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Program Publications: New York University School of Medicine: Carcinogenic Metals and Their Interactions With Other Toxicants (ARRA Funded)

Superfund Research Program

Carcinogenic Metals and Their Interactions With Other Toxicants (ARRA Funded)

Center Director: Max Costa
Grant Number: P42ES010344
Funding Period: 2000-2006 and 2009-2011

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  • Cai T, Li X, Ding J, Luo W, Li J, Huang C. 2011. A cross-talk between NFAT and NF-κB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Curr Cancer Drug Targets 11(5):548-559. PMID:21486220 PMCID:PMC3759234 (Completed with ARRA Funds)
  • Farley KJ, Carbonaro RF, Fanelli CJ, Costanzo R, Rader KJ, Di Toro DM. 2011. TICKET-UWM: a coupled kinetic, equilibrium, and transport screening model for metals in lakes. Environ Toxicol Chem 30(6):1278-1287. doi:10.1002/etc.518 PMID:21381089 (Completed with ARRA Funds)
  • Guo W, Yang Z, Xia Q, Liu J, Yu Y, Li J, Zuo Z, Zhang D, Li X, Shi X, Huang C. 2011. Arsenite stabilizes HIF-1 alpha protein through p85 alpha-mediated up-regulation of inducible Hsp70 protein expression. Cellular and Molecular Life Sciences 68(3):475-488. doi:10.1007/s00018-010-0459-7 PMID:20835880 PMCID:PMC3758129 (Completed with ARRA Funds)
  • Hu L, Liu X, Chervona Y, Wang F, Tang M, Darzynkiewicz Z, Dai W. 2011. Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors. Cell Cycle 10:2373-2379. doi:10.4161/cc.10.14.16310 PMID:21670593 PMCID:PMC3230526 (Completed with ARRA Funds)
  • Kiok K, Sun H, Clancy HA, Bose S, Kluz T, Wu F, Costa M. 2011. Liprin-alpha4 is required for nickel induced receptor protein tyrosine phosphatase-leukocyte antigen related receptor F (RPTP-LAR) activity. PLoS One 6(8):doi:10.1371/journal.pone.0022764 PMID:21829649 PMCID:PMC3150438 (Completed with ARRA Funds)
  • Liu J, Zhang D, Luo W, Yu Y, Li J, Zhang X, Zhang B, Chen J, Wu X, Rosas-Acosta G, Huang C. 2011. X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton. J Biol Chem 286:15630-15640. doi:10.1074/jbc.M110.176982 PMID:21402697 PMCID:PMC3091172 (Completed with ARRA Funds)
  • Rahaman O, Estrada TP, Doren DJ, Taufer M, Brooks CL, Armen RS. 2011. Evaluation of several two-step scoring functions based on linear interaction energy, effective ligand size, and empirical pair potentials for prediction of protein-ligand binding geometry and free energy. J Chem Inf Model 52(9):2047-2065. doi:10.1021/ci1003009 PMID:21644546 PMCID:PMC3183351 (Completed with ARRA Funds)
  • Rahaman O, van Duin AC, Goddard WA, Doren DJ. 2011. Development of a ReaxFF reactive force field for glycine and application to solvent effect and tautomerization. Journal of Physical Chemistry B 115(2):249-261. doi:10.1021/jp108642r PMID:21166434 PMCID:PMC3042430 (Completed with ARRA Funds)
  • Roy NK, Walker N, Chambers RC, Wirgin II. 2011. Characterization and expression of cytochrome P4501A in Atlantic sturgeon and shortnose sturgeon experimentally exposed to coplanar PCB 126 and TCDD. Aquat Toxicol 102(1-2):23-31. doi:10.1016/j.aquatox.2011.03.009 PMID:21543048 PMCID:PMC3119503 (Completed with ARRA Funds)
  • Song L, Gao M, Dong W, Hu M, Li J, Shi X, Hao Y, Li Y, Huang C. 2011. p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene 30(11):1360-1371. doi:10.1038/onc.2010.506 PMID:21057544 PMCID:PMC3761396 (Completed with ARRA Funds)
  • Sun H, Clancy HA, Kluz T, Zavadil J, Costa M. 2011. Comparison of gene expression profiles in chromate transformed BEAS-2B cells. PLoS One 6(3):1-13. doi:10.1371/journal.pone.0017982 PMID:21437242 PMCID:PMC3060877 (Completed with ARRA Funds)
  • Tao S, Li L, Ding J, Zhong J, Zhang D, Lu Y, Yang Y, Wang X, Cao J, Lu X, Liu W, Li X. 2011. Mobilization of soil-bound residue of organochlorine pesticides and polycyclic aromatic hydrocarbons in an in vitro gastrointestinal model. Environ Sci Technol 45(3):1127-1132. doi:10.1021/es1025849 PMID:21175124 PMCID:PMC3031735 (Completed with ARRA Funds)
  • Tchou-Wong KM, Kiok K, Tang Z, Kluz T, Smith PR, Brown S, Costa M, Arita A. 2011. Effects of nickel treatment on H3K4 trimethylation and gene expression. PLoS One 6(3):doi:10.1371/journal.pone.0017728 PMID:21455298 PMCID:PMC3063782 (Completed with ARRA Funds)
  • Wirgin II, Roy NK, Loftus M, Chambers RC, Franks DG, Hahn ME. 2011. Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River. Science 331(6022):1322-1325. doi:10.1126/science.1197296 PMID:21330491 PMCID:PMC3246799
  • Xu D, Dai W. 2011. The function of mammalian Polo-like kinase 1 in microtubule nucleation. Proc Natl Acad Sci U S A 108(28):11301-11302. doi:10.1073/pnas.1107723108 PMID:21705656 PMCID:PMC3136282 (Completed with ARRA Funds)


  • Chen H, Kluz T, Zhang R, Costa M. 2010. Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis 31:2136-2144. doi:10.1093/carcin/bgq197 PMID:20881000 PMCID:PMC2994281 (Completed with ARRA Funds)
  • Liu J, Zhang D, Mi X, Xia Q, Yu Y, Zuo Z, Guo W, Zhao X, Cao J, Yang Q, Zhu AG, Yang W, Shi X, Huang C, Li J. 2010. p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways. J Biol Chem 285:26058-26065. doi:10.1074/jbc.M110.100271 PMID:20566634 PMCID:PMC2924005 (Completed with ARRA Funds)
  • Song L, Dong W, Gao M, Li J, Hu M, Guo N, Huang C. 2010. A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression. Biochim Biophys Acta 1803(2):323-332. doi:10.1016/j.bbamcr.2010.01.006 PMID:20080131 PMCID:PMC2850076 (Completed with ARRA Funds)
  • van Duin AC, Bryantsev VS, Diallo MS, Goddard WA, Rahaman O, Doren DJ, Raymond D, Hermansson K. 2010. Development and validation of a ReaxFF reactive force field for Cu cation/water interactions and copper metal/metal oxide/metal hydroxide condensed phases. J Phys Chem A 114(35):9507-9514. doi:10.1021/jp102272z PMID:20707333 PMCID:PMC4224311 (Completed with ARRA Funds)
  • Zhang D, Li J, Costa M, Gao J, Huang C. 2010. JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 70(2):813-823. doi:10.1158/0008-5472.CAN-09-0448 PMID:20068160 PMCID:PMC2939838 (Completed with ARRA Funds)



  • Dai J, Jiang J, Bosland MC, Frenkel K, Bernhardt G, Huang X. 2008. Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status. Breast J 17(2):172-179. doi:10.1016/j.breast.2007.08.009 PMID:17928227 PMCID:PMC2957482
  • Garcia-Dominguez E, Mumford A, Rhine ED, Paschal A, Young LY. 2008. Novel autotrophic arsenite-oxidizing bacteria isolated from soil and sediments. FEMS Microbiol Ecol 66(2):401-410. doi:10.1111/j.1574-6941.2008.00569.x PMID:18717738
  • Ke Q, Ellen TP, Costa M. 2008. Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity. Toxicol Appl Pharmacol 228(2):190-199. doi:10.1016/j.taap.2007.12.015 PMID:18279901 PMCID:PMC2424130
  • Ke Q, Li Q, Ellen TP, Sun H, Costa M. 2008. Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Carcinogenesis 29(6):1276-1281. doi:10.1093/carcin/bgn084 PMID:18375956 PMCID:PMC2829883
  • Komissarova EV, Li P, Uddin AN, Chen X, Nadas A, Rossman TG. 2008. Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol 226(2):199-205. PMID:17976673
  • Zhou X, Sun H, Ellen TP, Chen H, Costa M. 2008. Arsenite alters global histone H3 methylation. Carcinogenesis 29(9):1831-1836. doi:10.1093/carcin/bgn063 PMID:18321869 PMCID:PMC2722848


  • Klein C, Leszczynska J, Hickey C, Rossman TG. 2007. Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol Appl Pharmacol 222(3):289-97. PMID:17316729
  • Rhine ED, Ni Chadhain SM, Zylstra GJ, Young LY. 2007. The arsenite oxidase genes (aroAB) in novel chemoautotrophic arsenite oxidizers. Biochem Biophys Res Commun 354(3):662-667. doi:10.1016/j.bbrc.2007.01.004 PMID:17257587
  • Uddin AN, Burns FJ, Rossman TG, Chen H, Kluz T, Costa M. 2007. Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Toxicol Appl Pharmacol 221(3):329-38. PMID:17499830


  • Arakawa H, Wu F, Costa M. 2006. Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. Carcinogenesis 27(3):639-645. PMID:16251206
  • Chen H, Ke Q, Kluz T, Yan Y, Costa M. 2006. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol 26(10):3728-3737. PMID:16648469
  • Costa M, Klein C. 2006. Toxicity and carcinogenicity of chromium compounds in humans. Crit Rev Toxicol 36(2):155-163. PMID:16736941
  • Davidson T, Chen H, Di Toro DM, D'Angelo G, Costa M. 2006. Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog 45(7):479-489. PMID:16649251
  • Feng Z, Hu W, Marnett LJ, Tang M. 2006. Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair. Mutat Res 601(1-2):125-36. PMID:16872641
  • Garrick MD, Singleton S, Vargas F, Kuo H, Zhao L, Knopfel M, Davidson T, Costa M, Paradkar P, Roth JA, Garrick LM. 2006. DMT1: which metals does it transport?. Biol Res 39(1):79-85. PMID:16629167
  • Kang GS, Li Q, Chen H, Costa M. 2006. Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. Mutat Res 610(1-2):48-55. doi:10.1016/j.mrgentox.2006.06.012 PMID:16877034
  • Ke Q, Davidson T, Chen H, Kluz T, Costa M. 2006. Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis 27(7):1481-1488. PMID:16522665
  • Li Q, Chen H, Huang X, Costa M. 2006. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol 213(3):245-255. doi:10.1016/j.taap.2005.11.006 PMID:16386771 PMCID:PMC2965073
  • Rhine ED, Phelps CD, Young LY. 2006. Anaerobic arsenite oxidation by novel denitrifying isolates. Environ Microbiol 8(5):899-908. doi:10.1111/j.1462-2920.2005.00977.x PMID:16623746
  • Roy NK, Courtenay SC, Chambers RC, Wirgin II. 2006. Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations. Environ Toxicol Chem 25(2):560-571. PMID:16519320
  • Wirgin II, Weis JS, McElroy AE. 2006. Physiological and genetic aspects of toxicity in Hudson River species. Chapter 30 in: The Hudson River Estuary. Cambridge University Press, New York, NY. pp.441-464.
  • Wu J, Eckard J, Chen H, Costa M, Frenkel K, Huang X. 2006. Altered iron homeostasis involvement in arsenite-mediated cell transformation. Free Radic Biol Med 40(3):444-452. PMID:16443159
  • Yuan Z, Courtenay SC, Chambers RC, Wirgin II. 2006. Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River. Environ Health Perspect 114(1):77-84. PMID:16393662
  • Yuan Z, Courtenay SC, Wirgin II. 2006. Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. Aquat Toxicol 76(3-4):306-320. PMID:16313980
  • Levinton J, Waldman JR, eds. 2006. The Hudson River Estuary Cambridge University Press, New York, NY.


  • Bisceglia KJ, Rader KJ, Carbonaro RF, Farley KJ, Mahony JD, Di Toro DM. 2005. Iron(II)-catalyzed oxidation of arsenic(III) in a sediment column. Environ Sci Technol 39(23):9217-9222. PMID:16382945
  • Carbonaro RF, Mahony JD, Halper EB, Walter AD, Di Toro DM. 2005. Experimental and modeling investigation of metal release from metal-spiked sediments. Environ Toxicol Chem 24(12):3007-3019. PMID:16445079
  • Chen H, Davidson T, Singleton S, Garrick MD, Costa M. 2005. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol 206(3):275-287. PMID:16039939
  • Davidson T, Chen H, Garrick MD, D'Angelo G, Costa M. 2005. Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem 279(1-2):157-162. PMID:16283525
  • Di Toro DM, McGrath JA, Hansen DJ, Berry WJ, Paquin PR, Mathew R, Wu KB, Santore RC. 2005. Predicting sediment metal toxicity using a sediment biotic ligand model: methodology and initial application. Environ Toxicol Chem 24(10):2410-2427. PMID:16268143
  • Dombrowski PM, Long W, Farley KJ, Mahony JD, Capitani JF, Di Toro DM. 2005. Thermodynamic analysis of arsenic methylation. Environ Sci Technol 39(7):2169-2176. PMID:15871252
  • Komissarova EV, Saha SK, Rossman TG. 2005. Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol Appl Pharmacol 202(1):99-107. PMID:15589980
  • Perez-Jimenez JR, DeFraia C, Young LY. 2005. Arsenate respiratory reductase gene (arrA) for Desulfosporosinus sp strain Y5. Biochem Biophys Res Commun 338(2):825-829. doi:10.1016/j.bbrc.2005.10.011 PMID:16242665
  • Rhine ED, Garcia-Dominguez E, Phelps CD, Young LY. 2005. Environmental microbes can speciate and cycle arsenic. Environ Sci Technol 39(24):9569-9573. doi:10.1021/es051047t PMID:16475337
  • Sorrentino C, Roy NK, Courtenay SC, Wirgin II. 2005. Co-exposure to metals modulates CYP1A1 mRNA inducibility in Atlantic tomcod Microgadus tomcod from two populations. Aquat Toxicol 75(3):238-252. PMID:16183146
  • Suen T, Tang M, Goss P. 2005. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. Biochim Biophys Acta 1728(3):126-134. PMID:15777733
  • Uddin AN, Burns FJ, Rossman TG. 2005. Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin. Carcinogenesis 26(12):2179-2186. doi:10.1093/carcin/bgi180 PMID:16014701
  • Wirgin II, Chambers RC. 2005. Atlantic tomcod (Microgadus tomcod): A model species for the response of Hudson River fish to toxicants. In: Hudson River Fishes and their Environment. (Waldman JR, Limburg KE, Strayer D, eds). Amer. Fish. Soc,
  • Wirgin II, Grunwald C, Carlson E, Stabile J, Peterson DL, Waldman JR. 2005. Range-wide population structure of shortnose sturgeon Acipenser brevirostrum based on sequence analysis of the mitochondrial DNA control region. Estuaries 28(3):406-421.
  • Yang C, Wu J, Zhang R, Zhang P, Eckard J, Yusuf R, Huang X, Rossman TG, Frenkel K. 2005. Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. Toxicology 213(1-2):81-96. PMID:16085347
  • Wirgin II, Chambers RC. 2005. Hudson River Fishes and their Environment (Waldman JR, Limburg KE, Strayer D, eds). Amer. Fish. Soc,


  • Bhattacharjee H, Carbrey JM, Rosen BP, Mukhopadhyay R. 2004. Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun 322(3):836-841. PMID:15336539
  • Burns FJ, Uddin AN, Wu F, Nadas A, Rossman TG. 2004. Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study. Environ Health Perspect 112(5):599-603. PMID:15064167
  • Caruso RP, Levinson B, Melamed J, Wieczorek R, Taneja S, Polsky D, Chang C, Zeleniuch-Jacquotte A, Salnikow K, Yee H, Costa M, Osman I. 2004. Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients. Clin Cancer Res 10(1):222-227. PMID:14734473
  • Couillard CM, Wirgin II, Lebeuf M, Legare B. 2004. Reduction of cytochrome P4501A with age in Atlantic tomcod from the St. Lawrence Estuary, Canada: relationship with emaciation and possible effect of contamination. Aquat Toxicol 68(3):233-247. PMID:15159050
  • Davidson T, Kluz T, Burns FJ, Rossman TG, Zhang Q, Uddin AN, Nadas A, Costa M. 2004. Exposure to chromium(VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol 196(3):431-437. PMID:15094314
  • Feng Z, Hu W, Tang M. 2004. Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A 101(23):8598-8602. PMID:15187227
  • Fernandez MP, Ikonomou MG, Courtenay SC, Wirgin II. 2004. Spatial variation in hepatic levels and patterns of PCBs and PCDD/Fs among young-of-the-year and adult Atlantic tomcod (Microgadus tomcod) in the Hudson River estuary. Environ Sci Technol 38(4):976-983. PMID:14998007
  • Gourbal B, Sonuc N, Bhattacharjee H, Legare D, Sundar S, Ouellette M, Rosen BP, Mukhopadhyay R. 2004. Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J Biol Chem 279(30):31010-31017. PMID:15138256
  • Hellweger FL, Farley KJ, Lall U, Di Toro DM. 2004. Greedy algae reduce arsenate. Limnology and Oceanography 48(6):2275-2288.
  • Hellweger FL, Lall U. 2004. Modeling the effect of algal dynamics on arsenic speciation in Lake Biwa. Environ Sci Technol 38(24):6716-6723. PMID:15669332
  • Hu W, Feng Z, Tang M. 2004. Chromium(VI) enhances (+/-)-anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repair. Biochemistry 43(44):14282-14289. doi:10.1021/bi048560o PMID:15518579
  • Hu W, Feng Z, Tang M. 2004. Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis. Carcinogenesis 25(3):455-462. PMID:14604891
  • Li J, Chen H, Ke Q, Feng Z, Tang M, Liu B, Amin S, Costa M, Huang C. 2004. Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappa B in mouse epidermal Cl41 cells. Mol Carcinog 40(2):104-115. PMID:15170815
  • Li J, Chen H, Tang M, Shi X, Amin S, Desai D, Costa M, Huang C. 2004. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol 165(1):77-86. PMID:15067018
  • Li J, Davidson G, Huang Y, Jiang B, Shi X, Costa M, Huang C. 2004. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res 64(1):94-101. PMID:14729612
  • Li J, Dokka S, Wang L, Shi X, Castranova V, Yan Y, Costa M, Huang C. 2004. Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. Mol Cell Biochem 255(1-2):217-225. PMID:14971662
  • Li J, Tang M, Liu B, Shi X, Huang C. 2004. A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells. Oncogene 23(22):3932-3944. doi:10.1038/sj.onc.1207501 PMID:15021902
  • Li P, Uddin AN, Liu Z, Mukhopadhyay R, Komissarova EV, Rosen BP, Rossman TG. 2004. Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts. Mol Cell Biochem 255(1-2):79-85. PMID:14971648
  • Liu A, Garcia-Dominguez E, Rhine ED, Young LY. 2004. A novel arsenate respiring isolate that can utilize aromatic substrates. FEMS Microbiol Ecol 48(3):323-332. doi:10.1016/j.femsec.2004.02.008 PMID:19712302
  • Liu Z, Boles E, Rosen BP. 2004. Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. J Biol Chem 279(17):17312-17318. doi:10.1074/jbc.M314006200 PMID:14966117
  • Liu Z, Carbrey JM, Agre P, Rosen BP. 2004. Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun 316(4):1178-1185. PMID:15044109
  • Rader KJ, Dombrowski PM, Farley KJ, Mahony JD, Di Toro DM. 2004. Effect of thioarsenite formation on arsenic(III) toxicity. Environ Toxicol Chem 23(7):1649-1654. PMID:15230317
  • Ramirez-Solis A, Mukopadhyay R, Rosen BP, Stemmler TL. 2004. Experimental and theoretical characterization of arsenite in water: Insights into the coordination environment of As-O. Inorg Chem 43(9):2954-2959. PMID:15106984
  • Rossman TG, Uddin AN. 2004. Selenium prevents spontaneous and arsenite-induced mutagenesis. Int Congr Ser 1275:173-179.
  • Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198(3):394-404. PMID:15276419
  • Sorrentino C, Roy NK, Chambers RC, Courtenay SC, Wirgin II. 2004. B[a]P-DNA binding in early life-stages of Atlantic tomcod: population differences and chromium modulation. Mar Environ Res 58(2-5):383-388. doi:10.1016/j.marenvres.2004.03.024 PMID:15178057
  • Wirgin II, Waldman JR. 2004. Resistance to contaminants in North American fish populations. Mutat Res 552(1-2):73-100. PMID:15288543
  • Wong MD, Fan B, Rosen BP. 2004. Bacterial transport ATPases for monovalent, divalent and trivalent soft metal ions. Chapter 6 in: Handbook of ATPases. Wiley-VCH, Weinheim, pp.159-176.
  • Yoon J, Besaratinia A, Feng Z, Tang M, Amin S, Luch A, Pfeifer GP. 2004. DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res 64(20):7321-7328. doi:10.1158/0008-5472.CAN-04-1094 PMID:15492252
  • Zhao J, Chen H, Davidson T, Kluz T, Zhang Q, Costa M. 2004. Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Toxicol Appl Pharmacol 196(3):404-409. PMID:15094311
  • Zhao J, Yan Y, Salnikow K, Kluz T, Costa M. 2004. Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol 194(1):60-68. PMID:14728980
  • Futai M, Wada Y, Kaplan JH, eds. 2004. Handbook of ATPases Wiley-VCH, Weinheim,


  • Chung F, Pan J, Choudhury S, Roy R, Hu W, Tang M. 2003. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutat Res 531(1-2):25-36. PMID:14637245
  • Costa M. 2003. Potential hazards of hexavalent Cr in our drinking water. Toxicol Appl Pharmacol 188(1):1-5. PMID:12668116
  • Costa M, Yan Y, Zhou D, Salnikow K. 2003. Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit 5(2):222-223. PMID:12729258
  • Davidson T, Salnikow K, Costa M. 2003. Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol 64(6):1485-1493. PMID:14645679
  • Dombrowski PM, Long W, Farley KJ, Mahony JD, Capitani JF, Di Toro DM. 2003. Computed and observed redox chemistry of methyl arsenic species. In: Abstracts Of Papers Of The American Chemical Society. pp.002GEOC.Part1.
  • Feng Z, Hu W, Amin S, Tang M. 2003. Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. Biochemistry 42(25):7848-7854. PMID:12820894
  • Feng Z, Hu W, Rom WN, Costa M, Tang M. 2003. Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. Carcinogenesis 24(4):771-778. PMID:12727806
  • Hu W, Feng Z, Tang M. 2003. Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms. Biochemistry 42(330:10012-10023. PMID:12924950
  • Mure K, Uddin AN, Lopez LC, Styblo M, Rossman TG. 2003. Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. Environ Mol Mutagen 41(5):322-331. PMID:12802802
  • Rader KJ, Dombrowski PM, Farley KJ. 2003. Effect of thioarsenite formation on As(III) toxicity. In: Abstracts Of Papers Of The American Chemical Society. pp.003GEOC.Part1.
  • Rossman TG. 2003. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat Res 533(1-2):37-65. PMID:14643412
  • Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2003. Does arsenic require a carcinogenic partner? (W.R. Chappell et al. eds. Elsevier, New York). In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY. pp.195-207.
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