Superfund Research Program

Toxicogenomic Analysis of Nuclear Xenobiotic Receptors

Project Leader: Ronald M. Evans (Salk Institute for Biological Studies)
Grant Number: P42ES010337
Funding Period: 2005-2017

Project-Specific Links

Publications

2017

• Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
• Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi H, Kang SG, Lee SE, Kim SJ, Kweon GR, Kim H, Lee C, Lee S, Wall CE, Downes M, Evans RM, Choi MJ, Jung S, Ryu MJ, Hwang JH, Auwerx J, Shong M. 2017. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol 216(1):149-165. doi:10.1083/jcb.201607110 PMID:27986797 PMCID:PMC5223607
• De Magalhaes Filho CD, Downes M, Evans RM. 2017. Farnesoid X receptor an emerging target to combat obesity. Dig Dis 35(3):185-190. doi:10.1159/000450909 PMID:28249279
• Doktorova M, Zwarts I, van Zutphen T, van Dijk TH, Bloks VW, Harkema L, de Bruin A, Downes M, Evans RM, Verkade HJ, Jonker JW. 2017. Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep 7:846. doi:10.1038/s41598-017-00889-z PMID:28404991
• Fan W, Evans RM. 2017. Exercise mimetics: impact on health and performance. Cell Metab 25(2):242-247. doi:10.1016/j.cmet.2016.10.022 PMID:27889389
• Fan W, Waizenegger W, Lin CS, Sorrentino V, He M, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM. 2017. PPARdelta promotes running endurance by preserving glucose. Cell Metab 25:1186-1193.e4. doi:10.1016/j.cmet.2017.04.006 PMID:28467934 PMCID:PMC549297
• Gasser E, Moutos CP, Downes M, Evans RM. 2017. FGF1-a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol 13(10):599-609. doi:10.1038/nrendo.2017.78 PMID:28664920 PMCID:PMC5839646
• Goetz A, Wilkinson MF. 2017. Stress and the nonsense-mediated RNA decay pathway. Cellular and Molecular Life Sciences 74(19):3509-3531. doi:10.1007/s00018-017-2537-6 PMID:28503708 PMCID:PMC568394
• Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM. 2017. Stromal cues regulate the pancreatic cancer epigenome and metabolome. Proc Natl Acad Sci U S A 114(5):1129-1134. doi:10.1073/pnas.1620164114 PMID:28096419 PMCID:PMC5293019
• Wu C, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. 2017. Structural basis for specific ligation of the peroxisome proliferater-activated receptor delta. Proc Natl Acad Sci U S A 114:13:E2563-2570. doi:10.1073/pnas.1621513114 PMID:28320959 PMCID:PMC5380080

2016

• Booth DR, Ding N, Parnell GP, Shahijanian F, Coulter S, Schibeci D, Atkins AR, Stewart GJ, Evans RM, Downes M, Liddle C. 2016. Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases. Genes Immun 17(4):213-219. doi:10.1038/gene.2016.12 PMID:26986782 PMCID:PMC4895389
• Liu W, Struik D, Nies VJ, Jurdzinski A, Harkema L, de Bruin A, Verkade HJ, Downes M, Evans RM, van Zutephen T, Jonker JW. 2016. Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 113(8):2288-2293. doi:10.1073/pnas.1525093113 PMID:26858440 PMCID:PMC4776526
• Wall CE, Yu RT, Atkins AR, Downes M, Evans RM. 2016. Nuclear receptors and AMPK: can exercise mimetics cure diabetes?. J Mol Endocrinol 57(1):R49-R58. doi:10.1530/JME-16-0073 PMID:27106806 PMCID:PMC4929025
• Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng TW, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. 2016. ERRγ is required for the metabolic maturation of therapeutically functional glucose-responsive β cells. Cell Metab 23(4):622-634. doi:10.1016/j.cmet.2016.03.005 PMID:27076077 PMCID:PMC4832237

2015

• Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. 2015. Calcipotriol targets LRP6 to inhibit Wnt signaling in pancreatic cancer. Mol Cancer Res 13(11):1509-1519. doi:10.1158/1541-7786.MCR-15-0204 PMID:26224368 PMCID:PMC4644680
• Bapat SP, Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, Leblanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528(7580):137-141. doi:10.1038/nature16151 PMID:26580014 PMCID:PMC4670283
• Ding N, Hah N, Yu RT, Sherman MH, Benner CW, Leblanc M, He M, Liddle C, Downes M, Evans RM. 2015. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A 112(51):15713-15718. doi:10.1073/pnas.1522163112 PMID:26644586 PMCID:PMC4697417
• Fan W, Evans RM. 2015. PPARs and ERRs: molecular mediators of mitochondrial metabolism. Curr Opin Cell Biol 33:49-54. doi:10.1016/j.ceb.2014.11.002 PMID:25486445 PMCID:PMC4380823
• Fang S, Suh J, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky J, Saltiel AR, Downes M, Evans RM. 2015. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 21(2):159-165. doi:10.1038/nm.3760 PMID:25559344 PMCID:PMC4320010
• Hah N, Benner CW, Chong L, Yu RT, Downes M, Evans RM. 2015. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A 112(3):E297-E302. doi:10.1073/pnas.1424028112 PMID:25564661 PMCID:PMC4311831
• Ranjit S, Dvornikov A, Hong S, Levi M, Evans RM, Gratton E, Stakic M. 2015. Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging. Sci Rep 5:13378. doi:10.1038/srep13378 PMID:26293987 PMCID:PMC4543938
• Suh J, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin Y, Yu RT, Liddle C, Atkins AR, Olefsky J, Mohammadi M, Downes M, Evans RM. 2015. Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 520(7547):388. doi:10.1038/nature14304 PMID:25739500 PMCID:PMC4184286

2014

• d'Uscio LV, He T, Santhanam AR, Tai L, Evans RM, Katusic ZS. 2014. Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene. Am J Physiol Heart Circ Physiol 306(7):H1001-H1010. doi:10.1152/ajpheart.00761.2013 PMID:24486511 PMCID:PMC3962632
• Evans RM, Mangelsdorf DJ. 2014. Nuclear receptors, RXR, and the Big Bang. Cell 157(1):255-266. doi:10.1016/j.cell.2014.03.012 PMID:24679540 PMCID:PMC4029515
• Hong S, Ahmadian M, Yu RT, Atkins AR, Downes M, Evans RM. 2014. Nuclear receptors and metabolism: from feast to famine. Diabetologia 57(5):860-867. doi:10.1007/s00125-014-3209-9 PMID:24619218 PMCID:PMC3980036
• Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. 2014. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159(1):80-93. doi:10.1016/j.cell.2014.08.007 PMID:25259922 PMCID:PMC4177038
• Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592
• Zhao X, Cho H, Yu RT, Atkins AR, Downes M, Evans RM. 2014. Nuclear receptors rock around the clock. EMBO J 15(5):518-528. doi:10.1002/embr.201338271 PMID:24737872 PMCID:PMC4210094

2013

• Ahmadian M, Suh J, Hah N, Liddle C, Atkins AR, Downes M, Evans RM. 2013. PPAR gamma signaling and metabolism: the good, the bad and the future. Nat Med 19:557-566. doi:10.1038/nm.3159 PMID:23652116 PMCID:PMC3870016
• Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM. 2013. A vitamin D receptor / SMAD genomic circuit gates hepatic fibrotic response. Cell 153(3):601-613. doi:10.1016/j.cell.2013.03.028 PMID:23622244 PMCID:PMC3673534
• Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP. 2013. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci U S A 110:8555-8560. doi:10.1073/pnas.1306182110 PMID:23653479 PMCID:PMC3666748
• Fan W, Atkins AR, Yu RT, Downes M, Evans RM. 2013. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol 51(3):T87-T100. doi:10.1530/JME-13-0258 PMID:24280961 PMCID:PMC3936671
• Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W. 2013. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. Pharm Res 30(9):2199-2208. doi:10.1007/s11095-013-1101-9 PMID:23896737 PMCID:PMC3771640
• Uhlenhaut N, Barish GD, Yu RT, Downes M, Karunasiri M, Liddle C, Schwalie P, Hubner N, Evans RM. 2013. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell 49(1):158-171. doi:10.1016/j.molcel.2012.10.013 PMID:23159735 PMCID:PMC3640846

2012

• Chen S, Yueh MF, Evans RM, Tukey RH. 2012. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT 1 mice. Hepatology 56(2):658-667. doi:10.1002/hep.25671 PMID:22371261 PMCID:PMC3383890
• Jonker JW, Liddle C, Downes M. 2012. FXR and PXR: Potential therapeutic targets in cholestasis. Psychiatr Pol 130(3-5):147-158. doi:10.1016/j.jsbmb.2011.06.012 PMID:21801835 PMCID:PMC4750880
• Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. 2012. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets 16(11):1075-1083. doi:10.1517/14728222.2012.715634 PMID:22913318 PMCID:PMC4319648
• Noreault-Conti TL, Fellows A, Jacobs JM, Trask HW, Strom S, Evans RM, Wrighton SA, Sinclair PR, Sinclair JF, Nichols RC. 2012. Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol 12(4):651-60. doi:10.1016/j.intimp.2012.01.008 PMID:22310326 PMCID:PMC3345897

2011

• Kacevska M, Downes M, Sharma R, Evans RM, Clarke SJ, Liddle C, Robertson GR. 2011. Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. Clin Cancer Res 17:3170-3180. doi:10.1158/1078-0432.ccr-10-3289 PMID:21498392 PMCID:PMC3096719

2009

• Vashisht AA, Kennedy PJ, Russell P. 2009. Centaurin-like protein Cnt5 contributes to arsenic and cadmium resistance in fission yeast. FEMS Yeast Res 9:257-69. PMID:19076239 PMCID:PMC2820371

2007

• Sonoda J, Mehl IR, Chong L, Nofsinger RR, Evans RM. 2007. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Chapter 104(12)in: Proceedings of the NAS (National Academy of Sciences) USA, 2007. pp.5223-8.