Superfund Research Program

Identification and Genetic Analysis of the Human Arsenite Efflux Pump

Project Leader: Toby G. Rossman
Grant Number: P42ES010344
Funding Period: 2000 - 2006

Project-Specific Links

Publications

2008

• Komissarova EV, Li P, Uddin AN, Chen X, Nadas A, Rossman TG. 2008. Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol 226(2):199-205. PMID:17976673

2007

• Klein C, Leszczynska J, Hickey C, Rossman TG. 2007. Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol Appl Pharmacol 222(3):289-97. PMID:17316729

2005

• Komissarova EV, Saha SK, Rossman TG. 2005. Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol Appl Pharmacol 202(1):99-107. PMID:15589980
• Uddin AN, Burns FJ, Rossman TG. 2005. Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin. Carcinogenesis 26(12):2179-2186. doi:10.1093/carcin/bgi180 PMID:16014701
• Yang C, Wu J, Zhang R, Zhang P, Eckard J, Yusuf R, Huang X, Rossman TG, Frenkel K. 2005. Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. Toxicology 213(1-2):81-96. PMID:16085347

2004

• Bhattacharjee H, Carbrey JM, Rosen BP, Mukhopadhyay R. 2004. Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun 322(3):836-841. PMID:15336539
• Burns FJ, Uddin AN, Wu F, Nadas A, Rossman TG. 2004. Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study. Environ Health Perspect 112(5):599-603. PMID:15064167
• Gourbal B, Sonuc N, Bhattacharjee H, Legare D, Sundar S, Ouellette M, Rosen BP, Mukhopadhyay R. 2004. Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J Biol Chem 279(30):31010-31017. PMID:15138256
• Li P, Uddin AN, Liu Z, Mukhopadhyay R, Komissarova EV, Rosen BP, Rossman TG. 2004. Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts. Mol Cell Biochem 255(1-2):79-85. PMID:14971648
• Liu Z, Boles E, Rosen BP. 2004. Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. J Biol Chem 279(17):17312-17318. doi:10.1074/jbc.M314006200 PMID:14966117
• Liu Z, Carbrey JM, Agre P, Rosen BP. 2004. Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun 316(4):1178-1185. PMID:15044109
• Ramirez-Solis A, Mukopadhyay R, Rosen BP, Stemmler TL. 2004. Experimental and theoretical characterization of arsenite in water: Insights into the coordination environment of As-O. Inorg Chem 43(9):2954-2959. PMID:15106984
• Rossman TG, Uddin AN. 2004. Selenium prevents spontaneous and arsenite-induced mutagenesis. Int Congr Ser 1275:173-179.
• Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198(3):394-404. PMID:15276419
• Wong MD, Fan B, Rosen BP. 2004. Bacterial transport ATPases for monovalent, divalent and trivalent soft metal ions. Chapter 6 in: Handbook of ATPases. Wiley-VCH, Weinheim, pp.159-176.
• Futai M, Wada Y, Kaplan JH, eds. 2004. Handbook of ATPases Wiley-VCH, Weinheim,

2003

• Mure K, Uddin AN, Lopez LC, Styblo M, Rossman TG. 2003. Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. Environ Mol Mutagen 41(5):322-331. PMID:12802802
• Rossman TG. 2003. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat Res 533(1-2):37-65. PMID:14643412
• Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2003. Does arsenic require a carcinogenic partner? (W.R. Chappell et al. eds. Elsevier, New York). In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY. pp.195-207.
• Rossman TG, Visalli MA, Komissarova EV. 2003. fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. Oncogene 22(12):1817-1821. PMID:12660817
• Shen J, Hsu C, Kang B, Rosen BP, Bhattacharjee H. 2003. The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance. Biometals 16(3):369-378. PMID:12680698

2001

• Li P, Rossman TG. 2001. Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity. Toxicol Sci 64:90-99. PMID:11606805
• Mure K, Rossman TG. 2001. Reduction of spontaneous mutagenesis in mismatch repair-deficient and proficient cells by dietary antioxidants. Mutat Res 480-481:85-95. PMID:11506802
• Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2001. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol 176(1):64-71. PMID:11578149
• Rossman TG, Visalli MA, Uddin AN, Hu Y. 2001. Human cell models for arsenic carcinogenicity and toxicity: Transformation and genetic susceptibility. In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY.
• Rossman TG, Weisburger JH. 2001. Arsenic in water. Chemical & Engineering News 79:2.
• Vogt BL, Rossman TG. 2001. Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity. Mutat Res 478:159-168. PMID:11406180