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Your Environment. Your Health.

Project Publications: Duke University: Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure

Superfund Research Program

Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure

Project Leader: Joel N. Meyer
Co-Investigators: Susan K. Murphy, Theodore A. Slotkin (Duke University Medical Center)
Grant Number: P42ES010356
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

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Publications

2019

  • Bachman H, Fu H, Huang P, Tian Z, Embry-Seckler J, Rufo J, Xie Z, Hartman JH, Zhao S, Yang S, Meyer JN, Huang TJ. 2019. Open source acoustofluidics. Lab Chip 19(14):2404-2414. doi:10.1039/c9lc00340a PMID:31240285 PMCID:PMC6934416
  • Berky AJ, Ryde IT, Feingold BJ, Ortiz EJ, Wyatt LH, Weinhouse C, Hsu-Kim H, Meyer JN, Pan WK. 2019. Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study. Environ Mol Mutagen 60(2):197-210. doi:10.1002/em.22244 PMID:30289587 PMCID:PMC6452630
  • Dreier DA, Mello DF, Meyer JN, Martyniuk CJ. 2019. Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: progress and considerations for mitochondrial adverse outcome pathways. Environ Toxicol Chem 38:1625-1634. doi:10.1002/etc.4453 PMID:31034624 PMCID:PMC6961808
  • Hartman JH, Gonzalez-Hunt CP, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN. 2019. Genetic defects in mitochondrial dynamics in Caenorhabditis elegans impact ultraviolet C radiation- and 6-hydroxydopamine-induced neurodegeneration. Int J Mol Sci 20(13):E3202. doi:10.3390/ijms20133202 PMID:31261893 PMCID:PMC6651461
  • Hershberger KA, Leuthner T, Waters TA, Meyer JN. 2019. Caenorhabditis elegans strain sensitivity to sodium arsenite exposure is varied based on age and outcome measured. micropub bio doi:10.17912/micropub.biology.000186
  • House JS, Hall J, Park S, Planchart A, Money ES, Maguire R, Huang Z, Mattingly CJ, Skaar D, Tzeng J, Darrah T, Vengosh A, Murphy SK, Jirtle R, Hoyo C. 2019. Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort. Environ Epigenet 5(3):dvz014. doi:10.1093/eep/dvz014 PMID:31528362 PMCID:PMC6736358
  • Leung MC, Meyer JN. 2019. Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. Reprod Toxicol 89:83-92. doi:10.1016/j.reprotox.2019.07.007 PMID:31315019 PMCID:PMC6766410
  • Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N. 2019. Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11:6535-6554. doi:10.18632/aging.102208 PMID:31454791 PMCID:PMC6738431
  • Sikdar S, Joehanes R, Joubert BR, Xu C, Vives-Usano M, Rezwan F, Felix J, Ward JM, Guan W, Richmond RC, Brody JA, Kupers LK, Baiz N, Haberg SE, Smith JA, Reese SE, Aslibekyan S, Hoyo C, Dhingra R, Markunas CA, Xu T, Reynolds LM, Just AC, Mandaviya PR, Ghantous A, Bennett BD, Wang T, BIOS-Consortium, Bakulski KM, Melen E, Zhao S, Juin J, Herceg Z, van Meurs JB, Taylor JA, Baccarelli A, Murphy SK, Liu Y, Minthe-Kaas MC, Deary IJ, Nystad W, Waldenberger M, Annesi-Maesano I, Conneely K, Jaddoe VW, Arnett D, Snieder H, Kardia SL, Relton CL, Ong KK, Ewart S, Moreno-Macias H, Romieu I, Sotoodehnia N, Fornage M, Motsinger-Reif A, Koppelman GH, Bustamante M, Levy D, London SJ. 2019. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics 11(13):1487-1500. doi:10.2217/epi-2019-0066 PMID:31536415 PMCID:PMC6836223
  • Smith LL, Ryde IT, Hartman JH, Romersi RF, Markovich Z, Meyer JN. 2019. Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. Neurotoxicology 74:209-220. doi:10.1016/j.neuro.2019.07.002 PMID:31323240 PMCID:PMC6751008
  • Zhang J, Yang S, Chen C, Hartman JH, Huang P, Wang L, Tian Z, Zhang P, Faulkenberry D, Meyer JN, Huang TJ. 2019. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab Chip 19(6):984-992. doi:10.1039/c8lc01012a PMID:30768117 PMCID:PMC6659422

2018

  • Cothren SD, Meyer JN, Hartman JH. 2018. Blinded visual scoring of images using the freely-available software Blinder. Bio Protoc 8(23):e3103. doi:10.21769/BioProtoc.3103 PMID:30761327 PMCID:PMC6370323
  • Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Drsicoll M, Sherwood DR, Meyer JN. 2018. Swimming exercise and transient food deprivation in Caenorhabditis elegans promote mitochondrial maintenance and protect against chemical-induced mitotoxicity. Sci Rep 8:8359. doi:10.1038/s41598-018-26552-9 PMID:29844465 PMCID:PMC597439
  • Hibshman JD, Leuthner T, Shoben C, Mello DF, Sherwood DR, Meyer JN, Baugh LR. 2018. Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. Am J Physiol Cell Physiol 315:C781-C792. doi:10.1152/ajpcell.00109.2018 PMID:30133321 PMCID:PMC6336938
  • Luz AL, Kassotis CD, Stapleton HM, Meyer JN. 2018. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARgamma activation, in 3T3-L1 cells. Toxicology 393:150-159. doi:10.1016/j.tox.2017.11.010 PMID:29127035 PMCID:PMC5726929
  • Maurer LL, Luz AL, Meyer JN. 2018. Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans. Chapter 43 in: Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. John Wiley & Sons, Inc., pp.655-689.
  • Meyer JN, Hartman JH, Mello DF. 2018. Mitochondrial toxicity. Toxicol Sci 162(1):15-23. doi:10.1093/toxsci/kfy008 PMID:29340618 PMCID:PMC5837373 (in press)
  • Sanders LH, Rouanet JP, Howlett EH, Leuthner T, Rooney JP, Greenamyre JT, Meyer JN. 2018. Newly revised quantitative PCR-based assay for mitochondrial and nuclear DNA damage. Curr Protoc Toxicol 76(1):e50. doi:10.1002/cptx.50 PMID:30040241 PMCID:PMC6060631
  • Weinhouse C, Truong L, Meyer JN, Allard P. 2018. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575. doi:10.1002/em.22203 PMID:30091255 PMCID:PMC6113102

2017

2002

  • Maurer LL, Luz AL, Meyer JN. 2002. Detection of mitochondrial toxicity of environmental pollutants using Caenorhabditis elegans. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY.
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