Superfund Research Program

Persisting Neurobehavioral Dysfunction Caused by Interacting Toxicant Exposures During Development: Mechanistic and Treatment Studies with Zebrafish and Rats

Project Leader: Edward D. Levin
Grant Number: P42ES010356
Funding Period: 2022-2027

Project-Specific Links

Publications

2024

• Hawkey AB, Shekey N, Dean C, Asrat H, Koburov R, Holloway Z, Kullman SW, Levin ED. 2024. Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish. Toxicol Sci doi:10.1093/toxsci/kfae001 PMID:38237923
• Marchese M, Zhu T, Hawkey AB, Wang K, Yuan E, Wen J, Be S, Levin ED, Feng L. 2024. Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development. Sci Total Environ 917:170459. doi:10.1016/j.scitotenv.2024.170459 PMID:38290673
• Stickler A, Hawkey AB, Gondal A, Natarajan S, Mead M, Levin ED. 2024. Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish. Neurotoxicol Teratol 102:107339. doi:10.1016/j.ntt.2024.107339 PMID:38452988 PMCID:10990771

2023

• Hawkey AB, Mead M, Natarajan S, Gondal A, Jarrett O, Levin ED. 2023. Embryonic exposure to PFAS causes long-term, compound-specific behavioral alterations in zebrafish. Neurotoxicol Teratol 97:107165. doi:10.1016/j.ntt.2023.107165 PMID:36801483 PMCID:PMC10198882
• Hawkey AB, Unal D, Holloway Z, Levin ED. 2023. Developmental exposure of zebrafish to neonicotinoid pesticides: long-term effects on neurobehavioral function. Neurotoxicology 96:240-253. doi:10.1016/j.neuro.2023.05.003 PMID:37149154 PMCID:PMC10204077
• Kozal JS, Jayasundara N, Massarsky A, Lindberg C, Oliveri A, Cooper EM, Levin ED, Meyer JN, Di Giulio RT. 2023. Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio. Aquat Toxicol 263:106658. doi:10.1016/j.aquatox.2023.106658 PMID:37722151 PMCID:PMC10591944

2022

• Hawkey AB, Evans J, Holloway Z, Pippen E, Jarrett O, Kenou B, Slotkin TA, Seidler FJ, Levin ED. 2022. Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction. Birth Defects Res doi:10.1002/bdr2.2125 PMID:36369782 PMCID:PMC10197196