Superfund Research Program

Cholinesterase Inhibition as a Target of Pesticide Residues and the Effect of Cholinergic Intervention on Gene Expression

Project Leader: Palmer W. Taylor
Grant Number: P42ES010337
Funding Period: 2000-2010

Project-Specific Links

Publications

2012

• De Jaco A, Comoletti D, Dubin N, Camp S, Taylor PW. 2012. Processing of cholinesterase-like alpha/beta-hydrolase fold proteins: alterations associated with congenital disorders. Protein Pept Lett 19:173-179. PMID:21933121 PMCID:PMC4755491

2011

• Bernard V, Girard E, Hrabovska A, Camp S, Taylor PW, Plaud B, Krejci E. 2011. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Mol Cell Neurosci 46(1):272-281. doi:10.1016/j.mcn.2010.09.010 PMID:20883790 PMCID:PMC4755503
• Miller MT, Mileni M, Comoletti D, Stevens RC, Harel M, Taylor PW. 2011. The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure 19(6):767-778. doi:10.1016/j.str.2011.03.011 PMID:21620717 PMCID:PMC3279696
• Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih P, Rao F, O'Connor DT, Taylor PW. 2011. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther 338(1):125-133. doi:10.1124/jpet.111.180091 PMID:21493754 PMCID:PMC3126649

2010

• Comoletti D, Miller MT, Jeffries CM, Wilson J, Demeler B, Taylor PW, Trewhella J, Nakagawa T. 2010. The macromolecular architecture of extracellular domain of alpha NRXN1: Domain organization, flexibility, and insights into trans-synaptic disposition. Structure 18(8):1044-1053. doi:10.1016/j.str.2010.06.005 PMID:20696403 PMCID:PMC2948785
• De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman MH, Butko MT, Tsien RY, Taylor PW. 2010. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. J Biol Chem 285:28674-28682. doi:10.1074/jbc.M110.139519 PMID:20615874 PMCID:PMC2937894
• Leone P, Comoletti D, Ferracci G, Conrod S, Garcia S, Taylor PW, Bourne P, Bourne Y, Marchot P. 2010. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J 29:2461-2471. doi:10.1038/emboj.2010.123 PMID:20543817 PMCID:PMC2910273
• Wang X, Lee J, Di Jeso B, Treglia A, Comoletti D, Dubi N, Taylor PW, Arvan P. 2010. Cis and trans actions of the cholinesterase-like domain within the thyroglobulin dimer. J Biol Chem 285(23):17564-17573. doi:10.1074/jbc.M110.111641 PMID:20353937 PMCID:PMC2878521

2009

• Taylor PW, Boudinot E, Bernard V, Camp S, Champagnat J, Krejci E, Foutz AS. 2009. Influence of differential expression of acetylcholinesterase in brain and muscle on respiration. Respir Physiol Neurobiol 165(1):40-48. doi:10.1016/j.resp.2008.10.003 PMID:18977317 PMCID:PMC2706911
• Taylor PW, Dobbertin A, Hrabovska A, Dembele K, Camp S, Krejci E, Bernard V. 2009. Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit. J Neurosci 29(14):4519-4530. doi:10.1523/JNEUROSCI.3863-08.2009 PMID:19357277 PMCID:PMC2695489

2008

• Camp S, De Jaco A, Zhang L, Marquez M, de la Torre B, Taylor PW. 2008. Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intron. J Neurosci 28(10):2459-2470. doi:10.1523/JNEUROSCI.4600-07.2008 PMID:18322091 PMCID:PMC2692871
• Comoletti D, Grishaev A, Whitten A, Taylor PW, Trewhella J. 2008. Characterization of the solution structure of a neuroligin/beta-neurexin complex. Chem Biol Interact 175(1-3):150-155. doi:10.1016/j.cbi.2008.04.040 PMID:18550038 PMCID:PMC2587492

2007

• Comoletti D, Grishaev A, Whitten A, Tsigelny I, Taylor PW, Trewhella J. 2007. Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering. Structure 15(6):693-705. doi:10.1016/j.str.2007.04.010 PMID:17562316 PMCID:PMC2677967

2006

• Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Sudhof TC, Taylor PW. 2006. Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry 45(42):12816-12827. PMID:17042500
• De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor PW. 2006. A mutation linked with autism reveals a common mechanism of endoplasmic retic a, B-beta-hydrolase fold protein family. J Biol Chem 281(14):9667-9676. PMID:16434405

2004

• Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor PW. 2004. Structural characterization of recombinant soluble rat neuroligin 1: Mapping of secondary structure and glycosylation by mass spectrometry. Biochemistry 43(6):1496-1506. PMID:14769026

2003

• Gong J, Lee DA, Schroeder JI. 2003. Long-distance root-to-shoot transport of phytochelatins and cadmium in Arabidopsis. Proc Natl Acad Sci U S A 100(17):10118-10123. PMID:12909714
• Jennings LL, Malecki M, Komives EA, Taylor PW. 2003. Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry. Biochemistry 42(37):11083-11091. PMID:12974645
• Lahner B, Gong J, Mahmoudian M, Smith EL, Abid KB, Rogers EE, Guerinot ML, Harper JF, Ward JM, McIntyre L, Schroeder JI, Salt DE. 2003. Genomic scale profiling of nutrient and trace elements in Arabidopsis thaliana. Nat Biotechnol 21(10):1215-1221. PMID:12949535
• Lee DA, Chen A, Schroeder JI. 2003. Ars1, an Arabidopsis mutant exhibiting increased tolerance to arsenate and increased phosphate uptake. Plant J 35(5):637-646. PMID:12940956
• Maier T, Yu C, Kullertz G, Clemens S. 2003. Localization and functional characterization of metal-binding sites in phytochelatin synthases. Planta 218(2):300-308. PMID:12905027
• Schroeder JI. 2003. Knockout of the guard cell K+ out channel and stomatal movements. Proc Natl Acad Sci U S A 100(9):4976-4977. PMID:12704226
• Shi J, Tai K, McCammon JA, Taylor PW, Johnson DA. 2003. Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop. J Biol Chem 278(33):30905-30911. PMID:12759360
• Thomine S, Lelievre F, Debarbieux E, Schroeder JI, Barbier-Brygoo H. 2003. AtNRAMP3, a multispecific vacuolar metal transporter involved in plant responses to iron deficiency. Plant J 34(5):685-695. PMID:12787249

2002

• Allen GJ, Murata Y, Chu SP, Nafisi M, Schroeder JI. 2002. Hypersensitivity of abscisic acid-induced cytosolic calcium increases in the Arabidopsis farnesyltransferase mutant era1-2. Plant Cell 14(7):1649-1662. PMID:12119381 PMCID:PMC150713
• Beachy R, Bennetzen JL, Chassy BM, Chrispeels M, Chory J, Ecker JR, Noel JP, Kay SA, Dean C, Lamb C, Jones J, Santerre CR, Schroeder JI, Umen J, Yanofsky M, Wessler S, Zhao Y, Parrott W. 2002. Divergent perspectives on GM food. Nat Biotechnol 20(12):1195-1196. PMID:12454665
• Kuchitsu K, Ward JM, Allen GJ, Schelle I, Schroeder JI. 2002. Loading acetoxymethyl ester fluorescent dyes into the cytoplasam of Arabidopsis and Commelina guard cells. New Phytologist 153:527-533.
• Maser P, Eckelman B, Vaidyanathan R, Horie T, Fairbairn DJ, Kubo M, Yamagami M, Yamaguchi K, Nishimura M, Uozumi N, Robertson W, Sussman MR, Schroeder JI. 2002. Altered shoot/root Na+ distribution and bifurcating salt sensitivity in Arabidopsis by genetic disruption of the Na+ transporter AtHKT1. FEBS Lett 531(2):157-161. PMID:12417304
• Maser P, Hosoo Y, Goshima S, Horie T, Eckelman B, Yamada K, Yoshida K, Bakker EP, Shinmyo A, Oiki S, Schroeder JI, Uozumi N. 2002. Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants. Proc Natl Acad Sci U S A 99(9):6428-6433. PMID:11959905
• Shi J, Radic Z, Taylor PW. 2002. Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase. J Biol Chem 277(45):43301-43308. doi:10.1074/jbc.M204391200 PMID:12196517
• Oksman-Caldentey KM, Bartz MH, eds. 2002. Molecular mechanisms that control plant tolerances to heavy metals and possible roles in manipulating metal accumulation. In: Plant Biotechnology and Transgenic Plants, New York. Marcel Kekker, Inc., New York, NY. pp.665-691.

2001

• Clemens S, Schroeder JI, Degenkolb T. 2001. Caenorhabditis elegans express a functional phytochelatin synthase. FEBS J 268(13):3640-3643.
• Ghassemian M, Waner DA, Tchieu J, Gribskov M, Schroeder JI. 2001. An integrated Arabidopsis annotation database for Affymetrix Genechip data analysis, and tools for regulatory motif searches. Trends Plant Sci 6(10):448-449. PMID:11590042
• LaCombe B, Becker D, Hedrich R, DeSalle R, Hollman M, Kwak JM, Schroeder JI, Le Novere N, Nam HG, Spalding EP, Tester M, Turano FJ, Chiu J, Coruzzi G. 2001. The identity of plant glutamate receptors. Science 292:1486-1487. PMID:11379626
• Schroeder JI, Kwak JM, Allen GJ. 2001. Guard cell abscisic acid signalling and engineering drought hardiness in plants. Nature 410:327-330. PMID:11268200

2000

• Pei Z, Murata Y, Benning G, Thomine S, Klusener B, Allen GJ, Grill E, Schroeder JI. 2000. Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells. Nature 406:731-734. PMID:10963598
• Thomine S, Wang R, Ward JM, Crawford NM, Schroeder JI. 2000. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A 97(9):4991-4996. PMID:10781110

1999

• Clemens S, Kim EJ, Neumann D, Schroeder JI. 1999. Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast. EMBO J 18(12):3325-3333. PMID:10369673