Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Program Publications: University of California-San Diego: Detection and Models of Toxicant Exposure

Superfund Research Program

Detection and Models of Toxicant Exposure

Center Director: Robert H. Tukey
Grant Number: P42ES010337
Funding Period: 2000-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's Twitter page Visit the grantee's Instagram page Visit the grantee's Facebook page Visit the grantee's Video page



  • Bohaczuk SC, Thackray VG, Shen J, Skowronska-Krawczyk D, Mellon PL. 2021. FSHB transcription is regulated by a novel 5' distal enhancer with a fertility-associated single nucleotide polymorphism. Endocrinology 162:doi:10.1210/endocr/bqaa181 PMID:33009549 PMCID:PMC7846141
  • Weber AA, Mennillo E, Yang X, van der Schoor LW, Jonker JW, Chen S, Tukey RH. 2021. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos 49:12-19. doi:10.1124/dmd.120.000240 PMID:33154041 PMCID:PMC7745083
  • Yu Q, Zhang Z, Wang M, Scavo A, Schroeder JI, Qiu B. 2021. Identification and characterization of SaeIF1 from the eukaryotic translation factor SUI1 family in cadmium hyperaccumulator Sedum alfredii. Planta 253:12. doi:10.1007/s00425-020-03539-3 PMID:33389204


  • Ajmera V, Liu A, Singh S, Yachoa G, Ramey M, Bhargava M, Zamani A, Lopez S, Mangla N, Bettencourt R, Rizo E, Valasek MA, Behling C, Richards L, Sirlin C, Loomba R. 2020. Clinical utility of an increase in magnetic resonance elastography in predicting fibrosis progression in nonalcoholic fatty liver disease. Hepatology 71(3):849-860. doi:10.1002/hep.30974 PMID:31556124 PMCID:PMC7828573
  • Cifarelli V, Beeman SC, Smith GI, Yoshino J, Morozov D, Beals JW, Kayser BD, Watrous JD, Jain M, Patterson BW, Klein S. 2020. Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity. J Clin Invest 130(12):6688-6699. doi:10.1172/JCI141828 PMID:33164985 PMCID:PMC7685757
  • Cooper AM, Felix D, Alcantara F, Zaslavsky I, Work A, Watson P, Pezzoli K, Yu Q, Zhu D, Scavo A, Zarabi Y, Schroeder JI. 2020. Monitoring and mitigation of toxic heavy metals and arsenic accumulation in food crops: a case study of an urban community garden. Plant Direct 4(1):e00198. doi:10.1002/pld3.198 PMID:31956855 PMCID:PMC6957986
  • Core N, Erni A, Hoffmann HM, Mellon PL, Saurin AJ, Beclin C, Cremer H. 2020. Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6. Elife 9:doi:10.7554/eLife.58215 PMID:32762844 PMCID:PMC7440913
  • Dhar D, Baglieri J, Kisseleva T, Brenner DA. 2020. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood) 13:doi:10.1177/1535370219898141 PMID:31924111 PMCID:PMC7016420
  • Gou L, Lim D, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu M, Fu X. 2020. Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1 catalyzed protamine phosphorylation. Cell 180:doi:10.1016/j.cell.2020.02.020 PMID:32169215
  • Han A, O'Brien WD, Erdman JW, Byra M, Heba E, Andre MP, Loomba R, Sirlin C. 2020. Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat with radiofrequency ultrasound data using one-dimensional convolutional neural networks. Radiology 295:342-350. doi:10.1148/radiol.2020191160 PMID:32096706 PMCID:PMC7193902
  • Han A, Zhang YN, Boehringer AS, Montes V, Andre MP, Erdman JW, Loomba R, Valasek MA, Sirlin C, O'Brien WD. 2020. Assessment of hepatic steatosis in nonalcoholic fatty liver disease by using quantitative US. Radiology 295:106-113. doi:10.1148/radiol.2020191152 PMID:32013792 PMCID:PMC7104700
  • Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. 2020. Differential role of LXRa and LXRy in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos 48:255-263. doi:10.1124/dmd.119.090068 PMID:31980500 PMCID:PMC7065491
  • He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Molina AD, Diaz-Meco MT, Moscat J, Sun B, Karin M. 2020. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol 72:1182-1195. doi:10.1016/j.jhep.2020.01.023 PMID:32105670
  • Hsu P, Dubeaux G, Takahashi Y, Schroeder JI. 2020. Signaling mechanisms in abscisic acid-mediated stomatal closure. The Plant Journal 15:doi:10.1111/tpj.15067 PMID:33145840
  • L.I. T, Lin H, Ahmed A, Shahriar H, Hasan R, Sarwar G, Eunus H, Ahsan H, Pierce BL. 2020. Research Participants Attitudes towards Receiving Information on Genetic Susceptibility to Arsenic Toxicity in Rural Bangladesh. Public Health Genomics 23:69-76. doi:10.1159/000505632 PMID:32069464 PMCID:PMC7605079
  • Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee J, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. 2020. Genomic and epigenomic landscaping defines new therapeutic targets for adenosquamous carcinoma of the pancreas. Cancer Res 80:4324-4334. doi:10.1158/0008-5472.Can-20-0078 PMID:32928922
  • Long MT, Gandhi S, Loomba R. 2020. Advances in non-invasive biomarkers for the diagnosis and monitoring of non-alcoholic fatty liver disease. Metabolism 111s:154259. doi:10.1016/j.metabol.2020.154259 PMID:32387227 PMCID:PMC7529729
  • Loomba R, Lim JK, Patton H, El-Serag HB. 2020. AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: Expert Review. Gastroenterology 158:1822-1830. doi:10.1053/j.gastro.2019.12.053 PMID:32006545
  • Lowey B, Whiteley AT, Keszei AF, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee AS, Kranzusch PJ. 2020. CBASS immunity uses CARF-related effectors to sense 3'-5'- and 2'-5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection. Cell 182:38. doi:10.1016/j.cell.2020.05.019 PMID:32544385
  • Ma H, Yamamoto G, Xu J, Liu X, Karin D, Kim J, Alexandrov LB, Koyama Y, Nishio T, Benner CW, Heinz S, Rosenthal S, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop I, Quehenberger O, Dennis EA, Saltiel AR, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. 2020. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol 72:946-959. doi:10.1016/j.jhep.2019.12.016 PMID:31899206 PMCID:PMC7167339
  • Mennillo E, Yang X, Paszek M, Auwerx J, Benner CW, Chen S. 2020. NCoR1 protects mice from dextran sodium sulfate-induced colitis by guarding colonic crypt cells from luminal insult. Cell Mol Gastroenterol Hepatol 10:133-147. doi:10.1016/j.jcmgh.2020.01.014 PMID:32044398 PMCID:PMC7229481 (ahead of print)
  • Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SB, Trejo J, Kauffman AS, Mellon PL, Lawson MA. 2020. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep 10:13063. doi:10.1038/s41598-020-69913-z PMID:32747664 PMCID:PMC7400764
  • Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. 2020. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis 9(100):doi:10.1038/s41389-020-00285-9 PMID:33168807 PMCID:PMC7653036
  • Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba E, Bettencourt R, Richards L, Raffatellu M, Dorrestein PC, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin C, Knight R, Downes M, Evans RM, Loomba R. 2020. A universal gut-microbiome-derived signature predicts cirrhosis. Cell Metab doi:10.1016/j.cmet.2020.06.005 PMID:32610095 (ahead of print)
  • Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba E, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin C, Downes M, Evans RM, Loomba R. 2020. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab 32:878-+. PMID:33147487
  • Paszek M, Tukey RH. 2020. NRF2-Independent regulation of intestinal constitutive androstane receptor by the pro-oxidants cadmium and isothiocyanate in hUGT1 mice. Drug Metab Dispos 48:25-30. doi:10.1124/dmd.119.089508 PMID:31704714 PMCID:PMC6904881
  • Quinn RA, Melnik A, Vrbanac AF, Fu T, Patras K, Christy M, Bodai Z, Belda-Ferre P, Tripathi A, Chung L, Downes M, Welch R, Quinn M, Humphrey G, Panitchpakdi M, Weldon K, Aksenov AA, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa E, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz J, Meehan M, Gentry E, Arthur T, Komor A, Poulsen O, Boland BS, Chang JT, Sandborn W, Lim M, Garg N, Lumeng J, Xavier R, Kazmierczak B, Jain R, Egan M, Rhee K, Ferguson D, Raffatellu M, Vlamakis H, Haddad G, Siegel D, Huttenhower C, Mazmanian S, Evans RM, Nizet V, Knight R, Dorrestein PC. 2020. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 579:123-129. doi:10.1038/s41586-020-2047-9 PMID:32103176
  • Schulze S, Dubeaux G, Ceciliato PH, Munemasa S, Nuhkat M, Yarmolinsky D, Aguilar J, Diaz R, Azoulay-Shemer T, Steinhorst L, Offenborn JN, Kudla J, KOLLIST H, Schroeder JI. 2020. A role for calcium-dependent protein kinases in differential CO2- and ABA-controlled stomatal closing and low CO2-induced stomatal opening in Arabidopsis. New Phytologist 15:doi:10.1111/nph.17079 PMID:33187027
  • Sriram K, Loomba R, Insel PA. 2020. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenge. Proc Natl Acad Sci U S A 117:29274-29282. doi:10.1073/pnas.2009875117 PMID:33203679 PMCID:PMC7703541
  • Stender S, Loomba R. 2020. PNPLA3 genotype and risk of liver and all-cause mortality. Hepatology 71:777-779. doi:10.1002/hep.31113 PMID:31954067
  • Sun X, Seidman J, Zhao P, Troutman T, Spann N, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida J, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. 2020. Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis. Cell Metab 31(1):189-206. doi:10.1016/j.cmet.2019.10.014 PMID:31761566 PMCID:PMC7028360
  • Takahashi Y, Zhang J, Hsu P, Ceciliato PH, Dubeaux G, Munemasa S, Ge C, Zhao Y, Hauser F, Schroeder JI. 2020. MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. Nat Commun 11(1):12. doi:10.1038/s41467-019-13875-y PMID:31896774 PMCID:PMC6940395
  • Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac AF, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. 2020. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab 2:1034-1045. doi:10.1038/s42255-020-0261-2 PMID:32839596
  • Verna EC, Serper M, Chu J, Corey K, Fix OK, Hoyt K, Page KA, Loomba R, Li M, Everson GT, Fried MW, Garcia-Tsao G, Terrault N, Lok AS, Chung RT, Reddy KR. 2020. Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation. Hepatology 72:1819-1837. doi:10.1002/hep.31491 PMID:32740969 PMCID:PMC7435542
  • Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. 2020. Immune-evasive human islet-like organoids ameliorate diabetes. Nature 586:606-611. doi:10.1038/s41586-020-2631-z PMID:32814902 PMCID:PMC7872080
  • Yoshino M, Kayser BD, Yoshino J, Stein RI, Reeds D, Eagon JC, Eckhouse SR, Watrous JD, Jain M, Knight R, Schechtman K, Patterson BW, Klein S. 2020. Effects of diet versus gastric bypass on metabolic function in diabetes. N Engl J Med 383:721-732. doi:10.1056/NEJMoa2003697 PMID:32813948
  • Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785


  • Baglieri J, Brenner DA, Kisseleva T. 2019. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Int J Mol Sci 20(7):1723. doi:10.3390/ijms20071723 PMID:30959975 PMCID:PMC6479943
  • Bailey-Serres J, Parker JE, Ainsworth EA, Oldroyd GE, Schroeder JI. 2019. Genetic strategies for improving crop yields. Nature 575:109-118. doi:10.1038/s41586-019-1679-0 PMID:31695205 PMCID:PMC7024682
  • Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To K, Kung H, Fiehn O, Zhao R, Evans RM, Chen H. 2019. RORgamma is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun 10(1):4621. doi:10.1038/s41467-019-12529-3 PMID:31604910 PMCID:PMC6789042
  • Castera L, Friedrich-Rust M, Loomba R. 2019. Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 156(5):1264-1281. doi:10.1053/j.gastro.2018.12.036
  • Caussy C, Bhargava M, Villesen I, Gudmann N, Leeming D, Karsdal M, Faulkner C, Bao D, Liu A, Lo M, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen C, Sirlin C, Loomba R. 2019. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology 70(1):127-141. doi:10.1002/hep.30610 PMID:30859582 PMCID:PMC6984974
  • Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu Z, Downes M, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. 2019. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun 10:1406. doi:10.1038/s41467-019-09455-9 PMID:30926798 PMCID:PMC6440960
  • Ceciliato PH, Zhang J, Liu Q, Shen X, Hu H, Liu C, Shaffner AR, Schroeder JI. 2019. Intact leaf gas exchange provides a robust method for measuring the kinetics of stomatal conductance responses to abscisic acid and other small molecules in Arabidopsis and grasses. Plant Methods 15:10. doi:10.1186/s13007-019-0423-y PMID:31019545 PMCID:PMC6472101
  • Chang C, Loo C, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y. 2019. The nuclear receptor REV-ERB alpha modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A 116:18528-18536. doi:10.1073/pnas.1907563116 PMID:31455731 PMCID:PMC6744854
  • Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. 2019. Preclinical models for studying NASH-driven HCC: How useful are they?. Cell Metab 29:18-26. doi:10.1016/j.cmet.2018.10.012 PMID:30449681 PMCID:PMC6326872
  • Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. 2019. FXR regulates intestinal cancer stem cell proliferation. Cell 176:1098-1112. doi:10.1016/j.cell.2019.01.036 PMID:30794774 PMCID:PMC6701863
  • Hauser F, Ceciliato PH, Lin Y, Guo D, Gregerson J, Abbasi N, Youhanna D, Park J, Dubeaux G, Shani E, Poomchongkho N, Schroeder JI. 2019. A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses. J Exp Bot 70:641-65. doi:10.1093/jxb/ery363 PMID:30346611 PMCID:PMC6322574
  • Hoffman HM, Larder R, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, Mellon PL. 2019. Differential CRE expression in Lhrh-cre and GnRH-cre alleles and the impact on fertility in Otx2-Flox mice. Neuroendocrinology 108:328-342. doi:10.1159/000497791 PMID:30739114 PMCID:PMC6753941
  • Hoffmann HM, Pandolfi EC, Larder R, Mellon PL. 2019. Haploinsufficiency of homeodomain proteins Six3, Vax1, and Otx2 causes subfertility in mice via distinct mechanisms. Neuroendocrinology 109:200-207. doi:10.1159/000494086 PMID:30261489 PMCID:PMC6437011
  • Liang S, Ma H, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. 2019. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology 156(4):1156-1172. doi:10.1053/j.gastro.2018.11.019 PMID:30445007 PMCID:PMC6409207
  • Loomba R, Adams L. 2019. The 20 Rule of NASH Progression: The Natural History of Advanced Fibrosis and Cirrhosis Caused by NASH. Hepatology 70(6):1885-1888. doi:10.1002/hep.30946
  • Mangla N, Ajmera V, Caussy C, Sirlin C, Brouha SS, Bajwa-Dulai S, Madamba E, Bettencourt R, Richards L, Loomba R. 2019. Liver Stiffness Severity is Associated With Increased Cardiovascular Risk in Patients With Type 2 Diabetes. Clin Gastroenterol Hepatol 18(3):744-746. doi:10.1016/j.cgh.2019.05.003 PMID:31100460 PMCID:PMC6984972
  • Mennillo E, Adeogun A, Arukwe A. 2019. Quality screening of the Lagos lagoon sediment by assessing the cytotoxicity and toxicological responses of rat hepatoma H4IIE and fish PLHC-1 cell-lines using different extraction approaches. Environ Res 182:108986. doi:10.1016/j.envres.2019.108986
  • Mennillo E, Cappelli F, Arukwe A. 2019. Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to organophosphate esters (OPEs). Toxicol Appl Pharmacol 371:84-94. doi:10.1016/j.taap.2019.04.004
  • Mills P, Caussy C, Loomba R. 2019. Glyphosate Excretion is Associated with Steatohepatitis and Advanced Liver Fibrosis in Patients with Fatty Liver Disease. Clin Gastroenterol Hepatol 18(3):741-743. doi:10.1016/j.cgh.2019.03.045 PMID:30954713 PMCID:PMC6776714
  • Mouzaki M, Loomba R. 2019. Insights into the evolving role of the gut microbiome in nonalcoholic fatty liver disease: rationale and prospects for therapeutic intervention. Therap Adv Gastroenterol 12:1756284819858470. doi:10.1177/1756284819858470 PMID:31258623 PMCID:PMC6591661
  • Nishio T, Hu RJ, Koyama Y, Liang S, Rosenthal S, Yamamoto G, Karin D, Baglieri J, Ma H, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T. 2019. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic fibrosis in MDR2 knock out mice. J Hepatol 71(3):573-585. doi:10.1016/j.jhep.2019.04.012
  • Pai R, Kleiner D, Hart J, Adeyi O, Clouston A, Behling C, Jain D, Kakar S, Brahmania M, Burgart L, Batts K, Valasek MA, Torbenson M, Guindi M, Wang H, Ajmera V, Adams L, Parker CE, Feagan B, Loomba R, Jairath V. 2019. Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials. Aliment Pharmacol Ther 50(10):1100-1111. doi:10.1111/apt.15503 PMID:31583739 PMCID:PMC6817398
  • Pandolfi EC, Breuer JA, Huu VN, Talluri T, Nguyen D, Lee JS, Hu R, Bharti K, Skowronska-Krawczyk D, Gorman MR, Mellon PL, Hoffmann HM. 2019. The homeodomain transcription factors vax1 and six6 are required for scn development and function. Mol Neurobiol 1-16. doi:10.1007/s12035-019-01781-9 PMID:31705443
  • Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. 2019. Deletion of the homeodomain protein Six6 from GnRH neurons decreases GnRH gene expression, resulting in infertility. Endocrinology 160:2151-2164. doi:10.1210/en.2019-00113 PMID:31211355 PMCID:PMC6821215
  • Park J, Kim T, Takahashi Y, Schwab R, Dressano K, Stephan AB, Ceciliato PH, Ramirez E, Garin V, Huffaker A, Schroeder JI. 2019. Chemical genetic identification of a lectin receptor kinase that transduces immune responses and interferes with abscisic acid signaling. The Plant Journal doi:10.1111/tpj.14232 PMID:30659683
  • Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. 2019. Choline Uptake and metabolism modulate macrophage IL-1 beta and IL-18 production. Cell Metab 29:1350. doi:10.1016/j.cmet.2019.03.011 PMID:30982734 PMCID:PMC6675591
  • Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui L, Lee J, Mellon PL. 2019. The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc 3(4):716-733. doi:10.1210/js.2018-00228 PMID:30906911 PMCID:PMC6425515
  • Wang L, Mazagova M, Pan C, Yang S, Brandl KL, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. 2019. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A 116:15184-15193. doi:10.1073/pnas.1904360116 PMID:31289229 PMCID:PMC6660779


  • Ahmadian M, Liu S, O'Reilly S, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. 2018. ERR gamma preserves brown fat innate thermogenic activity. Cell Rep 22(11):2849-2859. doi:10.1016/j.celrep.2018.02.061 PMID:29539415 PMCID:PMC5884669
  • Ajmera V, Park CC, Caussy C, Singh S, Hernandez C, Bettencourt R, Hooker J, Sy E, Behling C, Xu R, Middleton MS, Valasek MA, Faulkner C, Rizo E, Richards L, Sirlin CB, Loomba R. 2018. Magnetic Resonance Imaging Proton Density Fat Fraction Associates with Progression of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease. Gastroenterology 155(2):307-310. doi:10.1053/j.gastro.2018.04.014 PMID:29660324 PMCID:PMC6090543
  • Brenner DA. 2018. Of Mice and Men and Nonalcoholic Steatohepatitis. Hepatology 68(6):2059-2061. doi:10.1002/hep.30186 PMID:30033687 PMCID:PMC6398944
  • Brouha SS, Nguyen P, Bettencourt R, Sirlin CB, Loomba R. 2018. Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: a prospective study. Eur Radiol 28:1345-1355. doi:10.1007/s00330-017-5075-6 PMID:29058029 PMCID:PMC6310479
  • Caussy C, Hsu CL, Lo M, Liu A, Bettencourt R, Ajmera V, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen C, Loomba R. 2018. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology 68(3):918-932. doi:10.1002/hep.29892 PMID:29572891 PMCID:PMC6151296
  • Chen S, Tukey RH. 2018. Humanized UGT1 mice, regulation of UGT1A1, and the role of the intestinal tract in neonatal hyperbilirubinemia and breast milk-induced jaundice. Drug Metab Dispos 46(11):1745-1755. doi:10.1124/dmd.118.083212 PMID:30093417 PMCID:PMC6199628
  • Dangl J, Osbourn A, Orzaez D, Li Z, Long SP, Schroeder JI. 2018. What Is the Next Frontier in Plant Engineering?. Cell 174(3):499-500. doi:10.1016/j.cell.2018.07.012 PMID:30053421
  • Desai AP, Mohan P, Roubal AM, Bettencourt R, Loomba R. 2018. Geographic Variability in liver disease-related mortality rates in the United States. Am J Med 131:728-734. doi:10.1016/j.amjmed.2018.01.047 PMID:29496501 PMCID:PMC6090542
  • Dhar D, Antonucci L, Nakagawa H, Kim J, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. 2018. Liver cancer initiation requires p53 inhibition by CD44-enhanced growth factor signaling. Cancer Cell 33:1061. doi:10.1016/j.ccell.2018.05.003 PMID:29894692 PMCID:PMC6005359
  • Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. 2018. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888. doi:10.1073/pnas.1811029115 PMID:30287485 PMCID:PMC6196518
  • Fan W, He N, Lin CS, Wei Z, Hah N, Waizenegger W, He M, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM. 2018. ERRgamma promotes angiogenesis, mitochondrial biogenesis, and oxidative remodeling in PGC1alpha/beta-deficient muscle. Cell Rep 22:2521-2529. doi:10.1016/j.celrep.2018.02.047 PMID:29514081 PMCID:PMC5860878
  • Ganguly A, Guo L, Sun L, Suo F, Du LL, Russell P. 2018. Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. PLoS Genet 14:28. doi:10.1371/journal.pgen.1007595 PMID:30148840 PMCID:PMC6128646
  • Gonzalez FJ, Coughtrie MW, Tukey RH. 2018. Drug Metabolism. Chapter 6 in: The Pharmacological Basis of Therapeutics. McGraw Hill Education,
  • Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Starkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. 2018. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology doi:10.1002/hep.29676 PMID:29159825 PMCID:PMC5962369
  • Hoffman HM, Gong P, Tamrazian A, Mellon PL. 2018. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154. doi:10.1016/j.mce.2017.09.004 PMID:28890143 PMCID:PMC5756504
  • Hsu P, Takahashi Y, Munemasa S, Merilo E, Laanemets K, Waadt R, Patar D, KOLLIST H, Schroeder JI. 2018. Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A 115:E9971-E9980. doi:10.1073/pnas.1809204115 PMID:30282744 PMCID:PMC6196521
  • Karin M. 2018. New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance. Precis Clin Med 1(1):21-28. doi:10.1093/pcmedi/pby005 PMID:30687560 PMCID:PMC6333043
  • Kim J, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. 2018. ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P. Cell 175(1):133-145. doi:10.1016/j.cell.2018.08.020 PMID:30220454 PMCID:PMC6159928
  • Li Z, Takahashi Y, Scavo A, Brandt B, Nguyen D, Rieu P, Schroeder JI. 2018. Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases. Proc Natl Acad Sci U S A 115(19):E4522-E4531. doi:10.1073/pnas.1719659115 PMID:29686103 PMCID:PMC5948973
  • McNulty R, Cardone G, Gilcrease EB, Baker TS, Casjens SR, Johnson JE. 2018. Cryo-EM elucidation of the structure of bacteriophage P22 virions after genome release. Biophys J 114:1295-1301. doi:10.1016/j.bpj.2018.01.026 PMID:29590587 PMCID:PMC5883611
  • Pandolfi EC, Hoffmann HM, Schoeller EL, Gorman MR, Mellon PL. 2018. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol 55(11):8709-8727. doi:10.1007/s12035-018-1013-0 PMID:29589282 PMCID:PMC6156938
  • Que X, Hung M, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Maatta A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Yla-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. 2018. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301. doi:10.1038/s41586-018-0198-8 PMID:29875409 PMCID:PMC6033669
  • Ryan GE, Malik S, Mellon PL. 2018. Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology 159(4):1734-1747. doi:10.1210/en.2017-03218 PMID:29471436 PMCID:PMC6097580
  • Song IJ, Yang YM, Inokuchi-Shimizu S, Roh YS, Yang L, Seki E. 2018. The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer 142(1):81-91. doi:10.1002/ijc.31029 PMID:28875549 PMCID:PMC579019
  • Song N, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Xu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. 2018. IKK alpha inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A 115:E812-E821. doi:10.1073/pnas.1717520115 PMID:29311298 PMCID:PMC5789942
  • Tapper EB, Loomba R. 2018. Nonalcoholic fatty liver disease, metabolic syndrome, and the fight that will define clinical practice for a generation of hepatologists. Hepatology 67:1657-1659. doi:10.1002/hep.29722 PMID:29222913 PMCID:PMC5906195
  • Tapper EB, Loomba R. 2018. Noninvasive imaging biomarker assessment of liver fibrosis by elastography in NAFLD. Nat Rev Gastroenterol Hepatol 15:274-282. doi:10.1038/nrgastro.2018.10 PMID:29463906
  • Toldsepp K, Zhang J, Takahashi Y, Sindarovska y, Horack H, Ceciliato PH, Koolmeister K, Wang Y, Vaahtera L, Jakobson L, Park J, BROSCHE M, KOLLIST H, Schroeder JI. 2018. Mitogen-activated protein kinases MPK4 and MPK12 are key components mediating CO2-induced stomatal movements. The Plant Journal 96:1018-1035. doi:10.1111/tpj.14087 PMID:30203878 PMCID:PMC6261798
  • Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. 2018. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411. doi:10.1038/s41575-018-0011-z PMID:29748586 PMCID:PMC6319369
  • Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AF, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM. 2018. Vitamin D Switches BAF Complexes to Protect Beta Cells. Cell 173:1135-1149. doi:10.1016/j.cell.2018.04.013 PMID:29754817 PMCID:PMC5987229
  • Zhang Y, Nasser V, Pisanty O, Omary M, Wulff N, Donato MD, Tal I, Hauser F, Hao P, Roth O, Fromm H, Schroeder JI, Geisler M, Nour-Eldin HH, Shani E. 2018. A transportome-scale amiRNA-based screen identifies redundant roles of Arabidopsis ABCB6 and ABCB20 in auxin transport. Nat Commun 9:4204. doi:10.1038/s41467-018-06410-y PMID:30310073 PMCID:PMC6182007
  • Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin X, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. 2018. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560:198-203. doi:10.1038/s41586-018-0372-z PMID:30046112 PMCID:PMC6329306


  • Azoulay-Shemer T, Hsu P, Schroeder JI. 2017. Seeing is believing. Nat Plants 3(10):765-766. doi:10.1038/s41477-017-0025-5 PMID:28970562 PMCID:28970562
  • Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin D, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong L, Cho H, Xie J, Li Q, Muschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. 2017. Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A 114(47):12548-12553. doi:10.1073/pnas.1619119114 PMID:29109286 PMCID:PMC5703267
  • Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen C, Al Ikhwan M, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R. 2017. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest 127(7):2697–2704. doi:10.1172/JCI93465 PMID:28628033 PMCID:PMC5490764
  • Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
  • Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi H, Kang SG, Lee SE, Kim SJ, Kweon GR, Kim H, Lee C, Lee S, Wall CE, Downes M, Evans RM, Choi MJ, Jung S, Ryu MJ, Hwang JH, Auwerx J, Shong M. 2017. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol 216(1):149-165. doi:10.1083/jcb.201607110 PMID:27986797 PMCID:PMC5223607
  • De Magalhaes Filho CD, Downes M, Evans RM. 2017. Farnesoid X receptor an emerging target to combat obesity. Dig Dis 35(3):185-190. doi:10.1159/000450909 PMID:28249279
  • Dickey AS, Sanchez DN, Arreola M, Sampat KR, Fan W, Arbez N, Akimov S, Van Kanegan MJ, Ohnishi K, Gilmore-Hall SK, Flores AL, Nguyen JM, Lomas N, Hsu CL, Lo DC, Ross CA, Masliah E, Evans RM, La Spada AR. 2017. PPAR delta activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci Transl Med 9(419):eaal2332. doi:10.1126/scitranslmed.aal2332 PMID:29212711 PMCID:PMC5748332
  • Doktorova M, Zwarts I, van Zutphen T, van Dijk TH, Bloks VW, Harkema L, de Bruin A, Downes M, Evans RM, Verkade HJ, Jonker JW. 2017. Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep 7:846. doi:10.1038/s41598-017-00889-z PMID:28404991
  • Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. 2017. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight 2(24):92821. doi:10.1172/jci.insight.92821 PMID:29263300 PMCID:PMC5752303
  • Dulai PS, Singh S, Patel J, Soni M, Prokop LJ, Younossi Z, Sebastiani G, Ekstedt M, Hagstrom H, Nasr P, Stal P, Wong VW, Kechagias S, Hultcrantz R, Loomba R. 2017. Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta-analysis. Hepatology 65:1557-1565. doi:10.1002/hep.29085 PMID:28130788 PMCID:PMC5397356
  • Fan W, Evans RM. 2017. Exercise mimetics: impact on health and performance. Cell Metab 25(2):242-247. doi:10.1016/j.cmet.2016.10.022 PMID:27889389
  • Fan W, Waizenegger W, Lin CS, Sorrentino V, He M, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM. 2017. PPARdelta promotes running endurance by preserving glucose. Cell Metab 25:1186-1193.e4. doi:10.1016/j.cmet.2017.04.006 PMID:28467934 PMCID:PMC549297
  • Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. 2017. Severe neonatal hyperbilirubinemia in Crigler-Najjar Syndrome model mice can be reversed with zinc protoporphyrin. Hepatol Commun 1(8):792-802. doi:10.1002/hep4.1082 PMID:29399656 PMCID:PMC567892
  • Fujiwara R, Yoda E, Tukey RH. 2017. Species differences in drug glucuronidation: humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33(1):9-16. doi:10.1016/j.dmpk.2017.10.002 PMID:29079228 PMCID:PMC5809266
  • Gasser E, Moutos CP, Downes M, Evans RM. 2017. FGF1-a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol 13(10):599-609. doi:10.1038/nrendo.2017.78 PMID:28664920 PMCID:PMC5839646
  • Goetz A, Wilkinson MF. 2017. Stress and the nonsense-mediated RNA decay pathway. Cellular and Molecular Life Sciences 74(19):3509-3531. doi:10.1007/s00018-017-2537-6 PMID:28503708 PMCID:PMC568394
  • He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM. 2017. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. Proc Natl Acad Sci U S A 114(47):12542-12547. doi:10.1073/pnas.1715363114 PMID:29109251 PMCID:PMC5703326
  • Hirashima R, Itoh T, Tukey RH, Fujiwara R. 2017. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol 37:863-872. doi:10.1002/jat.3435 PMID:28138970 PMCID:PMC5500258
  • Kim RG, Loomba R, Prokop LJ, Singh S. 2017. Statin use and risk of cirrhosis and related complications in patients with chronic liver diseases: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 15(10):1521-1530. doi:10.1016/j.cgh.2017.04.039 PMID:28479502 PMCID:PMC5605397
  • Kobayashi NI, Yamaji N, Yamamoto H, Okubo K, Ueno H, Costa A, Tanoi K, Matsumura H, Fujii-Kashino M, Horiuchi T, Al Nayef M, Shabala S, An G, Ma JF, Horie T. 2017. OsHKT1;5 mediates Na+ exclusion in the vasculature to protect leaf blades and reproductive tissues from salt toxicity in rice. Plant J 91:657-670. doi:10.1111/tpj.13595 PMID:28488420
  • Koyama Y, Brenner DA. 2017. Liver inflammation and fibrosis. J Clin Invest 127(1):55-64. doi:10.1172/JCI88881 PMID:28045404 PMCID:PMC5199698
  • Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner CW, Heinz S, Bera T, Brenner DA, Kisseleva T. 2017. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest 127(4):1254-1270. doi:10.1172/JCI88845 PMID:28287406 PMCID:PMC5373891
  • Lin SC, Heba E, Bettencourt R, Lin GY, Valasek MA, Lunde O, Hamilton G, Sirlin CB, Loomba R. 2017. Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging. Aliment Pharmacol Ther 45(6):844-854. doi:10.1111/apt.13951 PMID:28116801 PMCID:PMC5346270
  • Liu Y, Yu C, Cao Z, Shvarts D, Trogler WC. 2017. A highly sensitive enzymatic catalysis system for trace detection of arsenic in water. Chem Eur J 23:10289-10292. doi:10.1002/chem.201702769 PMID:28631380 PMCID:PMC5665019
  • Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen C, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. 2017. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 25(5):1054-1062.e5. doi:10.1016/j.cmet.2017.04.001 PMID:28467925 PMCID:PMC550273
  • Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. 2017. Crypt organoid culture as an in vitro model in drug metabolism and cytotoxicity studies. Drug Metab Dispos 45:748-754. doi:10.1124/dmd.117.075945 PMID:28468837 PMCID:PMC5478905
  • Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Valasek MA, Rizo E, Brenner DA, Sirlin CB, Loomba R. 2017. Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. Gastroenterology 152(3):598-607.e2. doi:10.1053/j.gastro.2016.10.026 PMID:27911262 PMCID:PMC5285304
  • Reinders ME, Wardi G, Bettencourt R, Bouland D, Bazick J, Mendler M, Vodkin I, Kalmaz D, Savides T, Brenner DA, Sell RE, Loomba R. 2017. Increased risk of death, in the hospital and outside the intensive care unit, for patients with cirrhosis after cardiac arrest. Clin Gastroenterol Hepatol 15(11):1808-1810. doi:10.1016/j.cgh.2017.05.044 PMID:28602970 PMCID:PMC5723019
  • Shalapour S, Lin X, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner CW, Anstee QM, Karin M. 2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551(7680):340-345. doi:10.1038/nature24302 PMID:29144460 PMCID:PMC5884449
  • Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM. 2017. Stromal cues regulate the pancreatic cancer epigenome and metabolome. Proc Natl Acad Sci U S A 114(5):1129-1134. doi:10.1073/pnas.1620164114 PMID:28096419 PMCID:PMC5293019
  • Tukey RH. 2017. Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPAR alpha. Am J Physiol Endocrinol Metab 312:E244-E252. doi:10.1152/ajpendo.00396.2016 PMID:28096081 PMCID:PMC5406988
  • Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner DA, Duffield J, Burkly LC. 2017. Identification of novel fibrosis modifiers by in vivo siRNA silencing. Mol Ther Nucleic Acids 7:314-323. doi:10.1016/j.omtn.2017.04.014 PMID:28624207 PMCID:PMC5424569
  • Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. 2017. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun 8(1):959. doi:10.1038/s41467-017-00931-8 PMID:29038463 PMCID:PMC5643384
  • Wu C, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. 2017. Structural basis for specific ligation of the peroxisome proliferater-activated receptor delta. Proc Natl Acad Sci U S A 114:13:E2563-2570. doi:10.1073/pnas.1621513114 PMID:28320959 PMCID:PMC5380080
  • Xie H, Hoffmann HM, Iyer AK, Brayman MJ, Ngo C, Sunshine M, Mellon PL. 2017. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol 15(1):86. doi:10.1186/s12958-017-0304-z PMID:29065928 PMCID:PMC5655979
  • Xu J, Ma H, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. 2017. The role of human CYP2E1 in liver inflammation and fibrosis. Hepatol Commun 1:1043-1057. doi:10.1002/hep4.1115 PMID:29404441 PMCID:PMC572140
  • Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh Y, Seki E. 2017. TRIF differentially regulates hepatic steatosis and inflammation/fibrosis in mice. Cell Mol Gastroenterol Hepatol 3(3):469-483. doi:10.1016/j.jcmgh.2016.12.004 PMID:28462384 PMCID:PMC5438096
  • Yoda E, Paszek M, Konopnicki CM, Fujiwara R, Chen S, Tukey RH. 2017. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep 7:46489. doi:10.1038/srep46489 PMID:28422158 PMCID:PMC5395973
  • Yueh MF, Chen S, Nguyen N, Tukey RH. 2017. Developmental, genetic, dietary, and xenobiotic influences on neonatal hyperbilirubinemia. Mol Pharmacol 91(5):545-553. doi:10.1124/mol.116.107524 PMID:28283555 PMCID:PMC5416747



  • Adamson J, Gleason W, Pellow D, Pezzoli K, eds. 2015. Keywords in the Study of Environment and Culture New York University Press, New York City, NY.
  • Antonucci L, Fagman JB, Kim J, Todoric J, Gukovsky I, Mackey MR, Ellisman MH, Karin M. 2015. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A 112(45):E6166-E6174. doi:10.1073/pnas.1519384112 PMID:26512112 PMCID:PMC4653219
  • Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. 2015. Calcipotriol targets LRP6 to inhibit Wnt signaling in pancreatic cancer. Mol Cancer Res 13(11):1509-1519. doi:10.1158/1541-7786.MCR-15-0204 PMID:26224368 PMCID:PMC4644680
  • Azoulay-Shemer T, Palomares A, Bagheri A, Israelsson-Nordstrom M, Engineer C, Bargmann BO, Stephan AB, Schroeder JI. 2015. Guard cell photosynthesis is critical for stomatal turgor production, yet does not directly mediate CO2 - and ABA-induced stomatal closing. Plant J 83(4):567-581. doi:10.1111/tpj.12916 PMID:26096271 PMCID:PMC4532624
  • Bapat SP, Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, Leblanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528(7580):137-141. doi:10.1038/nature16151 PMID:26580014 PMCID:PMC4670283
  • Bourne Y, Sulzenbacher G, Radic Z, Araoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgo J, Taylor PW, Marchot P. 2015. Marine macrocyclic imines, pinnatoxins A and G: structural determinants and functional properties to distinguish neuronal α7 from muscle α1(2)βγδ nAChRs. Structure 23(6):1106-1115. doi:10.1016/j.str.2015.04.009 PMID:26004441 PMCID:PMC4461042
  • Brandt B, Munemasa S, Wang C, Nguyen D, Yong T, Yang PG, Poretsky E, Belknap TF, Waadt R, Aleman F, Schroeder JI. 2015. Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells. Elife 4:doi:10.7554/eLife.03599 PMID:26192964 PMCID:PMC4507714
  • Brenner DA, Paik Y, Schnabl B. 2015. Role of gut microbiota in liver disease. J Clin Gastroenterol 49Suppl1:S25-S27. doi:10.1097/MCG.0000000000000391 PMID:26447960 PMCID:PMC4602394
  • Ding N, Hah N, Yu RT, Sherman MH, Benner CW, Leblanc M, He M, Liddle C, Downes M, Evans RM. 2015. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A 112(51):15713-15718. doi:10.1073/pnas.1522163112 PMID:26644586 PMCID:PMC4697417
  • Fan W, Evans RM. 2015. PPARs and ERRs: molecular mediators of mitochondrial metabolism. Curr Opin Cell Biol 33:49-54. doi:10.1016/ PMID:25486445 PMCID:PMC4380823
  • Fang S, Suh J, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky J, Saltiel AR, Downes M, Evans RM. 2015. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 21(2):159-165. doi:10.1038/nm.3760 PMID:25559344 PMCID:PMC4320010
  • Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol 16(12):1235-1244. doi:10.1038/ni.3290 PMID:26502405 PMCID:PMC4653079
  • Font-Burgada J, Shalapour S, Ramasamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. 2015. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell 162(4):766-779. doi:10.1016/j.cell.2015.07.026 PMID:26276631 PMCID:PMC4545590
  • Fujiwara R, Maruo Y, Chen S, Tukey RH. 2015. Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol 289(1):124-132. doi:10.1016/j.taap.2015.08.018 PMID:26342858 PMCID:PMC4708261
  • Hah N, Benner CW, Chong L, Yu RT, Downes M, Evans RM. 2015. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A 112(3):E297-E302. doi:10.1073/pnas.1424028112 PMID:25564661 PMCID:PMC4311831
  • Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. 2015. A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice. Biol Reprod 93(3):69. doi:10.1095/biolreprod.115.131631 PMID:26203175 PMCID:PMC4710190
  • Keinath NF, Waadt R, Brugman R, Schroeder JI, Grossmann G, Schumacher K, Krebs M. 2015. Live Cell Imaging with R-GECO1 Sheds Light on flg22- and Chitin-Induced Transient [Ca(2+)]cyt Patterns in Arabidopsis. Mol Plant 8(8):1188-1200. doi:10.1016/j.molp.2015.05.006 PMID:26002145 PMCID:PMC5134422
  • Kim I, Kisseleva T, Brenner DA. 2015. Aging and liver disease. Curr Opin Gastroenterol 31(3):184-191. doi:10.1097/MOG.0000000000000176 PMID:25850346 PMCID:PMC4736713
  • Koyama Y, Brenner DA. 2015. New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol 39Suppl1:S75-S79. doi:10.1016/j.clinre.2015.06.011 PMID:26206573 PMCID:PMC4734896
  • Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. 2015. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos 43(7):1071-1076. doi:10.1124/dmd.115.063719 PMID:25953521 PMCID:PMC4468441
  • Lan T, Kisseleva T, Brenner DA. 2015. Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation. PLoS One 10(7):e0129743. doi:10.1371/journal.pone.0129743 PMID:26222337 PMCID:PMC4519306
  • Liu Y, Trogler WC. 2015. Comment on 'Fluorescence sensing of arsenate at nanomolar level in a greener way: naphthalene based probe for living cell imaging'. Chem Commun (Camb) 51(79):14775-14777. doi:10.1039/c5cc02494c PMID:26299989 PMCID:PMC4607275
  • Mazagova M, Wang L, Anfora A, Wissmueller M, Lesley S, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B. 2015. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J 29(3):1043-1055. doi:10.1096/fj.14-259515 PMID:25466902 PMCID:PMC4422368
  • Mejia-Ramirez E, Limbo O, Russell P. 2015. Critical Function of γH2A in S-Phase. PLoS Genet 11(9):e1005517. doi:10.1371/journal.pgen.1005517 PMID:26368543 PMCID:PMC4569340
  • Munemasa S, Hauser F, Park J, Waadt R, Brandt B, Schroeder JI. 2015. Mechanisms of abscisic acid-mediated control of stomatal aperture. Curr Opin Plant Biol 28:154-162. doi:10.1016/j.pbi.2015.10.010 PMID:26599955 PMCID:PMC4679528
  • Patel NS, Doycheva I, Peterson MR, Hooker J, Kisselva T, Schnabl B, Seki E, Sirlin CB, Loomba R. 2015. Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 13(3):561-568.e1. doi:10.1016/j.cgh.2014.08.039 PMID:25218667 PMCID:PMC4333065
  • Pezzoli K. 2015. Bioregionalism. Chapter 7 in: Keywords in the Study of Environment and Culture. New York University Press, New York City, NY. pp.25-29.
  • Pezzoli K. 2015. Bioregionalism. Chapter 7 in: Keywords in the Study of Environment and Culture. New York University Press, New York City, NY. pp.25-29.
  • Pezzoli K. 2015. Bioregionalism. Chapter 7 in: Keywords in the Study of Environment and Culture. New York University Press, New York City, NY. pp.25-29.
  • Ranjit S, Dvornikov A, Hong S, Levi M, Evans RM, Gratton E, Stakic M. 2015. Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging. Sci Rep 5:13378. doi:10.1038/srep13378 PMID:26293987 PMCID:PMC4543938
  • Roh Y, Loomba R, Seki E. 2015. The TM6SF2 variants, novel genetic predictors for nonalcoholic steatohepatitis. Gastroenterology 148(1):252-254. doi:10.1053/j.gastro.2014.11.014 PMID:25451657 PMCID:PMC4718074
  • Sakamoto M, Itoh T, Tukey RH, Fujiwara R. 2015. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet 30(4):269-275. doi:10.1016/j.dmpk.2015.04.004 PMID:26210671 PMCID:PMC4752199
  • Sanchez A, Roguev A, Krogan NJ, Russell P. 2015. Genetic interaction landscape reveals critical requirements for Schizosaccharomyces pombe Brc1 in DNA damage response mutants. G3 (Bethesda) 5(5):953-962. doi:10.1534/g3.115.017251 PMID:25795664 PMCID:PMC4426379
  • Seki E, Brenner DA. 2015. Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci 22(7):512-518. doi:10.1002/jhbp.245 PMID:25869468 PMCID:PMC4668270
  • Seki E, Schwabe RF. 2015. Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology 61(3):1066-1079. doi:10.1002/hep.27332 PMID:25066777 PMCID:PMC4306641
  • Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zin C, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong Z, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. 2015. P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma. Mol Cell 59(6):931-940. doi:10.1016/j.molcel.2015.07.027 PMID:26365380 PMCID:PMC4648709
  • Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon PL, Kauffman AS. 2015. Absent progesterone signaling in kisspeptin neurons disrupts the LH surge and impairs fertility in female mice. Endocrinology 156(9):3091-3097. doi:10.1210/en.2015-1300 PMID:26076042 PMCID:PMC4541622
  • Suh J, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin Y, Yu RT, Liddle C, Atkins AR, Olefsky J, Mohammadi M, Downes M, Evans RM. 2015. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 520(7547):388. doi:10.1038/nature14304 PMID:25739500 PMCID:PMC4184286
  • Waadt R, Hsu P, Schroeder JI. 2015. Abscisic acid and other plant hormones: methods to visualize distribution and signaling. Bioessays 37(12):1338-1349. doi:10.1002/bies.201500115 PMID:26577078 PMCID:PMC4677054
  • Xie H, Hoffman HM, Meadows JD, Mayo S, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL. 2015. Homeodomain proteins SIX3 and SIX6 regulate gonadotrope-specific genes during pituitary development. Mol Endocrinol 29(6):842-855. doi:10.1210/me.2014-1279 PMID:25915183 PMCID:PMC4447639
  • Yang YM, Roh YS, Seki E. 2015. MafG, a novel target of FXR that regulates bile acid homeostasis. Gastroenterology 149(7):1981-1983. doi:10.1053/j.gastro.2015.10.014 PMID:26501563 PMCID:PMC4744927
  • Yang YM, Seki E. 2015. TNFα in liver fibrosis. Curr Pathobiol Rep 3(4):253-261. doi:10.1007/s40139-015-0093-z PMID:26726307 PMCID:PMC4693602



  • Ahmadian M, Suh J, Hah N, Liddle C, Atkins AR, Downes M, Evans RM. 2013. PPAR gamma signaling and metabolism: the good, the bad and the future. Nat Med 19:557-566. doi:10.1038/nm.3159 PMID:23652116 PMCID:PMC3870016
  • Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. 2013. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A 110(47):19143-19148. doi:10.1073/pnas.1319123110 PMID:24191041 PMCID:PMC3839688
  • Clark DD, Gorman MR, Hatori M, Meadows JD, Panda S, Mellon PL. 2013. Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms 28(1):15-25. doi:10.1177/0748730412468084 PMID:23382588 PMCID:PMC3586279
  • Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM. 2013. A vitamin D receptor / SMAD genomic circuit gates hepatic fibrotic response. Cell 153(3):601-613. doi:10.1016/j.cell.2013.03.028 PMID:23622244 PMCID:PMC3673534
  • Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. 2013. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A 110(6):2377-2382. doi:10.1073/pnas.1221729110 PMID:23341606 PMCID:PMC3568328
  • Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP. 2013. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci U S A 110:8555-8560. doi:10.1073/pnas.1306182110 PMID:23653479 PMCID:PMC3666748
  • Fan W, Atkins AR, Yu RT, Downes M, Evans RM. 2013. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol 51(3):T87-T100. doi:10.1530/JME-13-0258 PMID:24280961 PMCID:PMC3936671
  • Geszvain K, McCarthy JK, Tebo BM. 2013. Elimination of manganese (II, III) oxidation in Pseudomonas putida GB-1 by a double knockout of two putative multicopper oxidase genes. Appl Environ Microbiol 79(1):357-366. doi:10.1128/aem.01850-12 PMID:23124227 PMCID:PMC3536112
  • Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon PL. 2013. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol 27(3):437-454. doi:10.1210/me.2012-1271 PMID:23393128 PMCID:PMC3589675
  • Hauser F, Chen W, Deinlein U, Chang K, Ossowski S, Fitz J, Hannon GJ, Schroeder JI. 2013. A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis. Plant Cell 25(8):2848-2863. doi:10.1105/tpc.113.112805 PMID:23956262 PMCID:PMC3784584
  • He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. 2013. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155(2):384-396. doi:10.1016/j.cell.2013.09.031 PMID:24120137 PMCID:PMC4015514
  • Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W. 2013. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. Pharm Res 30(9):2199-2208. doi:10.1007/s11095-013-1101-9 PMID:23896737 PMCID:PMC3771640
  • Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS. 2013. Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys 535(2):143-149. doi:10.1016/ PMID:23562620 PMCID:PMC4059507
  • Larder R, Kimura I, Meadows JD, Clark DD, Mayo S, Mellon PL. 2013. Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol 377(1-2):16-22. doi:10.1016/j.mce.2013.06.026 PMID:23811236 PMCID:PMC3771655
  • Lee J, Budanov AV, Karin M. 2013. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab 18(6):792-801. doi:10.1016/j.cmet.2013.08.018 PMID:24055102 PMCID:PMC3858445
  • Madsen DH, Leonard D, Masedunskas A, Moyer A, Jurgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. 2013. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 202(6):951-966. doi:10.1083/jcb.201301081 PMID:24019537 PMCID:PMC3776354
  • McDowell SC, Akmakjian GZ, Sladek C, Mendoza-Cozatl DG, Morrissey JB, Saini N, Mittler R, Baxter I, Salt DE, Ward JM, Schroeder JI, Guerinot ML, Harper JF. 2013. Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions. PLoS One 8(5):e63014. doi:10.1371/journal.pone.0063014 PMID:23671651 PMCID:PMC3646034
  • Roh Y, Seki E. 2013. Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol 28(S1):38-42. doi:10.1111/jgh.12019 PMID:23855294 PMCID:PMC3721430
  • Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. 2013. p38αlpha inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res 73(1):215-224. doi:10.1158/0008-5472.CAN-12-1602 PMID:23271722 PMCID:PMC3605785
  • Schroeder JI, Delhaize E, Frommer WB, Guerinot ML, Harrison MJ, Herrera-Estrella L, Horie T, Kochian LV, Munns R, Nishizawa NK, Tsay Y, Sanders D. 2013. Using membrane transporters to improve crops for sustainable food production. Nature 497:60-66. doi:10.1038/nature11909 PMID:23636397 PMCID:PMC3954111
  • Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R. 2013. Importance of UDP-Glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemias. Mol Pharmacol 84(5):679-686. doi:10.1124/mol.113.088112 PMID:23950218 PMCID:PMC3807078
  • Toyoda K, Tebo BM. 2013. The effect of Ca2+ ions and ionic strength on Mn(II) oxidation by spores of the marine Bacillus sp SG-1. Geochim Cosmochim Acta 101:1-11. doi:10.1016/j.gca.2012.10.008
  • Uhlenhaut N, Barish GD, Yu RT, Downes M, Karunasiri M, Liddle C, Schwalie P, Hubner N, Evans RM. 2013. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell 49(1):158-171. doi:10.1016/j.molcel.2012.10.013 PMID:23159735 PMCID:PMC3640846
  • Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Cross D, Kauffman AS, Mellon PL. 2013. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol 27(8):1283-1294. doi:10.1210/me.2012-1405 PMID:23770611 PMCID:PMC3725344
  • Xie H, Cherrington BD, Meadows JD, Whitham E, Mellon PL. 2013. Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during Gonadotrope development. Mol Endocrinol 27(3):422-436. doi:10.1210/me.2012-1289 PMID:23371388 PMCID:PMC3589667
  • Yang L, Inokuchi-Shimizu S, Roh Y, Song J, Loomba R, Park E, Seki E. 2013. Transforming growth factor-beta signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology 144(5):1042-1054. doi:10.1053/j.gastro.2013.01.056 PMID:23391818 PMCID:PMC3752402



  • Anderson CR, Davis RE, Bandolin NS, Baptista AM, Tebo BM. 2011. Analysis of in situ manganese(II) oxidation in the Columbia River and offshore plume: linking Aurantimonas and the associated microbial community to an active biogeochemical cycle. Environ Microbiol 13(6):1561-1576. doi:10.1111/j.1462-2920.2011.02462.x PMID:21418498
  • Bernard V, Girard E, Hrabovska A, Camp S, Taylor PW, Plaud B, Krejci E. 2011. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Mol Cell Neurosci 46(1):272-281. doi:10.1016/j.mcn.2010.09.010 PMID:20883790 PMCID:PMC4755503
  • Bohmer M, Schroeder JI. 2011. Quantitative transcriptomic analysis of abscisic acid-induced and reactive oxygen species-dependent expression changes and proteomic profiling in Arabidopsis suspension cells. Plant J 67(1):105-118. doi:10.1111/j.1365-313X.2011.04579.x PMID:21426425 PMCID:PMC3125488
  • Brauer SL, Adams C, Kranzler K, Murphy D, Xu M, Zuber P, Simon HM, Baptista AM, Tebo BM. 2011. Culturable Rhodobacter and Shewanella species are abundant in estuarine turbidity maxima of the Columbia River. Environ Microbiol 13(3):589-603. doi:10.1111/j.1462-2920.2010.02360.x PMID:20977571
  • Caputo N. 2011. Investigating Manganese Oxidation by Aurantimonas manganoxydans SI85-9A1. .
  • Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. 2011. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147(6):1233-1247. doi:10.1016/j.cell.2011.10.043 PMID:22153071 PMCID:PMC3251960
  • Hauser F, Waadt R, Schroeder JI. 2011. Evolution of abscisic acid synthesis and signaling mechanisms. Current Biology 21:R346-R355. doi:10.1016/j.cub.2011.03.015 PMID:21549957 PMCID:PMC3119208
  • Holzer RG, Park E, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. 2011. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147(1):173-184. doi:10.1016/j.cell.2011.08.034 PMID:21962514 PMCID:PMC3295636
  • Horie T, Brodsky DE, Costa A, Kaneko T, Lo Schiavo F, Katsuhara M, Schroeder JI. 2011. K+ transport by the OsHKT2;4 transporter from rice with atypical Na+ transport properties and competition in permeation of K+ over Mg2+ and Ca2+ ions. Plant Physiol 156:1493-1507. doi:10.1104/pp.110.168047 PMID:21610181 PMCID:PMC3135959
  • Jannat R, Uraji M, Morofuji M, Islam MM, Bloom RE, Nakamura Y, McClung CR, Schroeder JI, Mori IC, Murata Y. 2011. Roles of intracellular hydrogen peroxide accumulation in abscisic acid signaling in Arabidopsis guard cells. J Plant Physiol 168(16):1919-1926. doi:10.1016/j.jplph.2011.05.006 PMID:21665322 PMCID:PMC4073789
  • Kacevska M, Downes M, Sharma R, Evans RM, Clarke SJ, Liddle C, Robertson GR. 2011. Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. Clin Cancer Res 17:3170-3180. doi:10.1158/1078-0432.ccr-10-3289 PMID:21498392 PMCID:PMC3096719
  • Koch KS, Leffert HL. 2011. Ectopic expression of CD74 in Ikk beta-deleted mouse hepatocytes. Acta Histochemica 113:428-435. doi:10.1016/j.acthis.2010.03.004 PMID:20569972 PMCID:PMC2965206
  • Mendoza-Cozatl DG, Jobe TO, Hauser F, Schroeder JI. 2011. Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic. Curr Opin Plant Biol 14:554-562. doi:10.1016/j.pbi.2011.07.004 PMID:21820943 PMCID:PMC3191310
  • Miller MT, Mileni M, Comoletti D, Stevens RC, Harel M, Taylor PW. 2011. The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure 19(6):767-778. doi:10.1016/j.str.2011.03.011 PMID:21620717 PMCID:PMC3279696
  • Osterreicher C, Penz-Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108(1):308-313. doi:10.1073/pnas.1017547108 PMID:21173249 PMCID:PMC3017162
  • Pezzoli K. 2011. Creating Just and Healthy Bioregions: The Role of Action Research and Community Engagement.
  • Pezzoli K. 2011. Food Justice: Industrial Agriculture and the Quest for Alternative Food Systems.
  • Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih P, Rao F, O'Connor DT, Taylor PW. 2011. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther 338(1):125-133. doi:10.1124/jpet.111.180091 PMID:21493754 PMCID:PMC3126649
  • Xue S, Yao X, Luo W, Jha D, Tester M, Horie T, Schroeder JI. 2011. AtHKT1;1 mediates nernstian sodium channel transport properties in Arabidopsis root stelar cells. PLoS One 6(9):e24725.. doi:10.1371/journal.pone.0024725 PMID:21931830 PMCID:PMC3170383
  • Yueh MF, Mellon PL, Tukey RH. 2011. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol 79:1053-1060. doi:10.1124/mol.110.070649 PMID:21415305 PMCID:PMC3102552


  • Bodmer R, Bier E, Karin M, Lee J. 2010. Sestrins at the crossroad between stress and aging. Aging-US 2(6):369-374. doi:10.18632/aging.100157 PMID:20606249 PMCID:PMC2919257
  • Bourne Y, Radic Z, Araoz R, Talley TT, Benoit E, Servent D, Taylor PW, Molgo J, Marchot P. 2010. Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism. Proc Natl Acad Sci U S A 107(13):6076-6081. doi:10.1073/pnas.0912372107 PMID:20224036 PMCID:PMC2851920
  • Budanov AV, Lee J, Karin M. 2010. Stressin' Sestrins take an aging fight. EMBO Mol Med 2(10):388-400. doi:10.1002/emmm.201000097 PMID:20878915 PMCID:PMC3166214
  • Cai H, Nguyen N, Peterkin V, Yang Y, Hotz K, La Placa D, Chen S, Tukey RH, Stevens J. 2010. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos 38(5):879-886. doi:10.1124/dmd.109.030130 PMID:20124398 PMCID:PMC2872941
  • Comoletti D, Miller MT, Jeffries CM, Wilson J, Demeler B, Taylor PW, Trewhella J, Nakagawa T. 2010. The macromolecular architecture of extracellular domain of alpha NRXN1: Domain organization, flexibility, and insights into trans-synaptic disposition. Structure 18(8):1044-1053. doi:10.1016/j.str.2010.06.005 PMID:20696403 PMCID:PMC2948785
  • Costa A, Drago I, Behera S, Zottini M, Pizzo P, Schroeder JI, Pozzan T, Schiavo F. 2010. H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J 62(5):760-772. doi:10.1111/j.1365-313X.2010.04190.x PMID:20230493 PMCID:PMC2884081
  • De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman MH, Butko MT, Tsien RY, Taylor PW. 2010. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. J Biol Chem 285:28674-28682. doi:10.1074/jbc.M110.139519 PMID:20615874 PMCID:PMC2937894
  • Fujiwara R, Nguyen N, Chen S, Tukey RH. 2010. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A 107(11):5024-5029. doi:10.1073/pnas.0913290107 PMID:20194756 PMCID:PMC2841904
  • Junier P, Junier T, Podell S, Sims DR, Detter JC, Lykidis A, Han CS, Wigginton NS, Gaasterland T, Bernier-Latmani R. 2010. The genome of the Gram-positive metal- and sulfate-reducing bacterium Desulfotomaculum reducens strain MI-1. Environ Microbiol 12(10):2738-2754. doi:10.1111/j.1462-2920.2010.02242.x PMID:20482743
  • Lee J, Budanov AV, Park E, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. 2010. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327(5970):1223-1228. doi:10.1126/science.1182228 PMID:20203043 PMCID:PMC2866632
  • Leone P, Comoletti D, Ferracci G, Conrod S, Garcia S, Taylor PW, Bourne P, Bourne Y, Marchot P. 2010. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J 29:2461-2471. doi:10.1038/emboj.2010.123 PMID:20543817 PMCID:PMC2910273
  • Mendoza-Cozatl DG, Zhai Z, Jobe TO, Akmakjian GZ, Song W, Limbo O, Russell MR, Kozlovskyy VI, Martinoia E, Vatamaniuk OK, Russell P, Schroeder JI. 2010. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J Biol Chem 285(52):40416-40426. doi:10.1074/jbc.M110.155408 PMID:20937798 PMCID:PMC3003340
  • Nishimura N, Sarkeshik A, Park S, Wang A, Carvalho PC, Lee S, Caddell DF, Cutler SR, Chory J, Yates JR, Schroeder JI, Nito K. 2010. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J 61(2):290-299. doi:10.1111/j.1365-313X.2009.04054.x PMID:19874541 PMCID:PMC2807913
  • Park E, Lee J, Yu G, He G, Ali S, Holzer RG, Osterreicher CH, Takahashi H, Karin M. 2010. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140(2):197-208. doi:10.1016/j.cell.2009.12.052 PMID:20141834 PMCID:PMC2836922
  • Pyo Y, Gierth M, Schroeder JI, Cho M. 2010. High-affinity K(+) transport in Arabidopsis: AtHAK5 and AKT1 are vital for seedling establishment and postgermination growth under low-potassium conditions. Plant Physiol 153(2):863-875. doi:10.1104/pp.110.154369 PMID:20413648 PMCID:PMC2879780
  • Song W, Park J, Mendoza-Cózatl D, Suter-Grotemeyer M, Shim D, Hortensteiner S, Geisler M, Weder B, Rea PA, Rentsch D, Schroeder JI. 2010. Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters. Proc Natl Acad Sci U S A 107(49):21187-21192. doi:10.1073/pnas.1013964107 PMID:21078981 PMCID:PMC3000282
  • Suhr ST, Chang E, Tjong J, Alcasid N, Perkins GA, Goissis M, Ellisman MH, Perez GI, Cibelli J. 2010. Mitochondrial rejuvenation after induced pluripotency. PLoS One 5:e14095:doi:10.1371/journal.pone.0014095 PMID:21124794 PMCID:PMC2991355
  • Wang X, Lee J, Di Jeso B, Treglia A, Comoletti D, Dubi N, Taylor PW, Arvan P. 2010. Cis and trans actions of the cholinesterase-like domain within the thyroglobulin dimer. J Biol Chem 285(23):17564-17573. doi:10.1074/jbc.M110.111641 PMID:20353937 PMCID:PMC2878521
  • Yao X, Horie T, Xue S, Leung H, Katsuhara M, Brodsky DE, Wu Y, Schroeder JI. 2010. Differential sodium and potassium transport selectivities of the rice OsHKT2;1 and OsHKT2;2 transporters in plant cells. Plant Physiol 152(1):341-355. doi:10.1104/pp.109.145722 PMID:19889878 PMCID:PMC2799368



  • Camp S, De Jaco A, Zhang L, Marquez M, de la Torre B, Taylor PW. 2008. Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intron. J Neurosci 28(10):2459-2470. doi:10.1523/JNEUROSCI.4600-07.2008 PMID:18322091 PMCID:PMC2692871
  • Comoletti D, Grishaev A, Whitten A, Taylor PW, Trewhella J. 2008. Characterization of the solution structure of a neuroligin/beta-neurexin complex. Chem Biol Interact 175(1-3):150-155. doi:10.1016/j.cbi.2008.04.040 PMID:18550038 PMCID:PMC2587492
  • Dick GJ, Podell S, Johnson HA, Rivera-Espinoza Y, Bernier-Latmani R, McCarthy JK, Torpey JW, Clement BG, Gaasterland T, Tebo BM. 2008. Genomic insights into Mn(II) oxidation by the marine alphaproteobacterium Aurantimonas sp strain SI85-9A1. Appl Environ Microbiol 74(9):2646-2658. doi:10.1128/AEM.01656-07 PMID:18344346 PMCID:PMC2394881
  • Dick GJ, Torpey JW, Beveridge TJ, Tebo BM. 2008. Direct identification of a bacterial manganese(II) oxidase, the multicopper oxidase MnxG, from spores of several different marine Bacillus species. Appl Environ Microbiol 74(5):1527-1534. PMID:18165363
  • Horie T, Sugawara M, OKUNOU K, NAKAYAMA H, Schroeder JI, Shinmyo A, Yoshida K. 2008. Functions of HKT transporters in sodium transport in roots and in protecting leaves from salinity stress. Plant Biotechnology 25:233-239.
  • Johnson HA, Tebo BM. 2008. In vitro studies indicate a quinone is involved in bacterial Mn(II) oxidation. Arch Microbiol 189(1):59-69. doi:10.1007/s00203-007-0293-y PMID:17673976 PMCID:PMC2721854
  • Karin M, Budanov AV. 2008. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-460. doi:10.1016/j.cell.2008.06.028 PMID:18692468 PMCID:PMC2758522
  • Kennedy PJ, Vashisht AA, Hoe K, Kim D, Park H, Hayles J, Russell P. 2008. A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol Sci 106(1):124-139. doi:10.1093/toxsci/kfn153 PMID:18684775 PMCID:PMC2563147
  • Kim Y, Kim D, Shim D, Song W, Lee J, Schroeder JI, Kim S, Moran| N, Lee Y. 2008. Expression of the novel wheat gene TM20 confers enhanced cadmium tolerance to bakers' yeast. J Biol Chem 283:15893-15902. doi:10.1074/jbc.M708947200 PMID:18411273 PMCID:PMC2414300
  • Knott AB, Perkins GA, Schwarzenbacher R, Bossy-Wetzel E. 2008. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9(7):505-518. doi:10.1038/nrn2417 PMID:18568013 PMCID:PMC2711514
  • Mendoza-Cózatl D, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI. 2008. Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Plant J 54(2):249-259. doi:10.1111/j.1365-313X.2008.03410.x PMID:18208526 PMCID:PMC2839885
  • Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Belanger A, Tukey RH. 2008. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem 283(12):7901-7911. doi:10.1074/jbc.M709244200 PMID:18180294
  • Rodriguez-Gabriel MA, Russell P. 2008. Control of mRNA Stability by SAPKs. In: Topics in Current Genetics. pp.159-170.
  • VAHISALU T, KOLLIST H, Wang Y, Nishimura N, Chan W, Valerio G, LAMMINMÄKI A, BROSCHE M, DESIKAN R, Schroeder JI, KANGASJÄRVI J, MOLDAU H. 2008. SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling. Nature 452:487-491. PMID:18305484
  • Yamaguchi R, Lartigue L, Perkins GA, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. 2008. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell 31(4):557-569. doi:10.1016/j.molcel.2008.07.010 PMID:18691924 PMCID:PMC2636708
  • Yueh MF, Tukey RH, Chouinard S, Giton F, Fiet J, Pelletier G, Barbier O, Belanger A. 2008. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. Psychiatr Pol 109(3-5):247-253. doi:10.1016/j.jsbmb.2008.03.016 PMID:18467088


  • Bencheikh-Latmani R, Obraztsova AY, Mackey MR, Ellisman MH, Tebo BM. 2007. Toxicity of Cr(III) to Shewanella sp. strain MR-4 during Cr(VI) reduction. Environ Sci Technol 41(1):214-220. PMID:17265950
  • Bonzo JA, Belanger A, Tukey RH. 2007. The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology 45(2):349-360. PMID:17256720
  • Comoletti D, Grishaev A, Whitten A, Tsigelny I, Taylor PW, Trewhella J. 2007. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering. Structure 15(6):693-705. doi:10.1016/j.str.2007.04.010 PMID:17562316 PMCID:PMC2677967
  • Horie T, Costa A, Kim T, Han M, Horie R, Leung H, Miyao A, Hirochika H, An G, Schroeder JI. 2007. Rice OsHKT2;1 transporter mediates large Na+ influx component into K+-starved roots for growth. EMBO J 26(12):3003-14. PMID:17541409
  • Murray KJ, Tebo BM. 2007. Cr(III) is indirectly oxidized by the Mn(II)-oxidizing bacterium Bacillus sp strain SG-1. Environ Sci Technol 41(2):528-533. PMID:17310717
  • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317(5834):121-124. doi:10.1126/science.1140485 PMID:17615358
  • Operana T, Nguyen N, Chen S, Beaton D, Tukey RH. 2007. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci 95(1):98-107. doi:10.1093/toxsci/kfl144 PMID:17065433
  • Pezzoli K, Tukey RH, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman MH. 2007. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect 115(4):564-571. doi:10.1289/ehp.9817 PMID:17450225 PMCID:PMC1852670
  • Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. 2007. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35(3):419-427. doi:10.1124/dmd.106.013243 PMID:17151188
  • Sonoda J, Mehl IR, Chong L, Nofsinger RR, Evans RM. 2007. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Chapter 104(12)in: Proceedings of the NAS (National Academy of Sciences) USA, 2007. pp.5223-8.
  • Yueh MF, Tukey RH. 2007. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 282(12):8749-8758. doi:10.1074/jbc.M610790200 PMID:17259171


  • Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, Liu Y, Karin M. 2006. The E3 ubiquitin ligase itch couples JNK activation to TNF±-induced cell death by inducing c-FLIPL turnover. Cell 124:601-603. PMID:16469705
  • Chen A, Komives EA, Schroeder JI. 2006. An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis. Plant Physiol 141(1):108-120. doi:10.1104/pp.105.072637 PMID:16531489 PMCID:PMC1459314
  • Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Sudhof TC, Taylor PW. 2006. Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry 45(42):12816-12827. PMID:17042500
  • De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor PW. 2006. A mutation linked with autism reveals a common mechanism of endoplasmic retic a, B-beta-hydrolase fold protein family. J Biol Chem 281(14):9667-9676. PMID:16434405
  • Dick GJ, Lee YE, Tebo BM. 2006. Manganese(II)-oxidizing Bacillus spores in Guaymas Basin hydrothermal sediments and plumes. Appl Environ Microbiol 72(5):3184-3190. doi:10.1128/AEM.72.5.3184-3190.2006 PMID:16672456 PMCID:PMC1472353
  • Long JM, LaPorte P, Merscher S, Funke B, Saint-Jore B, Puech A, Kucherlapati R, Morrow BE, Skoultchi AI, Wynshaw-Boris A. 2006. Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics 7(4):247-57. PMID:16900388
  • Martin V, Rodriguez-Gabriel MA, McDonald WH, Watt S, Yates JR, Bahler J, Russell P. 2006. Cip1 and Cip2 are novel RNA-recognition-motif proteins that counteract Csx1 function during oxidative stress. Mol Biol Cell 17(3):1176-1183. PMID:16407405
  • Nguyen V, Schroeder JI. 2006. The role of reactive oxygen species in hormonal responses. Plant Physiol 141(2):323-329. PMID:16760482
  • Pezzoli K, Marciano R, Robertus J. 2006. Integrating Regional Watershed Management: A Strategic Vision. In: Proceedings of the 7th Annual International Conference on Digital Government Research, May 21-26. San Diego, CA.
  • Platten JD, Cotsaftis O, Berthomieu P, Bohnert H, Davenport RJ, Fairbairn DJ, Horie T, Leigh RA, Lin H, Luan S, Maser P, Pantoja O, Rodriguez-Navarro A, Schachtman DP, Schroeder JI, Sentenac H, Uozumi N, Very A, Zhu J, Dennis ES, Tester M. 2006. Nomenclature for HKT transporters, key determinants of plant salinity tolerance. Trends Plant Sci 11(8):372-374. PMID:16809061
  • Rodriguez-Gabriel MA, Watt S, Bahler J, Russell P. 2006. Upf1, an RNA Helicase Required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol Cell Biol 26(17):6347-6356. PMID:16914721
  • Sakurai T, Maeda S, Chang L, Karin M. 2006. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103(28):10544-10551. doi:10.1073/pnas.0603499103 PMID:16807293 PMCID:PMC1502270
  • Schroeder JI, Kuhn JM. 2006. Plant biology: abscisic acid in bloom. Nature 439(7074):277-278. doi:10.1038/439277a PMID:16421556
  • Schroeder JI, Nambara E. 2006. A quick release mechanism for abscisic acid. Cell 126(6):1023-1025. PMID:16990126
  • Shi J, Koeppe JR, Komives EA, Taylor PW. 2006. Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem 281(17):12170-12177. doi:10.1074/jbc.M600154200 PMID:16484218
  • Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes M. 2006. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc Natl Acad Sci U S A 103(30):11323-11328. PMID:16844773
  • Zaslavsky I, Pezzoli K, Valentine D, Lin A, Sarabia H, Ellisman MH, Tukey RH, Hull A, Miranda ML, Avakian MD. 2006. Intgrating GIS and portal Technologies for assessing environmental health impacts of Hurricane Katrina. In: Proceedings of the Second International Conference on Environmental Science and Technology Vol II, August 19-22. American Science Press, Houston, TX. pp.385-390.


  • Bencheikh-Latmani R, Obraztsova AY, Mackey MR, Ellisman MH, Tebo BM. 2005. Toxicity of uncomplexed trivalent chromium to Shewanella oneidensis MR-4 during Cr(VI) reduction. Environ Sci Technol
  • Bencheikh-Latmani R, Williams SM, Haucke L, Criddle CS, Wu L, Zhou J, Tebo BM. 2005. Global transcriptional profiling of Shewanella oneidensis MR-1 during Cr(VI) and U(VI) reduction. Appl Environ Microbiol 71(11):7453-7460. doi:10.1128/AEM.71.11.7453-7460.2005 PMID:16269787 PMCID:PMC1287662
  • Bonzo JA, Chen S, Galijatovic A, Tukey RH. 2005. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol 67(4):1247-1256. PMID:15630080
  • Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. 2005. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem 280(45):37547-37557. doi:10.1074/jbc.M506683200 PMID:16155002
  • Chen S, Operana T, Bonzo JA, Nguyen N, Tukey RH. 2005. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem 280(6):4350-4359. doi:10.1074/jbc.M411554200 PMID:15572374
  • Coggan JS, Bartol TM, Esquenazi E, Stiles JR, Lamont S, Martone ME, Berg DK, Ellisman MH, Sejnowski TJ. 2005. Evidence for ectopic neurotransmission at a neuronal synapse. Science 309:446-451. PMID:16020730
  • Giepmans BN, Deerinck TJ, Smarr BL, Jones YZ, Ellisman MH. 2005. Correlated light and electron microscopic imaging of multiple endogenous proteins using Quantum dots. Nat Methods 2(10):743-749. PMID:16179920
  • Kamata H, Honda S, Maeda S, Hirata H, Karin M. 2005. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120(5):649-661. doi:10.1016/j.cell.2004.12.041 PMID:15766528
  • Karin M, Greten FR. 2005. NF-ºB: Linking inflammmation and immunity to cancer development and progression. Nat Rev Immunol 5(10):749-759. PMID:16175180
  • Machemer DE, Tukey RH. 2005. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci 87(1):27-37. PMID:15947024
  • Maeda S, Kamata H, Luo J, Leffert HL, Karin M. 2005. IKKB couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-990. PMID:15989949
  • Murray KJ, Mozafarzadeh M, Tebo BM. 2005. Cr(III) oxidation and Cr toxicity in cultures of the manganese(II)-oxidizing Pseudomonas putida strain GB-1. Geomicrobiol J 22(2-3):151-159.
  • Pezzoli K, Marciano R, Purohit J. 2005. Developing tools for watershed-based analysis in support of city-region planning. In: Proceedings of the Twenty Fifth Annual ESRI International Users Conference. San Diego, CA.
  • Rodriguez-Gabriel MA, Russell P. 2005. Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryot Cell 4(8):1396-1402. PMID:16087744
  • Sosinsky GE, Deerinck TJ, Greco R, Buitenhuys CH, Bartol TM, Ellisman MH. 2005. Development of a model for microphysiological simulations: small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography. Neuroinformatics 3(2):133-162. doi:10.1385/NI:3:2:133 PMID:15988042
  • Sunarpi, Horie T, Motoda J, Kubo M, Yang H, Yoda K, Horie R, Chan W, Leung H, Hattori K, Konomi M, Osumi M, Yamagami M, Schroeder JI, Uozumi N. 2005. Enhanced salt tolerance mediated by AtHKT1 transporter-induced Na+ unloading from xylem vessels to xylem parenchyma cells. Plant J 44(6):928-938. PMID:16359386
  • Tebo BM, Johnson HA, McCarthy JK, Templeton AS. 2005. Geomicrobiology of manganese(II) oxidation. Trends Microbiol 13(9):421-428. PMID:16054815
  • Valledor AF. 2005. The innate immune response under the control of the LXR pathway. Immunobiology 210(2-4):127-132. PMID:16164019
  • Zhang M, Joseph B, Gupta S, Guest I, Xu M, Sell S, Son K, Koch KS, Leffert HL. 2005. Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult rats. Stem Cells 23(2):186-199. PMID:15671142


  • Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong N, Taylor SS. 2004. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry 43(1):85-96. doi:10.1021/bi035042p PMID:14705934
  • Bonizzi G, Karin M. 2004. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25(6):280-288. PMID:15145317
  • Boyd AE, Dunlop CS, Wong L, Radic Z, Taylor PW, Johnson DA. 2004. Nanosecond dynamics of acetylcholinesterase near the active center gorge. J Biol Chem 279(25):26612-26618. PMID:15078872
  • Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor PW. 2004. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci 24(20):4889-4893. PMID:15152050
  • Cunard R, Eto Y, Muljadi JT, Glass CK, Kelly CJ, Ricote M. 2004. Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma. J Immunol 172(12):7530-7536. PMID:15187132
  • Dooley CT, Dore TM, Hanson GT, Jackson WC, Remington SJ, Tsien RY. 2004. Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. J Biol Chem 279(21):22284-22293. PMID:14985369
  • Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo JA, Johnson RS, Maeda S, Karin M, Guengerich FP, Tukey RH. 2004. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem 279(23):23969-23976. PMID:15037607
  • Gong J, Waner DA, Horie T, Li S, Horie R, Abid KB, Schroeder JI. 2004. Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana. Proc Natl Acad Sci U S A 101(43):15404-15409. PMID:15486089
  • Greten FR, Eckmann L, Greten TF, Park JM, Li Z, Egan LJ, Kagnoff MF, Karin M. 2004. IKKB links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285-296. PMID:15294155
  • Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ. 2004. Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J Biol Chem 279(13):13044-13053. PMID:14722062
  • Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor PW. 2004. Structural characterization of recombinant soluble rat neuroligin 1: Mapping of secondary structure and glycosylation by mass spectrometry. Biochemistry 43(6):1496-1506. PMID:14769026
  • Hsu L, Park JM, Zhang K, Luo J, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428(6980):341-345. PMID:15029200
  • Jennings LL, Komives EA, Taylor PW. 2004. Organophosphate modifications of mouse acetylcholinesterase: detection of exposure by MALDI-TOF mass spectrometry. In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, N.C. VII International Meeting on Cholinesterases, Pucon, Chile. pp.265-268.
  • Kelner MJ, Bagnell RD, Morgenstern R. 2004. Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression. Biochim Biophys Acta 1678(2-3):163-169. doi:10.1016/j.bbaexp.2004.03.001 PMID:15157743
  • Khetani SR, Szulgit G, Del Rio JA, Barlow C, Bhatia SN. 2004. Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Hepatology 40(3):545-554. doi:10.1002/hep.20351 PMID:15349892
  • Li Y, Dhankher OP, Carreira L, Lee DA, Chen A, Schroeder JI, Balish RS, Meagher RB. 2004. Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant and Cell Physiology 45(12):1787-1797. PMID:15653797
  • Lin P, Chan WC, Badylak S, Bhatia SN. 2004. Assessing porcine liver-derived biomatrix for hepatic tissue engineering. Tissue Engineering Part A 10(7-8):1046-53. PMID:15363162
  • Long JM, LaPorte P, Paylor R, Wynshaw-Boris A. 2004. Expanded characterization of the social interaction abnormalities in mice lacking Dvl1. Genes Brain Behav 3(1):51-62. PMID:14960015
  • Martone ME, Gupta A, Ellisman MH. 2004. e-Neuroscience: challenges and triumphs in integrating distributed data from molecules to brains. Nat Neurosci 7:467-472. PMID:15114360
  • Schroeder JI, Mori IC. 2004. Reactive oxygen species activation of plant Ca2+ channels. A signaling mechanism in polar growth, hormone transduction, stress signaling, and hypothetically mechanotransduction. Plant Physiol 135(2):702-708. PMID:15208417
  • Shen H, Lin Y, Choksi S, Tran JH, Jin T, Chang L, Karin M, Zhang J, Liu Z. 2004. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 24(13):5914-22. PMID:15199146
  • Shi J, Radic Z, Johnson DA, Taylor PW. 2004. Analysis of acetylcholinesterase structure and dynamics by steady state and time-resolve fluorescence. In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, N.C. VII International Meeting on Cholinesterases, Pucon, Chile. pp.225-227.
  • Sil AK, Maeda S, Sano Y, Roop DR, Karin M. 2004. Abstract IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428(6983):660-664. PMID:15071597
  • Son K, Zhang M, Rucobo E, Nwaigwe D, Montgomery F, Leffert HL. 2004. Derivation and study of human epithelial cell lines resistant to killing by chromium trioxide. J Toxicol Environ Health A 67(13):1027-1049. PMID:15205032
  • Taylor PW, Shi J, Radic Z, Boyd AE, Johnson DA. 2004. Spectroscopic approaches to the study of acetylcholinesterase structure and function. In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, N.C. VII International Meeting on Cholinesterases, Pucon, Chile. pp.177-180.
  • Tebo BM, Bargar JR, Clement BG, Dick GJ, Murray KJ, Parker D, Verity R, Webb SM. 2004. Biogenic manganese oxides: properties and mechanisms of formation. Annual Review of Earth and Planetary Sciences 32:287-328.
  • Thomine S, Schroeder JI. 2004. Plant metal transporters with homology to proteins of the NRAMP family. In: The NRAMP Family. Landes Bioscience, Georgetown, TX. pp.11.
  • Valledor AF, Hsu L, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. 2004. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A 101(51):17813-17818. PMID:15601766
  • Wycisk K, Kim EJ, Schroeder JI, Kramer U. 2004. Enhancing the first enzymatic step in the histidine biosynthesis pathway increases the free histidine pool and nickel tolerance in Arabidopsis thaliana. FEBS Lett 578(1-2):128-134. PMID:15581629
  • Zhang L, Marquez M, de la Torre B, Taylor PW. 2004. Knockout mice with deletions of alternatively spliced exons of acetylcholinesterase. In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, N.C. VII International Meeting on Cholinesterases, Pucon, Chile. pp.43-47.


  • Allen JW, Bhatia SN. 2003. Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol Bioeng 82(3):253-262. doi:10.1002/bit.10569 PMID:12599251
  • Chen F, Castranova V, Li Z, Karin M, Shi X. 2003. Inhibitor of nuclear factor kappa B kinase deficiency enhances oxidative stress and prolongs c-jun NH2-terminal kinase activation induced by arsenic. Cancer Res 63(22):7689-7693. PMID:14633691
  • Chen L, Egan LJ, Li Z, Kagnoff MF, Karin M. 2003. The two faces of IKK and NF-kappa B inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-581. PMID:12692538
  • Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. 2003. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem 278(21):19526-19533. PMID:12637498
  • Ekstrom L, Lyrenas L, Jakobsson PJ, Morgenstern R, Kelner MJ. 2003. Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3. Biochim Biophys Acta 1627(2-3):79-84. PMID:12818425
  • George KM, Schule T, Sandoval LE, Jennings LL, Taylor PW, Thompson CM. 2003. Differentiation between acetylcholinesterase and the organophosphate-inhibited form using antibodies and the correlation of antibody recognition with reactivation mechanism and rate. J Biol Chem 278(46):45512-45518. PMID:12933813
  • Gong J, Lee DA, Schroeder JI. 2003. Long-distance root-to-shoot transport of phytochelatins and cadmium in Arabidopsis. Proc Natl Acad Sci U S A 100(17):10118-10123. PMID:12909714
  • Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. 2003. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng 81(5):578-587. PMID:12514807
  • Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. 2003. Evidence that reactive oxygen species do not mediate NF-kappa B activation. EMBO J 22(13July):3356-3366. PMID:12839997
  • He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. 2003. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A 100(3):1022-1027. doi:10.1073/pnas.0333594100 PMID:12540825 PMCID:PMC298719
  • Jennings LL, Malecki M, Komives EA, Taylor PW. 2003. Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry. Biochemistry 42(37):11083-11091. PMID:12974645
  • Koch KS, Leffert HL. 2003. Normal liver progenitor cells in culture. In: Stem Cells Handbook. Humana Press, Inc., Totowa, NJ.
  • Lahner B, Gong J, Mahmoudian M, Smith EL, Abid KB, Rogers EE, Guerinot ML, Harper JF, Ward JM, McIntyre L, Schroeder JI, Salt DE. 2003. Genomic scale profiling of nutrient and trace elements in Arabidopsis thaliana. Nat Biotechnol 21(10):1215-1221. PMID:12949535
  • Lee DA, Chen A, Schroeder JI. 2003. Ars1, an Arabidopsis mutant exhibiting increased tolerance to arsenate and increased phosphate uptake. Plant J 35(5):637-646. PMID:12940956
  • Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ. 2003. Polymer replicas of photonic porous silicon for sensing and drug delivery applications. Science 299(5615):2045-2047. PMID:12663921
  • Li Z, Omori SA, Labuda T, Karin M, Rickert RC. 2003. IKK beta is required for peripheral B cell survival and proliferation. J Immunol 170(9):4630-4637. PMID:12707341
  • Maeda S, Chang L, Li Z, Luo J, Leffert HL, Karin M. 2003. IKK beta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNF alpha. Immunity 19(5):725-737. PMID:14614859
  • Maier T, Yu C, Kullertz G, Clemens S. 2003. Localization and functional characterization of metal-binding sites in phytochelatin synthases. Planta 218(2):300-308. PMID:12905027
  • Martone ME, Zhang S, Gupta A, Qian X, He H, Price DL, Wong M, Santini S, Ellisman MH. 2003. The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy. Neuroinformatics 1(4):379-396. PMID:15043222
  • Middleton SS, Bencheikh-Latmani R, Mackey MR, Ellisman MH, Tebo BM, Criddle CS. 2003. Cometabolism of Cr(VI) by Shewanella oneidensis MR-1 produces cell-associated reduced chromium and inhibits growth. Biotechnol Bioeng 83(6):627-637. PMID:12889027
  • Ozkan M, Pisanic T, Scheel J, Barlow C, Esener S, Bhatia SN. 2003. Electro-optical platform for the manipulation of live cells. Langmuir 19(5):1532-1538.
  • Rodriguez-Gabriel MA, Burns G, McDonald WH, Martin V, Yates JR, Bahler J, Russell P. 2003. RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J 22(23):6256-6266. PMID:14633985
  • Schroeder JI. 2003. Knockout of the guard cell K+ out channel and stomatal movements. Proc Natl Acad Sci U S A 100(9):4976-4977. PMID:12704226
  • Shi J, Tai K, McCammon JA, Taylor PW, Johnson DA. 2003. Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop. J Biol Chem 278(33):30905-30911. PMID:12759360
  • Thomine S, Lelievre F, Debarbieux E, Schroeder JI, Barbier-Brygoo H. 2003. AtNRAMP3, a multispecific vacuolar metal transporter involved in plant responses to iron deficiency. Plant J 34(5):685-695. PMID:12787249
  • Vozzi G, Flaim C, Ahluwalia A, Bhatia SN. 2003. Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials 24(14):2533-2540. PMID:12695080
  • Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK. 2003. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A 100(11):6712-6717. PMID:12740443
  • Yueh MF, Huang Y, Hiller A, Chen S, Nguyen N, Tukey RH. 2003. Involvement of the xenobiotic response element (XRE) in ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem 278(17):15001-15006. PMID:12566446
  • Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu Y, Kao WW, Karin M, Xia Y. 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J 22(17):4443-4454. doi:10.1093/emboj/cdg440 PMID:12941696 PMCID:PMC202382
  • Zhang M, Sell S, Leffert HL. 2003. Hepatic progenitor cell lines from allyl alcohol-treated adult rats are derived from gamma-irradiated mouse STO cells. Stem Cells 21(4):449-458. PMID:12832698


  • Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. 2002. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biologiacal applications. J Am Chem Soc 124(21):6063-76. PMID:12022841
  • Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee Y, Ricote M, Glass CK, Brewer HB, Gonzalez FJ. 2002. Conditional disruption of the PPARg gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 22(8):2607-2619. PMID:11909955
  • Allen GJ, Murata Y, Chu SP, Nafisi M, Schroeder JI. 2002. Hypersensitivity of abscisic acid-induced cytosolic calcium increases in the Arabidopsis farnesyltransferase mutant era1-2. Plant Cell 14(7):1649-1662. PMID:12119381 PMCID:PMC150713
  • Beachy R, Bennetzen JL, Chassy BM, Chrispeels M, Chory J, Ecker JR, Noel JP, Kay SA, Dean C, Lamb C, Jones J, Santerre CR, Schroeder JI, Umen J, Yanofsky M, Wessler S, Zhao Y, Parrott W. 2002. Divergent perspectives on GM food. Nat Biotechnol 20(12):1195-1196. PMID:12454665
  • Corbo JC, Deuel TA, Long JM, LaPorte P, Tsai E, Wynshaw-Boris A, Walsh CA. 2002. Double cortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci 22(17):7548-7557. PMID:12196578
  • Cunard R, DiCampli D, Archer DC, Stevenson JL, Ricote M, Glass CK, Kelly CJ. 2002. WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo. J Immunol 169(12):6806-6812. PMID:12471112
  • Cunard R, Ricote M, DiCampli D, Archer DC, Kahn DA, Glass CK, Kelly CJ. 2002. Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J Immunol 168(6):2795-2802. PMID:11884448
  • Cunin F, Schmedake T, Link JR, Li YY, Koh J, Bhatia SN, Sailor MJ. 2002. Biomolecular screening with encoded porous-silicon photonic crystals. Nat Mater 1(1):39-41. doi:10.1038/nmat702 PMID:12618846
  • Francis CM, Tebo BM. 2002. Enzymatic manganese(II) oxidation by metabolically dormant spores of diverse Bacillus species. Appl Environ Microbiol 68(2):874-880. PMID:11823231 PMCID:PMC126666
  • Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. 2002. A central role for JNK in obesity and insulin resistance. Nature 420(6913):333-336. PMID:12447443
  • Huang Y, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH. 2002. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenet Genomics 12(4):287-297. PMID:12042666
  • Kuchitsu K, Ward JM, Allen GJ, Schelle I, Schroeder JI. 2002. Loading acetoxymethyl ester fluorescent dyes into the cytoplasam of Arabidopsis and Commelina guard cells. New Phytologist 153:527-533.
  • Lee DA, Schroeder JI. 2002. Heavy metal stress. In: Arabidopsis - A Laboratory Manual. Cold Spring Harbor Laboratory Press, pp.75-77.
  • Liu VA, Bhatia SN. 2002. Three-dimensional photopatterning of hydrogels containing living cells. Biomed Microdevices 4(4):257-66.
  • Liu VA, Jastromb WE, Bhatia SN. 2002. Engineering protein and cell adhesivity using PEO-terminated triblock polymers. J Biomed Mater Res 60(1):126-134. doi:10.1002/jbm.10005 PMID:11835168
  • Maser P, Eckelman B, Vaidyanathan R, Horie T, Fairbairn DJ, Kubo M, Yamagami M, Yamaguchi K, Nishimura M, Uozumi N, Robertson W, Sussman MR, Schroeder JI. 2002. Altered shoot/root Na+ distribution and bifurcating salt sensitivity in Arabidopsis by genetic disruption of the Na+ transporter AtHKT1. FEBS Lett 531(2):157-161. PMID:12417304
  • Maser P, Hosoo Y, Goshima S, Horie T, Eckelman B, Yamada K, Yoshida K, Bakker EP, Shinmyo A, Oiki S, Schroeder JI, Uozumi N. 2002. Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants. Proc Natl Acad Sci U S A 99(9):6428-6433. PMID:11959905
  • Obraztsova AY, Francis CM, Tebo BM. 2002. Sulfur disproportionation by the facultative anaerobe Pantoea agglomerans SP1 as a mechanism for chromium(VI) reduction. Geomicrobiol J 19(1):121-132.
  • Park JM, Greten FR, Li Z, Karin M. 2002. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297(5589):2048-2051. PMID:12202685
  • Shi J, Radic Z, Taylor PW. 2002. Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase. J Biol Chem 277(45):43301-43308. doi:10.1074/jbc.M204391200 PMID:12196517
  • Wang Y, Schachter H, Marth JD. 2002. Mice with a homozygous deletion of the Mgat2 gene encoding UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II: a model for congenital disorder of glycosylation type IIa. Biochim Biophys Acta 1573(3):301-311. PMID:12417412
  • Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass CK. 2002. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem 277(45):42821-42829. PMID:12215441
  • Yin L, Sun M, Ilic Z, Leffert HL, Sell S. 2002. Derivation, characterization, and phenotypic variation of hepatic progenitor cell lines isolated from adult rats. Hepatology 35(2):315-324. PMID:11826404
  • Oksman-Caldentey KM, Bartz MH, eds. 2002. Molecular mechanisms that control plant tolerances to heavy metals and possible roles in manipulating metal accumulation. In: Plant Biotechnology and Transgenic Plants, New York. Marcel Kekker, Inc., New York, NY. pp.665-691.


  • Allen JW, Hassanein T, Bhatia SN. 2001. Advances in bioartificial liver devices. Hepatology 34(3):447-455. PMID:11526528
  • Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson RS, Schmidt EV, Karin M. 2001. IKK± provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107:763-775. PMID:11747812
  • Chen BP, Li Y, Zhao Y, Chen K, Li S, Lao J, Yuan S, Shyy JY, Chien S. 2001. DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics 7(1):55-65. PMID:11595792
  • Chin V, Collins BE, Sailor MJ, Bhatia SN. 2001. Compatibility of primary hepatocytes on nanoporous silicon. Advanced Materials 13(24):1877-1880.
  • Clemens S, Schroeder JI, Degenkolb T. 2001. Caenorhabditis elegans express a functional phytochelatin synthase. FEBS J 268(13):3640-3643.
  • Fabregat I, Koch KS, Aoki T, Atkinson AE, Dang H, Amosova O, Fresco JR, Schildkraut CL, Leffert HL. 2001. Functional pleiotropy of an intramolecular triplex-forming fragment from the 3'UTR of the rat Pigr gene. Physiol Genomics 5(2):53-65. PMID:11242589
  • Francis CM, Co E, Tebo BM. 2001. Enzymatic manganese(II) oxidation by a marine alpha-proteobacterium. Appl Environ Microbiol 67(9):4024-4029. PMID:11526000 PMCID:PMC93124
  • Ghassemian M, Waner DA, Tchieu J, Gribskov M, Schroeder JI. 2001. An integrated Arabidopsis annotation database for Affymetrix Genechip data analysis, and tools for regulatory motif searches. Trends Plant Sci 6(10):448-449. PMID:11590042
  • Glass CK. 2001. Potential roles of the peroxisome proliferator-activated receptor-g in macrophage biology and atherosclerosis. Journal of Endocrinology 169:461-464. PMID:11375116
  • Glass CK, Witzum JL. 2001. Atherosclerosis, the road ahead. Cell 104:503-516. PMID:11239408
  • LaCombe B, Becker D, Hedrich R, DeSalle R, Hollman M, Kwak JM, Schroeder JI, Le Novere N, Nam HG, Spalding EP, Tester M, Turano FJ, Chiu J, Coruzzi G. 2001. The identity of plant glutamate receptors. Science 292:1486-1487. PMID:11379626
  • Murata T, Kurokawa R, Krones A, Tatsumi K, Ishii M, Taki T, Masuno M, Ohashi H, Yanagisawa M, Rosenfeld MG, Glass CK, Hayashi Y. 2001. Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi Syndrome. Hum Mol Genet 10(10):1071-1076. PMID:11331617
  • Murata Y, Pei Z, Mori IC, Schroeder JI. 2001. ABA activation of plasma membrane Ca2+ channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in the abi1-1 and abi2-1 PP2C mutants. Plant Cell 13:2513-2523.
  • Rosenfeld MG, Glass CK. 2001. Coregulator codes of transcriptional regulation by nuclear receptors. J Biol Chem 276:36865-36868. PMID:11459854
  • Schroeder JI, Kwak JM, Allen GJ. 2001. Guard cell abscisic acid signalling and engineering drought hardiness in plants. Nature 410:327-330. PMID:11268200
  • Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun S, Karin M. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495-1499. doi:10.1126/science.1062677 PMID:11520989
  • Straus DS, Glass CK. 2001. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21(3):185-210. PMID:11301410
  • Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. 2001. Inhibition of JNK activation by NF-kB target genes. Nature 414(6861):313-317. PMID:11713531
  • Wang Y, Tan J, Sutton-Smith M, Ditto D, Panico M, Campbell RM, Varki NM, Long JM, Jaeken J, Levinson SR, Wynshaw-Boris A, Morris HR, Le D, Dell A, Schachter H, Marth JD. 2001. Modeling human congenital disorder of glycosylation type Iia in the mouse: conservation of asparagines-linked slycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology 11(12):1051-1070. PMID:11805078
  • Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH. 2001. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis 22(6):943-950. PMID:11375903


  • Behnia K, Bhatia SN, Jastromb N, Balis U, Sullivan S, Yarmush M, Toner M. 2000. Xenobiotic metabolism by cultured primary porcine hepatocytes. Tissue Engineering Part A 6(5):467-479. PMID:11074934
  • Gross LA, Baird GS, Hoffman RC, Baldridge KK, Tsien RY. 2000. The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A 97(22):11990-11995. PMID:11050230
  • Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. 2000. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 275(46):36062-36066. doi:10.1074/jbc.M007204200 PMID:10967126
  • Kelner MJ, Bagnell RD, Montoya MA, Estes LA, Forsberg L, Morgenstern R. 2000. Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p131-132 Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. J Biol Chem 275(17):13000-13006. PMID:10777602
  • Pei Z, Murata Y, Benning G, Thomine S, Klusener B, Allen GJ, Grill E, Schroeder JI. 2000. Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells. Nature 406:731-734. PMID:10963598
  • Ricote M, Welch JS, Glass CK. 2000. Regulation of macrophage gene expression bythe peroxisome proliferator-actived receptor-gamma. Horm Res 54:275-280. PMID:11595817
  • Thomine S, Wang R, Ward JM, Crawford NM, Schroeder JI. 2000. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A 97(9):4991-4996. PMID:10781110


  • Balis U, Behnia K, Dwarakanath B, Bhatia SN, Sullivan S, Yarmush M, Toner M. 1999. Oxygen consumption characteristics of porcine hepatocytes. Metab Eng 1(1):49-62. PMID:10935754
  • Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Effect of cell-cell interactions in preservation of cellular phenotype: co-cultivation of hepatocytes and non-parenchymal cells. FASEB J 13(14):1883-1900. PMID:10544172
  • Bhatia SN, Chen CS. 1999. Tissue engineering at the micro-scale. Biomed Microdevices 2(2):131-144.
  • Clemens S, Kim EJ, Neumann D, Schroeder JI. 1999. Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast. EMBO J 18(12):3325-3333. PMID:10369673
  • Ledezma GA, Folch A, Bhatia SN, Balis U, Yarmush M, Toner M. 1999. Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes. J Biomech Eng 121(1):58-64. PMID:10080090


  • Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions. Biotechnol Prog 14(3):378-387. PMID:9622518
  • Bhatia SN, Balis U, Yarmush M, Toner M. 1998. Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. Journal of Biomaterials Science, Polymer Edition 9(11):1137-1160. PMID:9860177


  • Bhatia SN, Yarmush M, Toner M. 1997. Controling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts. J Biomed Mater Res 34(2):189-199. PMID:9029299


  • Bhatia SN, Toner M, Foy BD, Rotem A, Tompkins R, Yarmush M. 1996. Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes. Journal of Cellular Engineering 1:125-135.


  • Hee Lee J, Cho U, Karin M. 1989. Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata. Sci Signal 37(2):303-308. PMID:2727309
to Top