Superfund Research Program

DNA Microarray Technology

Project Leader: Shu Chien
Grant Number: P42ES010337
Funding Period: 2000 - 2005

Project-Specific Links

Publications

2004

• Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo JA, Johnson RS, Maeda S, Karin M, Guengerich FP, Tukey RH. 2004. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem 279(23):23969-23976. PMID:15037607
• Hsu L, Park JM, Zhang K, Luo J, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428(6980):341-345. PMID:15029200
• Shen H, Lin Y, Choksi S, Tran JH, Jin T, Chang L, Karin M, Zhang J, Liu Z. 2004. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 24(13):5914-22. PMID:15199146

2003

• Chen F, Castranova V, Li Z, Karin M, Shi X. 2003. Inhibitor of nuclear factor kappa B kinase deficiency enhances oxidative stress and prolongs c-jun NH2-terminal kinase activation induced by arsenic. Cancer Res 63(22):7689-7693. PMID:14633691
• Chen L, Egan LJ, Li Z, Kagnoff MF, Karin M. 2003. The two faces of IKK and NF-kappa B inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-581. PMID:12692538
• Li Z, Omori SA, Labuda T, Karin M, Rickert RC. 2003. IKK beta is required for peripheral B cell survival and proliferation. J Immunol 170(9):4630-4637. PMID:12707341
• Maeda S, Chang L, Li Z, Luo J, Leffert HL, Karin M. 2003. IKK beta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNF alpha. Immunity 19(5):725-737. PMID:14614859
• Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK. 2003. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A 100(11):6712-6717. PMID:12740443
• Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu Y, Kao WW, Karin M, Xia Y. 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J 22(17):4443-4454. doi:10.1093/emboj/cdg440 PMID:12941696 PMCID:PMC202382

2002

• Corbo JC, Deuel TA, Long JM, LaPorte P, Tsai E, Wynshaw-Boris A, Walsh CA. 2002. Double cortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci 22(17):7548-7557. PMID:12196578
• Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. 2002. A central role for JNK in obesity and insulin resistance. Nature 420(6913):333-336. PMID:12447443
• Park JM, Greten FR, Li Z, Karin M. 2002. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297(5589):2048-2051. PMID:12202685

2001

• Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson RS, Schmidt EV, Karin M. 2001. IKK± provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107:763-775. PMID:11747812
• Chen BP, Li Y, Zhao Y, Chen K, Li S, Lao J, Yuan S, Shyy JY, Chien S. 2001. DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics 7(1):55-65. PMID:11595792
• Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. 2001. Inhibition of JNK activation by NF-kB target genes. Nature 414(6861):313-317. PMID:11713531
• Wang Y, Tan J, Sutton-Smith M, Ditto D, Panico M, Campbell RM, Varki NM, Long JM, Jaeken J, Levinson SR, Wynshaw-Boris A, Morris HR, Le D, Dell A, Schachter H, Marth JD. 2001. Modeling human congenital disorder of glycosylation type Iia in the mouse: conservation of asparagines-linked slycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology 11(12):1051-1070. PMID:11805078