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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Oregon State University: Linking PAH Exposure to Health Outcomes Using Human Primary In Vitro Respiratory Model

Superfund Research Program

Linking PAH Exposure to Health Outcomes Using Human Primary In Vitro Respiratory Model

Project Leader: Susan C. Tilton
Co-Investigator: David E. Williams
Grant Number: P42ES016465
Funding Period: 2009-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2023

  • Maier ML, Siddens LK, Pennington JM, Uesugi S, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or brussels sprouts. Toxicol Appl Pharmacol 460:116377. doi:10.1016/j.taap.2023.116377 PMID:36642108 PMCID:PMC9946811
  • Rude CI, Tidwell LG, Tilton SC, Waters KM, Anderson KA, Tanguay RL. 2023. Coupling environmental whole mixture toxicity screening with unbiased RNA-Seq reveals site-specific biological responses in zebrafish. Toxics 11(3):201. doi:10.3390/toxics11030201 PMID:36976966 PMCID:PMC1005377
  • Vermillion Maier ML, Siddens LK, Pennington J, Uesugi S, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 382:110608. doi:10.1016/j.cbi.2023.110608

2022

  • Pande P, Madeen E, Williams DE, Crowell SR, Ognibene T, Turteltaub KW, Corley RA, Smith JN. 2022. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 438:doi:10.1016/j.taap.2021.115830 PMID:34933053 PMCID:PMC9264404
  • Rivera BN, Ghetu CC, Chang Y, Truong L, Tanguay RL, Anderson KA, Tilton SC. 2022. Leveraging multiple data streams for prioritization of mixtures for hazard characterization. Toxics 10(11):651. doi:10.3390/toxics10110651 PMID:36355943
  • Rivera BN, Wilson LB, Kim DN, Pande P, Anderson KA, Tilton SC, Tanguay RL. 2022. A comparative multi-system approach to characterizing bioactivity of commonly occurring chemicals. Int J Environ Res Public Health 19(7):3829. doi:10.3390/ijerph19073829 PMID:35409514 PMCID:PMC8998123
  • Vermillion Maier ML, Siddens LK, Pennington JM, Uesugi S, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2022. Benzo a pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with C-14 -BaP. Environ Int 159:doi:10.1016/j.envint.2021.107045 PMID:34920278 PMCID:PMC8791557

2021

  • Chang Y, Rager JE, Tilton SC. 2021. Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium. Chem Res Toxicol 34(6):1445-1455. doi:10.1021/acs.chemrestox.0c00333 PMID:34048650
  • Vermillion Maier ML, Siddens LK, Uesugi S, Choi J, Leonard SW, Pennington J, Tilton SC, Smith JN, Ho E, Chow S, Nguyen BD, Kolluri SK, Williams DE. 2021. 3,3'-diindolylmethane (BioResponse DIM) exhibits significant metabolism following oral dosing in humans. Drug Metab Dispos 49(8):doi:10.1124/dmd.120.000346 PMID:34035125 PMCID:PMC8407664 (ahead of print)

2020

2019

  • Brown J, Phillips AR, Lewis DA, Mans M, Chang Y, Tanguay RL, Peterson ES, Waters KM, Tilton SC. 2019. Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration. BMC Bioinformatics 20:255. doi:10.1186/s12859-019-2805-6 PMID:31101000
  • Chang Y, Siddens LK, Heine L, Sampson D, Yu Z, Fischer K, Lohr CV, Tilton SC. 2019. Comparative mechanisms of PAH toxicity by benzo a pyrene and dibenzo def,p chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 379:114644. doi:10.1016/j.taap.2019.114644 PMID:31255691 PMCID:PMC6708476
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