 5' distal enhancer with a fertility-associated single nucleotide polymorphism. Endocrinology 162:doi:10.1210/endocr/bqaa181 PMID:33009549 PMCID:PMC7846141
• Byra M, Han A, Boehringer AS, Zhang YN, O'Brien WD, Erdman JW, Loomba R, Sirlin C, Andre MP. 2021. Liver fat assessment in multiview sonography using transfer learning with convolutional neural networks. J Ultrasound Med 41(1):doi:10.1002/jum.15693 PMID:33749862 (ahead of print)
• Cariou B, Byrne CD, Loomba R, Sanyal AJ. 2021. Nonalcoholic fatty liver disease as a metabolic disease in humans: A literature review. Diabetes Obes Metab 23:1069-1083. doi:10.1111/dom.14322 PMID:33464677 PMCID:PMC8248154
• Caussy C, Aubin A, Loomba R. 2021. The relationship between type 2 diabetes, NAFLD, and cardiovascular risk. Curr Diab Rep 12:15. doi:10.1007/s11892-021-01383-7 PMID:33742318
• Dhar D, Loomba R. 2021. Emerging metabolic and transcriptomic signature of PNPLA3-Associated NASH. Hepatology 73:PMID:33544416
• Febbraio MA, Karin M. 2021. Sweet death: Fructose as a metabolic toxin that targets the gut-liver axis. Cell Metab 33(12):doi:10.1016/j.cmet.2021.09.004 PMID:34619076 PMCID:PMC8665123
• Haas ME, Friedman SN, Wang M, Emdin CA, Ajmera VH, Simon TG, Homburger JR, Guo X, Budoff M, Corey K, Zhou AY, Philippakis A, Ellinor PT, Loomba R, Batra P, Khera AV, Pirruccello JP. 2021. Machine learning enables new insights into genetic contributions to liver fat accumulation. Cell Genom 1(3):doi:10.1016/j.xgen.2021.100066 PMID:34957434 PMCID:PMC8699145
• Hagstrom H, Adams LA, Allen AM, Byrne CD, Chang Y, Gronbaek H, Ismail M, Kanwal F, Kramer J, Lazarus JV, Long MT, Loomba R, Newsome PN, Rowe IA, Ryu S, Schattenberg JM, Serper M, Sheron N, Simon TG, Tapper EB, Wild S, Wong VW, Yilmaz Y, Zelber-Sagi S, Aberg F. 2021. Administrative coding in electronic health care record-based research of NAFLD: An expert panel consensus statement. Hepatology 74:474-482. doi:10.1002/hep.31726 PMID:33486773 PMCID:PMC8515502
• Ho EV, Shi C, Cassin J, He MY, Nguyen RD, Ryan GE, Tonsfeldt KJ, Mellon PL. 2021. Reproductive deficits induced by prenatal Antimullerian hormone exposure require androgen receptor in kisspeptin cells. Endocrinology 162:doi:10.1210/endocr/bqab197 PMID:34529765 PMCID:PMC8507963
• Hoffmann HM, Meadows JD, Breuer JA, Yaw AM, Nguyen D, Tonsfeldt KJ, Chin AY, Devries BM, Trang C, Oosterhouse HJ, Lee JS, Doser JW, Gorman MR, Welsh DK, Mellon PL. 2021. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res PMID:34212416
• Huang DQ, El-Serag HB, Loomba R. 2021. Global epidemiology of NAFLD-related HCC: Trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 18:223-238. doi:10.1038/s41575-020-00381-6 PMID:33349658 PMCID:PMC8016738
• Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Suyama K, Nose T, Yoshihara E, Downes M, Evans RM, Matsushima A. 2021. Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor B. J Biol Chem 297(5):doi:10.1016/j.jbc.2021.101173 PMID:34499926 PMCID:PMC8551653
• Jalakas P, Takahashi Y, Waadt R, Schroeder JI, Merilo E. 2021. Molecular mechanisms of stomatal closure in response to rising vapour pressure deficit. New Phytol 232(2):doi:10.1111/nph.17592 PMID:34197630 (ahead of print)
• Jiao N, Loomba R, Yang Z, Wu D, Fang S, Bettencourt R, Lan P, Zhu R, Zhu L. 2021. Alterations in bile acid metabolizing gut microbiota and specific bile acid genes as a precision medicine to subclassify NAFLD. Physiol Genomics doi:10.1152/physiolgenomics.00011.2021 PMID:34151600
• Jobe TO, Yu Q, Hauser F, Xie Q, Meng Y, Maassen T, Kopriva S, Schroeder JI. 2021. The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana. FEBS Lett 595(12):1696-1707. doi:10.1002/1873-3468.14096 PMID:33960401 PMCID:PMC8238853
• Jung J, Loomba RR, Imajo K, Madamba E, Gandhi S, Bettencourt R, Singh S, Hernandez C, Valasek MA, Behling C, Richards L, Fowler K, Sirlin CB, Nakajima A, Loomba R. 2021. MRE combined with FIB-4 (MEFIB) index in detection of candidates for pharmacological treatment of NASH-related fibrosis. Gut 70:1946-1953. doi:10.1136/gutjnl-2020-322976 PMID:33214165 PMCID:PMC8131405
• Kanwal F, Shubrook JH, Adams LA, Pfotenhauer K, Wong VW, Wright E, Abdelmalek MF, Harrison SA, Loomba R, Mantzoros CS, Bugianesi E, Eckel RH, Kaplan LM, El-Serag HB, Cusi K. 2021. Clinical care pathway for the risk stratification and management of patients with nonalcoholic fatty liver disease. Gastroenterology 161:1657-1669. doi:10.1053/j.gastro.2021.07.049 PMID:34602251 PMCID:PMC8819923
• Kim J, He F, Karin M. 2021. From liver fat to cancer: Perils of the Western diet. Cancers (Basel) 13(5):doi:10.3390/cancers13051095 PMID:33806428 PMCID:PMC7961422
• Koponen KK, Salosensaari A, Ruuskanen MO, Havulinna AS, Mannisto S, Jousilahti P, Palmu J, Salido R, Sanders K, Brennan C, Humphrey G, Sanders JG, Meric G, Cheng S, Inouye M, Jain M, Niiranen TJ, Valsta LM, Knight R, Salomaa VV. 2021. Associations of healthy food choices with gut microbiota profiles. Am J Clin Nutr 114(2):605-616. doi:10.1093/ajcn/nqab077 PMID:34020448 PMCID:PMC8326043
• Lavalle SN, Chou T, Hernandez J, Naing NP, Tonsfeldt KJ, Hoffmann HM, Mellon PL. 2021. Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1. Mol Cell Endocrinol 534:111358. doi:10.1016/j.mce.2021.111358 PMID:34098016 (ahead of print)
• Loomba R. 2021. MRI-proton density fat fraction treatment response criteria in nonalcoholic steatohepatitis. Hepatology 73:881-883. doi:10.1002/hep.31624 PMID:33179266 PMCID:PMC8221026
• Loomba R, Ling L, Dinh DM, DePaoli AM, Lieu HD, Harrison SA, Sanyal AJ. 2021. The Commensal Microbe Veillonella as a Marker for Response to an FGF19 Analog in NASH. Hepatology 73:126-143. doi:10.1002/hep.31523 PMID:32794259 PMCID:PMC7898628
• Loomba R, Ratziu V, Harrison SA. 2021. Expert panel review to compare FDA and EMA guidance on drug development and endpoints in nonalcoholic steatohepatitis. Gastroenterology 162(3):doi:10.1053/j.gastro.2021.10.051 PMID:34822801
• Majzoub AM, Nayfeh T, Barnard A, Munaganuru N, Dave S, Singh S, Murad MH, Loomba R. 2021. Systematic review and network meta-analysis: Comparative efficacy of pharmacologic therapies for fibrosis improvement and resolution of NASH. Aliment Pharmacol Ther 54(7):880-889. doi:10.1111/apt.16583 PMID:34435378
• Moshensky A, Du M, Shin J, Advani I, Gunge D, Mathew D, Alkolla R, Du A, Javier C, Ma L, Tran A, Nguyen N, Olay J, Nilaad S, Ding J, Najhawan M, Watrous JD, Bojanowksi CM, Jain M, Christiani DC, Alexander LE. 2021. Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex. ERJ Open Res 7:doi:10.1183/23120541.00229-2021 PMID:34262972 PMCID:PMC8273396
• Okuda K, Umemura A, Umemura S, Kataoka S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser J, Shima T, Okanoue T, Karin M, Itoh Y. 2021. Honokiol prevents nonalcoholic steatohepatitis induced liver cancer via EGFR degradation through the glucocorticoid receptor MIG6 axis. Cancers (Basel) 13(7):doi:10.3390/cancers13071515 PMID:33806040 PMCID:PMC8037653
• Park JG, Jung J, Loomba R. 2021. Letter: coronary atherosclerosis in patients with significant hepatic fibrosis in non-alcoholic fatty liver disease-a realm for non-invasive testing. Author's reply. Aliment Pharmacol Ther 52(2):PMID:34170539
• Park JG, Jung J, Verma KK, Kang M, Madamba E, Lopez S, Yonan AQ, Liu A, Bettencourt R, Sirlin C, Loomba R. 2021. Liver stiffness by magnetic resonance elastography is associated with increased risk of cardiovascular disease in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther doi:10.1111/apt.16324 PMID:33764550
• Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas M, Ricciardelli E, Li RZ, Troutman T, Kisseleva T, Glass CK, Brenner DA. 2021. Heterogeneity of HSCs in a mouse model of NASH. Hepatology 74(2):667-685. doi:10.1002/hep.31743 PMID:33550587 PMCID:PMC8346581
• Ruuskanen MO, Aberg F, Mannisto V, Havulinna AS, Meric G, Liu Y, Loomba R, Vazquez-Baeza Y, Tripathi A, Valsta LM, Inouye M, Jousilahti P, Salomaa VV, Jain M, Knight R, Lahti L, Niiranen TJ. 2021. Links between gut microbiome composition and fatty liver disease in a large population sample. Gut Microbes 13:1-22. doi:10.1080/19490976.2021.1888673 PMID:33651661 PMCID:PMC7928040
• Ryan GE, Bohaczuk SC, Cassin J, Witham EA, Shojaei S, Ho EV, Thackray VG, Mellon PL. 2021. Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes. Mol Cell Endocrinol 530:doi:10.1016/j.mce.2021.111286 PMID:33872733 PMCID:PMC8177864
• Schoeller EL, Tonsfeldt KJ, Sinkovich M, Shi R, Mellon PL. 2021. Growth hormone pulses and liver gene expression are differentially regulated by the circadian clock gene Bmal1. Endocrinology 162(4):doi:10.1210/endocr/bqab023 PMID:33539533 PMCID:PMC7901660
• Sharpton SR, Schnabl B, Knight R, Loomba R. 2021. Current concepts, opportunities, and challenges of gut microbiome-based personalized medicine in nonalcoholic fatty liver disease. Cell Metab 33(1):21-32. doi:10.1016/j.cmet.2020.11.010 PMID:33296678 PMCID:PMC8414992
• Stine JG, Munaganuru N, Barnard A, Wang JL, Kaulback K, Argo CK, Singh S, Fowler KJ, Sirlin C, Loomba R. 2021. Change in MRI-PDFF and histologic response in patients with nonalcoholic steatohepatitis: A systematic review and meta-analysis. Clin Gastroenterol Hepatol 19(11):2274-2283.e5. doi:10.1016/j.cgh.2020.08.061 PMID:32882428 PMCID:PMC7914285
• Tamaki N, Imajo K, Sharpton S, Jung J, Kawamura N, Yoneda M, Valasek MA, Behling C, Sirlin CB, Nakajima A, Loomba R. 2021. Magnetic resonance elastography plus Fibrosis-4 versus FibroScan-aspartate aminotransferase in detection of candidates for pharmacological treatment of NASH-related fibrosis. Hepatology 75(3):doi:10.1002/hep.32145 PMID:34496054
• Tamaki N, Kurosaki M, Yasui Y, Mori N, Tsuji K, Hasebe C, Joko K, Akahane T, Furuta K, Kobashi H, Kimura H, Yagisawa H, Marusawa H, Kondo M, Kojima Y, Yoshida H, Uchida Y, Tada T, Nakamura S, Yasuda S, Toyoda H, Loomba R, Izumi N. 2021. Hepatocellular carcinoma risk assessment for patients with advanced fibrosis after eradication of Hepatitis C virus. Hepatol Commun PMID:34676692
• Tamaki N, Munaganuru N, Jung J, Valasek MA, Behling C, Loomba R, Yonan AQ, Bettencourt R, Ajmera VH. 2021. Clinical utility of change in nonalcoholic fatty liver disease activity score and change in fibrosis in NAFLD. Clin Gastroenterol Hepatol 19(12):doi:10.1016/j.cgh.2020.11.005 PMID:33157318 PMCID:PMC8438785
• Tang Q, Evans RM. 2021. Colon cancer checks in when bile acids check out: the bile acid-nuclear receptor axis in colon cancer. Essays Biochem 65(6):doi:10.1042/EBC20210038 PMID:34414429 PMCID:PMC8628182
• van der Schoor LW, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valaskova P, Jasprova J, Struik D, Bloks VW, Chen S, Schreuder AB, Vitek L, Tukey RH, Jonker JW. 2021. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. Sci Rep 11:11107. doi:10.1038/s41598-021-90687-5 PMID:34045606 PMCID:PMC8160219
• Vilarinho S, Ajmera VH, Zheng M, Loomba R. 2021. Emerging role of genomic analysis in clinical evaluation of lean individuals with NAFLD. Hepatology 74(4):doi:10.1002/hep.32047 PMID:34233030 PMCID:PMC8463418
• Wang L, Oh TG, Magida J, Estepa G, Obayomi SB, Chong L, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. 2021. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A 118(35):e2109517118. doi:10.1073/pnas.2109517118 PMID:34446564 PMCID:PMC8536317
• Ward C, Nallamshetty S, Watrous JD, Acres E, Long T, Mathews IT, Sharma S, Cheng S, Imam F, Jain M. 2021. Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome. J Mass Spectrom 56(8):e4772. doi:10.1002/jms.4772 PMID:34240506 (ahead of print)
• Weber AA, Mennillo E, Yang X, van der Schoor LW, Jonker JW, Chen S, Tukey RH. 2021. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos 49:12-19. doi:10.1124/dmd.120.000240 PMID:33154041 PMCID:PMC7745083
• Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre J, Arditi M, Karin M, Sanchez-Lopez E. 2021. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity 54:1463-1477. doi:10.1016/j.immuni.2021.05.004 PMID:34115964 PMCID:PMC8189765
• Xie Q, Yu Q, Jobe TO, Pham A, Ge C, Guo Q, Liu J, Liu H, Zhang H, Zhao Y, Xue S, Hauser F, Schroeder JI. 2021. An amiRNA screen uncovers redundant CBF and ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses. Plant Cell Environ 44(5):1692-1706. doi:10.1111/pce.14023 PMID:33554343 PMCID:PMC8068611
• Xu SA, Chaudhary O, Rodriguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AF, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho P, Witztum JL, Emu B, Cui G, Kaech SM. 2021. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors. Immunity 54:1561-1577. doi:10.1016/j.immuni.2021.05.003 PMID:34102100
• Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. 2021. Immune-evasive human islet-like organoids ameliorate diabetes. Nature 590:doi:10.1038/s41586-020-03109-3 PMID:33469222
• Yu Q, Zhang Z, Wang M, Scavo A, Schroeder JI, Qiu B. 2021. Identification and characterization of SaeIF1 from the eukaryotic translation factor SUI1 family in cadmium hyperaccumulator Sedum alfredii. Planta 253:12. doi:10.1007/s00425-020-03539-3 PMID:33389204 PMCID:PMC7847809
• Zhang L, Takahashi Y, Schroeder JI. 2021. Protein kinase sensors: An overview of new designs for visualizing kinase dynamics in single plant cells. Plant Physiol 187(2):527-536. doi:10.1093/plphys/kiab277
• Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li S, Welch R, Huang F, Qi L, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu E, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. 2021. Intestinal a1-2-fucosylation contributes to obesity and steatohepatitis in mice. Cell Mol Gastroenterol Hepatol 12(1):doi:10.1016/j.jcmgh.2021.02.009 PMID:33631374 PMCID:PMC8166943

2020

• Ajmera VH, Liu A, Singh S, Yachoa G, Ramey M, Bhargava M, Zamani A, Lopez S, Mangla N, Bettencourt R, Rizo E, Valasek MA, Behling C, Richards L, Sirlin C, Loomba R. 2020. Clinical utility of an increase in magnetic resonance elastography in predicting fibrosis progression in nonalcoholic fatty liver disease. Hepatology 71(3):849-860. doi:10.1002/hep.30974 PMID:31556124 PMCID:PMC7828573
• Balakrishnan M, Loomba R. 2020. The role of noninvasive tests for differentiating NASH from NAFL and diagnosing advanced fibrosis among patients with NAFLD. J Clin Gastroenterol 54(2):107-113. doi:10.1097/MCG.0000000000001284 PMID:31789757 PMCID:PMC7945957
• Cifarelli V, Beeman SC, Smith GI, Yoshino J, Morozov D, Beals JW, Kayser BD, Watrous JD, Jain M, Patterson BW, Klein S. 2020. Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity. J Clin Invest 130(12):6688-6699. doi:10.1172/JCI141828 PMID:33164985 PMCID:PMC7685757
• Cooper AM, Felix D, Alcantara F, Zaslavsky I, Work A, Watson P, Pezzoli K, Yu Q, Zhu D, Scavo A, Zarabi Y, Schroeder JI. 2020. Monitoring and mitigation of toxic heavy metals and arsenic accumulation in food crops: a case study of an urban community garden. Plant Direct 4(1):e00198. doi:10.1002/pld3.198 PMID:31956855 PMCID:PMC6957986
• Core N, Erni A, Hoffmann HM, Mellon PL, Saurin AJ, Beclin C, Cremer H. 2020. Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6. Elife 9:doi:10.7554/eLife.58215 PMID:32762844 PMCID:PMC7440913
• Dhar D, Baglieri J, Kisseleva T, Brenner DA. 2020. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood) 13:doi:10.1177/1535370219898141 PMID:31924111 PMCID:PMC7016420
• Dufour J, Caussy C, Loomba R. 2020. Combination therapy for non-alcoholic steatohepatitis: Rationale, opportunities and challenges. Gut 69:1877-1884. doi:10.1136/gutjnl-2019-319104 PMID:32381514 PMCID:PMC7497577
• Gou L, Lim D, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu M, Fu X. 2020. Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1 catalyzed protamine phosphorylation. Cell 180:doi:10.1016/j.cell.2020.02.020 PMID:32169215
• Han A, O'Brien WD, Erdman JW, Byra M, Heba E, Andre MP, Loomba R, Sirlin C. 2020. Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat with radiofrequency ultrasound data using one-dimensional convolutional neural networks. Radiology 295:342-350. doi:10.1148/radiol.2020191160 PMID:32096706 PMCID:PMC7193902
• Han A, Zhang YN, Boehringer AS, Montes V, Andre MP, Erdman JW, Loomba R, Valasek MA, Sirlin C, O'Brien WD. 2020. Assessment of hepatic steatosis in nonalcoholic fatty liver disease by using quantitative US. Radiology 295:106-113. doi:10.1148/radiol.2020191152 PMID:32013792 PMCID:PMC7104700
• Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. 2020. Differential role of LXRa and LXRy in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos 48:255-263. doi:10.1124/dmd.119.090068 PMID:31980500 PMCID:PMC7065491
• He F, Antonucci L, Karin M. 2020. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis 41:doi:10.1093/carcin/bgaa039 PMID:32347301 PMCID:PMC7298623 (accepted for publication)
• He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Molina AD, Diaz-Meco MT, Moscat J, Sun B, Karin M. 2020. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol 72:1182-1195. doi:10.1016/j.jhep.2020.01.023 PMID:32105670
• Hsu P, Dubeaux G, Takahashi Y, Schroeder JI. 2020. Signaling mechanisms in abscisic acid-mediated stomatal closure. The Plant Journal 15:doi:10.1111/tpj.15067 PMID:33145840
• Hydes TJ, Ravi S, Loomba R, Gray ME. 2020. Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH. Clin Mol Hepatol 26:doi:10.3350/cmh.2020.0067 PMID:32674529 PMCID:PMC7641567
• Lang S, Demir M, Martin A, Jiang L, Zhang X, Duan Y, Wisplinghoff H, Gao B, Kasper P, Roderburg C, Tacke F, Steffen H, Goeser T, Abraldes JG, Tu XM, Loomba R, Starkel P, Pride D, Fouts DE, Schnabl B. 2020. Intestinal virome signature associated with severity of nonalcoholic fatty liver disease. Gastroenterology 159:1839-1852. doi:10.1053/j.gastro.2020.07.005 PMID:32652145
• Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee J, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. 2020. Genomic and epigenomic landscaping defines new therapeutic targets for adenosquamous carcinoma of the pancreas. Cancer Res 80:4324-4334. doi:10.1158/0008-5472.CAN-20-0078 PMID:32928922
• Long MT, Gandhi S, Loomba R. 2020. Advances in non-invasive biomarkers for the diagnosis and monitoring of non-alcoholic fatty liver disease. Metabolism 111s:154259. doi:10.1016/j.metabol.2020.154259 PMID:32387227 PMCID:PMC7529729
• Loomba R, Lim JK, Patton H, El-Serag HB. 2020. AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: Expert Review. Gastroenterology 158:1822-1830. doi:10.1053/j.gastro.2019.12.053 PMID:32006545 PMCID:PMC8012107
• Lowey B, Whiteley AT, Keszei AF, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee AS, Kranzusch PJ. 2020. CBASS immunity uses CARF-related effectors to sense 3'-5'- and 2'-5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection. Cell 182:38. doi:10.1016/j.cell.2020.05.019 PMID:32544385 PMCID:PMC7728545
• Ma H, Yamamoto G, Xu J, Liu X, Karin D, Kim J, Alexandrov LB, Koyama Y, Nishio T, Benner CW, Heinz S, Rosenthal S, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop I, Quehenberger O, Dennis EA, Saltiel AR, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. 2020. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol 72:946-959. doi:10.1016/j.jhep.2019.12.016 PMID:31899206 PMCID:PMC7167339
• Mangla N, Ajmera VH, Caussy C, Sirlin C, Brouha SS, Bajwa-Dulai S, Madamba E, Bettencourt R, Richards L, Loomba R. 2020. Liver stiffness severity is associated with increased cardiovascular risk in patients with type 2 diabetes. Clin Gastroenterol Hepatol 18(3):744-746. doi:10.1016/j.cgh.2019.05.003 PMID:31100460 PMCID:PMC6984972
• Mennillo E, Yang X, Paszek M, Auwerx J, Benner CW, Chen S. 2020. NCoR1 protects mice from dextran sodium sulfate-induced colitis by guarding colonic crypt cells from luminal insult. Cell Mol Gastroenterol Hepatol 10:133-147. doi:10.1016/j.jcmgh.2020.01.014 PMID:32044398 PMCID:PMC7229481
• Mouzaki M, Loomba R. 2020. An update on the role of the microbiome in non-alcoholic fatty liver disease pathogenesis, diagnosis, and treatment. Curr Treat Options Gastroenterol 18:270-280. doi:10.1007/s11938-020-00290-2 PMID:33716495 PMCID:PMC7946055
• Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SB, Trejo J, Kauffman AS, Mellon PL, Lawson MA. 2020. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep 10:13063. doi:10.1038/s41598-020-69913-z PMID:32747664 PMCID:PMC7400764
• Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. 2020. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis 9(100):doi:10.1038/s41389-020-00285-9 PMID:33168807 PMCID:PMC7653036
• Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba E, Bettencourt R, Richards L, Raffatellu M, Dorrestein PC, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin C, Knight R, Downes M, Evans RM, Loomba R. 2020. A universal gut-microbiome-derived signature predicts cirrhosis. Cell Metab 32:doi:10.1016/j.cmet.2020.10.015 PMID:33147487 PMCID:PMC7891106 (accepted for publication)
• Paszek M, Tukey RH. 2020. NRF2-Independent regulation of intestinal constitutive androstane receptor by the pro-oxidants cadmium and isothiocyanate in hUGT1 mice. Drug Metab Dispos 48:25-30. doi:10.1124/dmd.119.089508 PMID:31704714 PMCID:PMC6904881
• Quinn RA, Melnik A, Vrbanac AF, Fu T, Patras K, Christy M, Bodai Z, Belda-Ferre P, Tripathi A, Chung L, Downes M, Welch R, Quinn M, Humphrey G, Panitchpakdi M, Weldon K, Aksenov AA, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa E, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz J, Meehan M, Gentry E, Arthur T, Komor A, Poulsen O, Boland BS, Chang JT, Sandborn W, Lim M, Garg N, Lumeng J, Xavier R, Kazmierczak B, Jain R, Egan M, Rhee K, Ferguson D, Raffatellu M, Vlamakis H, Haddad G, Siegel D, Huttenhower C, Mazmanian S, Evans RM, Nizet V, Knight R, Dorrestein PC. 2020. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 579:123-129. doi:10.1038/s41586-020-2047-9 PMID:32103176
• Schulze S, Dubeaux G, Ceciliato PH, Munemasa S, Nuhkat M, Yarmolinsky D, Aguilar J, Diaz R, Azoulay-Shemer T, Steinhorst L, Offenborn JN, Kudla J, KOLLIST H, Schroeder JI. 2020. A role for calcium-dependent protein kinases in differential CO2- and ABA-controlled stomatal closing and low CO2-induced stomatal opening in Arabidopsis. New Phytologist 15:doi:10.1111/nph.17079 PMID:33187027
• Sriram K, Loomba R, Insel PA. 2020. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenge. Proc Natl Acad Sci U S A 117:29274-29282. doi:10.1073/pnas.2009875117 PMID:33203679 PMCID:PMC7703541
• Stender S, Loomba R. 2020. PNPLA3 genotype and risk of liver and all-cause mortality. Hepatology 71:777-779. doi:10.1002/hep.31113 PMID:31954067
• Sun X, Seidman J, Zhao P, Troutman T, Spann N, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida J, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. 2020. Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis. Cell Metab 31(1):189-206. doi:10.1016/j.cmet.2019.10.014 PMID:31761566 PMCID:PMC7028360
• Takahashi Y, Zhang J, Hsu P, Ceciliato PH, Dubeaux G, Munemasa S, Ge C, Zhao Y, Hauser F, Schroeder JI. 2020. MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. Nat Commun 11(1):12. doi:10.1038/s41467-019-13875-y PMID:31896774 PMCID:PMC6940395
• Tamayo LI, Lin H, Ahmed A, Shahriar H, Hasan R, Sarwar G, Eunus H, Ahsan H, Pierce BL. 2020. Research Participants Attitudes towards Receiving Information on Genetic Susceptibility to Arsenic Toxicity in Rural Bangladesh. Public Health Genomics 23:69-76. doi:10.1159/000505632 PMID:32069464 PMCID:PMC7605079
• Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac AF, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. 2020. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab 2:1034-1045. doi:10.1038/s42255-020-0261-2 PMID:32839596 PMCID:PMC8018782
• Verna EC, Serper M, Chu J, Corey K, Fix OK, Hoyt K, Page KA, Loomba R, Li M, Everson GT, Fried MW, Garcia-Tsao G, Terrault N, Lok AS, Chung RT, Reddy KR. 2020. Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation. Hepatology 72:1819-1837. doi:10.1002/hep.31491 PMID:32740969 PMCID:PMC7435542
• Xu J, Ma H, Liu X, Rosenthal SB, Baglieri J, Mccubbin R, Sun M, Koyama Y, Geoffroy C, Saijo K, Shang L, Nishio T, Maricic I, Kriefeldt M, Kusumanchi P, Roberts a, Zheng B, Kumar V, Zengler K, Pizzo D, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob G, Kisseleva T. 2020. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight doi:10.1172/jci.insight.131277 PMID:32051339 PMCID:PMC7098802
• Yoshino M, Kayser BD, Yoshino J, Stein RI, Reeds D, Eagon JC, Eckhouse SR, Watrous JD, Jain M, Knight R, Schechtman K, Patterson BW, Klein S. 2020. Effects of diet versus gastric bypass on metabolic function in diabetes. N Engl J Med 383:721-732. doi:10.1056/NEJMoa2003697 PMID:32813948 PMCID:PMC7456610
• Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785
• Zhao P, Sun X, Chaggan C, Liao Z, Wong KI, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. 2020. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367:doi:10.1126/science.aay0542 PMID:32029622 PMCID:PMC8012106 (accepted for publication)

2019

• Baglieri J, Brenner DA, Kisseleva T. 2019. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int J Mol Sci 20(7):1723. doi:10.3390/ijms20071723 PMID:30959975 PMCID:PMC6479943
• Bailey-Serres J, Parker JE, Ainsworth EA, Oldroyd GE, Schroeder JI. 2019. Genetic strategies for improving crop yields. Nature 575:109-118. doi:10.1038/s41586-019-1679-0 PMID:31695205 PMCID:PMC7024682
• Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To K, Kung H, Fiehn O, Zhao R, Evans RM, Chen H. 2019. RORgamma is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun 10(1):4621. doi:10.1038/s41467-019-12529-3 PMID:31604910 PMCID:PMC6789042
• Castera L, Friedrich-Rust M, Loomba R. 2019. Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 156(5):1264-1281. doi:10.1053/j.gastro.2018.12.036 PMID:30660725 PMCID:PMC7505052
• Caussy C, Bhargava M, Villesen I, Gudmann N, Leeming D, Karsdal M, Faulkner C, Bao D, Liu A, Lo M, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen C, Sirlin C, Loomba R. 2019. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology 70(1):127-141. doi:10.1002/hep.30610 PMID:30859582 PMCID:PMC6984974
• Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu Z, Downes M, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. 2019. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun 10:1406. doi:10.1038/s41467-019-09455-9 PMID:30926798 PMCID:PMC6440960
• Ceciliato PH, Zhang J, Liu Q, Shen X, Hu H, Liu C, Shaffner AR, Schroeder JI. 2019. Intact leaf gas exchange provides a robust method for measuring the kinetics of stomatal conductance responses to abscisic acid and other small molecules in Arabidopsis and grasses. Plant Methods 15:10. doi:10.1186/s13007-019-0423-y PMID:31019545 PMCID:PMC6472101
• Chang C, Loo C, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y. 2019. The nuclear receptor REV-ERB alpha modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A 116:18528-18536. doi:10.1073/pnas.1907563116 PMID:31455731 PMCID:PMC6744854
• Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. 2019. Preclinical models for studying NASH-driven HCC: How useful are they?. Cell Metab 29:18-26. doi:10.1016/j.cmet.2018.10.012 PMID:30449681 PMCID:PMC6326872
• Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. 2019. FXR regulates intestinal cancer stem cell proliferation. Cell 176:1098-1112. doi:10.1016/j.cell.2019.01.036 PMID:30794774 PMCID:PMC6701863
• Hauser F, Ceciliato PH, Lin Y, Guo D, Gregerson J, Abbasi N, Youhanna D, Park J, Dubeaux G, Shani E, Poomchongkho N, Schroeder JI. 2019. A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses. J Exp Bot 70:641-65. doi:10.1093/jxb/ery363 PMID:30346611 PMCID:PMC6322574
• Hoffman HM, Larder R, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, Mellon PL. 2019. Differential CRE expression in Lhrh-cre and GnRH-cre alleles and the impact on fertility in Otx2-Flox mice. Neuroendocrinology 108:328-342. doi:10.1159/000497791 PMID:30739114 PMCID:PMC6753941
• Hoffmann HM, Pandolfi EC, Larder R, Mellon PL. 2019. Haploinsufficiency of homeodomain proteins Six3, Vax1, and Otx2 causes subfertility in mice via distinct mechanisms. Neuroendocrinology 109:200-207. doi:10.1159/000494086 PMID:30261489 PMCID:PMC6437011
• Liang S, Ma H, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. 2019. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology 156(4):1156-1172. doi:10.1053/j.gastro.2018.11.019 PMID:30445007 PMCID:PMC6409207
• Loomba R, Adams L. 2019. The 20 Rule of NASH Progression: The Natural History of Advanced Fibrosis and Cirrhosis Caused by NASH. Hepatology 70(6):1885-1888. doi:10.1002/hep.30946 PMID:31520407 PMCID:PMC7504908
• Mills P, Caussy C, Loomba R. 2019. Glyphosate Excretion is Associated with Steatohepatitis and Advanced Liver Fibrosis in Patients with Fatty Liver Disease. Clin Gastroenterol Hepatol 18(3):741-743. doi:10.1016/j.cgh.2019.03.045 PMID:30954713 PMCID:PMC6776714
• Mouzaki M, Loomba R. 2019. Insights into the evolving role of the gut microbiome in nonalcoholic fatty liver disease: rationale and prospects for therapeutic intervention. Therap Adv Gastroenterol 12:1756284819858470. doi:10.1177/1756284819858470 PMID:31258623 PMCID:PMC6591661
• Pai R, Kleiner D, Hart J, Adeyi O, Clouston A, Behling C, Jain D, Kakar S, Brahmania M, Burgart L, Batts K, Valasek MA, Torbenson M, Guindi M, Wang H, Ajmera VH, Adams L, Parker CE, Feagan B, Loomba R, Jairath V. 2019. Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials. Aliment Pharmacol Ther 50(10):1100-1111. doi:10.1111/apt.15503 PMID:31583739 PMCID:PMC6817398
• Pandolfi EC, Breuer JA, Huu VN, Talluri T, Nguyen D, Lee JS, Hu R, Bharti K, Skowronska-Krawczyk D, Gorman MR, Mellon PL, Hoffmann HM. 2019. The homeodomain transcription factors vax1 and six6 are required for scn development and function. Mol Neurobiol 1-16. doi:10.1007/s12035-019-01781-9 PMID:31705443 PMCID:PMC7035166
• Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. 2019. Deletion of the homeodomain protein Six6 from GnRH neurons decreases GnRH gene expression, resulting in infertility. Endocrinology 160:2151-2164. doi:10.1210/en.2019-00113 PMID:31211355 PMCID:PMC6821215
• Park J, Kim T, Takahashi Y, Schwab R, Dressano K, Stephan AB, Ceciliato PH, Ramirez E, Garin V, Huffaker A, Schroeder JI. 2019. Chemical genetic identification of a lectin receptor kinase that transduces immune responses and interferes with abscisic acid signaling. The Plant Journal doi:10.1111/tpj.14232 PMID:30659683 PMCID:PMC6488365
• Ruf-Zamojski F, Ge Y, Pincas H, Shan J, Song Y, Hines N, Kelley K, Montagna C, Nair P, Toufaily C, Bernard DJ, Mellon PL, Nair V, Turgeon JL, Sealfon SC. 2019. Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines. J Endocr Soc 3. doi:10.1210/js.2019-00064 PMID:31020055 PMCID:PMC6469952 (accepted for publication)
• Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. 2019. Choline Uptake and metabolism modulate macrophage IL-1 beta and IL-18 production. Cell Metab 29:1350. doi:10.1016/j.cmet.2019.03.011 PMID:30982734 PMCID:PMC6675591
• Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui L, Lee J, Mellon PL. 2019. The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc 3(4):716-733. doi:10.1210/js.2018-00228 PMID:30906911 PMCID:PMC6425515
• Wang L, Mazagova M, Pan C, Yang S, Brandl KL, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. 2019. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A 116:15184-15193. doi:10.1073/pnas.1904360116 PMID:31289229 PMCID:PMC6660779

2018

• Ahmadian M, Liu S, O'Reilly S, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. 2018. ERR gamma preserves brown fat innate thermogenic activity. Cell Rep 22(11):2849-2859. doi:10.1016/j.celrep.2018.02.061 PMID:29539415 PMCID:PMC5884669
• Ajmera VH, Park CC, Caussy C, Singh S, Hernandez C, Bettencourt R, Hooker J, Sy E, Behling C, Xu R, Middleton MS, Valasek MA, Faulkner C, Rizo E, Richards L, Sirlin CB, Loomba R. 2018. Magnetic Resonance Imaging Proton Density Fat Fraction Associates with Progression of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease. Gastroenterology 155(2):307-310. doi:10.1053/j.gastro.2018.04.014 PMID:29660324 PMCID:PMC6090543
• Brenner DA. 2018. Of Mice and Men and Nonalcoholic Steatohepatitis. Hepatology 68(6):2059-2061. doi:10.1002/hep.30186 PMID:30033687 PMCID:PMC6398944
• Brouha SS, Nguyen P, Bettencourt R, Sirlin CB, Loomba R. 2018. Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: a prospective study. Eur Radiol 28:1345-1355. doi:10.1007/s00330-017-5075-6 PMID:29058029 PMCID:PMC6310479
• Caussy C, Hsu CL, Lo M, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen C, Loomba R. 2018. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology 68(3):918-932. doi:10.1002/hep.29892 PMID:29572891 PMCID:PMC6151296
• Chen S, Tukey RH. 2018. Humanized UGT1 mice, regulation of UGT1A1, and the role of the intestinal tract in neonatal hyperbilirubinemia and breast milk-induced jaundice. Drug Metab Dispos 46(11):1745-1755. doi:10.1124/dmd.118.083212 PMID:30093417 PMCID:PMC6199628
• Dangl J, Osbourn A, Orzaez D, Li Z, Long SP, Schroeder JI. 2018. What Is the Next Frontier in Plant Engineering?. Cell 174(3):499-500. doi:10.1016/j.cell.2018.07.012 PMID:30053421
• Desai AP, Mohan P, Roubal AM, Bettencourt R, Loomba R. 2018. Geographic Variability in liver disease-related mortality rates in the United States. Am J Med 131:728-734. doi:10.1016/j.amjmed.2018.01.047 PMID:29496501 PMCID:PMC6090542
• Dhar D, Antonucci L, Nakagawa H, Kim J, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. 2018. Liver cancer initiation requires p53 inhibition by CD44-enhanced growth factor signaling. Cancer Cell 33:1061. doi:10.1016/j.ccell.2018.05.003 PMID:29894692 PMCID:PMC6005359
• Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. 2018. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888. doi:10.1073/pnas.1811029115 PMID:30287485 PMCID:PMC6196518
• Fan W, He N, Lin CS, Wei Z, Hah N, Waizenegger W, He M, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM. 2018. ERRgamma promotes angiogenesis, mitochondrial biogenesis, and oxidative remodeling in PGC1alpha/beta-deficient muscle. Cell Rep 22:2521-2529. doi:10.1016/j.celrep.2018.02.047 PMID:29514081 PMCID:PMC5860878
• Ganguly A, Guo L, Sun L, Suo F, Du LL, Russell P. 2018. Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. PLoS Genet 14:28. doi:10.1371/journal.pgen.1007595 PMID:30148840 PMCID:PMC6128646
• Gonzalez FJ, Coughtrie MW, Tukey RH. 2018. Drug Metabolism. Chapter 6 in: The Pharmacological Basis of Therapeutics. McGraw Hill Education,
• Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Starkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. 2018. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology doi:10.1002/hep.29676 PMID:29159825 PMCID:PMC5962369
• Hoffman HM, Gong P, Tamrazian A, Mellon PL. 2018. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154. doi:10.1016/j.mce.2017.09.004 PMID:28890143 PMCID:PMC5756504
• Hsu P, Takahashi Y, Munemasa S, Merilo E, Laanemets K, Waadt R, Patar D, KOLLIST H, Schroeder JI. 2018. Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A 115:E9971-E9980. doi:10.1073/pnas.1809204115 PMID:30282744 PMCID:PMC6196521
• Karin M. 2018. New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance. Precis Clin Med 1(1):21-28. doi:10.1093/pcmedi/pby005 PMID:30687560 PMCID:PMC6333043
• Kim J, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. 2018. ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P. Cell 175(1):133-145. doi:10.1016/j.cell.2018.08.020 PMID:30220454 PMCID:PMC6159928
• Li Z, Takahashi Y, Scavo A, Brandt B, Nguyen D, Rieu P, Schroeder JI. 2018. Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases. Proc Natl Acad Sci U S A 115(19):E4522-E4531. doi:10.1073/pnas.1719659115 PMID:29686103 PMCID:PMC5948973
• McNulty R, Cardone G, Gilcrease EB, Baker TS, Casjens SR, Johnson JE. 2018. Cryo-EM elucidation of the structure of bacteriophage P22 virions after genome release. Biophys J 114:1295-1301. doi:10.1016/j.bpj.2018.01.026 PMID:29590587 PMCID:PMC5883611
• Pandolfi EC, Hoffmann HM, Schoeller EL, Gorman MR, Mellon PL. 2018. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol 55(11):8709-8727. doi:10.1007/s12035-018-1013-0 PMID:29589282 PMCID:PMC6156938
• Que X, Hung M, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Maatta A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Yla-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. 2018. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301. doi:10.1038/s41586-018-0198-8 PMID:29875409 PMCID:PMC6033669
• Ryan GE, Malik S, Mellon PL. 2018. Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology 159(4):1734-1747. doi:10.1210/en.2017-03218 PMID:29471436 PMCID:PMC6097580
• Song IJ, Yang YM, Inokuchi-Shimizu S, Roh YS, Yang L, Seki E. 2018. The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer 142(1):81-91. doi:10.1002/ijc.31029 PMID:28875549 PMCID:PMC579019
• Song N, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Xu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. 2018. IKK alpha inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A 115:E812-E821. doi:10.1073/pnas.1717520115 PMID:29311298 PMCID:PMC5789942
• Tapper EB, Loomba R. 2018. Nonalcoholic fatty liver disease, metabolic syndrome, and the fight that will define clinical practice for a generation of hepatologists. Hepatology 67:1657-1659. doi:10.1002/hep.29722 PMID:29222913 PMCID:PMC5906195
• Tapper EB, Loomba R. 2018. Noninvasive imaging biomarker assessment of liver fibrosis by elastography in NAFLD. Nat Rev Gastroenterol Hepatol 15:274-282. doi:10.1038/nrgastro.2018.10 PMID:29463906
• Toldsepp K, Zhang J, Takahashi Y, Sindarovska y, Horack H, Ceciliato PH, Koolmeister K, Wang Y, Vaahtera L, Jakobson L, Park J, BROSCHE M, KOLLIST H, Schroeder JI. 2018. Mitogen-activated protein kinases MPK4 and MPK12 are key components mediating CO2-induced stomatal movements. The Plant Journal 96:1018-1035. doi:10.1111/tpj.14087 PMID:30203878 PMCID:PMC6261798
• Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. 2018. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411. doi:10.1038/s41575-018-0011-z PMID:29748586 PMCID:PMC6319369
• Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AF, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM. 2018. Vitamin D Switches BAF Complexes to Protect Beta Cells. Cell 173:1135-1149. doi:10.1016/j.cell.2018.04.013 PMID:29754817 PMCID:PMC5987229
• Zhang Y, Nasser V, Pisanty O, Omary M, Wulff N, Donato MD, Tal I, Hauser F, Hao P, Roth O, Fromm H, Schroeder JI, Geisler M, Nour-Eldin HH, Shani E. 2018. A transportome-scale amiRNA-based screen identifies redundant roles of Arabidopsis ABCB6 and ABCB20 in auxin transport. Nat Commun 9:4204. doi:10.1038/s41467-018-06410-y PMID:30310073 PMCID:PMC6182007
• Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin X, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. 2018. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560:198-203. doi:10.1038/s41586-018-0372-z PMID:30046112 PMCID:PMC6329306

2017

• Azoulay-Shemer T, Hsu P, Schroeder JI. 2017. Seeing is believing. Nat Plants 3(10):765-766. doi:10.1038/s41477-017-0025-5 PMID:28970562 PMCID:28970562
• Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin D, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong L, Cho H, Xie J, Li Q, Muschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. 2017. Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A 114(47):12548-12553. doi:10.1073/pnas.1619119114 PMID:29109286 PMCID:PMC5703267
• Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen C, Al Ikhwan M, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R. 2017. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest 127(7):2697–2704. doi:10.1172/JCI93465 PMID:28628033 PMCID:PMC5490764
• Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
• Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi H, Kang SG, Lee SE, Kim SJ, Kweon GR, Kim H, Lee C, Lee S, Wall CE, Downes M, Evans RM, Choi MJ, Jung S, Ryu MJ, Hwang JH, Auwerx J, Shong M. 2017. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol 216(1):149-165. doi:10.1083/jcb.201607110 PMID:27986797 PMCID:PMC5223607
• De Magalhaes Filho CD, Downes M, Evans RM. 2017. Farnesoid X receptor an emerging target to combat obesity. Dig Dis 35(3):185-190. doi:10.1159/000450909 PMID:28249279
• Dickey AS, Sanchez DN, Arreola M, Sampat KR, Fan W, Arbez N, Akimov S, Van Kanegan MJ, Ohnishi K, Gilmore-Hall SK, Flores AL, Nguyen JM, Lomas N, Hsu CL, Lo DC, Ross CA, Masliah E, Evans RM, La Spada AR. 2017. PPAR delta activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci Transl Med 9(419):eaal2332. doi:10.1126/scitranslmed.aal2332 PMID:29212711 PMCID:PMC5748332
• Doktorova M, Zwarts I, van Zutphen T, van Dijk TH, Bloks VW, Harkema L, de Bruin A, Downes M, Evans RM, Verkade HJ, Jonker JW. 2017. Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep 7:846. doi:10.1038/s41598-017-00889-z PMID:28404991
• Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. 2017. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight 2(24):92821. doi:10.1172/jci.insight.92821 PMID:29263300 PMCID:PMC5752303
• Dulai PS, Singh S, Patel J, Soni M, Prokop LJ, Younossi Z, Sebastiani G, Ekstedt M, Hagstrom H, Nasr P, Stal P, Wong VW, Kechagias S, Hultcrantz R, Loomba R. 2017. Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta-analysis. Hepatology 65:1557-1565. doi:10.1002/hep.29085 PMID:28130788 PMCID:PMC5397356
• Fan W, Evans RM. 2017. Exercise mimetics: impact on health and performance. Cell Metab 25(2):242-247. doi:10.1016/j.cmet.2016.10.022 PMID:27889389
• Fan W, Waizenegger W, Lin CS, Sorrentino V, He M, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM. 2017. PPARdelta promotes running endurance by preserving glucose. Cell Metab 25:1186-1193.e4. doi:10.1016/j.cmet.2017.04.006 PMID:28467934 PMCID:PMC549297
• Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. 2017. Severe neonatal hyperbilirubinemia in Crigler-Najjar Syndrome model mice can be reversed with zinc protoporphyrin. Hepatol Commun 1(8):792-802. doi:10.1002/hep4.1082 PMID:29399656 PMCID:PMC567892
• Fujiwara R, Yoda E, Tukey RH. 2017. Species differences in drug glucuronidation: humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33(1):9-16. doi:10.1016/j.dmpk.2017.10.002 PMID:29079228 PMCID:PMC5809266
• Gasser E, Moutos CP, Downes M, Evans RM. 2017. FGF1-a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol 13(10):599-609. doi:10.1038/nrendo.2017.78 PMID:28664920 PMCID:PMC5839646
• Goetz A, Wilkinson MF. 2017. Stress and the nonsense-mediated RNA decay pathway. Cellular and Molecular Life Sciences 74(19):3509-3531. doi:10.1007/s00018-017-2537-6 PMID:28503708 PMCID:PMC568394
• He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM. 2017. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. Proc Natl Acad Sci U S A 114(47):12542-12547. doi:10.1073/pnas.1715363114 PMID:29109251 PMCID:PMC5703326
• Hirashima R, Itoh T, Tukey RH, Fujiwara R. 2017. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol 37:863-872. doi:10.1002/jat.3435 PMID:28138970 PMCID:PMC5500258
• Kim RG, Loomba R, Prokop LJ, Singh S. 2017. Statin use and risk of cirrhosis and related complications in patients with chronic liver diseases: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 15(10):1521-1530. doi:10.1016/j.cgh.2017.04.039 PMID:28479502 PMCID:PMC5605397
• Kobayashi NI, Yamaji N, Yamamoto H, Okubo K, Ueno H, Costa A, Tanoi K, Matsumura H, Fujii-Kashino M, Horiuchi T, Al Nayef M, Shabala S, An G, Ma JF, Horie T. 2017. OsHKT1;5 mediates Na+ exclusion in the vasculature to protect leaf blades and reproductive tissues from salt toxicity in rice. Plant J 91:657-670. doi:10.1111/tpj.13595 PMID:28488420
• Koyama Y, Brenner DA. 2017. Liver inflammation and fibrosis. J Clin Invest 127(1):55-64. doi:10.1172/JCI88881 PMID:28045404 PMCID:PMC5199698
• Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner CW, Heinz S, Bera T, Brenner DA, Kisseleva T. 2017. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest 127(4):1254-1270. doi:10.1172/JCI88845 PMID:28287406 PMCID:PMC5373891
• Lin SC, Heba E, Bettencourt R, Lin GY, Valasek MA, Lunde O, Hamilton G, Sirlin CB, Loomba R. 2017. Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging. Aliment Pharmacol Ther 45(6):844-854. doi:10.1111/apt.13951 PMID:28116801 PMCID:PMC5346270
• Liu Y, Yu C, Cao Z, Shvarts D, Trogler WC. 2017. A highly sensitive enzymatic catalysis system for trace detection of arsenic in water. Chem Eur J 23:10289-10292. doi:10.1002/chem.201702769 PMID:28631380 PMCID:PMC5665019
• Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen C, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. 2017. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 25(5):1054-1062.e5. doi:10.1016/j.cmet.2017.04.001 PMID:28467925 PMCID:PMC550273
• Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. 2017. Crypt organoid culture as an in vitro model in drug metabolism and cytotoxicity studies. Drug Metab Dispos 45:748-754. doi:10.1124/dmd.117.075945 PMID:28468837 PMCID:PMC5478905
• Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Valasek MA, Rizo E, Brenner DA, Sirlin CB, Loomba R. 2017. Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. Gastroenterology 152(3):598-607.e2. doi:10.1053/j.gastro.2016.10.026 PMID:27911262 PMCID:PMC5285304
• Reinders ME, Wardi G, Bettencourt R, Bouland D, Bazick J, Mendler M, Vodkin I, Kalmaz D, Savides T, Brenner DA, Sell RE, Loomba R. 2017. Increased risk of death, in the hospital and outside the intensive care unit, for patients with cirrhosis after cardiac arrest. Clin Gastroenterol Hepatol 15(11):1808-1810. doi:10.1016/j.cgh.2017.05.044 PMID:28602970 PMCID:PMC5723019
• Shalapour S, Lin X, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner CW, Anstee QM, Karin M. 2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551(7680):340-345. doi:10.1038/nature24302 PMID:29144460 PMCID:PMC5884449
• Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM. 2017. Stromal cues regulate the pancreatic cancer epigenome and metabolome. Proc Natl Acad Sci U S A 114(5):1129-1134. doi:10.1073/pnas.1620164114 PMID:28096419 PMCID:PMC5293019
• Tukey RH. 2017. Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPAR alpha. Am J Physiol Endocrinol Metab 312:E244-E252. doi:10.1152/ajpendo.00396.2016 PMID:28096081 PMCID:PMC5406988
• Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner DA, Duffield J, Burkly LC. 2017. Identification of novel fibrosis modifiers by in vivo siRNA silencing. Mol Ther Nucleic Acids 7:314-323. doi:10.1016/j.omtn.2017.04.014 PMID:28624207 PMCID:PMC5424569
• Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. 2017. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun 8(1):959. doi:10.1038/s41467-017-00931-8 PMID:29038463 PMCID:PMC5643384
• Wu C, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. 2017. Structural basis for specific ligation of the peroxisome proliferater-activated receptor delta. Proc Natl Acad Sci U S A 114:13:E2563-2570. doi:10.1073/pnas.1621513114 PMID:28320959 PMCID:PMC5380080
• Xie H, Hoffmann HM, Iyer AK, Brayman MJ, Ngo C, Sunshine M, Mellon PL. 2017. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol 15(1):86. doi:10.1186/s12958-017-0304-z PMID:29065928 PMCID:PMC5655979
• Xu J, Ma H, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. 2017. The role of human CYP2E1 in liver inflammation and fibrosis. Hepatol Commun 1:1043-1057. doi:10.1002/hep4.1115 PMID:29404441 PMCID:PMC572140
• Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh Y, Seki E. 2017. TRIF differentially regulates hepatic steatosis and inflammation/fibrosis in mice. Cell Mol Gastroenterol Hepatol 3(3):469-483. doi:10.1016/j.jcmgh.2016.12.004 PMID:28462384 PMCID:PMC5438096
• Yoda E, Paszek M, Konopnicki CM, Fujiwara R, Chen S, Tukey RH. 2017. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep 7:46489. doi:10.1038/srep46489 PMID:28422158 PMCID:PMC5395973
• Yueh MF, Chen S, Nguyen N, Tukey RH. 2017. Developmental, genetic, dietary, and xenobiotic influences on neonatal hyperbilirubinemia. Mol Pharmacol 91(5):545-553. doi:10.1124/mol.116.107524 PMID:28283555 PMCID:PMC5416747

2016

• Aleman F, Yazaki J, Lee M, Takahashi Y, Kim AY, Li Z, Kinoshita T, Ecker JR, Schroeder JI. 2016. An ABA-increased interaction of the PYL6 ABA receptor with MYC2 transcription factor: a putative link of ABA and JA signaling. Sci Rep 6:28941. doi:10.1038/srep28941 PMID:27357749 PMCID:PMC4928087
• Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. 2016. Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia. Mol Pharmacol 89(1):84-93. doi:10.1124/mol.115.098228 PMID:26480925 PMCID:PMC4702100
• Booth DR, Ding N, Parnell GP, Shahijanian F, Coulter S, Schibeci D, Atkins AR, Stewart GJ, Evans RM, Downes M, Liddle C. 2016. Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases. Genes Immun 17(4):213-219. doi:10.1038/gene.2016.12 PMID:26986782 PMCID:PMC4895389
• Cui J, Chen C, Lo M, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin CB, Loomba R. 2016. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology 64(5):1547-1558. doi:10.1002/hep.28674 PMID:27315352 PMCID:PMC5090982
• Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. 2016. p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer. Cancer Cell 30(4):595-609. doi:10.1016/j.ccell.2016.09.004 PMID:27728806 PMCID:PMC5081228
• Engineer C, Hashimoto-Sugimoto M, Negi J, Israelsson-Nordstrom M, Azoulay-Shemer T, Rappel WJ, Iba K, Schroeder JI. 2016. CO2 sensing and CO2 regulation of stomatal conductance: advances and open questions. Trends Plant Sci 21(1):16-30. doi:10.1016/j.tplants.2015.08.014 PMID:26482956 PMCID:PMC4707055
• Guo L, Ganguly A, Sun LL, Suo F, Du LL, Russell P. 2016. Global fitness profiling identifies arsenic and cadmium tolerance mechanisms in fission yeast. G3 (Bethesda) 6(10):3317-3333. doi:10.1534/g3.116.033829 PMID:27558664 PMCID:PMC5068951
• Hee Lee J, Cho U, Karin M. 2016. Sestrin regulation of TORC1: Is Sestrin a leucine sensor?. Sci Signal 9(431):re5. doi:10.1126/scisignal.aaf2885 PMID:27273098 PMCID:PMC4902175
• Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R. 2016. Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity. Mol Pharmacol 90(3):265-274. doi:10.1124/mol.116.104174 PMID:27413119 PMCID:PMC4998668
• Hoffman HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL. 2016. Deletion of Vax1 from gonadotropin-releasing hormone (GnRH) neurons abolishes GnRH expression and leads to hypogonadism and infertility. J Neurosci 36(12):3506-3518. doi:10.1523/JNEUROSCI.2723-15.2016 PMID:27013679 PMCID:PMC4804008
• Hsin I, Montano E, Seki E. 2016. Finding a new role for NEMO: a key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1. Hepatology 64(1):295-297. doi:10.1002/hep.28627 PMID:27122117 PMCID:PMC4917439
• Huang PP, Brusman LE, Iyer AK, Webster NJ, Mellon PL. 2016. A novel gonadotropin-releasing hormone 1 (Gnrh1) enhancer-derived noncoding RNA regulates Gnrh1 gene expression in GnRH neuronal cell models. PLoS One 11(7):e0158597. doi:10.1371/journal.pone.0158597 PMID:27389022 PMCID:PMC4936741
• Jensen KL, Russell P. 2016. Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable. Nucleic Acids Res 44(17):8241-8249. doi:10.1093/nar/gkw557 PMID:27325741 PMCID:PMC5041466
• Karin M, Clevers H. 2016. Reparative inflammation takes charge of tissue regeneration. Nature 529(7586):307-315. doi:10.1038/nature17039 PMID:26791721 PMCID:PMC5228603
• Karin M, Dhar D. 2016. Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. Carcinogenesis 37(6):541-546. doi:10.1093/carcin/bgw060 PMID:27207669 PMCID:PMC4876993
• Koyama Y, Xu J, Liu X, Brenner DA. 2016. New developments on the treatment of liver fibrosis. Dig Dis 34(5):589-596. doi:10.1159/000445269 PMID:27332862 PMCID:PMC4961096
• Liang S, Kisseleva T, Brenner DA. 2016. The role of NADPH oxidases (NOXs) in liver fibrosis and the activation of myofibroblasts. Front Physiol 7:17. doi:10.3389/fphys.2016.00017 PMID:26869935 PMCID:PMC4735448
• Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki CM, Hao H, Tukey RH. 2016. Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol 110-111:37-46. doi:10.1016/j.bcp.2016.04.003 PMID:27060662 PMCID:PMC5010383
• Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. 2016. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol 2(1):63-76.e5. doi:10.1016/j.jcmgh.2015.08.008 PMID:26807433 PMCID:PMC4721636
• Liu W, Struik D, Nies VJ, Jurdzinski A, Harkema L, de Bruin A, Verkade HJ, Downes M, Evans RM, van Zutephen T, Jonker JW. 2016. Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 113(8):2288-2293. doi:10.1073/pnas.1525093113 PMID:26858440 PMCID:PMC4776526
• Lou C, Dumdie J, Shum EY, Brafman D, Liao X, Mora-Castilla S, Ramaiah M, Cook-Andersen H, Laurent LC, Wilkinson MF. 2016. Nonsense-mediated RNA decay influences human embryonic stem cell fate. Stem Cell Reports 6(6):844-857. doi:10.1016/j.stemcr.2016.05.008 PMID:27304915 PMCID:PMC4912386
• Matsushita H, Yang YM, Pandol SJ, Seki E. 2016. Exosome migration inhibitory factor as a marker and therapeutic target for pancreatic cancer. Gastroenterology 150(4):1033-1035. doi:10.1053/j.gastro.2016.02.051 PMID:26922869 PMCID:PMC4905572
• Mitsugi R, Sumida K, Fujie Y, Tukey RH, Itoh T, Fujiwara R. 2016. Acyl-glucuronide as a possible cause of trovafloxacin-induced liver toxicity: Induction of chemokine (C-X-C Motif) ligand 2 by trovafloxacin acyl-glucuronide. Biol Pharm Bull 39(10):1604-1610. doi:10.1248/bpb.b16-00195 PMID:27725437
• Moscat J, Karin M, Diaz-Meco MT. 2016. p62 in cancer: signaling adaptor beyond autophagy. Cell 167(3):606-609. doi:10.1016/j.cell.2016.09.030 PMID:27768885 PMCID:PMC5114003
• Patterson K, Walters LA, Olvera JG, Rosas MA, Rasmusson AG, Escobar MA. 2016. Nitrate-regulated glutaredoxins control Arabidopsis primary root growth. Plant Physiol 170(2):989-999. doi:10.1104/pp.15.01776 PMID:26662603 PMCID:PMC4734588
• Petersen J, Russell P. 2016. Growth and the environment of Schizosaccharomyces pombe. Cold Spring Harb Protoc 2016(3):pdb.top079764. doi:10.1101/pdb.top079764 PMID:26933253
• Pezzoli K, Roberts AL. 2016. Creating healthy and just bioregions. Rev Environ Health 31(1):103-109. doi:10.1515/reveh-2015-0050 PMID:26812849
• Schoeller EL, Clark DD, Dey S, Cao NV, Semaan SJ, Chao LW, Kauffman AS, Stowers L, Mellon PL. 2016. Bmal1 is required for normal reproductive behaviors in male mice. Endocrinology 157(12):4914-4929. doi:10.1210/en.2016-1620 PMID:27704948 PMCID:PMC5133342
• Seki E. 2016. Acrolein, a new villain in the development of alcoholic liver disease. Cell Mol Gastroenterol Hepatol 2(5):544-545. doi:10.1016/j.jcmgh.2016.06.005 PMID:28174735 PMCID:PMC5042884
• Seki E. 2016. HEDGEHOG Signal in hepatocytes mediates macrophage recruitment: a new mechanism and potential therapeutic target for fatty liver disease. Hepatology 63(4):1071-1073. doi:10.1002/hep.28381 PMID:26638191 PMCID:PMC4805480
• Stephan AB, Kunz H, Yang E, Schroeder JI. 2016. Rapid hyperosmotic-induced Ca2+ responses in Arabidopsis thaliana exhibit sensory potentiation and involvement of plastidial KEA transporters. Proc Natl Acad Sci U S A 113(35):E5242-E5249. doi:10.1073/pnas.1519555113 PMID:27528686 PMCID:PMC5024618
• Suzuki K, Yamaji N, Costa A, Okuma E, Kobayashi NI, Kashiwagi T, Katsuhara M, Wang C, Tanoi K, Murata Y, Schroeder JI, Ma JF, Horie T. 2016. OsHKT1;4-mediated Na(+) transport in stems contributes to Na(+) exclusion from leaf blades of rice at the reproductive growth stage upon salt stress. BMC Plant Biol 16:22. doi:10.1186/s12870-016-0709-4 PMID:26786707 PMCID:PMC4719677
• Taniguchi K, Yamachika S, He F, Karin M. 2016. p62/SQSTM1-Dr Jekyll and Mr Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett 590(15):2375-2397. doi:10.1002/1873-3468.12301 PMID:27404485 PMCID:PMC4983218
• Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. 2016. Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol 64(6):1315-1326. doi:10.1016/j.jhep.2016.02.028 PMID:26921690 PMCID:PMC5010388
• Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. 2016. p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell 29(6):935-948. doi:10.1016/j.ccell.2016.04.006 PMID:27211490 PMCID:PMC4907799
• Wall CE, Yu RT, Atkins AR, Downes M, Evans RM. 2016. Nuclear receptors and AMPK: can exercise mimetics cure diabetes?. J Mol Endocrinol 57(1):R49-R58. doi:10.1530/JME-16-0073 PMID:27106806 PMCID:PMC4929025
• Wang C, Hu H, Qin X, Zeise B, Xu D, Rappel WJ, Boron W, Schroeder JI. 2016. Reconstitution of CO2 regulation of SLAC1 anion channel and function of CO2-permeable PIP2;1 aquaporin as carbonic anhydrase 4 interactor. Plant Cell 28(2):568-582. doi:10.1105/tpc.15.00637 PMID:26764375 PMCID:PMC4790870
• Wang P, Koyama Y, Liu X, Xu J, Ma H, Liang S, Kim I, Brenner DA, Kisseleva T. 2016. Promising therapy candidates for liver fibrosis. Front Physiol 7:47. doi:10.3389/fphys.2016.00047 PMID:26909046 PMCID:PMC4754444
• Yamamoto Y, Negi J, Wang C, Isogai Y, Schroeder JI, Iba K. 2016. The transmembrane region of guard cell SLAC1 channels perceives CO2 signals via an ABA-independent pathway in Arabidopsis. Plant Cell 28(2):557-567. doi:10.1105/tpc.15.00583 PMID:26764376 PMCID:PMC4790869
• Yazaki J, Galli M, Kim AY, Nito K, Aleman F, Chang KN, Carvunis A, Quan R, Nguyen H, Song L, Alvarez J, Huang SC, Chen H, Ramachandran N, Altmann S, Gutierrez RA, Hill DE, Schroeder JI, Chory J, LaBaer J, Vidal M, Braun P, Ecker JR. 2016. Mapping transcription factor interactome networks using HaloTag protein arrays. Proc Natl Acad Sci U S A 113(29):E4238-E4247. doi:10.1073/pnas.1603229113 PMID:27357687 PMCID:PMC4961138
• Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng TW, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. 2016. ERRγ is required for the metabolic maturation of therapeutically functional glucose-responsive β cells. Cell Metab 23(4):622-634. doi:10.1016/j.cmet.2016.03.005 PMID:27076077 PMCID:PMC4832237
• Yueh MF, Tukey RH. 2016. Triclosan: a widespread environmental toxicant with many biological effects. Annu Rev Pharmacol Toxicol 56:251-272. doi:10.1146/annurev-pharmtox-010715-103417 PMID:26738475 PMCID:PMC4774862
• Zhang Z, Xie Q, Jobe TO, Kau AR, Wang C, Li Y, Qiu B, Wang Q, Mendoza-Cozatl DG, Schroeder JI. 2016. Identification of AtOPT4 as a plant glutathione transporter. Mol Plant 9(3):481-484. doi:10.1016/j.molp.2015.07.013 PMID:26283048 PMCID:PMC5139274
• Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins GA, Ali S, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. 2016. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164(5):896-910. doi:10.1016/j.cell.2015.12.057 PMID:26919428 PMCID:PMC4769378

2015

• Adamson J, Gleason W, Pellow D, Pezzoli K, eds. 2015. Keywords in the Study of Environment and Culture New York University Press, New York City, NY.
• Antonucci L, Fagman JB, Kim J, Todoric J, Gukovsky I, Mackey MR, Ellisman MH, Karin M. 2015. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A 112(45):E6166-E6174. doi:10.1073/pnas.1519384112 PMID:26512112 PMCID:PMC4653219
• Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. 2015. Calcipotriol targets LRP6 to inhibit Wnt signaling in pancreatic cancer. Mol Cancer Res 13(11):1509-1519. doi:10.1158/1541-7786.MCR-15-0204 PMID:26224368 PMCID:PMC4644680
• Azoulay-Shemer T, Palomares A, Bagheri A, Israelsson-Nordstrom M, Engineer C, Bargmann BO, Stephan AB, Schroeder JI. 2015. Guard cell photosynthesis is critical for stomatal turgor production, yet does not directly mediate CO2 - and ABA-induced stomatal closing. Plant J 83(4):567-581. doi:10.1111/tpj.12916 PMID:26096271 PMCID:PMC4532624
• Bapat SP, Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, Leblanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528(7580):137-141. doi:10.1038/nature16151 PMID:26580014 PMCID:PMC4670283
• Bourne Y, Sulzenbacher G, Radic Z, Araoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgo J, Taylor PW, Marchot P. 2015. Marine macrocyclic imines, pinnatoxins A and G: structural determinants and functional properties to distinguish neuronal α7 from muscle α1(2)βγδ nAChRs. Structure 23(6):1106-1115. doi:10.1016/j.str.2015.04.009 PMID:26004441 PMCID:PMC4461042
• Brandt B, Munemasa S, Wang C, Nguyen D, Yong T, Yang PG, Poretsky E, Belknap TF, Waadt R, Aleman F, Schroeder JI. 2015. Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells. Elife 4:doi:10.7554/eLife.03599 PMID:26192964 PMCID:PMC4507714
• Brenner DA, Paik Y, Schnabl B. 2015. Role of gut microbiota in liver disease. J Clin Gastroenterol 49Suppl1:S25-S27. doi:10.1097/MCG.0000000000000391 PMID:26447960 PMCID:PMC4602394
• Ding N, Hah N, Yu RT, Sherman MH, Benner CW, Leblanc M, He M, Liddle C, Downes M, Evans RM. 2015. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A 112(51):15713-15718. doi:10.1073/pnas.1522163112 PMID:26644586 PMCID:PMC4697417
• Fan W, Evans RM. 2015. PPARs and ERRs: molecular mediators of mitochondrial metabolism. Curr Opin Cell Biol 33:49-54. doi:10.1016/j.ceb.2014.11.002 PMID:25486445 PMCID:PMC4380823
• Fang S, Suh J, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky J, Saltiel AR, Downes M, Evans RM. 2015. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 21(2):159-165. doi:10.1038/nm.3760 PMID:25559344 PMCID:PMC4320010
• Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol 16(12):1235-1244. doi:10.1038/ni.3290 PMID:26502405 PMCID:PMC4653079
• Font-Burgada J, Shalapour S, Ramasamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. 2015. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell 162(4):766-779. doi:10.1016/j.cell.2015.07.026 PMID:26276631 PMCID:PMC4545590
• Fujiwara R, Maruo Y, Chen S, Tukey RH. 2015. Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol 289(1):124-132. doi:10.1016/j.taap.2015.08.018 PMID:26342858 PMCID:PMC4708261
• Hah N, Benner CW, Chong L, Yu RT, Downes M, Evans RM. 2015. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A 112(3):E297-E302. doi:10.1073/pnas.1424028112 PMID:25564661 PMCID:PMC4311831
• Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. 2015. A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice. Biol Reprod 93(3):69. doi:10.1095/biolreprod.115.131631 PMID:26203175 PMCID:PMC4710190
• Keinath NF, Waadt R, Brugman R, Schroeder JI, Grossmann G, Schumacher K, Krebs M. 2015. Live Cell Imaging with R-GECO1 Sheds Light on flg22- and Chitin-Induced Transient [Ca(2+)]cyt Patterns in Arabidopsis. Mol Plant 8(8):1188-1200. doi:10.1016/j.molp.2015.05.006 PMID:26002145 PMCID:PMC5134422
• Kim I, Kisseleva T, Brenner DA. 2015. Aging and liver disease. Curr Opin Gastroenterol 31(3):184-191. doi:10.1097/MOG.0000000000000176 PMID:25850346 PMCID:PMC4736713
• Koyama Y, Brenner DA. 2015. New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol 39Suppl1:S75-S79. doi:10.1016/j.clinre.2015.06.011 PMID:26206573 PMCID:PMC4734896
• Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. 2015. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos 43(7):1071-1076. doi:10.1124/dmd.115.063719 PMID:25953521 PMCID:PMC4468441
• Lan T, Kisseleva T, Brenner DA. 2015. Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation. PLoS One 10(7):e0129743. doi:10.1371/journal.pone.0129743 PMID:26222337 PMCID:PMC4519306
• Liu Y, Trogler WC. 2015. Comment on 'Fluorescence sensing of arsenate at nanomolar level in a greener way: naphthalene based probe for living cell imaging'. Chem Commun (Camb) 51(79):14775-14777. doi:10.1039/c5cc02494c PMID:26299989 PMCID:PMC4607275
• Mazagova M, Wang L, Anfora A, Wissmueller M, Lesley S, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B. 2015. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J 29(3):1043-1055. doi:10.1096/fj.14-259515 PMID:25466902 PMCID:PMC4422368
• Mejia-Ramirez E, Limbo O, Russell P. 2015. Critical Function of γH2A in S-Phase. PLoS Genet 11(9):e1005517. doi:10.1371/journal.pgen.1005517 PMID:26368543 PMCID:PMC4569340
• Munemasa S, Hauser F, Park J, Waadt R, Brandt B, Schroeder JI. 2015. Mechanisms of abscisic acid-mediated control of stomatal aperture. Curr Opin Plant Biol 28:154-162. doi:10.1016/j.pbi.2015.10.010 PMID:26599955 PMCID:PMC4679528
• Patel NS, Doycheva I, Peterson MR, Hooker J, Kisselva T, Schnabl B, Seki E, Sirlin CB, Loomba R. 2015. Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 13(3):561-568.e1. doi:10.1016/j.cgh.2014.08.039 PMID:25218667 PMCID:PMC4333065
• Pezzoli K. 2015. Bioregionalism. Chapter 7 in: Keywords in the Study of Environment and Culture. New York University Press, New York City, NY. pp.25-29.
• Pezzoli K. 2015. Bioregionalism. Chapter 7 in: Keywords in the Study of Environment and Culture. New York University Press, New York City, NY. pp.25-29.
• Pezzoli K. 2015. Bioregionalism. Chapter 7 in: Keywords in the Study of Environment and Culture. New York University Press, New York City, NY. pp.25-29.
• Ranjit S, Dvornikov A, Hong S, Levi M, Evans RM, Gratton E, Stakic M. 2015. Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging. Sci Rep 5:13378. doi:10.1038/srep13378 PMID:26293987 PMCID:PMC4543938
• Roh Y, Loomba R, Seki E. 2015. The TM6SF2 variants, novel genetic predictors for nonalcoholic steatohepatitis. Gastroenterology 148(1):252-254. doi:10.1053/j.gastro.2014.11.014 PMID:25451657 PMCID:PMC4718074
• Sakamoto M, Itoh T, Tukey RH, Fujiwara R. 2015. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet 30(4):269-275. doi:10.1016/j.dmpk.2015.04.004 PMID:26210671 PMCID:PMC4752199
• Sanchez A, Roguev A, Krogan NJ, Russell P. 2015. Genetic interaction landscape reveals critical requirements for Schizosaccharomyces pombe Brc1 in DNA damage response mutants. G3 (Bethesda) 5(5):953-962. doi:10.1534/g3.115.017251 PMID:25795664 PMCID:PMC4426379
• Seki E, Brenner DA. 2015. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci 22(7):512-518. doi:10.1002/jhbp.245 PMID:25869468 PMCID:PMC4668270
• Seki E, Schwabe RF. 2015. Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology 61(3):1066-1079. doi:10.1002/hep.27332 PMID:25066777 PMCID:PMC4306641
• Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zin C, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong Z, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. 2015. P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma. Mol Cell 59(6):931-940. doi:10.1016/j.molcel.2015.07.027 PMID:26365380 PMCID:PMC4648709
• Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon PL, Kauffman AS. 2015. Absent progesterone signaling in kisspeptin neurons disrupts the LH surge and impairs fertility in female mice. Endocrinology 156(9):3091-3097. doi:10.1210/en.2015-1300 PMID:26076042 PMCID:PMC4541622
• Suh J, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin Y, Yu RT, Liddle C, Atkins AR, Olefsky J, Mohammadi M, Downes M, Evans RM. 2015. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 520(7547):388. doi:10.1038/nature14304 PMID:25739500 PMCID:PMC4184286
• Waadt R, Hsu P, Schroeder JI. 2015. Abscisic acid and other plant hormones: methods to visualize distribution and signaling. Bioessays 37(12):1338-1349. doi:10.1002/bies.201500115 PMID:26577078 PMCID:PMC4677054
• Xie H, Hoffman HM, Meadows JD, Mayo S, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL. 2015. Homeodomain proteins SIX3 and SIX6 regulate gonadotrope-specific genes during pituitary development. Mol Endocrinol 29(6):842-855. doi:10.1210/me.2014-1279 PMID:25915183 PMCID:PMC4447639
• Yang YM, Roh YS, Seki E. 2015. MafG, a novel target of FXR that regulates bile acid homeostasis. Gastroenterology 149(7):1981-1983. doi:10.1053/j.gastro.2015.10.014 PMID:26501563 PMCID:PMC4744927
• Yang YM, Seki E. 2015. TNFα in liver fibrosis. Curr Pathobiol Rep 3(4):253-261. doi:10.1007/s40139-015-0093-z PMID:26726307 PMCID:PMC4693602

2014

• Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. 2014. KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology 155(11):4433-4446. doi:10.1210/en.2014-1304 PMID:25147978 PMCID:PMC4197989
• Al-Delaimy W, Wood Larsen C, Pezzoli K. 2014. Differences in health symptoms among residents living near illegal dump sites in Los Laureles Canyon, Tijuana, Mexico: a cross sectional survey. Int J Environ Res Public Health 11(9):9532-9552. doi:10.3390/ijerph110909532 PMID:25226411 PMCID:PMC4199034
• Aoshima N, Fujie Y, Itoh T, Tukey RH, Fujiwara R. 2014. Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia. Sci Rep 4:6343. doi:10.1038/srep06343 PMID:25209391 PMCID:PMC4160704
• Breen KM, Mellon PL. 2014. Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol Cell Endocrinol 385(1-2):71-77. doi:10.1016/j.mce.2013.08.014 PMID:24012628 PMCID:PMC3942370
• d'Uscio LV, He T, Santhanam AR, Tai L, Evans RM, Katusic ZS. 2014. Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene. Am J Physiol Heart Circ Physiol 306(7):H1001-H1010. doi:10.1152/ajpheart.00761.2013 PMID:24486511 PMCID:PMC3962632
• Deinlein U, Stephan AB, Horie T, Luo W, Xu G, Schroeder JI. 2014. Plant salt-tolerance mechanisms. Trends Plant Sci 19(6):371-379. doi:10.1016/j.tplants.2014.02.001 PMID:24630845 PMCID:PMC4041829
• Dhar D, Seki E, Karin M. 2014. NCOA5, IL-6, type 2 diabetes, and HCC: the deadly quartet. Cell Metab 19(1):6-7. doi:10.1016/j.cmet.2013.12.010 PMID:24411937 PMCID:PMC3947913
• Dowding JM, Song W, Bossy K, Karakoti A, Kumar A, Kim AH, Bossy B, Seal S, Ellisman MH, Perkins GA, Self WT, Bossy-Wetzel E. 2014. Cerium oxide nanoparticles protect against A beta -induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ 21(10):1622-1632. doi:10.1038/cdd.2014.72 PMID:24902900 PMCID:PMC4158687
• Engineer C, Ghassemian M, Anderson JC, Peck SC, Hu H, Schroeder JI. 2014. Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development. Nature 513(7517):246-250. doi:10.1038/nature13452 PMID:25043023 PMCID:PMC4274335
• Evans RM, Mangelsdorf DJ. 2014. Nuclear receptors, RXR, and the Big Bang. Cell 157(1):255-266. doi:10.1016/j.cell.2014.03.012 PMID:24679540 PMCID:PMC4029515
• Glidewell-Kenney CA, Trang C, Shao PP, Gutierrez-Reed N, Uzo-Okereke AM, Coss D, Mellon PL. 2014. Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology 155(10):3909-3919. doi:10.1210/en.2014-1263 PMID:25057795 PMCID:PMC4164922
• Hoffmann HM, Tamrazian A, Xie H, Perez-Millan MI, Kauffman AS, Mellon PL. 2014. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology 155(10):4043-4053. doi:10.1210/en.2014-1277 PMID:25060364 PMCID:PMC4164932
• Hong S, Ahmadian M, Yu RT, Atkins AR, Downes M, Evans RM. 2014. Nuclear receptors and metabolism: from feast to famine. Diabetologia 57(5):860-867. doi:10.1007/s00125-014-3209-9 PMID:24619218 PMCID:PMC3980036
• Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. 2014. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124(8):3566-3578. doi:10.1172/JCI74068 PMID:24983318 PMCID:PMC4109552
• Kiyani A, Seki E. 2014. Kupffer Cells. In: Signaling Pathways in Liver Diseases. Wiley-Blackwell, Oxford, England.
• Kudoh K, Uchinami H, Yoshioka M, Seki E, Yamamoto Y. 2014. Nrf2 activation protects the liver from ischemia/reperfusion injury in mice. Ann Surg 260(1):118-127. doi:10.1097/SLA.0000000000000287 PMID:24368646 PMCID:PMC4047210
• Kunz H, Gierth M, Herdean A, Satoh-Cruz M, Kramer DM, Spetea C, Schroeder JI. 2014. Plastidial transporters KEA1, -2, and -3 are essential for chloroplast osmoregulation, integrity, and pH regulation in Arabidopsis. Proc Natl Acad Sci U S A 111(20):7480-7485. doi:10.1073/pnas.1323899111 PMID:24794527 PMCID:PMC4034250
• Kutsuno Y, Itoh T, Tukey RH, Fujiwara R. 2014. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos 42(7):1146-1152. doi:10.1124/dmd.114.057083 PMID:24764149 PMCID:PMC4053997
• Lee S, Parker D, Geszvain K, Tebo BM. 2014. Effects of exogenous pyoverdines on Fe availability and their impacts on Mn(II) oxidation by Pseudomonas putida GB-1. Front Microbiol 5:301. doi:10.3389/fmicb.2014.00301 PMID:25009534 PMCID:PMC4070179
• Liberman A, Mendez N, Trogler WC, Kummel AC. 2014. Synthesis and surface functionalization of silica nanoparticles for nanomedicine. Surf Sci Rep 69(2-3):132-158. doi:10.1016/j.surfrep.2014.07.001 PMID:25364083 PMCID:PMC4212223
• Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. 2014. Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem 289(10):7082-7091. doi:10.1074/jbc.M113.543769 PMID:24448807 PMCID:PMC3945368
• Lopez-Sanchez I, Dunkel Y, Roh Y, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. 2014. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun 5:4451. doi:10.1038/ncomms5451 PMID:25043713 PMCID:PMC4107319
• Maruo Y, Morioka Y, Fujito H, Nakahara S, Yanagi T, Matsui K, Mori A, Sato H, Tukey RH, Takeuchi Y. 2014. Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice. J Pediatr 165(1):36-41.e1. doi:10.1016/j.jpeds.2014.01.060 PMID:24650397 PMCID:PMC4123958
• Mendoza-Cozatl DG, Xie Q, Akmakjian GZ, Jobe TO, Patel AU, Stacey MG, Song L, Demoin DW, Jurisson SS, Stacey G, Schroeder JI. 2014. OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. Mol Plant 7(9):1455-1469. doi:10.1093/mp/ssu067 PMID:24880337 PMCID:PMC4153440
• Mitchell KK, Sandoval S, Cortes-Mateos MJ, Alfaro J, Kummel AC, Trogler WC. 2014. Self-assembled targeting of cancer cells by iron(III)-doped, silica nanoparticles. J Mater Chem B Mater Biol Med 2(45):8017-8025. doi:10.1039/C4TB01429D PMID:25364507 PMCID:PMC4214387
• Moles A, Murphy L, Wilson C, Chakraborty JB, Fox C, Park E, Mann J, Oakley F, Howarth R, Brain JD, Masson S, Karin M, Seki E, Mann DA. 2014. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol 60(4):782-791. doi:10.1016/j.jhep.2013.12.005 PMID:24333183 PMCID:PMC3960359
• Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. 2014. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell 26(3):331-343. doi:10.1016/j.ccr.2014.07.001 PMID:25132496 PMCID:PMC4165611
• Paik Y, Kim J, Aoyama T, De Minicis S, Bataller R, Brenner DA. 2014. Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal 20(17):2854-2872. doi:10.1089/ars.2013.5619 PMID:24040957 PMCID:PMC4026397
• Parker D, Lee S, Geszvain K, Davis RE, Gruffaz C, Meyer J, Torpey JW, Tebo BM. 2014. Pyoverdine synthesis by the Mn(II)-oxidizing bacterium Pseudomonas putida GB-1. Front Microbiol 5:202. doi:10.3389/fmicb.2014.00202 PMID:24847318 PMCID:PMC4019867
• Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan K, Karin M, Budanov AV. 2014. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep 9(4):1281-1291. doi:10.1016/j.celrep.2014.10.019 PMID:25457612 PMCID:PMC4303546
• Pezzoli K, Kozo J, Ferran K, Wooten W, Rangel G, Al-Delaimy W. 2014. One bioregion/one health: an integrative narrative for transboundary planning along the US-Mexico border. Glob Soc 28(4):419-440. doi:10.1080/13600826.2014.951316 PMID:26097402 PMCID:PMC4470564
• Roh Y, Park S, Kim J, Lim C, Seki E, Kim B. 2014. Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. Hepatology 60(1):237-249. doi:10.1002/hep.26981 PMID:24375615 PMCID:PMC4273749
• Roh Y, Song J, Seki E. 2014. TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol 49(2):185-194. doi:10.1007/s00535-013-0931-x PMID:24443058 PMCID:PMC3952073
• Roybal LL, Hambarchyan A, Meadows JD, Barakat AI, Pepa PA, Breen KM, Mellon PL, Coss D. 2014. Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol 28(10):1640-1655. doi:10.1210/me.2014-1008 PMID:25105693 PMCID:PMC4179627
• Schnabl B, Brenner DA. 2014. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146(6):1513-1524. doi:10.1053/j.gastro.2014.01.020 PMID:24440671 PMCID:PMC3996054
• Seki E. 2014. TAK1-dependent autophagy: a suppressor of fatty liver disease and hepatic oncogenesis. Mol Cell Oncol 1(4):doi:10.4161/23723548.2014.968507 PMID:26709386 PMCID:PMC4687902
• Seki E, Brenner DA. 2014. NF-kB. In: Signaling Pathways in Liver Diseases. Wiley-Blackwell, Oxford, England.
• Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. 2014. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159(1):80-93. doi:10.1016/j.cell.2014.08.007 PMID:25259922 PMCID:PMC4177038
• Song W, Mendoza-Cozatl DG, Lee Y, Schroeder JI, Ahn S, Lee H, Wicker T, Martinoia E. 2014. Phytochelatin-metal(loid) transport into vacuoles shows different substrate preferences in barley and Arabidopsis. Plant Cell Environ 37(5):1192-1201. doi:10.1111/pce.12227 PMID:24313707 PMCID:PMC4123957
• Stephan AB, Schroeder JI. 2014. Plant salt stress status is transmitted systemically via propagating calcium waves. Proc Natl Acad Sci U S A 111(17):6126-6127. doi:10.1073/pnas.1404895111 PMID:24737890 PMCID:PMC4036006
• Umemura A, Park E, Taniguchi K, Lee J, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. 2014. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab 20(1):133-144. doi:10.1016/j.cmet.2014.05.001 PMID:24910242 PMCID:PMC4079758
• Waadt R, Hitomi K, Nishimura N, Hitomi C, Adams SR, Getzoff ED, Schroeder JI. 2014. FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis. Elife 3:e01739. doi:10.7554/eLife.01739 PMID:24737861 PMCID:PMC3985518
• Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D. 2014. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci U S A 111(52):18566-18571. doi:10.1073/pnas.1420227112 PMID:25512493 PMCID:PMC4284531
• Yueh MF, Chen S, Nguyen N, Tukey RH. 2014. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem 289(8):4699-4709. doi:10.1074/jbc.M113.518613 PMID:24403077 PMCID:PMC3931032
• Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592
• Zhao X, Cho H, Yu RT, Atkins AR, Downes M, Evans RM. 2014. Nuclear receptors rock around the clock. EMBO J 15(5):518-528. doi:10.1002/embr.201338271 PMID:24737872 PMCID:PMC4210094

2013

• Ahmadian M, Suh J, Hah N, Liddle C, Atkins AR, Downes M, Evans RM. 2013. PPAR gamma signaling and metabolism: the good, the bad and the future. Nat Med 19:557-566. doi:10.1038/nm.3159 PMID:23652116 PMCID:PMC3870016
• Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. 2013. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A 110(47):19143-19148. doi:10.1073/pnas.1319123110 PMID:24191041 PMCID:PMC3839688
• Clark DD, Gorman MR, Hatori M, Meadows JD, Panda S, Mellon PL. 2013. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms 28(1):15-25. doi:10.1177/0748730412468084 PMID:23382588 PMCID:PMC3586279
• Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM. 2013. A vitamin D receptor / SMAD genomic circuit gates hepatic fibrotic response. Cell 153(3):601-613. doi:10.1016/j.cell.2013.03.028 PMID:23622244 PMCID:PMC3673534
• Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. 2013. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A 110(6):2377-2382. doi:10.1073/pnas.1221729110 PMID:23341606 PMCID:PMC3568328
• Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP. 2013. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci U S A 110:8555-8560. doi:10.1073/pnas.1306182110 PMID:23653479 PMCID:PMC3666748
• Fan W, Atkins AR, Yu RT, Downes M, Evans RM. 2013. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol 51(3):T87-T100. doi:10.1530/JME-13-0258 PMID:24280961 PMCID:PMC3936671
• Geszvain K, McCarthy JK, Tebo BM. 2013. Elimination of manganese (II, III) oxidation in Pseudomonas putida GB-1 by a double knockout of two putative multicopper oxidase genes. Appl Environ Microbiol 79(1):357-366. doi:10.1128/aem.01850-12 PMID:23124227 PMCID:PMC3536112
• Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon PL. 2013. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol 27(3):437-454. doi:10.1210/me.2012-1271 PMID:23393128 PMCID:PMC3589675
• Hauser F, Chen W, Deinlein U, Chang K, Ossowski S, Fitz J, Hannon GJ, Schroeder JI. 2013. A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis. Plant Cell 25(8):2848-2863. doi:10.1105/tpc.113.112805 PMID:23956262 PMCID:PMC3784584
• He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. 2013. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155(2):384-396. doi:10.1016/j.cell.2013.09.031 PMID:24120137 PMCID:PMC4015514
• Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W. 2013. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. Pharm Res 30(9):2199-2208. doi:10.1007/s11095-013-1101-9 PMID:23896737 PMCID:PMC3771640
• Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS. 2013. Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys 535(2):143-149. doi:10.1016/j.abb.2013.03.012 PMID:23562620 PMCID:PMC4059507
• Larder R, Kimura I, Meadows JD, Clark DD, Mayo S, Mellon PL. 2013. Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol 377(1-2):16-22. doi:10.1016/j.mce.2013.06.026 PMID:23811236 PMCID:PMC3771655
• Lee J, Budanov AV, Karin M. 2013. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab 18(6):792-801. doi:10.1016/j.cmet.2013.08.018 PMID:24055102 PMCID:PMC3858445
• Madsen DH, Leonard D, Masedunskas A, Moyer A, Jurgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. 2013. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 202(6):951-966. doi:10.1083/jcb.201301081 PMID:24019537 PMCID:PMC3776354
• McDowell SC, Akmakjian GZ, Sladek C, Mendoza-Cozatl DG, Morrissey JB, Saini N, Mittler R, Baxter I, Salt DE, Ward JM, Schroeder JI, Guerinot ML, Harper JF. 2013. Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions. PLoS One 8(5):e63014. doi:10.1371/journal.pone.0063014 PMID:23671651 PMCID:PMC3646034
• Roh Y, Seki E. 2013. Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol 28(S1):38-42. doi:10.1111/jgh.12019 PMID:23855294 PMCID:PMC3721430
• Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. 2013. p38αlpha inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res 73(1):215-224. doi:10.1158/0008-5472.CAN-12-1602 PMID:23271722 PMCID:PMC3605785
• Schroeder JI, Delhaize E, Frommer WB, Guerinot ML, Harrison MJ, Herrera-Estrella L, Horie T, Kochian LV, Munns R, Nishizawa NK, Tsay Y, Sanders D. 2013. Using membrane transporters to improve crops for sustainable food production. Nature 497:60-66. doi:10.1038/nature11909 PMID:23636397 PMCID:PMC3954111
• Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R. 2013. Importance of UDP-Glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemias. Mol Pharmacol 84(5):679-686. doi:10.1124/mol.113.088112 PMID:23950218 PMCID:PMC3807078
• Toyoda K, Tebo BM. 2013. The effect of Ca2+ ions and ionic strength on Mn(II) oxidation by spores of the marine Bacillus sp SG-1. Geochim Cosmochim Acta 101:1-11. doi:10.1016/j.gca.2012.10.008
• Uhlenhaut N, Barish GD, Yu RT, Downes M, Karunasiri M, Liddle C, Schwalie P, Hubner N, Evans RM. 2013. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell 49(1):158-171. doi:10.1016/j.molcel.2012.10.013 PMID:23159735 PMCID:PMC3640846
• Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Cross D, Kauffman AS, Mellon PL. 2013. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol 27(8):1283-1294. doi:10.1210/me.2012-1405 PMID:23770611 PMCID:PMC3725344
• Xie H, Cherrington BD, Meadows JD, Whitham E, Mellon PL. 2013. Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during Gonadotrope development. Mol Endocrinol 27(3):422-436. doi:10.1210/me.2012-1289 PMID:23371388 PMCID:PMC3589667
• Yang L, Inokuchi-Shimizu S, Roh Y, Song J, Loomba R, Park E, Seki E. 2013. Transforming growth factor-beta signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology 144(5):1042-1054. doi:10.1053/j.gastro.2013.01.056 PMID:23391818 PMCID:PMC3752402

2012

• Brayman MJ, Mellon PL, Berdy SE, Pepa PA. 2012. Androgen receptor repression of GnRH gene transcription. Mol Endocrinol 26:2-13. doi:10.1210/me.2011-1015 PMID:22074952 PMCID:PMC3248321
• Brayman MJ, Pepa PA, Mellon PL. 2012. Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol Cell Endocrinol 363(1-2):92-99. doi:10.1016/j.mce.2012.07.012 PMID:22877652 PMCID:PMC3447085
• Chen S, Yueh MF, Evans RM, Tukey RH. 2012. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT 1 mice. Hepatology 56(2):658-667. doi:10.1002/hep.25671 PMID:22371261 PMCID:PMC3383890
• De Jaco A, Comoletti D, Dubin N, Camp S, Taylor PW. 2012. Processing of cholinesterase-like alpha/beta-hydrolase fold proteins: alterations associated with congenital disorders. Protein Pept Lett 19:173-179. PMID:21933121 PMCID:PMC4755491
• De Jaco A, Dubi N, Camp S, Taylor PW. 2012. Congenital hypothyroidism mutations affect common folding and trafficking in the α/β-hydrolase fold proteins. FEBS J 279(23):4293-4305. doi:10.1111/febs.12019 PMID:23035660
• Falivelli G, De Jaco A, Favaloro FL, Kim H, Wilson J, Dubi N, Ellisman MH, Abrahams BS, Taylor PW, Comoletti D. 2012. Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation. Hum Mol Genet 21:4761-4773. doi:10.1093/hmg/dds320 PMID:22872700 PMCID:PMC3471401
• Fujiwara R, Chen S, Karin M, Tukey RH. 2012. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-kappa B leads to hyperbilirubinemia. Gastroenterology 142:109-U259. doi:10.1053/j.gastro.2011.09.045 PMID:21983082 PMCID:PMC3428231
• Guo L, Ghassemian M, Komives EA, Russell P. 2012. Cadmium-induced proteome remodeling regulated by Spc I/Sty I and Zip I in fission yeast. Toxicol Sci 129(1):200-212. doi:10.1093/toxsci/kfs179 PMID:22610605 PMCID:PMC3713068
• Jobe TO, Sung D, Akmakjian GZ, Pham AL, Komives EA, Mendoza-Cozatl DG, Schroeder JI. 2012. Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient y-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation. Plant J 70:783-795. doi:10.1111/j.1365-313X.2012.04924.x PMID:22283708 PMCID:PMC4688143
• Jonker JW, Liddle C, Downes M. 2012. FXR and PXR: Potential therapeutic targets in cholestasis. Psychiatr Pol 130(3-5):147-158. doi:10.1016/j.jsbmb.2011.06.012 PMID:21801835 PMCID:PMC4750880
• Lee J, Budanov AV, Talukdar S, Park E, Park H, Park H, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. 2012. Maintenance of metabolic homeostasis by Sestrin 2 and Sestrin 3. Cell Metab 16(3):311-321. doi:10.1016/j.cmet.2012.08.004 PMID:22958918 PMCID:PMC3687365
• Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. 2012. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets 16(11):1075-1083. doi:10.1517/14728222.2012.715634 PMID:22913318 PMCID:PMC4319648
• Noreault-Conti TL, Fellows A, Jacobs JM, Trask HW, Strom S, Evans RM, Wrighton SA, Sinclair PR, Sinclair JF, Nichols RC. 2012. Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol 12(4):651-60. doi:10.1016/j.intimp.2012.01.008 PMID:22310326 PMCID:PMC3345897
• Perkins GA, Scott RT, Perez A, Ellisman MH, Johnson JE, Fox DA. 2012. Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: Electron microscopy, tomography and oxygen consumption. Mol Vis 18:3029-3048. PMID:23288995 PMCID:PMC3534145
• Seki E, Brenner DA, Karin M. 2012. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 143(2):307-320. doi:10.1053/j.gastro.2012.06.004 PMID:22705006 PMCID:PMC3523093
• Sun B, Karin M. 2012. Obesity, inflammation, and liver cancer. J Hepatol 56(3):704-713. doi:10.1016/j.jhep.2011.09.020 PMID:22120206 PMCID:PMC3889660
• Whitham E, Meadows JD, Shojaei S, Kauffman AS, Mellon PL. 2012. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology 153(9):4522-4532. doi:10.1210/en.2012-1283 PMID:22778229 PMCID:PMC3423623
• Yu G, He G, Li C, Tang M, Grivennikov S, Tsai W, Wu M, Hsu C, Tsai Y, Wang L, Karin M. 2012. Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell 48(2):313-321. doi:10.1016/j.molcel.2012.07.032 PMID:22959272 PMCID:PMC3483424
• Yueh MF, Li T, Evans RM, Hammock BD, Tukey RH. 2012. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One 7(6):e37705. doi:10.1371/journal.pone.0037705 PMID:22761658 PMCID:PMC3376094 (Completed with ARRA Funds)

2011

• Anderson CR, Davis RE, Bandolin NS, Baptista AM, Tebo BM. 2011. Analysis of in situ manganese(II) oxidation in the Columbia River and offshore plume: linking Aurantimonas and the associated microbial community to an active biogeochemical cycle. Environ Microbiol 13(6):1561-1576. doi:10.1111/j.1462-2920.2011.02462.x PMID:21418498
• Bernard V, Girard E, Hrabovska A, Camp S, Taylor PW, Plaud B, Krejci E. 2011. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Mol Cell Neurosci 46(1):272-281. doi:10.1016/j.mcn.2010.09.010 PMID:20883790 PMCID:PMC4755503
• Bohmer M, Schroeder JI. 2011. Quantitative transcriptomic analysis of abscisic acid-induced and reactive oxygen species-dependent expression changes and proteomic profiling in Arabidopsis suspension cells. Plant J 67(1):105-118. doi:10.1111/j.1365-313X.2011.04579.x PMID:21426425 PMCID:PMC3125488
• Brauer SL, Adams C, Kranzler K, Murphy D, Xu M, Zuber P, Simon HM, Baptista AM, Tebo BM. 2011. Culturable Rhodobacter and Shewanella species are abundant in estuarine turbidity maxima of the Columbia River. Environ Microbiol 13(3):589-603. doi:10.1111/j.1462-2920.2010.02360.x PMID:20977571
• Caputo N. 2011. Investigating Manganese Oxidation by Aurantimonas manganoxydans SI85-9A1. .
• Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. 2011. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147(6):1233-1247. doi:10.1016/j.cell.2011.10.043 PMID:22153071 PMCID:PMC3251960
• Hauser F, Waadt R, Schroeder JI. 2011. Evolution of abscisic acid synthesis and signaling mechanisms. Current Biology 21:R346-R355. doi:10.1016/j.cub.2011.03.015 PMID:21549957 PMCID:PMC3119208
• Holzer RG, Park E, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. 2011. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147(1):173-184. doi:10.1016/j.cell.2011.08.034 PMID:21962514 PMCID:PMC3295636
• Horie T, Brodsky DE, Costa A, Kaneko T, Lo Schiavo F, Katsuhara M, Schroeder JI. 2011. K+ transport by the OsHKT2;4 transporter from rice with atypical Na+ transport properties and competition in permeation of K+ over Mg2+ and Ca2+ ions. Plant Physiol 156:1493-1507. doi:10.1104/pp.110.168047 PMID:21610181 PMCID:PMC3135959
• Jannat R, Uraji M, Morofuji M, Islam MM, Bloom RE, Nakamura Y, McClung CR, Schroeder JI, Mori IC, Murata Y. 2011. Roles of intracellular hydrogen peroxide accumulation in abscisic acid signaling in Arabidopsis guard cells. J Plant Physiol 168(16):1919-1926. doi:10.1016/j.jplph.2011.05.006 PMID:21665322 PMCID:PMC4073789
• Kacevska M, Downes M, Sharma R, Evans RM, Clarke SJ, Liddle C, Robertson GR. 2011. Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. Clin Cancer Res 17:3170-3180. doi:10.1158/1078-0432.ccr-10-3289 PMID:21498392 PMCID:PMC3096719
• Koch KS, Leffert HL. 2011. Ectopic expression of CD74 in Ikk beta-deleted mouse hepatocytes. Acta Histochemica 113:428-435. doi:10.1016/j.acthis.2010.03.004 PMID:20569972 PMCID:PMC2965206
• Mendoza-Cozatl DG, Jobe TO, Hauser F, Schroeder JI. 2011. Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic. Curr Opin Plant Biol 14:554-562. doi:10.1016/j.pbi.2011.07.004 PMID:21820943 PMCID:PMC3191310
• Miller MT, Mileni M, Comoletti D, Stevens RC, Harel M, Taylor PW. 2011. The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure 19(6):767-778. doi:10.1016/j.str.2011.03.011 PMID:21620717 PMCID:PMC3279696
• Osterreicher C, Penz-Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108(1):308-313. doi:10.1073/pnas.1017547108 PMID:21173249 PMCID:PMC3017162
• Pezzoli K. 2011. Creating Just and Healthy Bioregions: The Role of Action Research and Community Engagement.
• Pezzoli K. 2011. Food Justice: Industrial Agriculture and the Quest for Alternative Food Systems.
• Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih P, Rao F, O'Connor DT, Taylor PW. 2011. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther 338(1):125-133. doi:10.1124/jpet.111.180091 PMID:21493754 PMCID:PMC3126649
• Xue S, Yao X, Luo W, Jha D, Tester M, Horie T, Schroeder JI. 2011. AtHKT1;1 mediates nernstian sodium channel transport properties in Arabidopsis root stelar cells. PLoS One 6(9):e24725.. doi:10.1371/journal.pone.0024725 PMID:21931830 PMCID:PMC3170383
• Yueh MF, Mellon PL, Tukey RH. 2011. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol 79:1053-1060. doi:10.1124/mol.110.070649 PMID:21415305 PMCID:PMC3102552

2010

• Bodmer R, Bier E, Karin M, Lee J. 2010. Sestrins at the crossroad between stress and aging. Aging-US 2(6):369-374. doi:10.18632/aging.100157 PMID:20606249 PMCID:PMC2919257
• Bourne Y, Radic Z, Araoz R, Talley TT, Benoit E, Servent D, Taylor PW, Molgo J, Marchot P. 2010. Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism. Proc Natl Acad Sci U S A 107(13):6076-6081. doi:10.1073/pnas.0912372107 PMID:20224036 PMCID:PMC2851920
• Budanov AV, Lee J, Karin M. 2010. Stressin' Sestrins take an aging fight. EMBO Mol Med 2(10):388-400. doi:10.1002/emmm.201000097 PMID:20878915 PMCID:PMC3166214
• Cai H, Nguyen N, Peterkin V, Yang Y, Hotz K, La Placa D, Chen S, Tukey RH, Stevens J. 2010. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos 38(5):879-886. doi:10.1124/dmd.109.030130 PMID:20124398 PMCID:PMC2872941
• Comoletti D, Miller MT, Jeffries CM, Wilson J, Demeler B, Taylor PW, Trewhella J, Nakagawa T. 2010. The macromolecular architecture of extracellular domain of alpha NRXN1: Domain organization, flexibility, and insights into trans-synaptic disposition. Structure 18(8):1044-1053. doi:10.1016/j.str.2010.06.005 PMID:20696403 PMCID:PMC2948785
• Costa A, Drago I, Behera S, Zottini M, Pizzo P, Schroeder JI, Pozzan T, Schiavo F. 2010. H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J 62(5):760-772. doi:10.1111/j.1365-313X.2010.04190.x PMID:20230493 PMCID:PMC2884081
• De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman MH, Butko MT, Tsien RY, Taylor PW. 2010. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. J Biol Chem 285:28674-28682. doi:10.1074/jbc.M110.139519 PMID:20615874 PMCID:PMC2937894
• Fujiwara R, Nguyen N, Chen S, Tukey RH. 2010. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A 107(11):5024-5029. doi:10.1073/pnas.0913290107 PMID:20194756 PMCID:PMC2841904
• Junier P, Junier T, Podell S, Sims DR, Detter JC, Lykidis A, Han CS, Wigginton NS, Gaasterland T, Bernier-Latmani R. 2010. The genome of the Gram-positive metal- and sulfate-reducing bacterium Desulfotomaculum reducens strain MI-1. Environ Microbiol 12(10):2738-2754. doi:10.1111/j.1462-2920.2010.02242.x PMID:20482743
• Lee J, Budanov AV, Park E, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. 2010. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327(5970):1223-1228. doi:10.1126/science.1182228 PMID:20203043 PMCID:PMC2866632
• Leone P, Comoletti D, Ferracci G, Conrod S, Garcia S, Taylor PW, Bourne P, Bourne Y, Marchot P. 2010. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J 29:2461-2471. doi:10.1038/emboj.2010.123 PMID:20543817 PMCID:PMC2910273
• Mendoza-Cozatl DG, Zhai Z, Jobe TO, Akmakjian GZ, Song W, Limbo O, Russell MR, Kozlovskyy VI, Martinoia E, Vatamaniuk OK, Russell P, Schroeder JI. 2010. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J Biol Chem 285(52):40416-40426. doi:10.1074/jbc.M110.155408 PMID:20937798 PMCID:PMC3003340
• Nishimura N, Sarkeshik A, Park S, Wang A, Carvalho PC, Lee S, Caddell DF, Cutler SR, Chory J, Yates JR, Schroeder JI, Nito K. 2010. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J 61(2):290-299. doi:10.1111/j.1365-313X.2009.04054.x PMID:19874541 PMCID:PMC2807913
• Park E, Lee J, Yu G, He G, Ali S, Holzer RG, Osterreicher CH, Takahashi H, Karin M. 2010. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140(2):197-208. doi:10.1016/j.cell.2009.12.052 PMID:20141834 PMCID:PMC2836922
• Pyo Y, Gierth M, Schroeder JI, Cho M. 2010. High-affinity K(+) transport in Arabidopsis: AtHAK5 and AKT1 are vital for seedling establishment and postgermination growth under low-potassium conditions. Plant Physiol 153(2):863-875. doi:10.1104/pp.110.154369 PMID:20413648 PMCID:PMC2879780
• Song W, Park J, Mendoza-Cózatl D, Suter-Grotemeyer M, Shim D, Hortensteiner S, Geisler M, Weder B, Rea PA, Rentsch D, Schroeder JI. 2010. Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters. Proc Natl Acad Sci U S A 107(49):21187-21192. doi:10.1073/pnas.1013964107 PMID:21078981 PMCID:PMC3000282
• Suhr ST, Chang E, Tjong J, Alcasid N, Perkins GA, Goissis M, Ellisman MH, Perez GI, Cibelli J. 2010. Mitochondrial rejuvenation after induced pluripotency. PLoS One 5:e14095:doi:10.1371/journal.pone.0014095 PMID:21124794 PMCID:PMC2991355
• Wang X, Lee J, Di Jeso B, Treglia A, Comoletti D, Dubi N, Taylor PW, Arvan P. 2010. Cis and trans actions of the cholinesterase-like domain within the thyroglobulin dimer. J Biol Chem 285(23):17564-17573. doi:10.1074/jbc.M110.111641 PMID:20353937 PMCID:PMC2878521
• Yao X, Horie T, Xue S, Leung H, Katsuhara M, Brodsky DE, Wu Y, Schroeder JI. 2010. Differential sodium and potassium transport selectivities of the rice OsHKT2;1 and OsHKT2;2 transporters in plant cells. Plant Physiol 152(1):341-355. doi:10.1104/pp.109.145722 PMID:19889878 PMCID:PMC2799368

2009

• Anderson CR, Dick GJ, Chu M, Bräuer S, Cho J, Davis RE, Tebo BM. 2009. Aurantimonas manganoxydans, sp nov and Aurantimonas litoralis, sp nov: Mn(II) oxidizing representatives of a globally distributed clade of alpha-Proteobacteria from the order Rhizobiales. Geomicrobiol J 26(3):189-198. doi:10.1080/01490450902724840 PMID:19768133 PMCID:PMC2746641
• Anderson CR, Johnson HA, Caputo N, Davis RE, Torpey JW, Tebo BM. 2009. Mn(II) oxidation is catalyzed by heme peroxidases in "Aurantimonas manganoxydans" strain SI85-9A1 and Erythrobacter sp strain SD-21. Appl Environ Microbiol 75(12):4130-4138. doi:10.1128/AEM.02890-08 PMID:19411418 PMCID:PMC2698374
• Haybaeck J, Zeller N, Wolf MJ, Weber A, Kurrer M, Bremer J, lezzi G, Graf R, Clavien P, Ndeospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M, Wagner U, Thimme R, Blum H. 2009. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16(4):295-308. doi:10.1016/j.ccr.2009.08.021 PMID:19800575 PMCID:PMC4422166
• Horie T, Hauser F, Schroeder JI. 2009. HKT transporter-mediated salinity resistance mechanisms in Arabidopsis and monocot crop plants. Trends Plant Sci 14(12):660-668. doi:10.1016/j.tplants.2009.08.009 PMID:19783197 PMCID:PMC2787891
• Koch KS, Maeda S, Karin M, Leffert HL, He G. 2009. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun 380(2):349-354. doi:10.1016/j.bbrc.2009.01.085 PMID:19171122 PMCID:PMC2663043
• Maser P, Schroeder JI, Ward JM. 2009. Plant ion channels: gene families, physiology, and functional genomics analyses. Annu Rev Physiol 71:59-82. doi:10.1146/annurev.physiol.010908.163204 PMID:18842100 PMCID:PMC4790454
• Nishimura N, Schroeder JI, Getzoff ED, Cutler SR, Hitomi C, Rambo RP, Arvai AS, Hitomi K. 2009. Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science 326(5958):1373-1379. doi:10.1126/science.1181829 PMID:19933100 PMCID:PMC2835493
• Perkins GA, Bossy-Wetzel E, Ellisman MH. 2009. New insights into mitochondrial structure during cell death. Experimental Neurology 218(2):183-92. doi:10.1016/j.expneurol.2009.05.021 PMID:19464290 PMCID:PMC2712651
• Perkins GA, Sun M, Frey TG. 2009. Chapter 2 Correlated light and electron microscopy/electron tomography of mitochondria in situ. Methods Enzymol 456:29-52. doi:10.1016/S0076-6879(08)04402-9 PMID:19348881 PMCID:PMC2730195
• Savas U, Machemer DE, Hsu M, Gaynor P, Lasker JM, Tukey RH, Johnson EF. 2009. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem 284(24):16541-16552. doi:10.1074/jbc.M902074200 PMID:19366684 PMCID:PMC2713544
• Senekeo-Effenberger K, Tukey RH, Remmel RP, Larson EE, Argikar U. 2009. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica 39(11):826-835. doi:10.3109/00498250903188985 PMID:19845433 PMCID:PMC2891280
• Sung D, Kim T, Komives EA, Mendoza-Cózatl D, Schroeder JI. 2009. ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis. Plant J 59(5):802-813. doi:10.1111/j.1365-313X.2009.03914.x PMID:19453443 PMCID:PMC2830867
• Taylor PW, Boudinot E, Bernard V, Camp S, Champagnat J, Krejci E, Foutz AS. 2009. Influence of differential expression of acetylcholinesterase in brain and muscle on respiration. Respir Physiol Neurobiol 165(1):40-48. doi:10.1016/j.resp.2008.10.003 PMID:18977317 PMCID:PMC2706911
• Taylor PW, Dobbertin A, Hrabovska A, Dembele K, Camp S, Krejci E, Bernard V. 2009. Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit. J Neurosci 29(14):4519-4530. doi:10.1523/JNEUROSCI.3863-08.2009 PMID:19357277 PMCID:PMC2695489
• Vashisht AA, Kennedy PJ, Russell P. 2009. Centaurin-like protein Cnt5 contributes to arsenic and cadmium resistance in fission yeast. FEMS Yeast Res 9:257-69. PMID:19076239 PMCID:PMC2820371
• Yamaguchi R, Perkins GA. 2009. Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochim Biophys Acta 1787(8):963-972. doi:10.1016/j.bbabio.2009.02.005 PMID:19245786 PMCID:PMC2773558

2008

• Camp S, De Jaco A, Zhang L, Marquez M, de la Torre B, Taylor PW. 2008. Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intron. J Neurosci 28(10):2459-2470. doi:10.1523/JNEUROSCI.4600-07.2008 PMID:18322091 PMCID:PMC2692871
• Comoletti D, Grishaev A, Whitten A, Taylor PW, Trewhella J. 2008. Characterization of the solution structure of a neuroligin/beta-neurexin complex. Chem Biol Interact 175(1-3):150-155. doi:10.1016/j.cbi.2008.04.040 PMID:18550038 PMCID:PMC2587492
• Dick GJ, Podell S, Johnson HA, Rivera-Espinoza Y, Bernier-Latmani R, McCarthy JK, Torpey JW, Clement BG, Gaasterland T, Tebo BM. 2008. Genomic insights into Mn(II) oxidation by the marine alphaproteobacterium Aurantimonas sp strain SI85-9A1. Appl Environ Microbiol 74(9):2646-2658. doi:10.1128/AEM.01656-07 PMID:18344346 PMCID:PMC2394881
• Dick GJ, Torpey JW, Beveridge TJ, Tebo BM. 2008. Direct identification of a bacterial manganese(II) oxidase, the multicopper oxidase MnxG, from spores of several different marine Bacillus species. Appl Environ Microbiol 74(5):1527-1534. PMID:18165363
• Horie T, Sugawara M, OKUNOU K, NAKAYAMA H, Schroeder JI, Shinmyo A, Yoshida K. 2008. Functions of HKT transporters in sodium transport in roots and in protecting leaves from salinity stress. Plant Biotechnology 25:233-239.
• Johnson HA, Tebo BM. 2008. In vitro studies indicate a quinone is involved in bacterial Mn(II) oxidation. Arch Microbiol 189(1):59-69. doi:10.1007/s00203-007-0293-y PMID:17673976 PMCID:PMC2721854
• Karin M, Budanov AV. 2008. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-460. doi:10.1016/j.cell.2008.06.028 PMID:18692468 PMCID:PMC2758522
• Kennedy PJ, Vashisht AA, Hoe K, Kim D, Park H, Hayles J, Russell P. 2008. A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol Sci 106(1):124-139. doi:10.1093/toxsci/kfn153 PMID:18684775 PMCID:PMC2563147
• Kim Y, Kim D, Shim D, Song W, Lee J, Schroeder JI, Kim S, Moran| N, Lee Y. 2008. Expression of the novel wheat gene TM20 confers enhanced cadmium tolerance to bakers' yeast. J Biol Chem 283:15893-15902. doi:10.1074/jbc.M708947200 PMID:18411273 PMCID:PMC2414300
• Knott AB, Perkins GA, Schwarzenbacher R, Bossy-Wetzel E. 2008. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9(7):505-518. doi:10.1038/nrn2417 PMID:18568013 PMCID:PMC2711514
• Mendoza-Cózatl D, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI. 2008. Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Plant J 54(2):249-259. doi:10.1111/j.1365-313X.2008.03410.x PMID:18208526 PMCID:PMC2839885
• Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Belanger A, Tukey RH. 2008. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem 283(12):7901-7911. doi:10.1074/jbc.M709244200 PMID:18180294
• Rodriguez-Gabriel MA, Russell P. 2008. Control of mRNA Stability by SAPKs. In: Topics in Current Genetics. pp.159-170.
• VAHISALU T, KOLLIST H, Wang Y, Nishimura N, Chan W, Valerio G, LAMMINMÄKI A, BROSCHE M, DESIKAN R, Schroeder JI, KANGASJÄRVI J, MOLDAU H. 2008. SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling. Nature 452:487-491. PMID:18305484
• Yamaguchi R, Lartigue L, Perkins GA, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. 2008. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell 31(4):557-569. doi:10.1016/j.molcel.2008.07.010 PMID:18691924 PMCID:PMC2636708
• Yueh MF, Tukey RH, Chouinard S, Giton F, Fiet J, Pelletier G, Barbier O, Belanger A. 2008. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. Psychiatr Pol 109(3-5):247-253. doi:10.1016/j.jsbmb.2008.03.016 PMID:18467088

2007

• Bencheikh-Latmani R, Obraztsova AY, Mackey MR, Ellisman MH, Tebo BM. 2007. Toxicity of Cr(III) to Shewanella sp. strain MR-4 during Cr(VI) reduction. Environ Sci Technol 41(1):214-220. PMID:17265950
• Bonzo JA, Belanger A, Tukey RH. 2007. The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology 45(2):349-360. PMID:17256720
• Comoletti D, Grishaev A, Whitten A, Tsigelny I, Taylor PW, Trewhella J. 2007. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering. Structure 15(6):693-705. doi:10.1016/j.str.2007.04.010 PMID:17562316 PMCID:PMC2677967
• Horie T, Costa A, Kim T, Han M, Horie R, Leung H, Miyao A, Hirochika H, An G, Schroeder JI. 2007. Rice OsHKT2;1 transporter mediates large Na+ influx component into K+-starved roots for growth. EMBO J 26(12):3003-14. PMID:17541409
• Murray KJ, Tebo BM. 2007. Cr(III) is indirectly oxidized by the Mn(II)-oxidizing bacterium Bacillus sp strain SG-1. Environ Sci Technol 41(2):528-533. PMID:17310717
• Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317(5834):121-124. doi:10.1126/science.1140485 PMID:17615358
• Operana T, Nguyen N, Chen S, Beaton D, Tukey RH. 2007. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci 95(1):98-107. doi:10.1093/toxsci/kfl144 PMID:17065433
• Pezzoli K, Tukey RH, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman MH. 2007. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect 115(4):564-571. doi:10.1289/ehp.9817 PMID:17450225 PMCID:PMC1852670
• Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. 2007. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35(3):419-427. doi:10.1124/dmd.106.013243 PMID:17151188
• Sonoda J, Mehl IR, Chong L, Nofsinger RR, Evans RM. 2007. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Chapter 104(12)in: Proceedings of the NAS (National Academy of Sciences) USA, 2007. pp.5223-8.
• Yueh MF, Tukey RH. 2007. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 282(12):8749-8758. doi:10.1074/jbc.M610790200 PMID:17259171

2006

• Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, Liu Y, Karin M. 2006. The E3 ubiquitin ligase itch couples JNK activation to TNF±-induced cell death by inducing c-FLIPL turnover. Cell 124:601-603. PMID:16469705
• Chen A, Komives EA, Schroeder JI. 2006. An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiol 141(1):108-120. doi:10.1104/pp.105.072637 PMID:16531489 PMCID:PMC1459314
• Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Sudhof TC, Taylor PW. 2006. Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry 45(42):12816-12827. PMID:17042500
• De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor PW. 2006. A mutation linked with autism reveals a common mechanism of endoplasmic retic a, B-beta-hydrolase fold protein family. J Biol Chem 281(14):9667-9676. PMID:16434405
• Dick GJ, Lee YE, Tebo BM. 2006. Manganese(II)-oxidizing Bacillus spores in Guaymas Basin hydrothermal sediments and plumes. Appl Environ Microbiol 72(5):3184-3190. doi:10.1128/AEM.72.5.3184-3190.2006 PMID:16672456 PMCID:PMC1472353
• Long JM, LaPorte P, Merscher S, Funke B, Saint-Jore B, Puech A, Kucherlapati R, Morrow BE, Skoultchi AI, Wynshaw-Boris A. 2006. Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics 7(4):247-57. PMID:16900388
• Martin V, Rodriguez-Gabriel MA, McDonald WH, Watt S, Yates JR, Bahler J, Russell P. 2006. Cip1 and Cip2 are novel RNA-recognition-motif proteins that counteract Csx1 function during oxidative stress. Mol Biol Cell 17(3):1176-1183. PMID:16407405
• Nguyen V, Schroeder JI. 2006. The role of reactive oxygen species in hormonal responses. Plant Physiol 141(2):323-329. PMID:16760482
• Pezzoli K, Marciano R, Robertus J. 2006. Integrating Regional Watershed Management: A Strategic Vision. In: Proceedings of the 7^th Annual International Conference on Digital Government Research, May 21-26. San Diego, CA.
• Platten JD, Cotsaftis O, Berthomieu P, Bohnert H, Davenport RJ, Fairbairn DJ, Horie T, Leigh RA, Lin H, Luan S, Maser P, Pantoja O, Rodriguez-Navarro A, Schachtman DP, Schroeder JI, Sentenac H, Uozumi N, Very A, Zhu J, Dennis ES, Tester M. 2006. Nomenclature for HKT transporters, key determinants of plant salinity tolerance. Trends Plant Sci 11(8):372-374. PMID:16809061
• Rodriguez-Gabriel MA, Watt S, Bahler J, Russell P. 2006. Upf1, an RNA Helicase Required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol Cell Biol 26(17):6347-6356. PMID:16914721
• Sakurai T, Maeda S, Chang L, Karin M. 2006. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103(28):10544-10551. doi:10.1073/pnas.0603499103 PMID:16807293 PMCID:PMC1502270
• Schroeder JI, Kuhn JM. 2006. Plant biology: abscisic acid in bloom. Nature 439(7074):277-278. doi:10.1038/439277a PMID:16421556
• Schroeder JI, Nambara E. 2006. A quick release mechanism for abscisic acid. Cell 126(6):1023-1025. PMID:16990126
• Shi J, Koeppe JR, Komives EA, Taylor PW. 2006. Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem 281(17):12170-12177. doi:10.1074/jbc.M600154200 PMID:16484218
• Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes M. 2006. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc Natl Acad Sci U S A 103(30):11323-11328. PMID:16844773
• Zaslavsky I, Pezzoli K, Valentine D, Lin A, Sarabia H, Ellisman MH, Tukey RH, Hull A, Miranda ML, Avakian MD. 2006. Intgrating GIS and portal Technologies for assessing environmental health impacts of Hurricane Katrina. In: Proceedings of the Second International Conference on Environmental Science and Technology Vol II, August 19-22. American Science Press, Houston, TX. pp.385-390.

2005

• Bencheikh-Latmani R, Obraztsova AY, Mackey MR, Ellisman MH, Tebo BM. 2005. Toxicity of uncomplexed trivalent chromium to Shewanella oneidensis MR-4 during Cr(VI) reduction. Environ Sci Technol
• Bencheikh-Latmani R, Williams SM, Haucke L, Criddle CS, Wu L, Zhou J, Tebo BM. 2005. Global transcriptional profiling of Shewanella oneidensis MR-1 during Cr(VI) and U(VI) reduction. Appl Environ Microbiol 71(11):7453-7460. doi:10.1128/AEM.71.11.7453-7460.2005 PMID:16269787 PMCID:PMC1287662
• Bonzo JA, Chen S, Galijatovic A, Tukey RH. 2005. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol 67(4):1247-1256. PMID:15630080
• Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. 2005. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem 280(45):37547-37557. doi:10.1074/jbc.M506683200 PMID:16155002
• Chen S, Operana T, Bonzo JA, Nguyen N, Tukey RH. 2005. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem 280(6):4350-4359. doi:10.1074/jbc.M411554200 PMID:15572374
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2004

• Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong N, Taylor SS. 2004. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry 43(1):85-96. doi:10.1021/bi035042p PMID:14705934
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• Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor PW. 2004. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci 24(20):4889-4893. PMID:15152050
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• Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor PW. 2004. Structural characterization of recombinant soluble rat neuroligin 1: Mapping of secondary structure and glycosylation by mass spectrometry. Biochemistry 43(6):1496-1506. PMID:14769026
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• Kelner MJ, Bagnell RD, Morgenstern R. 2004. Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression. Biochim Biophys Acta 1678(2-3):163-169. doi:10.1016/j.bbaexp.2004.03.001 PMID:15157743
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• Sil AK, Maeda S, Sano Y, Roop DR, Karin M. 2004. Abstract IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428(6983):660-664. PMID:15071597
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• Tebo BM, Bargar JR, Clement BG, Dick GJ, Murray KJ, Parker D, Verity R, Webb SM. 2004. Biogenic manganese oxides: properties and mechanisms of formation. Annual Review of Earth and Planetary Sciences 32:287-328.
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• Wycisk K, Kim EJ, Schroeder JI, Kramer U. 2004. Enhancing the first enzymatic step in the histidine biosynthesis pathway increases the free histidine pool and nickel tolerance in Arabidopsis thaliana. FEBS Lett 578(1-2):128-134. PMID:15581629
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2003

• Allen JW, Bhatia SN. 2003. Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol Bioeng 82(3):253-262. doi:10.1002/bit.10569 PMID:12599251
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• Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. 2003. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem 278(21):19526-19533. PMID:12637498
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• Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. 2003. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng 81(5):578-587. PMID:12514807
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• He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. 2003. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A 100(3):1022-1027. doi:10.1073/pnas.0333594100 PMID:12540825 PMCID:PMC298719
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• Lahner B, Gong J, Mahmoudian M, Smith EL, Abid KB, Rogers EE, Guerinot ML, Harper JF, Ward JM, McIntyre L, Schroeder JI, Salt DE. 2003. Genomic scale profiling of nutrient and trace elements in Arabidopsis thaliana. Nat Biotechnol 21(10):1215-1221. PMID:12949535
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• Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ. 2003. Polymer replicas of photonic porous silicon for sensing and drug delivery applications. Science 299(5615):2045-2047. PMID:12663921
• Li Z, Omori SA, Labuda T, Karin M, Rickert RC. 2003. IKK beta is required for peripheral B cell survival and proliferation. J Immunol 170(9):4630-4637. PMID:12707341
• Maeda S, Chang L, Li Z, Luo J, Leffert HL, Karin M. 2003. IKK beta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNF alpha. Immunity 19(5):725-737. PMID:14614859
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• Martone ME, Zhang S, Gupta A, Qian X, He H, Price DL, Wong M, Santini S, Ellisman MH. 2003. The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy. Neuroinformatics 1(4):379-396. PMID:15043222
• Middleton SS, Bencheikh-Latmani R, Mackey MR, Ellisman MH, Tebo BM, Criddle CS. 2003. Cometabolism of Cr(VI) by Shewanella oneidensis MR-1 produces cell-associated reduced chromium and inhibits growth. Biotechnol Bioeng 83(6):627-637. PMID:12889027
• Ozkan M, Pisanic T, Scheel J, Barlow C, Esener S, Bhatia SN. 2003. Electro-optical platform for the manipulation of live cells. Langmuir 19(5):1532-1538.
• Rodriguez-Gabriel MA, Burns G, McDonald WH, Martin V, Yates JR, Bahler J, Russell P. 2003. RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J 22(23):6256-6266. PMID:14633985
• Schroeder JI. 2003. Knockout of the guard cell K+ out channel and stomatal movements. Proc Natl Acad Sci U S A 100(9):4976-4977. PMID:12704226
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• Thomine S, Lelievre F, Debarbieux E, Schroeder JI, Barbier-Brygoo H. 2003. AtNRAMP3, a multispecific vacuolar metal transporter involved in plant responses to iron deficiency. Plant J 34(5):685-695. PMID:12787249
• Vozzi G, Flaim C, Ahluwalia A, Bhatia SN. 2003. Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials 24(14):2533-2540. PMID:12695080
• Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK. 2003. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A 100(11):6712-6717. PMID:12740443
• Yueh MF, Huang Y, Hiller A, Chen S, Nguyen N, Tukey RH. 2003. Involvement of the xenobiotic response element (XRE) in ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem 278(17):15001-15006. PMID:12566446
• Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu Y, Kao WW, Karin M, Xia Y. 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J 22(17):4443-4454. doi:10.1093/emboj/cdg440 PMID:12941696 PMCID:PMC202382
• Zhang M, Sell S, Leffert HL. 2003. Hepatic progenitor cell lines from allyl alcohol-treated adult rats are derived from gamma-irradiated mouse STO cells. Stem Cells 21(4):449-458. PMID:12832698

2002

• Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. 2002. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biologiacal applications. J Am Chem Soc 124(21):6063-76. PMID:12022841
• Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee Y, Ricote M, Glass CK, Brewer HB, Gonzalez FJ. 2002. Conditional disruption of the PPARg gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 22(8):2607-2619. PMID:11909955
• Allen GJ, Murata Y, Chu SP, Nafisi M, Schroeder JI. 2002. Hypersensitivity of abscisic acid-induced cytosolic calcium increases in the Arabidopsis farnesyltransferase mutant era1-2. Plant Cell 14(7):1649-1662. PMID:12119381 PMCID:PMC150713
• Beachy R, Bennetzen JL, Chassy BM, Chrispeels M, Chory J, Ecker JR, Noel JP, Kay SA, Dean C, Lamb C, Jones J, Santerre CR, Schroeder JI, Umen J, Yanofsky M, Wessler S, Zhao Y, Parrott W. 2002. Divergent perspectives on GM food. Nat Biotechnol 20(12):1195-1196. PMID:12454665
• Corbo JC, Deuel TA, Long JM, LaPorte P, Tsai E, Wynshaw-Boris A, Walsh CA. 2002. Double cortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci 22(17):7548-7557. PMID:12196578
• Cunard R, DiCampli D, Archer DC, Stevenson JL, Ricote M, Glass CK, Kelly CJ. 2002. WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo. J Immunol 169(12):6806-6812. PMID:12471112
• Cunard R, Ricote M, DiCampli D, Archer DC, Kahn DA, Glass CK, Kelly CJ. 2002. Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J Immunol 168(6):2795-2802. PMID:11884448
• Cunin F, Schmedake T, Link JR, Li YY, Koh J, Bhatia SN, Sailor MJ. 2002. Biomolecular screening with encoded porous-silicon photonic crystals. Nat Mater 1(1):39-41. doi:10.1038/nmat702 PMID:12618846
• Francis CM, Tebo BM. 2002. Enzymatic manganese(II) oxidation by metabolically dormant spores of diverse Bacillus species. Appl Environ Microbiol 68(2):874-880. PMID:11823231 PMCID:PMC126666
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• Huang Y, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH. 2002. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenet Genomics 12(4):287-297. PMID:12042666
• Kuchitsu K, Ward JM, Allen GJ, Schelle I, Schroeder JI. 2002. Loading acetoxymethyl ester fluorescent dyes into the cytoplasam of Arabidopsis and Commelina guard cells. New Phytologist 153:527-533.
• Lee DA, Schroeder JI. 2002. Heavy metal stress. In: Arabidopsis - A Laboratory Manual. Cold Spring Harbor Laboratory Press, pp.75-77.
• Liu VA, Bhatia SN. 2002. Three-dimensional photopatterning of hydrogels containing living cells. Biomed Microdevices 4(4):257-66.
• Liu VA, Jastromb WE, Bhatia SN. 2002. Engineering protein and cell adhesivity using PEO-terminated triblock polymers. J Biomed Mater Res 60(1):126-134. doi:10.1002/jbm.10005 PMID:11835168
• Maser P, Eckelman B, Vaidyanathan R, Horie T, Fairbairn DJ, Kubo M, Yamagami M, Yamaguchi K, Nishimura M, Uozumi N, Robertson W, Sussman MR, Schroeder JI. 2002. Altered shoot/root Na+ distribution and bifurcating salt sensitivity in Arabidopsis by genetic disruption of the Na+ transporter AtHKT1. FEBS Lett 531(2):157-161. PMID:12417304
• Maser P, Hosoo Y, Goshima S, Horie T, Eckelman B, Yamada K, Yoshida K, Bakker EP, Shinmyo A, Oiki S, Schroeder JI, Uozumi N. 2002. Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants. Proc Natl Acad Sci U S A 99(9):6428-6433. PMID:11959905
• Obraztsova AY, Francis CM, Tebo BM. 2002. Sulfur disproportionation by the facultative anaerobe Pantoea agglomerans SP1 as a mechanism for chromium(VI) reduction. Geomicrobiol J 19(1):121-132.
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2001

• Allen JW, Hassanein T, Bhatia SN. 2001. Advances in bioartificial liver devices. Hepatology 34(3):447-455. PMID:11526528
• Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson RS, Schmidt EV, Karin M. 2001. IKK± provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107:763-775. PMID:11747812
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• Fabregat I, Koch KS, Aoki T, Atkinson AE, Dang H, Amosova O, Fresco JR, Schildkraut CL, Leffert HL. 2001. Functional pleiotropy of an intramolecular triplex-forming fragment from the 3'UTR of the rat Pigr gene. Physiol Genomics 5(2):53-65. PMID:11242589
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• Murata Y, Pei Z, Mori IC, Schroeder JI. 2001. ABA activation of plasma membrane Ca2+ channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in the abi1-1 and abi2-1 PP2C mutants. Plant Cell 13:2513-2523.
• Rosenfeld MG, Glass CK. 2001. Coregulator codes of transcriptional regulation by nuclear receptors. J Biol Chem 276:36865-36868. PMID:11459854
• Schroeder JI, Kwak JM, Allen GJ. 2001. Guard cell abscisic acid signalling and engineering drought hardiness in plants. Nature 410:327-330. PMID:11268200
• Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun S, Karin M. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495-1499. doi:10.1126/science.1062677 PMID:11520989
• Straus DS, Glass CK. 2001. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21(3):185-210. PMID:11301410
• Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. 2001. Inhibition of JNK activation by NF-kB target genes. Nature 414(6861):313-317. PMID:11713531
• Wang Y, Tan J, Sutton-Smith M, Ditto D, Panico M, Campbell RM, Varki NM, Long JM, Jaeken J, Levinson SR, Wynshaw-Boris A, Morris HR, Le D, Dell A, Schachter H, Marth JD. 2001. Modeling human congenital disorder of glycosylation type Iia in the mouse: conservation of asparagines-linked slycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology 11(12):1051-1070. PMID:11805078
• Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH. 2001. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis 22(6):943-950. PMID:11375903

2000

• Behnia K, Bhatia SN, Jastromb N, Balis U, Sullivan S, Yarmush M, Toner M. 2000. Xenobiotic metabolism by cultured primary porcine hepatocytes. Tissue Engineering Part A 6(5):467-479. PMID:11074934
• Gross LA, Baird GS, Hoffman RC, Baldridge KK, Tsien RY. 2000. The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A 97(22):11990-11995. PMID:11050230
• Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. 2000. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 275(46):36062-36066. doi:10.1074/jbc.M007204200 PMID:10967126
• Kelner MJ, Bagnell RD, Montoya MA, Estes LA, Forsberg L, Morgenstern R. 2000. Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p131-132 Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. J Biol Chem 275(17):13000-13006. PMID:10777602
• Pei Z, Murata Y, Benning G, Thomine S, Klusener B, Allen GJ, Grill E, Schroeder JI. 2000. Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells. Nature 406:731-734. PMID:10963598
• Ricote M, Welch JS, Glass CK. 2000. Regulation of macrophage gene expression bythe peroxisome proliferator-actived receptor-gamma. Horm Res 54:275-280. PMID:11595817
• Thomine S, Wang R, Ward JM, Crawford NM, Schroeder JI. 2000. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A 97(9):4991-4996. PMID:10781110

1999

• Balis U, Behnia K, Dwarakanath B, Bhatia SN, Sullivan S, Yarmush M, Toner M. 1999. Oxygen consumption characteristics of porcine hepatocytes. Metab Eng 1(1):49-62. PMID:10935754
• Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Effect of cell-cell interactions in preservation of cellular phenotype: co-cultivation of hepatocytes and non-parenchymal cells. FASEB J 13(14):1883-1900. PMID:10544172
• Bhatia SN, Chen CS. 1999. Tissue engineering at the micro-scale. Biomed Microdevices 2(2):131-144.
• Clemens S, Kim EJ, Neumann D, Schroeder JI. 1999. Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast. EMBO J 18(12):3325-3333. PMID:10369673
• Ledezma GA, Folch A, Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes. J Biomech Eng 121(1):58-64. PMID:10080090

1998

• Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions. Biotechnol Prog 14(3):378-387. PMID:9622518
• Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. Journal of Biomaterials Science, Polymer Edition 9(11):1137-1160. PMID:9860177

1997

• Bhatia SN, Yarmush M, Toner M. 1997. Controling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts. J Biomed Mater Res 34(2):189-199. PMID:9029299

1996

• Bhatia SN, Toner M, Foy BD, Rotem A, Tompkins R, Yarmush M. 1996. Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes. Journal of Cellular Engineering 1:125-135.

1989

• Hee Lee J, Cho U, Karin M. 1989. Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata. Sci Signal 37(2):303-308. PMID:2727309