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Your Environment. Your Health.

Program Publications: New York University School of Medicine: Carcinogenic Metals and Their Interactions With Other Toxicants (ARRA Funded)

Superfund Research Program

Carcinogenic Metals and Their Interactions With Other Toxicants (ARRA Funded)

Center Director: Max Costa
Grant Number: P42ES010344
Funding Period: 2000-2006 and 2009-2011

Publications

2018

2015

2014

2013

2012

2011

  • Cai T, Li X, Ding J, Luo W, Li J, Huang C. 2011. A cross-talk between NFAT and NF-κB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Curr Cancer Drug Targets 11(5):548-559. PMID:21486220 PMCID:PMC3759234 (Completed with ARRA Funds)
  • Farley KJ, Carbonaro RF, Fanelli CJ, Costanzo R, Rader KJ, Di Toro DM. 2011. TICKET-UWM: a coupled kinetic, equilibrium, and transport screening model for metals in lakes. Environ Toxicol Chem 30(6):1278-1287. doi:10.1002/etc.518 PMID:21381089 (Completed with ARRA Funds)
  • Guo W, Yang Z, Xia Q, Liu J, Yu Y, Li J, Zuo Z, Zhang D, Li X, Shi X, Huang C. 2011. Arsenite stabilizes HIF-1 alpha protein through p85 alpha-mediated up-regulation of inducible Hsp70 protein expression. Cellular and Molecular Life Sciences 68(3):475-488. doi:10.1007/s00018-010-0459-7 PMID:20835880 PMCID:PMC3758129 (Completed with ARRA Funds)
  • Hu L, Liu X, Chervona Y, Wang F, Tang M, Darzynkiewicz Z, Dai W. 2011. Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors. Cell Cycle 10:2373-2379. doi:10.4161/cc.10.14.16310 PMID:21670593 PMCID:PMC3230526 (Completed with ARRA Funds)
  • Kiok K, Sun H, Clancy HA, Bose S, Kluz T, Wu F, Costa M. 2011. Liprin-alpha4 is required for nickel induced receptor protein tyrosine phosphatase-leukocyte antigen related receptor F (RPTP-LAR) activity. PLoS One 6(8):doi:10.1371/journal.pone.0022764 PMID:21829649 PMCID:PMC3150438 (Completed with ARRA Funds)
  • Liu J, Zhang D, Luo W, Yu Y, Li J, Zhang X, Zhang B, Chen J, Wu X, Rosas-Acosta G, Huang C. 2011. X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton. J Biol Chem 286:15630-15640. doi:10.1074/jbc.M110.176982 PMID:21402697 PMCID:PMC3091172 (Completed with ARRA Funds)
  • Rahaman O, Estrada TP, Doren DJ, Taufer M, Brooks CL, Armen RS. 2011. Evaluation of several two-step scoring functions based on linear interaction energy, effective ligand size, and empirical pair potentials for prediction of protein-ligand binding geometry and free energy. J Chem Inf Model 52(9):2047-2065. doi:10.1021/ci1003009 PMID:21644546 PMCID:PMC3183351 (Completed with ARRA Funds)
  • Rahaman O, van Duin AC, Goddard WA, Doren DJ. 2011. Development of a ReaxFF reactive force field for glycine and application to solvent effect and tautomerization. Journal of Physical Chemistry B 115(2):249-261. doi:10.1021/jp108642r PMID:21166434 PMCID:PMC3042430 (Completed with ARRA Funds)
  • Roy NK, Walker N, Chambers RC, Wirgin II. 2011. Characterization and expression of cytochrome P4501A in Atlantic sturgeon and shortnose sturgeon experimentally exposed to coplanar PCB 126 and TCDD. Aquat Toxicol 102(1-2):23-31. doi:10.1016/j.aquatox.2011.03.009 PMID:21543048 PMCID:PMC3119503 (Completed with ARRA Funds)
  • Song L, Gao M, Dong W, Hu M, Li J, Shi X, Hao Y, Li Y, Huang C. 2011. p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene 30(11):1360-1371. doi:10.1038/onc.2010.506 PMID:21057544 PMCID:PMC3761396 (Completed with ARRA Funds)
  • Sun H, Clancy HA, Kluz T, Zavadil J, Costa M. 2011. Comparison of gene expression profiles in chromate transformed BEAS-2B cells. PLoS One 6(3):1-13. doi:10.1371/journal.pone.0017982 PMID:21437242 PMCID:PMC3060877 (Completed with ARRA Funds)
  • Tao S, Li L, Ding J, Zhong J, Zhang D, Lu Y, Yang Y, Wang X, Cao J, Lu X, Liu W, Li X. 2011. Mobilization of soil-bound residue of organochlorine pesticides and polycyclic aromatic hydrocarbons in an in vitro gastrointestinal model. Environ Sci Technol 45(3):1127-1132. doi:10.1021/es1025849 PMID:21175124 PMCID:PMC3031735 (Completed with ARRA Funds)
  • Tchou-Wong KM, Kiok K, Tang Z, Kluz T, Smith PR, Brown S, Costa M, Arita A. 2011. Effects of nickel treatment on H3K4 trimethylation and gene expression. PLoS One 6(3):doi:10.1371/journal.pone.0017728 PMID:21455298 PMCID:PMC3063782 (Completed with ARRA Funds)
  • Wirgin II, Roy NK, Loftus M, Chambers RC, Franks DG, Hahn ME. 2011. Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River. Science 331(6022):1322-1325. doi:10.1126/science.1197296 PMID:21330491 PMCID:PMC3246799
  • Xu D, Dai W. 2011. The function of mammalian Polo-like kinase 1 in microtubule nucleation. Proc Natl Acad Sci U S A 108(28):11301-11302. doi:10.1073/pnas.1107723108 PMID:21705656 PMCID:PMC3136282 (Completed with ARRA Funds)

2010

  • Chen H, Kluz T, Zhang R, Costa M. 2010. Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis 31:2136-2144. doi:10.1093/carcin/bgq197 PMID:20881000 PMCID:PMC2994281 (Completed with ARRA Funds)
  • Liu J, Zhang D, Mi X, Xia Q, Yu Y, Zuo Z, Guo W, Zhao X, Cao J, Yang Q, Zhu AG, Yang W, Shi X, Huang C, Li J. 2010. p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways. J Biol Chem 285:26058-26065. doi:10.1074/jbc.M110.100271 PMID:20566634 PMCID:PMC2924005 (Completed with ARRA Funds)
  • Song L, Dong W, Gao M, Li J, Hu M, Guo N, Huang C. 2010. A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression. Biochim Biophys Acta 1803(2):323-332. doi:10.1016/j.bbamcr.2010.01.006 PMID:20080131 PMCID:PMC2850076 (Completed with ARRA Funds)
  • van Duin AC, Bryantsev VS, Diallo MS, Goddard WA, Rahaman O, Doren DJ, Raymond D, Hermansson K. 2010. Development and validation of a ReaxFF reactive force field for Cu cation/water interactions and copper metal/metal oxide/metal hydroxide condensed phases. J Phys Chem A 114(35):9507-9514. doi:10.1021/jp102272z PMID:20707333 PMCID:PMC4224311 (Completed with ARRA Funds)
  • Zhang D, Li J, Costa M, Gao J, Huang C. 2010. JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 70(2):813-823. doi:10.1158/0008-5472.CAN-09-0448 PMID:20068160 PMCID:PMC2939838 (Completed with ARRA Funds)

2009

2008

  • Dai J, Jiang J, Bosland MC, Frenkel K, Bernhardt G, Huang X. 2008. Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status. Breast J 17(2):172-179. doi:10.1016/j.breast.2007.08.009 PMID:17928227 PMCID:PMC2957482
  • Garcia-Dominguez E, Mumford A, Rhine ED, Paschal A, Young LY. 2008. Novel autotrophic arsenite-oxidizing bacteria isolated from soil and sediments. FEMS Microbiol Ecol 66(2):401-410. doi:10.1111/j.1574-6941.2008.00569.x PMID:18717738
  • Ke Q, Ellen TP, Costa M. 2008. Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity. Toxicol Appl Pharmacol 228(2):190-199. doi:10.1016/j.taap.2007.12.015 PMID:18279901 PMCID:PMC2424130
  • Ke Q, Li Q, Ellen TP, Sun H, Costa M. 2008. Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Carcinogenesis 29(6):1276-1281. doi:10.1093/carcin/bgn084 PMID:18375956 PMCID:PMC2829883
  • Komissarova EV, Li P, Uddin AN, Chen X, Nadas A, Rossman TG. 2008. Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol 226(2):199-205. PMID:17976673
  • Zhou X, Sun H, Ellen TP, Chen H, Costa M. 2008. Arsenite alters global histone H3 methylation. Carcinogenesis 29(9):1831-1836. doi:10.1093/carcin/bgn063 PMID:18321869 PMCID:PMC2722848

2007

  • Klein C, Leszczynska J, Hickey C, Rossman TG. 2007. Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol Appl Pharmacol 222(3):289-97. PMID:17316729
  • Rhine ED, Ni Chadhain SM, Zylstra GJ, Young LY. 2007. The arsenite oxidase genes (aroAB) in novel chemoautotrophic arsenite oxidizers. Biochem Biophys Res Commun 354(3):662-667. doi:10.1016/j.bbrc.2007.01.004 PMID:17257587
  • Uddin AN, Burns FJ, Rossman TG, Chen H, Kluz T, Costa M. 2007. Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Toxicol Appl Pharmacol 221(3):329-38. PMID:17499830

2006

  • Arakawa H, Wu F, Costa M. 2006. Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. Carcinogenesis 27(3):639-645. PMID:16251206
  • Chen H, Ke Q, Kluz T, Yan Y, Costa M. 2006. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol 26(10):3728-3737. PMID:16648469
  • Costa M, Klein C. 2006. Toxicity and carcinogenicity of chromium compounds in humans. Crit Rev Toxicol 36(2):155-163. PMID:16736941
  • Davidson T, Chen H, Di Toro DM, D'Angelo G, Costa M. 2006. Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog 45(7):479-489. PMID:16649251
  • Feng Z, Hu W, Marnett LJ, Tang M. 2006. Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair. Mutat Res 601(1-2):125-36. PMID:16872641
  • Garrick MD, Singleton S, Vargas F, Kuo H, Zhao L, Knopfel M, Davidson T, Costa M, Paradkar P, Roth JA, Garrick LM. 2006. DMT1: which metals does it transport?. Biol Res 39(1):79-85. PMID:16629167
  • Kang GS, Li Q, Chen H, Costa M. 2006. Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. Mutat Res 610(1-2):48-55. doi:10.1016/j.mrgentox.2006.06.012 PMID:16877034
  • Ke Q, Davidson T, Chen H, Kluz T, Costa M. 2006. Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis 27(7):1481-1488. PMID:16522665
  • Li Q, Chen H, Huang X, Costa M. 2006. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol 213(3):245-255. doi:10.1016/j.taap.2005.11.006 PMID:16386771 PMCID:PMC2965073
  • Rhine ED, Phelps CD, Young LY. 2006. Anaerobic arsenite oxidation by novel denitrifying isolates. Environ Microbiol 8(5):899-908. doi:10.1111/j.1462-2920.2005.00977.x PMID:16623746
  • Roy NK, Courtenay SC, Chambers RC, Wirgin II. 2006. Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations. Environ Toxicol Chem 25(2):560-571. PMID:16519320
  • Wirgin II, Weis JS, McElroy AE. 2006. Physiological and genetic aspects of toxicity in Hudson River species. Chapter 30 in: The Hudson River Estuary. Cambridge University Press, New York, NY. pp.441-464.
  • Wu J, Eckard J, Chen H, Costa M, Frenkel K, Huang X. 2006. Altered iron homeostasis involvement in arsenite-mediated cell transformation. Free Radic Biol Med 40(3):444-452. PMID:16443159
  • Yuan Z, Courtenay SC, Chambers RC, Wirgin II. 2006. Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River. Environ Health Perspect 114(1):77-84. PMID:16393662
  • Yuan Z, Courtenay SC, Wirgin II. 2006. Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. Aquat Toxicol 76(3-4):306-320. PMID:16313980
  • Levinton J, Waldman JR, eds. 2006. The Hudson River Estuary Cambridge University Press, New York, NY.

2005

  • Bisceglia KJ, Rader KJ, Carbonaro RF, Farley KJ, Mahony JD, Di Toro DM. 2005. Iron(II)-catalyzed oxidation of arsenic(III) in a sediment column. Environ Sci Technol 39(23):9217-9222. PMID:16382945
  • Carbonaro RF, Mahony JD, Halper EB, Walter AD, Di Toro DM. 2005. Experimental and modeling investigation of metal release from metal-spiked sediments. Environ Toxicol Chem 24(12):3007-3019. PMID:16445079
  • Chen H, Davidson T, Singleton S, Garrick MD, Costa M. 2005. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol 206(3):275-287. PMID:16039939
  • Davidson T, Chen H, Garrick MD, D'Angelo G, Costa M. 2005. Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem 279(1-2):157-162. PMID:16283525
  • Di Toro DM, McGrath JA, Hansen DJ, Berry WJ, Paquin PR, Mathew R, Wu KB, Santore RC. 2005. Predicting sediment metal toxicity using a sediment biotic ligand model: methodology and initial application. Environ Toxicol Chem 24(10):2410-2427. PMID:16268143
  • Dombrowski PM, Long W, Farley KJ, Mahony JD, Capitani JF, Di Toro DM. 2005. Thermodynamic analysis of arsenic methylation. Environ Sci Technol 39(7):2169-2176. PMID:15871252
  • Komissarova EV, Saha SK, Rossman TG. 2005. Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol Appl Pharmacol 202(1):99-107. PMID:15589980
  • Perez-Jimenez JR, DeFraia C, Young LY. 2005. Arsenate respiratory reductase gene (arrA) for Desulfosporosinus sp strain Y5. Biochem Biophys Res Commun 338(2):825-829. doi:10.1016/j.bbrc.2005.10.011 PMID:16242665
  • Rhine ED, Garcia-Dominguez E, Phelps CD, Young LY. 2005. Environmental microbes can speciate and cycle arsenic. Environ Sci Technol 39(24):9569-9573. doi:10.1021/es051047t PMID:16475337
  • Sorrentino C, Roy NK, Courtenay SC, Wirgin II. 2005. Co-exposure to metals modulates CYP1A1 mRNA inducibility in Atlantic tomcod Microgadus tomcod from two populations. Aquat Toxicol 75(3):238-252. PMID:16183146
  • Suen T, Tang M, Goss P. 2005. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. Biochim Biophys Acta 1728(3):126-134. PMID:15777733
  • Uddin AN, Burns FJ, Rossman TG. 2005. Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin. Carcinogenesis 26(12):2179-2186. doi:10.1093/carcin/bgi180 PMID:16014701
  • Wirgin II, Chambers RC. 2005. Atlantic tomcod (Microgadus tomcod): A model species for the response of Hudson River fish to toxicants. In: Hudson River Fishes and their Environment. (Waldman JR, Limburg KE, Strayer D, eds). Amer. Fish. Soc,
  • Wirgin II, Grunwald C, Carlson E, Stabile J, Peterson DL, Waldman JR. 2005. Range-wide population structure of shortnose sturgeon Acipenser brevirostrum based on sequence analysis of the mitochondrial DNA control region. Estuaries 28(3):406-421.
  • Yang C, Wu J, Zhang R, Zhang P, Eckard J, Yusuf R, Huang X, Rossman TG, Frenkel K. 2005. Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. Toxicology 213(1-2):81-96. PMID:16085347
  • Wirgin II, Chambers RC. 2005. Hudson River Fishes and their Environment (Waldman JR, Limburg KE, Strayer D, eds). Amer. Fish. Soc,

2004

  • Bhattacharjee H, Carbrey JM, Rosen BP, Mukhopadhyay R. 2004. Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun 322(3):836-841. PMID:15336539
  • Burns FJ, Uddin AN, Wu F, Nadas A, Rossman TG. 2004. Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study. Environ Health Perspect 112(5):599-603. PMID:15064167
  • Caruso RP, Levinson B, Melamed J, Wieczorek R, Taneja S, Polsky D, Chang C, Zeleniuch-Jacquotte A, Salnikow K, Yee H, Costa M, Osman I. 2004. Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients. Clin Cancer Res 10(1):222-227. PMID:14734473
  • Couillard CM, Wirgin II, Lebeuf M, Legare B. 2004. Reduction of cytochrome P4501A with age in Atlantic tomcod from the St. Lawrence Estuary, Canada: relationship with emaciation and possible effect of contamination. Aquat Toxicol 68(3):233-247. PMID:15159050
  • Davidson T, Kluz T, Burns FJ, Rossman TG, Zhang Q, Uddin AN, Nadas A, Costa M. 2004. Exposure to chromium(VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol 196(3):431-437. PMID:15094314
  • Feng Z, Hu W, Tang M. 2004. Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A 101(23):8598-8602. PMID:15187227
  • Fernandez MP, Ikonomou MG, Courtenay SC, Wirgin II. 2004. Spatial variation in hepatic levels and patterns of PCBs and PCDD/Fs among young-of-the-year and adult Atlantic tomcod (Microgadus tomcod) in the Hudson River estuary. Environ Sci Technol 38(4):976-983. PMID:14998007
  • Gourbal B, Sonuc N, Bhattacharjee H, Legare D, Sundar S, Ouellette M, Rosen BP, Mukhopadhyay R. 2004. Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J Biol Chem 279(30):31010-31017. PMID:15138256
  • Hellweger FL, Farley KJ, Lall U, Di Toro DM. 2004. Greedy algae reduce arsenate. Limnology and Oceanography 48(6):2275-2288.
  • Hellweger FL, Lall U. 2004. Modeling the effect of algal dynamics on arsenic speciation in Lake Biwa. Environ Sci Technol 38(24):6716-6723. PMID:15669332
  • Hu W, Feng Z, Tang M. 2004. Chromium(VI) enhances (+/-)-anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repair. Biochemistry 43(44):14282-14289. doi:10.1021/bi048560o PMID:15518579
  • Hu W, Feng Z, Tang M. 2004. Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis. Carcinogenesis 25(3):455-462. PMID:14604891
  • Li J, Chen H, Ke Q, Feng Z, Tang M, Liu B, Amin S, Costa M, Huang C. 2004. Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappa B in mouse epidermal Cl41 cells. Mol Carcinog 40(2):104-115. PMID:15170815
  • Li J, Chen H, Tang M, Shi X, Amin S, Desai D, Costa M, Huang C. 2004. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol 165(1):77-86. PMID:15067018
  • Li J, Davidson G, Huang Y, Jiang B, Shi X, Costa M, Huang C. 2004. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res 64(1):94-101. PMID:14729612
  • Li J, Dokka S, Wang L, Shi X, Castranova V, Yan Y, Costa M, Huang C. 2004. Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. Mol Cell Biochem 255(1-2):217-225. PMID:14971662
  • Li J, Tang M, Liu B, Shi X, Huang C. 2004. A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells. Oncogene 23(22):3932-3944. doi:10.1038/sj.onc.1207501 PMID:15021902
  • Li P, Uddin AN, Liu Z, Mukhopadhyay R, Komissarova EV, Rosen BP, Rossman TG. 2004. Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts. Mol Cell Biochem 255(1-2):79-85. PMID:14971648
  • Liu A, Garcia-Dominguez E, Rhine ED, Young LY. 2004. A novel arsenate respiring isolate that can utilize aromatic substrates. FEMS Microbiol Ecol 48(3):323-332. doi:10.1016/j.femsec.2004.02.008 PMID:19712302
  • Liu Z, Boles E, Rosen BP. 2004. Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. J Biol Chem 279(17):17312-17318. doi:10.1074/jbc.M314006200 PMID:14966117
  • Liu Z, Carbrey JM, Agre P, Rosen BP. 2004. Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun 316(4):1178-1185. PMID:15044109
  • Rader KJ, Dombrowski PM, Farley KJ, Mahony JD, Di Toro DM. 2004. Effect of thioarsenite formation on arsenic(III) toxicity. Environ Toxicol Chem 23(7):1649-1654. PMID:15230317
  • Ramirez-Solis A, Mukopadhyay R, Rosen BP, Stemmler TL. 2004. Experimental and theoretical characterization of arsenite in water: Insights into the coordination environment of As-O. Inorg Chem 43(9):2954-2959. PMID:15106984
  • Rossman TG, Uddin AN. 2004. Selenium prevents spontaneous and arsenite-induced mutagenesis. Int Congr Ser 1275:173-179.
  • Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198(3):394-404. PMID:15276419
  • Sorrentino C, Roy NK, Chambers RC, Courtenay SC, Wirgin II. 2004. B[a]P-DNA binding in early life-stages of Atlantic tomcod: population differences and chromium modulation. Mar Environ Res 58(2-5):383-388. doi:10.1016/j.marenvres.2004.03.024 PMID:15178057
  • Wirgin II, Waldman JR. 2004. Resistance to contaminants in North American fish populations. Mutat Res 552(1-2):73-100. PMID:15288543
  • Wong MD, Fan B, Rosen BP. 2004. Bacterial transport ATPases for monovalent, divalent and trivalent soft metal ions. Chapter 6 in: Handbook of ATPases. Wiley-VCH, Weinheim, pp.159-176.
  • Yoon J, Besaratinia A, Feng Z, Tang M, Amin S, Luch A, Pfeifer GP. 2004. DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res 64(20):7321-7328. doi:10.1158/0008-5472.CAN-04-1094 PMID:15492252
  • Zhao J, Chen H, Davidson T, Kluz T, Zhang Q, Costa M. 2004. Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Toxicol Appl Pharmacol 196(3):404-409. PMID:15094311
  • Zhao J, Yan Y, Salnikow K, Kluz T, Costa M. 2004. Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol 194(1):60-68. PMID:14728980
  • Futai M, Wada Y, Kaplan JH, eds. 2004. Handbook of ATPases Wiley-VCH, Weinheim,

2003

  • Chung F, Pan J, Choudhury S, Roy R, Hu W, Tang M. 2003. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutat Res 531(1-2):25-36. PMID:14637245
  • Costa M. 2003. Potential hazards of hexavalent Cr in our drinking water. Toxicol Appl Pharmacol 188(1):1-5. PMID:12668116
  • Costa M, Yan Y, Zhou D, Salnikow K. 2003. Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit 5(2):222-223. PMID:12729258
  • Davidson T, Salnikow K, Costa M. 2003. Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol 64(6):1485-1493. PMID:14645679
  • Dombrowski PM, Long W, Farley KJ, Mahony JD, Capitani JF, Di Toro DM. 2003. Computed and observed redox chemistry of methyl arsenic species. In: Abstracts Of Papers Of The American Chemical Society. pp.002GEOC.Part1.
  • Feng Z, Hu W, Amin S, Tang M. 2003. Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. Biochemistry 42(25):7848-7854. PMID:12820894
  • Feng Z, Hu W, Rom WN, Costa M, Tang M. 2003. Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. Carcinogenesis 24(4):771-778. PMID:12727806
  • Hu W, Feng Z, Tang M. 2003. Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms. Biochemistry 42(330:10012-10023. PMID:12924950
  • Mure K, Uddin AN, Lopez LC, Styblo M, Rossman TG. 2003. Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. Environ Mol Mutagen 41(5):322-331. PMID:12802802
  • Rader KJ, Dombrowski PM, Farley KJ. 2003. Effect of thioarsenite formation on As(III) toxicity. In: Abstracts Of Papers Of The American Chemical Society. pp.003GEOC.Part1.
  • Rossman TG. 2003. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat Res 533(1-2):37-65. PMID:14643412
  • Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2003. Does arsenic require a carcinogenic partner? (W.R. Chappell et al. eds. Elsevier, New York). In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY. pp.195-207.
  • Rossman TG, Visalli MA, Komissarova EV. 2003. fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. Oncogene 22(12):1817-1821. PMID:12660817
  • Salnikow K, Davidson T, Kluz T, Chen H, Zhou D, Costa M. 2003. GeneChip analysis of signaling pathways effected by nickel. J Environ Monit 5(2):206-209. PMID:12729255
  • Salnikow K, Davidson T, Zhang Q, Chen L, Su W, Costa M. 2003. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res 63(13):3524-3530. PMID:12839937
  • Shen J, Hsu C, Kang B, Rosen BP, Bhattacharjee H. 2003. The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance. Biometals 16(3):369-378. PMID:12680698
  • Wu J, Eckard J, Rossman TG, Yang C, Frenkel K. 2003. p53 Signaling pathway involved in arsenite-induced HOS cell transformation and its prevention by caffeic acid phenethyl ester (CAPE). Toxicol Sci 72(1):1307Suppl.S.
  • Wu J, Yang C, Eckard J, Rossman TG, Frenkel K. 2003. Arsenite-induced human cell tranformation and down-regulation of stress and toxicity-related genes: Reversal by caffeic acid phenethyl ester (CAPE). In: Proceedings of the Ninety Fourth (AACR) American Association for Cancer Researcht, April 5-9, 2003, Toronto. Toronto, Canada.
  • Yan Y, Kluz T, Zhang P, Chen H, Costa M. 2003. Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol 190(3):272-277. PMID:12902198
  • Yang C, Frenkel K. 2003. Caffeic acid phenethyl ester (CAPE) inhibits arsenite-induced human cell transformation and induces G2/M phase arrest of arsenite-transformed human cells. Toxicol Sci 72(1):1029Suppl.S.
  • Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M. 2003. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol 192(3):201-211. PMID:14575637

2002

  • Cangul H, Broday L, Salnikow K, Sutherland JE, Peng W, Zhang Q, Poltaratsky V, Yee H, Zoroddu MA, Costa M. 2002. Molecular mechanisms of nickel carcinogenesis. Toxicol Lett 127(1-3):69-75. PMID:12052643
  • Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. 2002. Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis. Cell Biol Toxicol 18(2):87-96. PMID:12046693
  • Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. 2002. Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells. Environ Health Perspect 110(Suppl.5):783-788. PMID:12429530
  • Costa M. 2002. Molecular mechanisms of nickel carcinogenesis. Biol Chem 383(6):961-967. doi:10.1515/BC.2002.102 PMID:12222685
  • Costa M, Salnikow K, Sutherland JE, Broday L, Peng W, Zhang Q, Kluz T. 2002. The role of oxidative stress in nickel and chromate genotoxicity. Mol Cell Biochem 234-235(1-2):265-275. PMID:12162442
  • Feng Z, Hu W, Chen JX, Pao A, Li H, Rom WN, Hung M, Tang M. 2002. Carcinogen-DNA adducts are preferentially formed and poorly repaired at codon 12 of the K-ras gene, a mutation hotspot in lung cancers of cigarette smokers. J Natl Cancer Inst 90:1527-1536.
  • Feng Z, Hu W, Chen JX, Pao A, Li H, Rom WN, Hung M, Tang M. 2002. Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J Natl Cancer Inst 94(20):1527-1536. PMID:12381705
  • Feng Z, Hu W, Rom WN, Beland FA, Tang M. 2002. 4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene. Carcinogenesis 23(10):1721-1727. PMID:12376482
  • Feng Z, Hu W, Rom WN, Beland FA, Tang M. 2002. N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylation. Biochemistry 41(20):6414-6421. PMID:12009904
  • Frenkel K. 2002. Carcinogenesis: Role of reactive oxygen and nitrogen species. In: Encyclopedia of Cancer, 2nd Edition. pp.359-367.
  • Frenkel K, Rossman TG, Yang C. 2002. Caffeic acid phenethyl ester (CAPE) prevents arsenic-mediated transformation of human cells and down-regulation of inflammatory cytokines. Cancer Detect Prev 67.
  • Hu W, Feng Z, Eveleigh J, Iyer G, Pan J, Amin S, Chung F, Tang M. 2002. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis 23(11):1781-1789. PMID:12419825
  • Huang X, Dai J, Fournier J, Ali AM, Zhang Q, Frenkel K. 2002. Ferrous ion autoxidation and its chelation in iron-loaded human liver HepG2 cells. Free Radic Biol Med 32(1):84-92. PMID:11755320
  • Li X, Eckard J, Shah R, Malluck C, Frenkel K. 2002. Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses. Cancer Res 62(2):417-423. PMID:11809690
  • Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P, Rosen BP. 2002. Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A 99(9):6053-6058. PMID:11972053
  • Mukhopadhyay R, Rosen BP. 2002. Arsenate reductases in prokaryotes and eukaryotes. Environ Health Perspect 110(5):745-748. PMID:12426124
  • Rosen BP. 2002. Biochemistry of arsenic detoxification. FEBS Lett 529(1):86-97. PMID:12354618
  • Roy NK, Courtenay SC, Maxwell G, Yuan Z, Chambers RC, Wirgin II. 2002. Cytochrome P4501A1 is induced by PCB 77 and benzo[a]pyrene treatment but not by exposure to the Hudson River environment in Atlantic tomcod (Microgadus tomcod) post-yolk sac larvae. Biomarkers 7(2):162-173.
  • Salnikow K, Davidson T, Costa M. 2002. The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environ Health Perspect 110(Suppl.5):831-834. PMID:12426141
  • Salnikow K, Kluz T, Costa M, Piquemal D, Demidenko ZN, Xie K, Blagosklonny MV. 2002. The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol 22(6):1734-1741. PMID:11865053 PMCID:PMC135615
  • Tang M, Pfeifer GP, Denissenko MF, Feng Z, Hu W, Pao A, Zheng Y, Zheng JB, Li H, Chen JX. 2002. Mapping polycyclic aromatic hydrocarbon and aromatic amine-induced DNA damage in cancer-related genes at the sequence level. Int J Hyg Environ Health 205(1-2):103-113. PMID:12018002
  • Yang C, Frenkel K. 2002. Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis. J Environ Pathol Toxicol Oncol 21(4):331-342. PMID:12510962
  • Yang C, Zhang RH, Eckard J, Yusuf R, Rossman TG, Frenkel K. 2002. Critical role of inflammatory cytokines in the inhibition of arsenic-induced cell transformation by caffeic acid phenethyl ester (CAPE). In: Proceedings of Ninety Third Annual Meeting of the (AACR) American Association of Cancer Research, April 6-10, 2002, San Francisco. pp.1034.
  • Zhang Q, Kluz T, Salnikow K, Costa M. 2002. Comparison of the cytotoxicity, cellular uptake, and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell lines derived from three different individuals. Biol Trace Elem Res 86(1):11-22. PMID:12002656
  • Zoroddu MA, Peana M, Kowalik-Jankowska T, Kozlowski H, Costa M. 2002. The binding of Ni(II) and Cu(II) with the N-terminal tail of the histone H4. Journal of the Chemical Society - Dalton Transactions 3:458-465.

2001

  • Cooney RV, Maskarinec G, Frank AA, Okinaka L, Karkoszka J, Wilkens LR, Frenkel K. 2001. Association of tocopherols with circulating autoantibody levels against an oxidized DNA nucleoside in humans. Free Radic Biol Med 31:460-468. PMID:11498279
  • Costa M, Sutherland JE, Peng W, Salnikow K, Broday L, Kluz T. 2001. Molecular biology of nickel carcinogenesis. Mol Cell Biochem 222(1-2):205-211. PMID:11678603
  • Huang C, Li J, Costa M, Zhang Z, Leonard SS, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res 61:8051-8057. PMID:11719426
  • Huang C, Li J, Ding M, Costa M, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Transactivation of RARE and GRE in the cellular response to arsenic. Mol Cell Biochem 222:119-125. PMID:11678593
  • Huang C, Li J, Ding M, Wang L, Shi X, Castranova V, Vallyathan V, Ju G, Costa M. 2001. Arsenic-induced NF kappa beta transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells. Mol Cell Biochem 222:29-34. PMID:11678607
  • Huang C, Zhang Q, Li J, Shi X, Castranova V, Ju G, Costa M, Dong Z. 2001. Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo. Mol Cell Biochem 222(1-2):141-147. doi:10.1023/A:1017953927347 PMID:11678596
  • Huang X, Powell J, Mooney LA, Li CL, Frenkel K. 2001. Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analyses. Free Radic Biol Med 31:1341-1351. PMID:11728805
  • Li P, Rossman TG. 2001. Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity. Toxicol Sci 64:90-99. PMID:11606805
  • Mahabir S, Frenkel K, Brady MS, Coit D, Lewis JJ, Leibes L, Roush G, Berwick M. 2001. Antibodies against 5-hydroxymethyl-2-deoxyuridine: a pilot trial. FASEB J 15:A282.
  • Mooney LA, Perera F, Van Bennekum AM, Blaner WS, Karkoszka J, Covey L, Hsu YZ, Cooper TB, Frenkel K. 2001. Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers. Cancer Epidemiol Biomarkers Prev 10:641-648. PMID:11401914
  • Mure K, Rossman TG. 2001. Reduction of spontaneous mutagenesis in mismatch repair-deficient and proficient cells by dietary antioxidants. Mutat Res 480-481:85-95. PMID:11506802
  • Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2001. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol 176(1):64-71. PMID:11578149
  • Rossman TG, Visalli MA, Uddin AN, Hu Y. 2001. Human cell models for arsenic carcinogenicity and toxicity: Transformation and genetic susceptibility. In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY.
  • Rossman TG, Weisburger JH. 2001. Arsenic in water. Chemical & Engineering News 79:2.
  • Roy NK, Courtenay SC, Yuan Z, Ikonomou MG, Wirgin II. 2001. An evaluation of the etiology of reduced CYP1A1 messenger RNA expression in the Atlantic tomcod from the Hudson River, New York, USA, using reverse transcriptase polymerase chain reaction analysis. Environ Toxicol Chem 20(5):1022-1030. PMID:11337864
  • Sutherland JE, Peng W, Zhang Q, Costa M. 2001. The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells. Mutat Res 479(1-2):225-233. PMID:11470494
  • Vogt BL, Rossman TG. 2001. Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity. Mutat Res 478:159-168. PMID:11406180
  • Walsh MG, Bain MB, Squiers T, Waldman JR, Wirgin II. 2001. Morphological and genetic variation among shortnose sturgeon Acipenser brevirostrum from adjacent and distant rivers. Estuaries 24:41-48.
  • Wirgin II, Oppermann T, Stabile J. 2001. Genetic divergence of robust redhorse Moxostoma robustum (Cypriniformes Catostomidae) from the Oconee River and the Savannah River based on mitochondrial DNA control region sequences. Copeia 526-530.
  • Yuan Z, Wirgin M, Courtenay SC, Ikonomou MG, Wirgin II. 2001. Is hepatic cytochrome P4501A1 expression predictive of hepatic burdens of dioxins, furans, and PCBs in Atlantic tomcod from the Hudson River estuary?. Aquat Toxicol 54(3-4):217-230. PMID:11489308
  • Yusuf R, Frenkel K. 2001. Oxidative stress-mediated transformation of MCF-10 human mammary cells: roles of hydrocortisone (HC), 17beta-estradiol (E2), and 7,12-dimethylbenz[a]anthracene (DMBA). Free Radic Biol Med 31:427.
  • Zoroddu MA, Kowalik-Jankowska T, Kozlowski H, Salnikow K, Costa M. 2001. Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR. J Inorg Biochem 84:47-54. PMID:11330481

2000

  • Cohen M, Costa M. 2000. Chromium. In: Environmental Toxicants, Human Exposures and their Health Effects (2nd Edition). John Wiley & Sons, Inc, New York, NY. pp.173-192.
  • Costa M. 2000. Chromium. In: Molecular Biology and Toxicology of Metals. Taylor & Francis, Inc., New York, NY. pp.113-128.
  • Sutherland JE, Zhitkovich A, Kluz T, Costa M. 2000. Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium. Biol Trace Elem Res 74(1):41-53. PMID:11049199
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