Superfund Research Program

Epigenetic Mechanisms of Ni, As, Chromate and BaP Carcinogenesis (ARRA Funded)

Project Leader: Max Costa
Grant Number: P42ES010344
Funding Period: 2009-2011

Project-Specific Links

Publications

2018

• Munoz A, Eldridge WJ, Jakobsen NM, Sorensen H, Wax A, Costa M. 2018. Cellular shear stiffness reflects progression of arsenic-induced transformation during G(1). Carcinogenesis 39(2):109-117. doi:10.1093/carcin/bgx116 PMID:29069374 PMCID:PMC5862275

2015

• Brocato J, Hernandez M, Laulicht F, Sun H, Shamy MY, Alghamdi MA, Khoder MI, Kluz T, Chen L, Costa M. 2015. In vivo exposures to particulate matter collected from Saudi Arabia or nickel chloride display similar dysregulation of metabolic syndrome genes. J Toxicol Environ Health A 78(23-24):1421-1436. doi:10.1080/15287394.2015.1095689 PMID:26692068 PMCID:PMC4709028 (Completed with ARRA Funds)
• Brocato J, Wu F, Chen Y, Shamy MY, Alghamdi MA, Khoder MI, Alkhatim AA, Costa M, Abdou MH. 2015. Association between sleeping hours and cardiometabolic risk factors for metabolic syndrome in a Saudi Arabian population. BMJ Open 5(11):e008590. doi:10.1136/bmjopen-2015-008590 PMID:26621514 PMCID:PMC4679834
• Niu Y, DesMarais TL, Tong Z, Yao Y, Costa M. 2015. Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med 82:22-28. doi:10.1016/j.freeradbiomed.2015.01.028 PMID:25656994 PMCID:PMC4464695 (Completed with ARRA Funds)

2014

• Brocato J, Chervona Y, Costa M. 2014. Molecular responses to hypoxia-inducible factor 1α and beyond. Mol Pharmacol 85(5):651-657. doi:10.1124/mol.113.089623 PMID:24569087 PMCID:PMC3990019 (Completed with ARRA Funds)

2012

• Wu F, Sun H, Kluz T, Clancy HA, Kiok K, Costa M. 2012. Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol 258:166-175. doi:10.1016/j.taap.2011.10.018 PMID:22079256 PMCID:PMC3259276 (Completed with ARRA Funds)

2009

• Ellen TP, Kluz T, Harder ME, Xiong J, Costa M. 2009. Heterochromatinization as a potential mechanism of nickel-induced carcinogenesis. Biochemistry 48(21):4626-4632. doi:10.1021/bi900246h PMID:19338343 PMCID:PMC2713359 (Completed with ARRA Funds)
• Sun H, Zhou X, Chen H, Li Q, Costa M. 2009. Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium. Toxicol Appl Pharmacol 237(3):258-266. doi:10.1016/j.taap.2009.04.008 PMID:19376149 PMCID:PMC2701251 (Completed with ARRA Funds)
• Zhou X, Li Q, Arita A, Sun H, Costa M. 2009. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol 236(1):78-84. doi:10.1016/j.taap.2009.01.009 PMID:19371620 PMCID:PMC2684878 (Completed with ARRA Funds)