Superfund Research Program

Biological Dosimetry of Hexavalent Chromium

Project Leader: Anatoly Zhitkovich
Grant Number: P42ES013660
Funding Period: 2005-2014

Project-Specific Links

Publications

2013

• Green SE, Luczak MW, Morse JL, DeLoughery Z, Zhitkovich A. 2013. Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity. Toxicol Sci 136:467-477. doi:10.1093/toxsci/kft214 PMID:24068677 PMCID:PMC3858198
• Luczak MW, Zhitkovich A. 2013. Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II). Free Radic Biol Med 65:262–269. doi:10.1016/j.freeradbiomed.2013.06.028 PMID:23792775 PMCID:PMC3823631
• Wong VC, Morse JL, Zhitkovich A. 2013. P53 activation by Ni(II) is a HIF-1alpha independent response causing caspases 9/3-mediated apoptosis in human lung cells. Toxicol Appl Pharmacol 269(3):233-239. doi:10.1016/j.taap.2013.03.023 PMID:23566959 PMCID:PMC3666101

2012

• Wong VC, Armknecht S, Zhitkovich A. 2012. Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process. Journal of Trace Elements in Medicine and Biology 26:192-196. doi:10.1016/j.jtemb.2012.04.016 PMID:22572042 PMCID:PMC3380165

2011

• Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB. 2011. Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124(1):138-148. doi:10.1093/toxsci/kfr206 PMID:21828359 PMCID:PMC3196652 (Completed with ARRA Funds)

2010

• Zecevic A, Hagan E, Reynolds M, Poage G, Johnston T, Zhitkovich A. 2010. XPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromate. Mutagenesis 25(4):381-388. doi:10.1093/mutage/geq017 PMID:20410141 PMCID:PMC2893307
• Zhitkovich A, Hagan E, Macfie A. 2010. Mechanism of DNA-protein cross-linking by chromium. Chem Res Toxicol 23(2):341-347. doi:10.1021/tx9003402 PMID:19877617 PMCID:PMC2822107

2009

• Zecevic A, Menard H, Gurel V, Hagan E, DeCaro R, Zhitkovich A. 2009. WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts. Cell Cycle 8(17):2769-78. PMID:19652551

2008

• Guttmann D, Poage G, Johnston T, Zhitkovich A. 2008. Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism. Chem Res Toxicol 21(11):2188-2194. doi:10.1021/tx800265g PMID:18808157 PMCID:PMC2665875
• Salnikow K, Zhitkovich A. 2008. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21(1):28-44. doi:10.1021/tx700198a PMID:17970581 PMCID:PMC2602826
• Zhitkovich A, Branco R, Chung AP, Johnston T, Gurel V, Morais P. 2008. The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to chromium(VI) and superoxide. J Bacteriol 190(21):6996-7003. doi:10.1128/JB.00289-08 PMID:18776016 PMCID:PMC2580707

2007

• Liu X, Gurel V, Morris D, Murray DW, Zhitkovich A, Kane AB, Hurt RH. 2007. Bioavailability of nickel in single-wall carbon nanotubes. Advanced Materials 19:2790-96.
• Reynolds M, Stoddard L, Bespalov I, Zhitkovich A. 2007. Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair. Nucleic Acids Res 35(2):465-476. doi:10.1093/nar/gkl1069 PMID:17169990 PMCID:PMC1802609
• Reynolds M, Zhitkovich A. 2007. Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53. Carcinogenesis 28(7):1613-1620. PMID:17301063

2006

• Quievryn G, Messer J, Zhitkovich A. 2006. Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate. Carcinogenesis 27(11):2316-2321. PMID:16714765