Superfund Research Program

Thyroid Metabolism Disruption Key in Toxicant-Induced Developmental Impairment

Project Leader: Heather M. Stapleton
Co-Investigator: P. Lee Ferguson
Grant Number: P42ES010356
Funding Period: 2011-2017

Project-Specific Links

Publications

2017

• Macaulay LJ, Chernick M, Chen A, Hinton DE, Bailey JM, Kullman SW, Levin ED, Stapleton HM. 2017. Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. Environ Toxicol Chem 36(1):36-48. doi:10.1002/etc.3535 PMID:27329031

2016

• Carignan C, Fang M, Stapleton HM, Heiger-Bernays WJ, McClean MD, Webster TF. 2016. Urinary biomarkers of flame retardant exposure among collegiate US gymnasts. Environ Int 94:362-368. doi:10.1016/j.envint.2016.06.030 PMID:27395335 PMCID:PMC4980234
• Cooper EM, Kroeger G, Davis K, Clark C, Ferguson PL, Stapleton HM. 2016. Results from screening polyurethane foam based consumer products for flame retardant chemicals: assessing impacts on the change in the furniture flammability standards. Environ Sci Technol 50(19):10653-10660. doi:10.1021/acs.est.6b01602 PMID:27552529 PMCID:PMC5052662
• Lefevre E, Cooper EM, Stapleton HM, Gunsch C. 2016. Characterization and adaptation of anaerobic sludge microbial communities exposed to tetrabromobisphenol A. PLoS One 11(7):e0157622. doi:10.1371/journal.pone.0157622 PMID:27463972 PMCID:PMC4963083

2015

• Macaulay LJ, Bailey JM, Levin ED, Stapleton HM. 2015. Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. Neurotoxicol Teratol 52(PtB):119-126. doi:10.1016/j.ntt.2015.05.002 PMID:25979796 PMCID:PMC4644107
• Macaulay LJ, Chen A, Rock KD, Dishaw L, Dong W, Hinton DE, Stapleton HM. 2015. Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β. Aquat Toxicol 168:38-47. doi:10.1016/j.aquatox.2015.09.007 PMID:26433919 PMCID:PMC4618599

2014

• Dong W, Macaulay LJ, Kwok KW, Hinton DE, Ferguson PL, Stapleton HM. 2014. The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos. Endocr Disruptors (Austin) 2(1):doi:10.4161/23273739.2014.969072 PMID:25767823 PMCID:PMC4354867
• Levin ED, Cauley M, Johnson JE, Cooper EM, Stapleton HM, Ferguson PL, Seidler FJ, Slotkin TA. 2014. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicol Teratol 41:35-42. doi:10.1016/j.ntt.2013.10.004 PMID:24177596 PMCID:PMC3943881
• Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. 2014. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122(11):1225-1232. doi:10.1289/ehp.1408111 PMID:25062436 PMCID:PMC4216168

2013

• Clark BW, Cooper EM, Stapleton HM, Di Giulio RT. 2013. Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River Estuary (Virginia, USA). Environ Sci Technol 47(18):10556-10566. doi:10.1021/es401604b PMID:24003986 PMCID:PMC4079253
• Dong W, Macaulay LJ, Kwok KW, Hinton DE, Stapleton HM. 2013. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Aquat Toxicol 132-133:190-199. doi:10.1016/j.aquatox.2013.02.008 PMID:23531416 PMCID:PMC3642849
• Slotkin TA, Cooper EM, Stapleton HM, Seidler FJ. 2013. Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?. Environ Toxicol Pharmacol 36(2):284-287. doi:10.1016/j.etap.2013.04.003 PMID:23686008 PMCID:PMC3745805