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Harvard School of Public Health: Publication Details

Superfund Research Program

Epidemiology of Developmental Windows, Metal Mixtures and Neurodevelopment

Project Leader: Robert O. Wright (Mount Sinai School of Medicine)
Co-Investigator: Maitreyi Mazumdar (Children's Hospital Boston)
Grant Number: P42ES016454
Funding Period: 2010-2015
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2017

  • Henn BC, Bellinger DC, Hopkins MR, Coull BA, Ettinger AS, Jim R, Hatley EL, Christiani DC, Wright RO. 2017. Maternal and cord blood manganese concentrations and early childhood neurodevelopment among residents near a mining-impacted superfund site. Environ Health Perspect 125:9. doi:10.1289/ehp925 PMID:28665786
  • Tamayo y Ortiz M, Tellez-Rojo MM, Trejo-Valdivia B, Schnaas L, Osorio-Valencia E, Coull BA, Bellinger DC, Wright RJ, Wright RO. 2017. Maternal stress modifies the effect of exposure to lead during pregnancy and 24-month old children's neurodevelopment. Environ Int 98:191-197. doi:10.1016/j.envint.2016.11.005 PMID:27865525 PMCID:PMC5221478
  • Valeri L, Mazumdar M, Bobb JF, Henn BC, Rodrigues EG, Sharif OI, Kile ML, Quamruzzaman Q, Afroz S, Golam M, Amarasiriwardena C, Bellinger DC, Christiani DC, Coull BA, Wright RO. 2017. Effect of prenatal exposure to metal mixtures on neurodevelopmental outcomes at 20-40 months of age: Evidence from Rural Bangladesh. Environ Health Perspect 125:11. doi:10.1289/ehp614 PMID:28669934
  • Wagner PJ, Park HR, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. 2017. In vitro effects of lead on gene expression in neural stem cells and associations between upregulated genes and cognitive scores in children. Environ Health Perspect 125(4):721-729. doi:10.1289/ehp265 PMID:27562236
  • Wang Z, Henn BC, Wang C, Wei Y, Li S, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright RO, Bellinger DC, Kile ML, Mazumdar M, Tellez-Rojo M, Schnaas L, Christiani DC. 2017. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health 16:81. doi:10.1186/s12940-017-0288-3 PMID:28754176 PMCID:PMC5534076

2016

  • Claus Henn B, Ettinger AS, Hopkins MR, Jim R, Amarasiriwardena CJ, Christiani DC, Coull BA, Bellinger DC, Wright RO. 2016. Prenatal arsenic exposure and birth outcomes among a population residing near a mining-related Superfund site. Environ Health Perspect 124(8):1308-1315. doi:10.1289/ehp.1510070 PMID:26859631 PMCID:PMC4977047
  • Gleason K, Valeri L, Shankar AH, Hasan O, Quamruzzaman Q, Rodrigues EG, Christiani DC, Wright RO, Bellinger DC, Mazumdar M. 2016. Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years. Environ Health 15(1):103. doi:10.1186/s12940-016-0190-4 PMID:27809911 PMCID:PMC5096334
  • Kappil M, Wright RO, Sanders AP. 2016. Developmental origins of common disease: epigenetic contributions to obesity. Annu Rev Genomics Hum Genet 17:177-192. doi:10.1146/annurev-genom-090314-050057 PMID:27216778 PMCID:PMC5045029
  • Rodrigues EG, Bellinger DC, Valeri L, Hasan OS, Quamruzzaman Q, Golam M, Kile ML, Christiani DC, Wright RO, Mazumdar M. 2016. Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health 15:44. doi:10.1186/s12940-016-0127-y PMID:26968381 PMCID:PMC4788832
  • Stroustrup A, Hsu H, Svensson K, Schnaas L, Cantoral A, Solano-Gonzalez M, Torres-Calapiz M, Amarasiriwardena CJ, Bellinger DC, Coull BA, Tellez-Rojo MM, Wright RO, Wright RJ. 2016. Toddler temperament and prenatal exposure to lead and maternal depression. Environ Health 15(1):71. doi:10.1186/s12940-016-0147-7 PMID:27312840 PMCID:PMC4910201
  • Tamayo y Ortiz M, Tellez-Rojo MM, Wright RJ, Coull BA, Wright RO. 2016. Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12-24 month-old infants from Mexico City. Environ Health 15:41. doi:10.1186/s12940-016-0124-1 PMID:26926653 PMCID:PMC4772459

2015

  • Bobb JF, Valeri L, Henn BC, Wright RO, Mazumdar M, Godleski J, Coull BA, Christiani DC. 2015. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics 16(3):493-508. doi:10.1093/biostatistics/kxu058 PMID:25532525
  • Kile ML, Mazumdar M. 2015. Arsenic and reproductive health. In: Handbook of arsenic toxicology. Elsevier,
  • Lakshmanan A, Chiu YH, Coull BA, Just AC, Maxwell SL, Schwartz J, Gryparis A, Kloog I, Wright RJ, Wright RO. 2015. Associations between prenatal traffic-related air pollution exposure and birth weight: Modification by sex and maternal pre-pregnancy body mass index. Environ Res 137:268-277. doi:10.1016/j.envres.2014.10.035 PMID:25601728 PMCID:PMC4354711
  • Mazumdar M, Christiani DC, Biswas SK, Hasan OS, Kapur K. 2015. Elevated sweat chloride levels due to arsenic toxicity. N Engl J Med 372(6):582-584. doi:10.1056/NEJMc1413312 PMID:25651269 PMCID:PMC4368195
  • Mazumdar M, Valeri L, Rodrigues EG, Hasan OS, Hamid R, Paul L, Selhub J, Silva F, Mostofa G, Quamruzzaman Q, Rahman M, Christiani DC. 2015. Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele. Birth Defects Res A Clin Mol Teratol 103(9):754-762. doi:10.1002/bdra.23399 PMID:26250961 PMCID:PMC4565773
  • Sanders AP, Burris HH, Just AC, Motta V, Svensson K, Mercado-Garcia A, Pantic I, Schwartz J, Tellez-Rojo MM, Wright RO, Baccarelli A. 2015. microRNA expression in the cervix during pregnancy is associated with length of gestation. Epigenetics 10(3):221-228. doi:10.1080/15592294.2015.1006498 PMID:25611922 PMCID:PMC4623248
  • Sanders AP, Claus Henn B, Wright RO. 2015. Perinatal and childhood exposure to cadmium, manganese, and metal mixtures and effects on cognition and behavior: a review of recent literature. Curr Environ Health Rep 2(3):284-294. doi:10.1007/s40572-015-0058-8 PMID:26231505 PMCID:PMC4531257

2014

  • Arora M, Austin C, Sarrafpour B, Hernandez-Avila M, Hu H, Wright RO, Tellez-Rojo MM. 2014. Determining prenatal, early childhood and cumulative long-term lead exposure using micro-spatial deciduous dentine levels. PLoS One 9(5):e97805. doi:10.1371/journal.pone.0097805 PMID:24841926 PMCID:PMC4026445
  • Bliznyuk N, Paciorek CJ, Schwartz J, Coull BA. 2014. Nonlinear predictive latent process models for integrating spatio-temporal exposure data from multiple sources. Annals of Applied Statistics 8(3):1538-1560. doi:10.1214/14-aoas737
  • Braun JM, Wright RJ, Just AC, Power MC, Ortiz MT, Schnaas L, Hu H, Wright RO, Tellez-Rojo MM. 2014. Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: A cross-sectional study. Environ Health 13:50. doi:10.1186/1476-069x-13-50 PMID:24916609 PMCID:PMC4068833
  • Brunst KJ, Wright RO, DiGioia K, Enlow MB, Fernandez H, Wright RJ, Kannan S. 2014. Racial/ethnic and sociodemographic factors associated with micronutrient intakes and inadequacies among pregnant women in an urban US population. Public Health Nutr 17(9):1960-1970. doi:10.1017/S1368980013003224 PMID:24476840 PMCID:PMC4071127
  • Burris HH, Baccarelli A, Motta V, Byun H, Just AC, Mercado-Garcia A, Schwartz J, Svensson K, Tellez-Rojo MM, Wright RO. 2014. Association between length of gestation and cervical DNA methylation of PTGER2 and LINE 1-HS. Epigenetics 9(8):1083-1091. doi:10.4161/epi.29170 PMID:24827772 PMCID:PMC4164493
  • Claus Henn B, Coull BA, Wright RO. 2014. Chemical mixtures and children's health. Curr Opin Pediatr 26(2):223-229. doi:10.1097/MOP.0000000000000067 PMID:24535499 PMCID:PMC4043217
  • Fossati S, Baccarelli A, Zanobetti A, Hoxha M, Vokonas PS, Wright RO, Schwartz J. 2014. Ambient particulate air pollution and microRNAs in elderly men. Epidemiology 25(1):68-78. doi:10.1097/ede.0000000000000026 PMID:24257509 PMCID:PMC3977338
  • Gleason K, Shine JP, Shobnam N, Rokoff LB, Suchanda HS, Hasan OS, Mostofa G, Amarasiriwardena CJ, Quamruzzaman Q, Rahman M, Kile ML, Bellinger DC, Christiani DC, Wright RO, Mazumdar M. 2014. Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. J Environ Public Health 2014:730636. doi:10.1155/2014/730636 PMID:25214856 PMCID:PMC4158309
  • Grashow R, Zhang J, Fang SC, Weisskopf MG, Christiani DC, Kile ML, Cavallari JM. 2014. Inverse association between toenail arsenic and body mass index in a population of welders. Environ Res 131:131-133. doi:10.1016/j.envres.2014.03.010 PMID:24721130 PMCID:PMC4035809
  • Horton MK, Margolis AE, Tang C, Wright RO. 2014. Neuroimaging is a novel tool to understand the impact of environmental chemicals on neurodevelopment. Curr Opin Pediatr 26(2):230-236. doi:10.1097/MOP.0000000000000074 PMID:24535497 PMCID:PMC4104673
  • Kalish BT, Rifas-Shiman SL, Wright RO, Amarasiriwardena CJ, Jayawardene I, Gillman MW, Lipshultz SE, Oken E. 2014. Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure: a prospective study. Environ Res 133:327-333. doi:10.1016/j.envres.2014.06.004 PMID:25019468 PMCID:PMC4364915
  • Karwowski MP, Just AC, Bellinger DC, Jim R, Hatley EL, Ettinger AS, Hu H, Wright RO. 2014. Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study. Environ Health 13:77. doi:10.1186/1476-069X-13-77 PMID:25287020 PMCID:PMC4271345
  • Orenstein ST, Thurston SW, Bellinger DC, Schwartz J, Amarasiriwardena CJ, Altshul LM, Korrick SA. 2014. Prenatal organochlorine and methylmercury exposure and memory and learning in school-age children in communities near the New Bedford Harbor Superfund Site, Massachusetts. Environ Health Perspect 122:1253-1259. doi:10.1289/ehp.1307804 PMID:25062363 PMCID:PMC4216164
  • Zanobetti A, Coull BA, Gryparis A, Kloog I, Sparrow D, Vokonas PS, Wright RO, Gold DR, Schwartz J. 2014. Associations between arrhythmia episodes and temporally and spatially resolved black carbon and particulate matter in elderly patients. Occup Environ Med 71(3):201-207. doi:10.1136/oemed-2013-101526 PMID:24142987 PMCID:PMC4371778

2013

  • Burris HH, Braun JM, Byun H, Tarantini L, Mercado-Garcia A, Wright RJ, Schnaas L, Baccarelli A, Wright RO, Tellez-Rojo MM. 2013. Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu. Epigenomics 5:271-281. doi:10.2217/epi.13.24 PMID:23750643 PMCID:PMC3787720
  • Ciesielski T, Bellinger DC, Schwartz J, Hauser R, Wright RO. 2013. Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults. Environ Health 12:13. doi:10.1186/1476-069x-12-13 PMID:23379984 PMCID:PMC3599125
  • Oken E, Guthrie LB, Bloomingdale A, Platek DN, Price S, Haines J, Gillman MW, Olsen SF, Bellinger DC, Wright RO. 2013. A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. Nutr J 12:33. doi:10.1186/1475-2891-12-33 PMID:23496848 PMCID:PMC3616846
  • Sagiv SK, Epstein JN, Bellinger DC, Korrick SA. 2013. Pre- and postnatal risk factors for ADHD in a nonclinical pediatric population. J Atten Disord 17:47-57. doi:10.1177/1087054711427563 PMID:22298092 PMCID:PMC3878902

2012

  • Afeiche M, Peterson KE, Sanchez BN, Schnaas L, Cantonwine DE, Ettinger AS, Solano-Gonzalez M, Hernandez-Avila M, Hu H, Tellez-Rojo MM. 2012. Windows of lead exposure sensitivity, attained height, and body mass index at 48 months. J Pediatr 160(6):1044-1049. doi:10.1016/j.jpeds.2011.12.022 PMID:22284921 PMCID:PMC3360798
  • Braun JM, Hoffman E, Schwartz J, Sanchez BN, Schnaas L, Mercado-Garcia A, Solano-Gonzalez M, Bellinger DC, Lanphear BP, Hu H, Tellez-Rojo MM, Wright RO, Hernandez-Avila M. 2012. Assessing windows of susceptibility to lead-induced cognitive deficits in Mexican children. Neurotoxicology 33:1040-1047. doi:10.1016/j.neuro.2012.04.022 PMID:22579785 PMCID:PMC3576696
  • Braun JM, Lucchini R, Bellinger DC, Hoffman E, Nazzaro M, Smith D, Wright RO. 2012. Predictors of virtual radial arm maze performance in adolescent Italian children. Neurotoxicology 33(5):1203-1211. doi:10.1016/j.neuro.2012.06.012 PMID:22771383 PMCID:PMC3470779
  • Ciesielski T, Weuve J, Bellinger DC, Schwartz J, Lanphear BP, Wright RO. 2012. Cadmium exposure and neurodevelopmental outcomes in U.S. children. Environ Health Perspect 120(5):758-763. doi:10.1289/ehp.1104152 PMID:22289429 PMCID:PMC3346779
  • Fleisch AF, Wright RO, Baccarelli A. 2012. Environmental epigenetics: a role in endocrine disease?. J Mol Endocrinol 49:R61-67. doi:10.1530/jme-12-0066 PMID:22798698 PMCID:PMC3752847
  • Roels HA, Bowler RM, Kim Y, Claus Henn B, Mergler D, Hoet P, Gocheva VV, Bellinger DC, Wright RO, Harris MG, Chang Y, Bouchard MF, Riojas-Rodriguez H, Menezes-Filho JA, Tellez-Rojo MM. 2012. Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity. Neurotoxicology 33(4):872-880. doi:10.1016/j.neuro.2012.03.009 PMID:22498092 PMCID:PMC3839941
  • Seow W, Pan W, Kile ML, Baccarelli A, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lin X, Christiani DC. 2012. Arsenic reduction in drinking water and improvement in skin lesions: A follow-up study in Bangladesh. Environ Health Perspect 121:1733-1738. doi:10.1289/ehp.1205381 PMID:23060367 PMCID:PMC3548283

2011

  • Claus Henn B, Kim J, Wessling-Resnick M, Tellez-Rojo MM, Jayawardene I, Ettinger AS, Hernandez-Avila M, Schwartz J, Christiani DC, Hu H, Wright RO. 2011. Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models. Environ Health 10(1):97. doi:10.1186/1476-069X-10-97 PMID:22074419 PMCID:PMC3248860
  • Claus Henn B, Wright RO, Schnaas L, Ettinger AS, Schwartz J, Lamadrid-Figueroa H, Hernandez-Avila M, Amarasiriwardena CJ, Hu H, Bellinger DC, Tellez-Rojo MM. 2011. Associations of early childhood manganese and lead coexposure with neurodevelopment. Environ Health Perspect 120:126-131. doi:10.1289/ehp.1003300 PMID:21885384 PMCID:PMC3261931
  • Kile ML, Hoffman E, Rodrigues EG, Breton CV, Quamruzzaman Q, Rahman M, Mahiuddin G, Hsueh Y, Christiani DC. 2011. A pathway-based analysis of urinary arsenic metabolites and skin lesions. Am J Epidemiol 173(7):778-786. doi:10.1093/aje/kwq427 PMID:21378128 PMCID:PMC3105278
  • Kordas K, Ettinger AS, Bellinger DC, Schnaas L, Tellez-Rojo MM, Hernandez-Avila M, Hu H, Wright RO. 2011. A dopamine receptor (DRD2) but not dopamine transporter (DAT1) gene polymorphism is associated with neurocognitive development of Mexican preschool children with lead exposure. J Pediatr 159:638-643. doi:10.1016/j.jpeds.2011.03.043 PMID:21592505 PMCID:PMC3158955
  • Nie LH, Wright RO, Bellinger DC, Hussain J, Amarasiriwardena CJ, Chettle DR, Pejovic-Milic A, Woolf AD, Shannon MW. 2011. Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children. Biomarkers 16(6):517-24. doi:10.3109/1354750X.2011.604133 PMID:21827276 PMCID:PMC3229913
  • Palaniappan K, Roy A, Balakrishnan K, Gopalakrishnan L, Mukherjee B, Hu H, Bellinger DC. 2011. Lead exposure and visual-motor abilities in children from Chennai, India. Neurotoxicology 32:465-470. doi:10.1016/j.neuro.2011.03.011 PMID:21510976 PMCID:PMC3115626
  • Peters J, Kubzansky LD, Ikeda A, Spiro, III A, Wright RO, Weisskopf MG, Kim D, Sparrow D, Nie LH, Hu H, Schwartz J. 2011. Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. Am J Epidemiol 174:1345-1353. doi:10.1093/aje/kwr269 PMID:22071587 PMCID:PMC3276297
  • Peters JL, Kubzansky LD, Ikeda A, Fang SC, Sparrow D, Weisskopf MG, Wright RO, Vokonas PS, Hu H, Schwartz J. 2011. Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the Normative Aging Study. Environ Health Perspect 120:361-366. doi:10.1289/ehp.1103467 PMID:22142875 PMCID:PMC3295335
  • Roy A, Hu H, Bellinger DC, Mukherjee B, Modali R, Nasaruddin K, Schwartz J, Wright RO, Ettinger AS, Palaniapan K, Balakrishnan K. 2011. Hemoglobin, lead exposure, and intelligence quotient: effect modification by the DRD2 Taq IA polymorphism. Environ Health Perspect 119(1):144-149. doi:10.1289/ehp.0901878 PMID:21205584 PMCID:PMC3018494
  • Zota AR, Schaider LA, Ettinger AS, Wright RO, Shine JP, Spengler JD. 2011. Metal sources and exposures in the homes of young children living near a mining-impacted Superfund site. J Expo Sci Environ Epidemiol 21:495-505. doi:10.1038/jes.2011.21 PMID:21587306 PMCID:PMC3161168

2010

  • Claus Henn B, Ettinger AS, Schwartz J, Tellez-Rojo MM, Lamadrid-Figueroa H, Hernandez-Avila M, Schnaas L, Amarasiriwardena CJ, Bellinger DC, Hu H, Wright RO. 2010. Early postnatal blood manganese levels and children's neurodevelopment. Epidemiology 21(4):433-439. doi:10.1097/EDE.0b013e3181df8e52 PMID:20549838 PMCID:PMC3127440
  • Kile ML, Baccarelli A, Tarantini L, Hoffman E, Wright RO, Christiani DC. 2010. Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS One 5(10):e13730. doi:10.1371/journal.pone.0013730 PMID:21060777 PMCID:PMC2966409
  • Zhang A, Park S, Wright RO, Weisskopf MG, Mukherjee B, Nie H, Sparrow D, Hu H. 2010. HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: The Normative Aging Study. Environ Health Perspect 118:1261-1266. doi:10.1289/ehp.1002251 PMID:20478760 PMCID:PMC2944087