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Project Publications: Brown University: Training Core

Superfund Research Program

Training Core

Project Leader: Agnes B. Kane
Grant Number: P42ES013660
Funding Period: 2005-2021

Project-Specific Links





  • Kabadi PK, Rodd AL, Simmons AE, Messier N, Hurt RH, Kane AB. 2019. A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations. Part Fibre Toxicol 16(1):15. doi:10.1186/s12989-019-0298-0 PMID:30943996 PMCID:PMC6448215
  • Kane AB. 2019. Inflammation. Chapter 17 in: Tumour Site Concordance and Mechanisms of Carcinogenesis. IARC Publications, pp.165-174.
  • Kingsley SL, Walker DI, Calafat AM, Chen A, Papandonatos GD, Xu Y, Jones DP, Lanphear BP, Pennell KD, Braun JM. 2019. Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study. Metabolomics 15(7):95. doi:10.1007/s11306-019-1560-z PMID:31227916
  • McDonough CA, Guelfo J, Higgins CP. 2019. Measuring total PFASs in water: the tradeoff between selectivity and inclusivity. Current Opinion in Environmental Science & Health 7:13-18. doi:10.1016/j.coesh.2018.08.005
  • Stermer A, Klein D, Wilson S, Dalaijamts C, Bai CY, Hall SJ, Madnick SJ, Bianchi E, Chiu WA, Boekelheide K. 2019. Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environ Toxicol Pharmacol 68:1-3. doi:10.1016/j.etap.2019.02.003 PMID:30836291 PMCID:PMC6594756
  • Stermer A, Reyes G, Hall SJ, Boekelheide K. 2019. Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether. Toxicol Sci 169(2):399-408. doi:10.1093/toxsci/kfz041 PMID:30768127 PMCID:PMC6934889
  • Verginelli I, Yao Y, Suuberg EM. 2019. Risk Assessment Tool for Chlorinated Vapor Intrusion Based on a Two-Dimensional Analytical Model Involving Vertical Heterogeneity. Environ Eng Sci 36(8):969-980. doi:10.1089/ees.2018.0468
  • Wang G, Ma S, Strom J, Suuberg EM, Yao Y, Zeng L. 2019. Investigating two-dimensional soil gas transport of trichloroethylene in vapor intrusion scenarios involving surface pavements using a pilot-scale tank. J Hazard Mater 371:138-145. doi:10.1016/j.jhazmat.2019.02.069 PMID:30849568


  • Bianchi E, Stermer A, Boekelheide K, Sigman M, Hall SJ, Reyes G, Dere E, Hwang K. 2018. High-quality human and rat spermatozoal RNA isolation for functional genomic studies. J Androl 6:374-383. doi:10.1111/andr.12471 PMID:29470852 PMCID:PMC6309170
  • Chen P, Zhang M, Liu M, Wong IY, Hurt RH. 2018. Ultrastretchable graphene-based molecular barriers for chemical protection, detection, and actuation. ACS Nano 12:234-244. doi:10.1021/acsnano.7b05961 PMID:29165991 PMCID:PMC5780244 (in press)
  • Gray EP, Browning CL, Wang M, Gion K, Chao EY, Koski K, Kane AB, Hurt RH. 2018. Biodissolution and cellular response to MoO3 nanoribbons and a new framework for early hazard screening for 2D materials. Environ Sci Nano 5(11):2545-2559. doi:10.1039/C8EN00362A
  • Guelfo J, Adamson DT. 2018. Evaluation of a national data set for insights into sources, composition, and concentrations of per- and polyfluoroalkyl substances (PFASs) in U.S. drinking water. Environ Pollut 236:505-513. doi:10.1016/j.envpol.2018.01.066 PMID:29427949 PMCID:PMC5849529
  • Kane AB, Hurt RH, Gao H. 2018. The asbestos-carbon nanotube analogy: An update. Toxicol Appl Pharmacol 361:68-80. doi:10.1016/j.taap.2018.06.027 PMID:29960000 PMCID:PMC6298811
  • Rodd AL, Castilho CJ, Chaparro CE, Rangel-Mendez JR, Hurt RH, Kane AB. 2018. Impact of emerging, high-production-volume graphene-based materials on the bioavailability of benzo(a)pyrene to brine shrimp and fish liver cells. Environ Sci Nano 5(9):2144-2161. doi:10.1039/C8EN00352A
  • Spade DJ, Bai CY, Lambright C, Conley JM, Boekelheide K, Gray LE. 2018. Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells. Toxicol Lett 290:55-61. doi:10.1016/j.toxlet.2018.03.018 PMID:29571896 PMCID:PMC5921076
  • Thompson MR, Barcott DS. 2018. The Role of the Nurse Scientist as a Knowledge Broker. J Nurs Scholarsh 51(1):26-39. doi:10.1111/jnu.12439 PMID:30354032 PMCID:PMC6329672
  • Toral-Sanchez E, Rangel-Mendez JR, Hurt RH, Ascacio Valdes JA, Aguilar CN, Cervantes FJ. 2018. Novel application of magnetic nano-carbon composite as redox mediator in the reductive biodegradation of iopromide in anaerobic continuous systems. Appl Microbiol Biotechnol 1-11. doi:10.1007/s00253-018-9250-8 PMID:30058007
  • Wilson S, Dere E, Klein D, Schorl C, Hall SJ, Boekelheide K. 2018. Localization of dimethylated histone three lysine four in the Rattus norvegicus sperm genome. Biol Reprod 99(2):266-268. doi:10.1093/biolre/ioy051 PMID:29506216
  • Yao Y, Verginelli I, Suuberg EM, Eklund B. 2018. Examining the Use of USEPA's Generic Attenuation Factor in Determining Groundwater Screening Levels for Vapor Intrusion. Ground Water Monit Remediat 38(2):79-89. doi:10.1111/gwmr.12276 PMID:30524180 PMCID:PMC6277045


  • Chen P, Liu M, Wang Z, Hurt RH, Wong IY. 2017. From Flatland to Spaceland: Higher Dimensional Patterning with Two-Dimensional Materials. Advanced Materials 29:doi:10.1002/adma.201605096 PMID:28244157 PMCID:PMC5549278
  • Kuempel E, Jaurand MC, Moller P, Morimoto Y, Kobayashi N, Pinkerton KE, Sargent LM, Vermeulen R, Fubini B, Kane AB. 2017. Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Crit Rev Toxicol 47(1):1-58. doi:10.1080/10408444.2016.1206061 PMID:27537422
  • Qui Y, Moore S, Hurt RH, Kulaots I. 2017. Influence of external heating rate on the structure and porosity of thermally exfoliated graphite oxide. Carbon N Y 111:651-657. doi:10.1016/j.carbon.2016.10.051 PMID:28042164 PMCID:PMC5198721
  • Rodd AL, Messier N, Vaslet CA, Kane AB. 2017. A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144. doi:10.1016/j.aquatox.2017.02.018 PMID:28282620 PMCID:PMC5436724
  • Steinberg R, Cruz M, Mahfouz NG, Qui Y, Hurt RH. 2017. Breathable vapor toxicant barriers based on multilayer graphene oxide. ACS Nano 11:5670-5679. doi:10.1021/acsnano.7b01106 PMID:28582974
  • Wang Z, Zhang Y, Liu M, Peterson A, Hurt RH. 2017. Oxidation suppression during hydrothermal phase reversion allows synthesis of monolayer semiconducting MoS2 in stable aqueous suspension. Nanoscale 9:5398-5403. doi:10.1039/c7nr01193h PMID:28426079
  • Yao Y, Wang Y, Zhong Z, Tang M, Suuberg EM. 2017. Investigating the role of soil texture in vapor intrusion from groundwater sources. J Environ Qual 46:776-784. doi:10.2134/jeq2017.01.0011 PMID:28783798




  • Avissar-Whiting M, Koestler DC, Houseman EA, Christensen BC, Kelsey KT, Marsit CJ. 2011. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics 6:703-709. doi:10.4161/epi.6.6.16158 PMID:21610323 PMCID:PMC3230543 (Completed with ARRA Funds)
  • Banister CE, Koestler DC, Maccani MA, Houseman EA, Padbury JF, Marsit CJ. 2011. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics 6:920-927. doi:10.4161/epi.6.7.16079 PMID:21758004 PMCID:PMC3154432 (Completed with ARRA Funds)
  • Brown P, Cordner A. 2011. Lessons learned from flame retardant use and regulation could enhance future control of potentially hazardous chemicals. Health Aff (Millwood) 30(5):906-914. doi:10.1377/hlthaff.2010.1228 PMID:21555474
  • Filiberto AC, Maccani MA, Koestler DC, Wilhelm-Benartzi C, Gagne LA, Marsit CJ. 2011. Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics 6(5):566-572. doi:10.4161/epi.6.5.15236 PMID:21521940 PMCID:PMC3121971
  • Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT. 2011. DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol 29(9):1133-1139. doi:10.1200/JCO.2010.31.3577 PMID:21343564 PMCID:PMC3083868 (Completed with ARRA Funds)
  • Wilhelm-Benartzi C, Christensen BC, Koestler DC, Houseman EA, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2011. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes Control 22(8):1205-1213. doi:10.1007/s10552-011-9788-6 PMID:21660454 PMCID:PMC3140591 (Completed with ARRA Funds)


  • Christensen BC, Smith A, Zheng S, Koestler DC, Houseman E, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK. 2010. DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Natl Cancer Inst 103:143-153. doi:10.1093/jnci/djq497 PMID:21163902 PMCID:PMC3022619
  • Gee GV, Koestler DC, Christensen BC, Sugarbaker DJ, Ugolini DJ, Ivaldi GP, Resnick MB, Houseman E, Kelsey KT, Marsit CJ. 2010. Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma. Int J Cancer 127(12):2859-2869. doi:10.1002/ijc.25285 PMID:21351265 PMCID:PMC2911512
  • Ito H, Matsuo K, Tanaka H, Koestler DC, Ombao H, Fulton J, Shibata A, Fujita M, Sugiyama H, Soda M, Sobue T, Mor V. 2010. Non-filter and filter cigarette consumption and the incidence of lung cancer by histological type in Japan and the United States: analysis of 30-year data from population based cancer registries. Int J Cancer 128:1918-28. doi:10.1002/ijc.25531 PMID:20589676
  • Koestler DC, Marsit CJ, Christensen BC, Karagas MR, Bueno R, Sugarbaker DJ, Kelsey KT, Houseman EA. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics 26(20):2578-2585. doi:10.1093/bioinformatics/btq470 PMID:20834038 PMCID:PMC2951086 (Completed with ARRA Funds)
  • Liu X, Hurt RH, Kane AB. 2010. Biodurability of single-walled carbon nanotubes depends on surface functionalization. Carbon N Y 48(7):1961-1969. doi:10.1016/j.carbon.2010.02.002 PMID:20352066 PMCID:PMC2844903
  • Rice JW, Fu J, Suuberg EM. 2010. Anthracene + pyrene solid mixtures: eutectic and azeotropic character. Journal of Chemical & Engineering Data 55(9):3598-3605. doi:10.1021/je100208e PMID:21116474 PMCID:PMC2992339
  • Wilhelm-Benartzi C, Koestler DC, Houseman E, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis 31(11):1972-1976. doi:10.1093/carcin/bgq178 PMID:20802236 PMCID:PMC2966555 (Completed with ARRA Funds)



  • Guo L, Liu XY, Sanchez V, Vaslet CA, Kane AB, Hurt RH. 2007. A window of opportunity: designing carbon nanomaterials for environmental safety and health. Material Science Forum 544-545:511-516.
  • Guo L, Morris DG, Liu X, Vaslet CA, Hurt RH, Kane AB. 2007. Iron bioavailability and redox activity in diverse carbon nanotube samples. Chemistry of Materials 19(14):3472-3478. doi:10.1021/cm062691p


  • Shipley JM, Waxman DJ. 2003. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma. Mol Pharmacol 64(2):355-364. PMID:12869640
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