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Your Environment. Your Health.

Project Publications: Columbia University: Administrative Core

Superfund Research Program

Administrative Core

Project Leader: Ana Navas-Acien
Co-Investigators: Joseph H. Graziano, Alexander F. van Geen
Grant Number: P42ES010349
Funding Period: 2000-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Jin P, Lu W, Chen Y, Liu M. 2022. Change-plane analysis for subgroup detection with a continuous treatment. Biometrics doi:10.1111/biom.13762 PMID:36134534
  • Parks RM, Benavides J, Anderson GB, Nethery RC, Navas-Acien A, Dominici F, Ezzati M, Kioumourtzoglou M. 2022. Association of tropical cyclones with county-level mortality in the US. JAMA - Journal of the American Medical Association 327:doi:10.1001/jama.2022.1682 PMID:35258534 PMCID:PMC8905400
  • Ravalli F, Parada XV, Ujueta F, Pinotti R, Anstrom KJ, Lamas GA, Navas-Acien A. 2022. Chelation therapy in patients with cardiovascular disease: A systematic review. J Am Heart Assoc 11(22):doi:10.1161/jaha.121.024648 PMID:35229619
  • Sobel MH, Navas-Acien A, Powers M, Grau-Perez M, Goessler W, Best LG, Umans JG, Oelsner EC, Podolanczuk A, Sanchez TR. 2022. Environmental-level exposure to metals and metal-mixtures associated with spirometry-defined lung disease in American Indian adults: Evidence from the Strong Heart Study. Environ Res 207:doi:10.1016/j.envres.2021.112194 PMID:34653410 PMCID:PMC8810711
  • Yang JJ, Yu D, Shu X, Wen W, Rahman S, Abe SL, Saito E, Gupta PC, He J, Tsugane S, Gao Y, Yuan J, Koh W, Sadakane A, Tomata Y, Tsuji I, Sugawara Y, Matsuo K, Ahn Y, Park SK, Chen Y, Inoue M, Kang D, Zheng W. 2022. Reduction in total and major cause-specific mortality from tobacco smoking cessation: a pooled analysis of 16 population-based cohort studies in Asia. Int J Epidemiol 50(6):2070-2081. doi:10.1093/ije/dyab087 PMID:34999862 PMCID:PMC8743132


  • Abuawad A, Spratlen MJ, Parvez F, Slavkovich VN, Ilievski V, Lomax-Luu A, Saxena R, Shahriar H, Uddin MN, Islam T, Graziano JH, Navas-Acien A, Gamble MV. 2021. Association between body mass index and arsenic methylation in three studies of Bangladeshi adults and adolescents. Environ Int doi:10.1016/j.envint.2021.106401 PMID:33549917 PMCID:PMC7976732
  • Butler-Dawson J, James KA, Krisher L, Jaramillo D, Dally M, Neumann N, Pilloni D, Cruz A, Asensio C, Johnson RJ, Adgate JL, Newman L. 2021. Environmental metal exposures and kidney function of Guatemalan sugarcane workers. J Expo Sci Environ Epidemiol doi:10.1038/s41370-021-00292-x PMID:33603096 (ahead of print)
  • Domingo-Relloso A, Huan T, Haack K, Riffo-Campos AL, Levy D, Fallin MD, Terry MB, Zhang Y, Rhoades DA, Herreros-Martinez M, Garcia-Esquinas E, Cole SA, Tellez-Plaza M, Navas-Acien A. 2021. DNA methylation and cancer incidence: Lymphatic-hematopoietic versus solid cancers in the Strong Heart Study. Clin Epigenetics 13:43. doi:10.1186/s13148-021-01030-8 PMID:33632303 PMCID:PMC7908806
  • Galvez-Fernandez M, Grau-Perez M, Garcia-Barrera T, Ramirez-Acosta S, Gomez-Ariza JL, Galan-Labaca I, Navas-Acien A, Redon J, Briongos-Figuero LS, Duenas-Laita A, Perez-Castrillon JL, Tellez-Plaza M, Martin-Escudero JC. 2021. Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study. Free Radic Biol Med 162:392-400. doi:10.1016/j.freeradbiomed.2020.10.318 PMID:33137469
  • Grau-Perez M, Voruganti VS, Balakrishnan P, Haack K, Goessler W, Franceschini N, Redon J, Cole SA, Navas-Acien A, Tellez-Plaza M. 2021. Genetic variation and urine cadmium levels: ABCC1 effects in the Strong Heart Family Study. Environ Pollut 276:doi:10.1016/j.envpol.2021.116717 PMID:33640655 PMCID:PMC8026674
  • Hill-Briggs F, Adler NE, Berkowitz SA, Chin MH, Gary-Webb TL, Navas-Acien A, Thornton PL, Haire-Joshu D. 2021. Social determinants of health and diabetes: A scientific review. Diabetes Care 44(1):258-279. doi:10.2337/dci20-0053 PMID:33139407 (ahead of print)
  • Kaufman JA, Mattison C, Fretts A, Umans JG, Cole SA, Voruganti VS, Goessler W, Best LG, Zhang Y, Navas-Acien A, Gribble MO, Tellez-Plaza M. 2021. Arsenic, blood pressure, and hypertension in the Strong Heart Family Study. Environ Res 195:110864. doi:10.1016/j.envres.2021.110864 PMID:33581093 PMCID:PMC8021390
  • Khan KM, Hatch LC, Akhter S, Eunus M, Zhou Z, Parvez F, Rohlman DS. 2021. Reliability of a computer-based neurobehavioral assessment test battery for Bangladeshi adolescent children. Neurotoxicology 85:47-53. doi:10.1016/j.neuro.2021.04.005 PMID:33940044
  • McGraw KE, Riggs DW, Rai SN, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy SS, Taylor KC, Conklin DJ, DeFilippis A, Srivastava S, Bhatnagar A. 2021. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res 196:110903. doi:10.1016/j.envres.2021.110903 PMID:33636185 PMCID:PMC8119348
  • Navas-Acien A, Domingo-Relloso A, Subedi P, Riffo-Campos AL, Xia R, Gomez L, Haack K, Goldsmith A, Howard BV, Best LG, Devereux RB, Tauqeer A, Zhang Y, Fretts A, Pichler G, Levy D, Vasan RS, Baccarelli A, Herreros-Martinez M, Tang W, Bressler JP, Fornage M, Umans JG, Tellez-Plaza M, Fallin MD, Zhao J, Cole SA. 2021. Blood DNA methylation and incident coronary heart disease: Evidence from the Strong Heart Study. JAMA Cardiol 6(11):doi:10.1001/jamacardio.2021.2704 PMID:34347013 PMCID:PMC8340006 (ahead of print)
  • Nigra AE, Moon KA, Jones MR, Sanchez TR, Navas-Acien A. 2021. Urinary arsenic and heart disease mortality in NHANES 2003-2014. Environ Res 200:111387. doi:10.1016/j.envres.2021.111387 PMID:34090890 PMCID:PMC8403626
  • Parks RM, Anderson GB, Nethery RC, Navas-Acien A, Dominici F, Kioumourtzoglou M. 2021. Tropical cyclone exposure is associated with increased hospitalization rates in older adults. Nat Commun 12:1545. doi:10.1038/s41467-021-21777-1 PMID:33750775 PMCID:PMC7943804
  • Salcedo-Bellido I, Gutierrez-Gonzalez E, Garcia-Esquinas E, Navas-Acien A, Tellez-Plaza M, Pastor-Barriuso R, Lope V, Gomez-Ariza JL, Garcia-Barrera T, Pollan M, Juan Jimenez Moleon J, Perez-Gomez B, Fernandez de Larrea-Baz N. 2021. Toxic metals in toenails as biomarkers of exposure: A review. Environ Res 197:PMID:33753073
  • Shea S, Navas-Acien A, Shimbo D, Brown ER, Budoff M, Bancks MP, Barr RG, Kronmal R. 2021. Spatially weighted coronary artery calcium score and coronary heart disease events in the multi-ethnic study of atherosclerosis. Circ-Cardiovasc Imaging 14:e011981. doi:10.1161/CIRCIMAGING.120.011981 PMID:33461306 PMCID:PMC7987729
  • Signes-Pastor AJ, Gutierrez-Gonzalez E, Garcia-Villarino M, Rodriguez-Cabrera FD, Lopez-Moreno JJ, Varea-Jimenez E, Pastor-Barriuso R, Pollan M, Navas-Acien A, Perez-Gomez B, Karagas MR. 2021. Toenails as a biomarker of exposure to arsenic: A review. Environ Res 195:110286. doi:10.1016/j.envres.2020.110286 PMID:33075355 PMCID:PMC7987585
  • Sobolevskaia V, Cardenas M, Hasanov AK, Knappett PS. 2021. Aquifer diffusivity estimation through joint inversion of the amplitude ratios and time lags of dominant frequencies of fluctuating head. Water Resour Res 57:12. doi:10.1029/2020WR027912
  • Wu F, Yang L, Hao Y, Zhou B, Hu J, Yang Y, Bedi S, Sanichar NG, Cheng C, Perez-Perez G, Tseng W, Tseng W, Tseng M, Francois F, Khan AR, Li Y, Blaser MJ, Shu X, Long J, Li H, Pei Z, Chen Y. 2021. Oral and gastric microbiome in relation to gastric intestinal metaplasia. Int J Cancer 150(6):doi:10.1002/ijc.33848 PMID:34664721 (ahead of print)


  • Alam Z, Ujueta F, Nigra AE, Navas-Acien A, Lamas GA, Arenas I. 2020. Urinary Metal Levels after Repeated Edetate Disodium Infusions: Preliminary Findings. Int J Environ Res Public Health 17:doi:10.3390/ijerph17134684 PMID:32610666 PMCID:PMC7370001
  • Crocker KC, Domingo-Relloso A, Haack K, Fretts A, Tang W, Herreros-Martinez M, Tellez-Plaza M, Fallin MD, Cole SA, Navas-Acien A. 2020. DNA methylation and adiposity phenotypes: An epigenome-wide association study among adults in the Strong Heart Study. Int J Obes 10:doi:10.1038/s41366-020-0646-z PMID:32728124
  • Hosgood H, Slavkovich VN, Hua S, Klugman M, Grau-Perez M, Thyagarajan B, Graziano JH, Cai J, Shaw PA, Kaplan R, Navas-Acien A, Mossavar-Rahmani Y. 2020. Urinary arsenic species are detectable in urban underserved Hispanic/Latino populations: A pilot study from the Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS). Int J Environ Res Public Health 17(7):2247. doi:10.3390/ijerph17072247 PMID:32230710 PMCID:PMC7178047
  • Navas-Acien A, Martinez-Morata I, Hilpert M, Rule A, Shimbo D, LoIacono NJ. 2020. Early Cardiovascular Risk in E-cigarette Users: the Potential Role of Metals. Curr Environ Health Rep doi:10.1007/s40572-020-00297-y PMID:33242201
  • Nigra AE, Chen Q, Chillrud SN, Wang L, Harvey DE, Mailloux BJ, Factor-Litvak P, Navas-Acien A. 2020. Inequalities in public water arsenic concentrations in counties and community water systems across the United States, 2006-2011. Environ Health Perspect 128(12):127001. doi:10.1289/EHP7313 PMID:33295795 PMCID:PMC7724967
  • Nigra AE, Navas-Acien A. 2020. Arsenic in US correctional facility drinking water, 2006-2011. Environ Res 188:109768. doi:10.1016/j.envres.2020.109768 PMID:32585331 PMCID:PMC7483613
  • Stewart OA, Wu F, Chen Y. 2020. The role of gastric microbiota in gastric cancer. Gut Microbes 11:1220-1230. doi:10.1080/19490976.2020.1762520 PMID:32449430


  • Domingo-Relloso A, Grau-Perez M, Galan-Chilet I, Garrido-Martinez MJ, Tormos C, Navas-Acien A, Gomez-Ariza JL, Monzo-Beltran L, Saez-Tormo G, Garcia-Barrera T, Laita AD, Briongos-Figuero LS, Martin-Escudero JC, Chaves FJ, Redon J, Tellez-Plaza M. 2019. Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: the Hortega Study. Environ Int 123:171-180. doi:10.1016/j.envint.2018.11.055 PMID:30529889
  • Grau-Perez M, Zhao J, Pierce BL, Francesconi KA, Goessler W, Zhu Y, An Q, Umans JG, Best LG, Cole SA, Navas-Acien A, Tellez-Plaza M. 2019. Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study. Environ Pollut 246:311-318. doi:10.1016/j.envpol.2018.12.010 PMID:30557805 PMCID:PMC6363843
  • Huang L, Liu L, Zhang T, Zhao D, Li H, Sun H, Kinney PL, Pitiranggon M, Chillrud SN, Ma LQ, Navas-Acien A, Bi J, Yan B. 2019. An interventional study of rice for reducing cadmium exposure in a Chinese industrial town. Environ Int 122:301-309. doi:10.1016/j.envint.2018.11.019 PMID:30477816 PMCID:PMC6368677
  • Landes FC, Paltseva A, Sobolewski JM, Cheng Z, Ellis T, Mailloux BJ, van Geen AF. 2019. A field procedure to screen soil for hazardous lead. Anal Chem 91(13):8192-8198. doi:10.1021/acs.analchem.9b00681 PMID:31177771 PMCID:PMC6610547
  • Moreno RC, Navas-Acien A, Escolar E, Nathan DM, Newman JD, Schmedtje JF, Diaz D, Lamas GA, Fonseca V. 2019. Potential role of metal chelation to prevent the cardiovascular complications of diabetes. J Clin Endocrinol Metab doi:10.1210/jc.2018-01484 PMID:30869793
  • Navas-Acien A, Spratlen MJ, Abuawad A, Lolacono NJ, Bozack AK, Gamble MV. 2019. Early life arsenic exposure, nutritional status, and adult diabetes risk. Curr Diab Rep 19:147. doi:10.1007/s11892-019-1272-9 PMID:31758285 PMCID:PMC7004311
  • Navasumrit P, Chaisatra K, Promvijit J, Parnlob V, Waraprasit S, Chompoobut C, Binh T, Hai D, Bao N, Hai N, Kim K, Samson LD, Graziano JH, Mahidol C, Ruchirawat K. 2019. Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study. Environ Health 18:51. doi:10.1186/s12940-019-0481-7 PMID:31174534 PMCID:PMC6555940
  • Powers M, Sanchez TR, Grau-Perez M, Yeh F, Francesconi KA, Goessler W, George CM, Heaney C, Best LG, Umans JG, Brown RH, Navas-Acien A. 2019. Low moderate arsenic exposure and respiratory in American Indian communities in the strong heart study. Environ Health 18:104. doi:10.1186/s12940-019-0539-6 PMID:31779614 PMCID:PMC6883619
  • Radke EG, Glenn B, Galizia A, Persad A, Nachman R, Bateson T, Wright J, Navas-Acien A, Arroyave WD, Puett R, Harville EW, Pollack AZ, Burns JS, Lynch CD, Sagiv SK, Stein C, Cooper GS. 2019. Development of outcome-specific criteria for study evaluation in systematic reviews of epidemiology studies. Environ Int 130:104884. doi:10.1016/j.envint.2019.05.078 PMID:31299560
  • Spratlen MJ, Grau-Perez M, Umans JG, Yracheta J, Best LG, Francesconi KA, Goessler W, Bottiglieri T, Gamble MV, Cole SA, Zhao J, Navas-Acien A. 2019. Targeted metabolomics to understand the association between arsenic metabolism and diabetes-related outcomes: Preliminary evidence from the Strong Heart Family Study. Environ Res 168:146-157. doi:10.1016/j.envres.2018.09.034 PMID:30316100 PMCID:PMC6298442
  • Thomas ED, Gittelsohn J, Yracheta J, Powers M, O'Leary M, Harvey DE, Cloud RR, Best LG, Bear AB, Navas-Acien A, George CM. 2019. The Strong Heart Water Study: Informing and designing a multi-level intervention to reduce arsenic exposure among private well users in Great Plains Indian Nations. Sci Total Environ 650:3120-3133. doi:10.1016/j.scitotenv.2018.09.204 PMID:30373089


  • Grau-Perez M, Navas-Acien A, Galan-Chilet I, Briongos-Figuero LS, Morchon-Simon D, Bermudez JD, Crainiceanu C, de Marco G, Rentero-Garrido P, Garcia-Barrera T, Gomez-Ariza JL, Casasnovas JA, Martin-Escudero JC, Redon J, Chaves FJ, Tellez-Plaza M. 2018. Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain. Environ Pollut 235:948-955. doi:10.1016/j.envpol.2018.01.008 PMID:29751399 PMCID:PMC6443087
  • Moon KA, Zhang Y, Guallar E, Francesconi KA, Goessler W, Umans JG, Best LG, Howard BV, Devereux RB, Okin PM, Navas-Acien A. 2018. Association of low-moderate urine arsenic and QT interval: cross-sectional and longitudinal evidence from the Strong Heart Study. Environ Pollut 240:894-902. doi:10.1016/j.envpol.2018.04.129 PMID:29793197
  • Sanchez TR, Powers M, Perzanowski M, George CM, Graziano JH, Navas-Acien A. 2018. A meta-analysis of arsenic exposure and lung function: Is there evidence of restrictive or obstructive lung disease?. Curr Environ Health Rep 5:244-254. doi:10.1007/s40572-018-0192-1 PMID:29637476 PMCID:PMC6149528
  • Sanchez TR, Slavkovich VN, LoIacono NJ, van Geen AF, Ellis T, Chillrud SN, Balac O, Islam T, Parvez F, Ahsan H, Graziano JH, Navas-Acien A. 2018. Urinary metals and metal mixtures in Bangladesh: Exploring environmental sources in the Health Effects of Arsenic Longitudinal Study (HEALS). Environ Int 121:852-860. doi:10.1016/j.envint.2018.10.031 PMID:30343184 PMCID:PMC6231410
  • Spratlen MJ, Grau-Perez M, Umans JG, Yracheta J, Best LG, Francesconi K, Goessler W, Balakrishnan P, Cole SA, Gamble MV, Howard BV, Navas-Acien A. 2018. Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. Environ Int 121:728-740. doi:10.1016/j.envint.2018.09.048 PMID:30321848 PMCID:PMC6221918
  • Tellez-Plaza M, Guallar E, Navas-Acien A. 2018. Environmental metals and cardiovascular disease. BMJ 362. doi:10.1136/bmj.k3435 PMID:30158104 PMCID:PMC6283369
  • Wasserman GA, Liu X, Parvez F, Chen Y, Factor-Litvak P, Lolacono NJ, Levy D, Shahriar H, Uddin MN, Islam T, Lomax A, Saxena R, Gibson EA, Kioumourtzoglou M, Balac O, Sanchez TR, Kline JK, Santiago D, Ellis T, Graziano JH, van Geen AF. 2018. A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. Environ Int 118:304-313. doi:10.1016/j.envint.2018.05.037 PMID:29933234


  • Horneman AH, Stute M, Schlosser P, Smethie WM, Santella RM, Ho DT, Mailloux BJ, Gorman E, Zheng Y, van Geen AF. 2008. Degradation rates of CFC-11, CFC-12 and CFC-113 in anoxic shallow aquifers of Araihazar, Bangladesh. J Contam Hydrol 97(1-2):27-41. doi:10.1016/j.jconhyd.2007.12.001 PMID:18262680


  • Stute M, Zheng Y, Schlosser P, Horneman AH, Dhar RK, Datta S, Hoque MA, Seddique V, Shamsudduha M, Ahmed A, van Geen AF. 2007. Hydrological control of arsenic concentrations in Bangladesh aquifers. Water Resour Res 43:1029.
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