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Your Environment. Your Health.

Program Publications: Oregon Health and Science University: Neurotoxic Superfund Chemicals and Biomarkers

Superfund Research Program

Neurotoxic Superfund Chemicals and Biomarkers

Center Director: Peter S. Spencer
Grant Number: P42ES010338
Funding Period: 2000-2006

Learn More About the Grantee

Visit the grantee's eNewsletter page



  • Shankar P, Geier MC, Truong L, McClure RS, Pande P, Waters KM, Tanguay RL. 2019. Coupling genome-wide transcriptomics and developmental toxicity profiles in zebrafish to characterize polycyclic aromatic hydrocarbon (PAH) hazard. Int J Mol Sci 20:2570. doi:10.3390/ijms20102570 PMID:31130617 PMCID:PMC6566387



  • Dziennis S, Yang, D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. 2008. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environ Health Perspect 116(4):474-80. PMID:18414629
  • Skinner AM, Turker MS. 2008. High frequency induction of CC to TT tandem mutations in DNA repair-proficient mammalian cells. Photochemistry and Photobiology 84(1):222-7. PMID:18173724
  • Zeng XY, Simonich SL, Robrock KR, Korytar P, Alvarez-Cohen L, Barofsky DF. 2008. Development and validation of a congener specific photodegradation model for PBDEs. Environ Toxicol Chem 27(12):2427-2435. PMID:18613751


  • Trimpin S, Deinzer ML. 2007. Solvent-free MALDI-MS for the analysis of a membrane protein via the mini ball mill approach: case study of bacteriorhodopsin. Anal Chem 79(1):71-78. PMID:17194123
  • Trimpin S, McEwen CN. 2007. Multisample preparation methods for the solvent-free MALDI-MS analysis of synthetic polymers. J Am Soc Mass Spectrom 18(3):377-81. PMID:17113783


  • Kisby GE, Olivas A, Standley M, Lu X, Pattee P, O'Malley JP, Li X, Muniz J, Nagalla SR. 2006. Genotoxicants target distinct molecular networks in neonatal neurons. Environ Health Perspect 114(11):1703-12. PMID:17107856
  • Vasilev YV, Figard BJ, Voinov VG, Barofsky DF, Deinzer ML. 2006. Resonant electron capture by some amino acids and their methyl esters. J Am Chem Soc 128(16):5506-15. PMID:16620124
  • Wang Q, Ponomareva ON, Lasarev MR, Turker MS. 2006. High frequency induction of mitotic recombination by ionizing radiation in Mlh1 null mouse cells. Mutat Res 594(1-2):189-198. PMID:16343558


  • Ennis EG, Reed RL, Dolan ME, Semprini L, Istok JD, Field JA. 2005. Reductive dechlorination of the vinyl chloride surrogate chlorofluoroethene in TCE-contaminated groundwater. Environ Sci Technol 39(17):6777-6785. PMID:16190239
  • Kisby GE, Standley M, Lu X, O'Malley JP, Lin B, Muniz J, Luo NL, Pattee P, Back SA, Nagalla SR. 2005. Molecular networks perturbed in a developmental animal model of brain injury. Neurobiol Dis 19(1-2):108-118. doi:10.1016/j.nbd.2004.11.014 PMID:15837566
  • LePage J, Hebert VR, Tomaszewska EM, Rothlein J, McCauley L. 2005. Determination of acephate in human urine. J AOAC Int 88(6):1788-1792. PMID:16526463
  • Rohlman D, Arcury TA, Quandt SA, Lasarev MR, Rothlein J, Travers R, Tamulinas A, Scherer J, Early J, Martin A, Phillips J, McCauley L. 2005. Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. Neurotoxicology 26(4):589-598. doi:10.1016/j.neuro.2004.12.002 PMID:16112324
  • Shin-Darlak CY, Skinner AM, Turker MS. 2005. A role for Pms2 in the prevention of tandem CC -> TT substitutions induced by ultraviolet radiation and oxidative stress. DNA Repair (Amst) 4(1):51-57. PMID:15533837
  • Trimpin S, Deinzer ML. 2005. Solvent-free MALDI-MS for the analysis of biological samples via a mini-ball mill approach. J Am Soc Mass Spectrom 16(4):542-547. PMID:15792723
  • Trimpin S, Deinzer ML. 2005. Techniques essay: solvent-free mass spectrometry for hydrophobic peptide sequence analysis and protein conformation studies. Biotechniques 39(6):799-805.
  • Tshala-Katumbay DD, Palmer VS, Kayton RJ, Sabri MI, Spencer PS. 2005. A new murine model of giant proximal axonopathy. Acta Neuropathol 109(4):405-410. PMID:15759132


  • Hageman KJ, Field JA, Istok JD, Semprini L. 2004. Quantifying the effects of fumarate on in situ reductive dechlorination rates. J Contam Hydrol 75(3-4):281-296. PMID:15610903
  • Kisby GE, Lam-Lesselroth H, Olivas A, Samson LD, Gold B, Tanaka K, Turker MS. 2004. Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death. DNA Repair (Amst) 3(6):617-627. PMID:15135729
  • Palmer VS, Tshala-Katumbay DD, Hashemi SB, Sabri MI, Spencer PS. 2004. Tetralin and metabolites: protein reactivity, chromogenicity and neurotoxicity. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Pon G, Semprini L. 2004. Anaerobic reductive dechlorination of 1-chloro-1-fluoroethene to track the transformation of vinyl chloride. Environ Sci Technol 38(24):6803-6808. PMID:15669342
  • Quadri SA, Doran AM, Rao P, Hoppin JA, Snively BM, Arcury TA. 2004. Reporting pesticide assessment results to farmworker families: development, implementation, and evaluation of a risk communication strategy. Environ Health Perspect 112(5):636-642. PMID:15064174
  • Thrall K, Woodstock AD. 2004. Evaluation of the dermal bioavailability of aqueous xylene in F344 rats and human volunteers. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Trimpin S, Mixon AE, Stapels MD, Kim M, Spencer PS, Deinzer ML. 2004. Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. Biochemistry 43(7):2091-2105. PMID:14967049
  • Tshala-Katumbay DD, Palmer VS, Dixon DA, Deinzer ML, Sabri MI, Spencer PS. 2004. Structural requirements for hydrocarbon axonopathy. J Neurochem 90:19-19Suppl.1.
  • Voinov VG, Vasilev YV, Ji H, Figard BJ, Morre JT, Egan TF, Barofsky DF, Deinzer ML. 2004. A gas chromatograph/resonant electron capture-TOF mass spectrometer for four dimensions of negative ion analytical information. Anal Chem 76(10):2951-2957. PMID:15144209
  • Zhan C, Spencer PS, Dixon DA. 2004. Chromogenic and neurotoxic effects of an aliphatic gamma-diketone: Computational insights into the molecular structures and mechanism. Journal of Physical Chemistry B 108(19):6098-6104.


  • Dixon DA, Zhan C. 2003. High performance computing, computational chemistry, and toxicology. In: Proceedings of the 226th ACS (American Chemical Society) National Meeting - Fall 2003. New York, NY. pp.028-TOXIPart1.
  • Dixon DA, Zhan C, Spencer PS, Sabri MI, Kim M. 2003. Theoretical determination of chromophores to determine the chromogenic effects of neurotoxicants. In: Proceedings of the 226th ACS (American Chemical Society) National Meeting - Fall 2003. New York, NY.
  • Hageman KJ, Field JA, Istok JD, Schroth MH. 2003. "Forced mass balance" technique for estimating in situ transformation rates of sorbing solutes in groundwater. Environ Sci Technol 37(17):3920-3925. PMID:12967114
  • Higgins G, Muniz J, McCauley L. 2003. Monitoring acetylcholinesterase levels in migrant agricultural workers and their children using a portable test kit. J Agric Saf Health 7(1):35-49. PMID:11398901
  • Hirata S, Zhan C, Apra E, Windus TL, Dixon DA. 2003. A new, self-contained asymptotic correction scheme to exchange-correlation potentials for time-dependent density functional theory. J Phys Chem A 107(47):10154-10158.
  • Kim M, Lasarev MR, Hashemi SB, Nagalla SR, Sabri MI, Spencer PS. 2003. Gene modulation patterns associated with aromatic y-diketones neurotoxicity. Environ Health Perspect 67:740.
  • Kisby GE, Standley M, Lu X, O'Malley JP, Muniz J, Luo NL, Back SA, Pattee P, Nagalla SR. 2003. Global gene expression perturbation by the genotoxin methylazoxymethanol (MAM) in the developing cerebral cortex and cerebellum of mice. Society for Neuroscience Abstracts 529.22.
  • Kisby GE, Standley M, Pattee P, O'Malley JP, Muniz J, Olivas A, Nagalla SR. 2003. Gene expression in methylazoxymethanol (MAM) treated cerebellar neurons is distinct when compared with other DNA damaging agents. Society for Neuroscience Abstracts 529.22.
  • Leonard JM, Bollman SR, Hays JB. 2003. Reduction of stability of arabidopsis genomic and transgenic DNA-repeat sequences (microsatellites) by inactivation of AtMSH2 mismatch-repair function. Plant Physiol 133(1):328-338. PMID:12970498
  • McCauley L, Michaels S, Rothlein J, Muniz J, Lasarev MR, Ebbert C. 2003. Pesticide exposure and self reported home hygiene: practices in agricultural families. American Association of Occupational Health Nurses Journal 51(3):113-119. PMID:12670098
  • McCauley L, Rohlman DS, Rothlein J, Weston S, Tamulinas A, Muniz J, Lasarev MR, Scherer J. 2003. Orgnophosphate pesticide exposure: neurobehavioral assessment of Latino adults and children residing in agricultural communities. In: Proceedings of the Annual NIEHS SBRP (National Institute of Environmental Health Sciences and Superfund Basic Research Program) Conference: Integration Perspectives: Interdisciplinary Research and Outreach within the NIEHS SBRP, November 9-12. Dartmouth College, Hanover, NH.
  • Murry MM, Thrall K, Kisby GE, Higgins G, Withers G, Wallace C. 2003. Combining biomarkers across disciplines to assess toxicant effects on neural development: The vinyl chloride metabolite chloroacetaldehyde (CAA) as a test case. In: Presented at the Superfund Basic Research Program (SBRP ) Annual Meeting, November 9-12, 2003. Dartmouth College, Hanover, NH.
  • Pon G, Hyman MR, Semprini L. 2003. Acetylene inhibition of trichloroethene and vinyl chloride reductive dechlorination. Environ Sci Technol 37(14):3181-3188. PMID:12901668
  • Pon G, Semprini L. 2003. The use of anaerobic reductive dechlorination of 1,1-cholro-fluoroethene to track the transformation of vinyl choloride. In: In Situ and On-site Bioremediation Seventh International Symposium, June 2-5. Orlando, FL.
  • Rohlman DS, Arcury TA, Quadri SA, Rothlein J, Traver RD, Early J, Phillips J, Marin A, Zavala A, Weston S, Tamulinas A, Scherer J, McCauley L. 2003. Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. In: Proceedings of the 21st International Neurotoxicology Conference: Infant and Child Neurotoxicity Studies: Subltle and Long-term Effects. Honolulu, HI.
  • Sabri MI, Hashemi SB, Spencer PS. 2003. Neurotoxicity and reactivity of 1,2-diacetylbenzene (1,2-DAB) with motor and cytoskeletal proteins in rat spinal cord and sciatic nerves. Toxicol Lett 144(Suppl.1):s130.
  • Thrall K. 2003. Dermal bioavailability of common solvents found at Superfund Sites. In: Presented at the Superfund Basic Research Program (SBRP ) Annual Meeting, November 9-12, 2003. Dartmouth College, Hanover, NH.
  • Thrall K, Weitz KK, Woodstock AD. 2003. Evaluation of the dermal absorption of common solvents. In: Presented at the NIOSH(National Institute for Occupational Safety and Health)-Sponsored Symposium: Working Partnerships, Applying Research to Practice, June 23-24. Arlinton, VA.
  • Thrall K, Woodstock AD. 2003. Evaluation of the dermal bioavailability of aqueous xylene in F344 rats and human volunteers. J Toxicol Environ Health A 66(13):1267-1281. PMID:12851123
  • Tshala-Katumbay DD, Palmer VS, Kayton RJ, Sabri MI, Spencer PS. 2003. Demonstration of murine neurotoxic responses to 1,2-diacetylbenzene preparatory to toxicogenomic characterization. Environ Health Perspect 67:357.
  • Voinov VG, Vasilev YV, Morre JT, Barofsky DF, Deinzer ML, Gonin M, Egan TF, Fuhrer K. 2003. A resonant electron capture time-of-flight MS with trochoidal electron monochromator. Anal Chem 75(13):3001-3009. PMID:12964744
  • Wallace C, Reitzenstein J, Withers G. 2003. Diminished experience-dependent neuroanatomical plasticity: evidence for an improved biomarker of subtle neurotoxic damage to the developing rat brain. Environ Health Perspect 111(10):1294-1298. PMID:12896849
  • Zhan C, Spencer PS, Dixon DA. 2003. Computational insights into the chemical structures and mechanisms of the chromogenic and neurotoxic effects of aromatic gamma-diketones. Journal of Physical Chemistry B 107(12):2853-2861.


  • Kim M, Spencer PS, Sabri MI. 2002. Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. Toxicol Appl Pharmacol 183(1):55-65. PMID:12217642
  • Kim M, Taylor MJ, Sabri MI, Spencer PS. 2002. In vivo reactivity of the axonal toxin 1,2-diacetylbenzene with neurofilament and microtubule proteins. Environ Health Perspect 66:15.
  • Sabri MI, Hashemi SB, Kim M, Spencer PS. 2002. Aromatic hydrocarbon 1,2-diacetylbenzene cross-links neurofilaments and other proteins. J Neurochem 81:103.
  • Sabri MI, Spencer PS. 2002. How does acrylamide perturb axon transport and induce nerve fiber degeneration? Commentary on forum position paper. Neurotoxicology 23(2):259-63;discussion265-70. PMID:12224766
  • Shin CY, Mellon I, Turker MS. 2002. Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells. Oncogene 21(11):1768-1776. PMID:11896608
  • Shin CY, Ponomareva ON, Connolly L, Turker MS. 2002. A mouse kidney cell line with a G:C --> C:G transversion mutator phenotype. Mutat Res 503(1-2):69-76. PMID:12052505
  • Shin CY, Turker MS. 2002. A:T --> G:C base pair substitutions occur at a higher rate than other substitution events in Pms2 deficient mouse cells. DNA Repair (Amst) 1(12):995-1001. PMID:12531009
  • Spencer PS, Kim M, Sabri MI. 2002. Aromatic as well as aliphatic hydrocarbon solvent axonopathy. Int J Hyg Environ Health 205(1-2):131-136. PMID:12018006
  • Thrall K, Gies RA, Muniz J, Woodstock AD, Higgins G. 2002. Route-of-entry and brain tissue partition coefficients for common Superfund contaminants. J Toxicol Environ Health A 65(24):2075-2086. PMID:12515587
  • Thrall K, Weitz KK, Woodstock AD. 2002. Use of real-time breath analysis and physiologically based pharmacokinetic modeling to evaluate dermal absorption of aqueous toluene in human volunteers. Toxicol Sci 68(2):280-287. PMID:12151623
  • Zhan C, Dixon DA. 2002. Electronic excitations in pyrrole: A test case for determination of chromophores in the chromogenic effects of neurotoxic hydrocarbons by time-dependent density functional theory and single-excitation configuration interaction methods. Journal of Molecular Spectroscopy 216(1):81-89.
  • Zhan C, Dixon DA, Spencer PS, Kim M, Sabri MI. 2002. Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants. J Am Chem Soc 124(11):2744-2752. PMID:11890826


  • Hageman KJ, Istok JD, Field JA, Buscheck TE, Semprini L. 2001. In situ anaerobic transformation of trichlorofluoroethene in trichloroethene-contaminated groundwater. Environ Sci Technol 35(9):1729-1735. PMID:11355185
  • Kim M, Sabri MI, Miller VH, Kayton RJ, Dixon DA, Spencer PS. 2001. 1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. Toxicol Appl Pharmacol 177(2):121-131. PMID:11740911
  • Kim M, Spencer PS. 2001. Protein reactivity of the neurotoxic metabolite (1,2-DAB) of the aromatic hydrocarbon solvent 1,2-diethylbenzene. Environ Health Perspect 60(1):366.
  • McCauley L, Lasarev MR, Higgins G, Rothlein J, Muniz J, Ebbert C, Phillips J. 2001. Work characteristics and pesticide exposures among migrant agricultural families: a community-based research approach. Environ Health Perspect 109:533-538. PMID:11401767


  • Sabri MI, Kim M, Spencer PS. 2000. The aromatic hydrocarbon 1,2-diacetylbenzene induces pathological changes in the rodent nervous system. Toxicol Lett 116(1):72.
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