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Your Environment. Your Health.

Project Publications: Duke University: Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure

Superfund Research Program

Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure

Project Leader: Joel N. Meyer
Co-Investigators: Susan K. Murphy, Theodore A. Slotkin (Duke University Medical Center)
Grant Number: P42ES010356
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Berky AJ, Robie E, Chipa SN, Ortiz EJ, Palmer EJ, Rivera NA, Avalos AM, Hsu-Kim H, Pan WK. 2022. Risk of lead exposure from wild game consumption from cross-sectional studies in Madre de Dios, Peru. Lancet Regional Health- Americas 12:100266. doi:10.1016/j.lana.2022.100266
  • Joglekar R, Grenier C, Hoyo C, Hoffman K, Murphy SK. 2022. Maternal tobacco smoke exposure is associated with increased DNA methylation at human metastable epialleles in infant cord blood. Environ Epigenet 8(1):doi:10.1093/eep/dvac005 PMID:35355955 PMCID:PMC8962709
  • King DE, Sparling A, Lloyd D, Satusky MJ, Martinez M, Grenier C, Bergemann CM, Maguire R, Hoyo C, Meyer JN, Murphy SK. 2022. Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes. Epigenetics doi:10.1080/15592294.2022.2043591 PMID:35238269
  • Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, Raimundo N, Meyer JN, Distelmaier F, Ventura N. 2022. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nat Commun doi:10.1038/s41467-022-29972-4 PMID:35551180 PMCID:PMC9098500
  • Mello DF, Bergemann CM, Fisher K, Chitrakar R, Bijwadia SR, Wang Y, Caldwell A, Baugh LR, Meyer JN. 2022. Rotenone modulates Caenorhabditis elegans immunometabolism and pathogen susceptibility. Front Immunol 13:840272. doi:10.3389/fimmu.2022.840272 PMID:35273616 PMCID:PMC8902048
  • Mello DF, Maurer LL, Ryde IT, Songr D, Marinakos SM, Jiang C, Wiesner MR, Hsu-Kim H, Meyer JN. 2022. In vivo effects of silver nanoparticles on development, behavior, and mitochondrial function are altered by genetic defects in mitochondrial dynamics. Environ Sci Technol 56:1113-1124. doi:10.1021/acs.est.1c05915 PMID:35038872 PMCID:PMC8802983


  • Bijwadia SR, Morton KS, Meyer JN. 2021. Quantifying levels of dopaminergic neuron morphological alteration and degeneration in Caenorhabditis elegans. J Vis Exp 177:doi:10.3791/62894 PMID:34866619
  • Hartman JH, Widmayer SJ, Bergemann CM, King DE, Morton KS, Romersi RF, Jameson LE, Leung MC, Andersen EC, Taubert S, Meyer JN. 2021. Xenobiotic metabolism and transport in Caenorhabditis elegans. J Toxicol Environ Health B Crit Rev 24(2):51-94. doi:10.1080/10937404.2021.1884921 PMID:33616007 PMCID:PMC7958427
  • Hershberger KA, Rooney JP, Turner EA, Donoghue LJ, Bodhicharla R, Maurer LL, Ryde IT, Kim JJ, Joglekar R, Hibshman JD, Smith LL, Bhatt DP, Ilkayeva OR, Hirschey MD, Meyer JN. 2021. Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans. Redox Biol 43:102000. doi:10.1016/j.redox.2021.102000 PMID:33993056 PMCID:PMC8134077
  • King DE, Sparling A, Joglekar R, Meyer JN, Murphy SK. 2021. Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing. micropub bio doi:10.17912/micropub.biology.000444 PMID:34423283 PMCID:PMC8377520
  • Leuthner T, Hartman JH, Ryde IT, Meyer JN. 2021. PCR-based determination of mitochondrial DNA copy number in multiple species. Methods Mol Biol 2310:91-111. doi:10.1007/978-1-0716-1433-4_8 PMID:34096001
  • Leuthner T, Meyer JN. 2021. Mitochondrial DNA mutagenesis: Feature of and biomarker for environmental exposures and aging. Curr Environ Health Rep 8(4):doi:10.1007/s40572-021-00329-1 PMID:34761353 (ahead of print)
  • Wang L, Mello DF, Zucker RM, Rivera NA, Rogers NM, Geitner NK, Boyes W, Wiesner MR, Hsu-Kim H, Meyer JN. 2021. Lack of detectable direct effects of silver and silver nanoparticles on mitochondria in mouse hepatocytes. Environ Sci Technol 11166-11175. doi:10.1021/acs.est.1c02295 PMID:34346225 (ahead of print)


  • Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkayeva OR, Bhatt DP, Hirschey MD, Meyer JN. 2020. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Toxicology 447(10):152630. doi:10.1016/j.tox.2020.152630 PMID:33188857 PMCID:PMC7750303
  • Harris JB, Hartman JH, Luz AL, Wilson JY, Dinyari A, Meyer JN. 2020. Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. Toxicology 440(11):doi:10.1016/j.tox.2020.152473 PMID:32360973 PMCID:PMC7313633
  • Zhang J, Hartman JH, Chen C, Yang S, Li Q, Tian Z, Huang P, Wang L, Meyer JN, Huang TJ. 2020. Fluorescence-based Sorting of Caenorhabditis Elegans via Acoustofluidics. Chem Sci 20:1729-1739. doi:10.1039/d0lc00051e PMID:32292982 PMCID:PMC723976


  • Bachman H, Fu H, Huang P, Tian Z, Embry-Seckler J, Rufo J, Xie Z, Hartman JH, Zhao S, Yang S, Meyer JN, Huang TJ. 2019. Open source acoustofluidics. Lab Chip 19(14):2404-2414. doi:10.1039/c9lc00340a PMID:31240285 PMCID:PMC6934416
  • Berky AJ, Ryde IT, Feingold BJ, Ortiz EJ, Wyatt LH, Weinhouse C, Hsu-Kim H, Meyer JN, Pan WK. 2019. Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study. Environ Mol Mutagen 60(2):197-210. doi:10.1002/em.22244 PMID:30289587 PMCID:PMC6452630
  • Dreier DA, Mello DF, Meyer JN, Martyniuk CJ. 2019. Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: progress and considerations for mitochondrial adverse outcome pathways. Environ Toxicol Chem 38:1625-1634. doi:10.1002/etc.4453 PMID:31034624 PMCID:PMC6961808
  • Hartman JH, Gonzalez-Hunt CP, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN. 2019. Genetic defects in mitochondrial dynamics in Caenorhabditis elegans impact ultraviolet C radiation- and 6-hydroxydopamine-induced neurodegeneration. Int J Mol Sci 20(13):E3202. doi:10.3390/ijms20133202 PMID:31261893 PMCID:PMC6651461
  • Hershberger KA, Leuthner T, Waters TA, Meyer JN. 2019. Caenorhabditis elegans strain sensitivity to sodium arsenite exposure is varied based on age and outcome measured. micropub bio doi:10.17912/micropub.biology.000186 PMID:32550437 PMCID:PMC7252313
  • House JS, Hall J, Park S, Planchart A, Money ES, Maguire R, Huang Z, Mattingly CJ, Skaar D, Tzeng J, Darrah T, Vengosh A, Murphy SK, Jirtle R, Hoyo C. 2019. Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort. Environ Epigenet 5(3):dvz014. doi:10.1093/eep/dvz014 PMID:31528362 PMCID:PMC6736358
  • Leung MC, Meyer JN. 2019. Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. Reprod Toxicol 89:83-92. doi:10.1016/j.reprotox.2019.07.007 PMID:31315019 PMCID:PMC6766410
  • Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N. 2019. Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11:6535-6554. doi:10.18632/aging.102208 PMID:31454791 PMCID:PMC6738431
  • Sikdar S, Joehanes R, Joubert BR, Xu C, Vives-Usano M, Rezwan F, Felix J, Ward JM, Guan W, Richmond RC, Brody JA, Kupers LK, Baiz N, Haberg SE, Smith JA, Reese SE, Aslibekyan S, Hoyo C, Dhingra R, Markunas CA, Xu T, Reynolds LM, Just AC, Mandaviya PR, Ghantous A, Bennett BD, Wang T, BIOS-Consortium, Bakulski KM, Melen E, Zhao S, Juin J, Herceg Z, van Meurs JB, Taylor JA, Baccarelli A, Murphy SK, Liu Y, Minthe-Kaas MC, Deary IJ, Nystad W, Waldenberger M, Annesi-Maesano I, Conneely K, Jaddoe VW, Arnett D, Snieder H, Kardia SL, Relton CL, Ong KK, Ewart S, Moreno-Macias H, Romieu I, Sotoodehnia N, Fornage M, Motsinger-Reif A, Koppelman GH, Bustamante M, Levy D, London SJ. 2019. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics 11(13):1487-1500. doi:10.2217/epi-2019-0066 PMID:31536415 PMCID:PMC6836223
  • Smith LL, Ryde IT, Hartman JH, Romersi RF, Markovich Z, Meyer JN. 2019. Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. Neurotoxicology 74:209-220. doi:10.1016/j.neuro.2019.07.002 PMID:31323240 PMCID:PMC6751008
  • Zhang J, Yang S, Chen C, Hartman JH, Huang P, Wang L, Tian Z, Zhang P, Faulkenberry D, Meyer JN, Huang TJ. 2019. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab Chip 19(6):984-992. doi:10.1039/c8lc01012a PMID:30768117 PMCID:PMC6659422


  • Cothren SD, Meyer JN, Hartman JH. 2018. Blinded visual scoring of images using the freely-available software Blinder. Bio Protoc 8(23):e3103. doi:10.21769/BioProtoc.3103 PMID:30761327 PMCID:PMC6370323
  • Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Drsicoll M, Sherwood DR, Meyer JN. 2018. Swimming exercise and transient food deprivation in Caenorhabditis elegans promote mitochondrial maintenance and protect against chemical-induced mitotoxicity. Sci Rep 8:8359. doi:10.1038/s41598-018-26552-9 PMID:29844465 PMCID:PMC597439
  • Hibshman JD, Leuthner T, Shoben C, Mello DF, Sherwood DR, Meyer JN, Baugh LR. 2018. Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. Am J Physiol Cell Physiol 315:C781-C792. doi:10.1152/ajpcell.00109.2018 PMID:30133321 PMCID:PMC6336938
  • Luz AL, Kassotis CD, Stapleton HM, Meyer JN. 2018. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARgamma activation, in 3T3-L1 cells. Toxicology 393:150-159. doi:10.1016/j.tox.2017.11.010 PMID:29127035 PMCID:PMC5726929
  • Maurer LL, Luz AL, Meyer JN. 2018. Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans. Chapter 43 in: Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. John Wiley & Sons, Inc., pp.655-689.
  • Meyer JN, Hartman JH, Mello DF. 2018. Mitochondrial toxicity. Toxicol Sci 162(1):15-23. doi:10.1093/toxsci/kfy008 PMID:29340618 PMCID:PMC5837373 (in press)
  • Sanders LH, Rouanet JP, Howlett EH, Leuthner T, Rooney JP, Greenamyre JT, Meyer JN. 2018. Newly revised quantitative PCR-based assay for mitochondrial and nuclear DNA damage. Curr Protoc Toxicol 76(1):e50. doi:10.1002/cptx.50 PMID:30040241 PMCID:PMC6060631
  • Weinhouse C, Truong L, Meyer JN, Allard P. 2018. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575. doi:10.1002/em.22203 PMID:30091255 PMCID:PMC6113102



  • Maurer LL, Luz AL, Meyer JN. 2002. Detection of mitochondrial toxicity of environmental pollutants using Caenorhabditis elegans. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY.
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