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Your Environment. Your Health.

Program Publications: University of Louisville: Environmental Exposure and Cardiometabolic Disease

Superfund Research Program

Environmental Exposure and Cardiometabolic Disease

Center Director: Sanjay Srivastava
Grant Number: P42ES023716
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2021

  • Coleman CJ, Yeager R, Riggs DW, Coleman NC, Garcia GR, Bhatnagar A, Pope CA. 2021. Greenness, air pollution, and mortality risk: A US cohort study of cancer patients and survivors. Environ Int 157:PMID:34332301
  • Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. 2021. Plasma metabolomics analysis of polyvinyl chloride workers identifies altered processes and candidate biomarkers for hepatic hemangiosarcoma and its development. Int J Mol Sci 22:doi:10.3390/ijms22105093 PMID:34065028 PMCID:PMC8150673
  • Haberzettl P, Jin L, Riggs DW, Zhao J, O'Toole TE, Conklin DJ. 2021. Fine particulate matter air pollution and aortic perivascular adipose tissue: Oxidative stress, leptin, and vascular dysfunction. Physiol Rep 9:e14980. doi:10.14814/phy2.14980 PMID:34327871 PMCID:PMC8322754
  • Hardesty JE, Wahlang B, Prough RA, Head KZ, Wilkey D, Merchant ML, Shi H, Jin J, Cave MC. 2021. Effect of epidermal growth factor treatment and polychlorinated biphenyl exposure in a dietary-exposure mouse model of steatohepatitis. Environ Health Perspect 129:37010. doi:10.1289/EHP8222 PMID:33788613 PMCID:PMC8011667
  • Jin L, Conklin DJ. 2021. A novel evaluation of endothelial dysfunction ex vivo: Teaching an Old Drug a New Trick. Physiol Rep 9(21):e15120. doi:10.14814/phy2.15120 PMID:34755498 PMCID:PMC8579072
  • Jin L, Lorkiewicz P, Xie Z, Bhatnagar A, Srivastava S, Conklin DJ. 2021. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Toxicol Appl Pharmacol 426:115647. doi:10.1016/j.taap.2021.115647 PMID:34271065 PMCID:PMC8343963
  • Jin L, Lynch J, Richardson A, Lorkiewicz P, Srivastava S, Theis W, Shirk G, Hand A, Bhatnagar A, Srivastava S, Conklin D. 2021. Electronic cigarette solvents, pulmonary irritation and endothelial dysfunction: role of acetaldehyde and formaldehyde. Am J Physiol Heart Circ Physiol doi:10.1152/ajpheart.00878.2020 PMID:33543686
  • Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko I, Uchida S, Hill BG, Sutaria S, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. 2021. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol 431(9):115742. doi:10.1016/j.taap.2021.115742 PMID:34624356
  • McGraw KE, Riggs DW, Rai SN, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy SS, Taylor KC, Conklin D, DeFilippis A, Srivastava S, Bhatnagar A. 2021. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res 196:110903. doi:10.1016/j.envres.2021.110903 PMID:33636185 PMCID:PMC8119348
  • Pfeiffer JA, Hart J, Wood LA, Bhatnagar A, Keith RJ, Yeager R, Smith T, Tomlinson M, Gilkey D, Kerstiens S, Gao H, Srivastava S, Walker KL. 2021. The importance of urban planning: Views of greenness and open space is reversely associated with self-reported views and depressive symptoms. Popul Med 3:20. doi:10.18332/popmed/139173 PMID:34368779 PMCID:PMC8341459
  • Riggs DW, Yeager R, Conklin D, DeJarnett N, Keith RJ, DeFilippis A, Rai SN, Bhatnagar A. 2021. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol doi:10.1152/ajpheart.00689.2020 PMID:33416460 (ahead of print)
  • Tevis DS, Flores SR, Kenwood BM, Bhandari D, Jacob P, Liu J, Lorkiewicz P, Conklin D, Hecht SS, Goniewicz ML, Blount BC, De Jesus VR. 2021. Harmonization of acronyms for volatile organic compound metabolites using a standardized naming system. Int J Hyg Environ Health 235:113749. doi:10.1016/j.ijheh.2021.113749 PMID:33962120
  • Wahlang B, Alexander II NC, Li X, Rouchka EC, Kirpich IA, Cave MC. 2021. Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. Toxicol Rep 8:doi:10.1016/j.toxrep.2021.03.010 PMID:33777700 PMCID:PMC7985695
  • Wood LA, Tomlinson M, Pfeiffer JA, Walker KL, Keith RJ, Smith T, Yeager R, Bhatnagar A, Kerstiens S, Gilkey D, Gao H, Srivastava S, Hart J. 2021. Time spent outdoors and sleep normality: A preliminary investigation. Popul Med 3:7. doi:10.18332/popmed/132119 PMID:34485920 PMCID:PMC8411876
  • Zelko I, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B, Malovichko MV, Cave MC, Srivastava S. 2021. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environ Toxicol PMID:34717031

2020

  • Cave MC. 2020. Environmental Pollution and the Developmental Origins of Childhood Liver Disease. Hepatology 72:1518-1521. doi:10.1002/hep.31549 PMID:32910501
  • Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S. 2020. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol 9:569-585. doi:10.1016/j.jcmgh.2019.10.005 PMID:31654770 PMCID:PMC7078548
  • Hong KU, Doll MA, Lykoudi A, Salazar-Gonzalez R, Habil MR, Walls KM, Bakr AF, Ghare S, Barve S, Arteel GE, Hein DW. 2020. Acetylator genotype-dependent dyslipidemia in rats congenic for N-acetyltransferase 2. Toxicol Rep 7:1319-1330. doi:10.1016/j.toxrep.2020.09.011 PMID:33083237 PMCID:PMC7553889
  • Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. 2020. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res 29:1247-1263. doi:10.1007/s00044-020-02581-w
  • Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz P, Hamburg NM, DeFilippis A, Blaha MJ, Bhatnagar A. 2020. Characterization of volatile organic compound metabolites in cigarette smokers, electronic nicotine device users, dual users, and nonusers of tobacco. Nicotine Tob Res 22:264-272. doi:10.1093/ntr/ntz021 PMID:30759242 PMCID:PMC7297089
  • Konkle S, Zierold K, Taylor KC, Riggs DW, Bhatnagar A. 2020. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res 182:10. doi:10.1016/j.envres.2019.108991 PMID:31835113
  • Leggett CS, Doll MA, States JC, Hein DW. 2020. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes. Arch Toxicol 95:doi:10.1007/s00204-020-02901-4 PMID:33136180
  • Mohamed TM, Conklin D. 2020. Emerging technology and platforms for cardiotoxicity testing. Toxicol Appl Pharmacol 408:doi:10.1016/j.taap.2020.115262 PMID:33017593
  • Rai SN, Qian C, Pan J, McClain CJ, McClain M, Eichenberger MR, Galandiuk S. 2020. Statistical issues and group classification in plasma microRNA studies with data application. Evol Bioinform 16:9. doi:10.1177/1176934320913338 PMID:32313420 PMCID:PMC7157974
  • Riggs DW, Zafar N, Krishnasamy SS, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. 2020. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 180:doi:10.1016/j.envres.2019.108890 PMID:31718786 PMCID:PMC6899204
  • Sibakoti T, Jasinski J, Nantz MH, Zamborini F. 2020. Iodine activation: a general method for catalytic enhancement of thiolate monolayer-protected metal clusters. Nanoscale 12(22):12027-12037. doi:10.1039/d0nr00844c PMID:32467955 PMCID:PMC7350617
  • Werder EJ, Beier JI, Sandler DP, Falkner K, Gripshover T, Wahlang B, Engel LS, Cave MC. 2020. Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents. Food Chem Toxicol 139:doi:10.1016/j.fct.2020.111242 PMID:32205228
  • Xie Z, Ramakrishnam Raju MV, Adhihetty P, Fu X, Nantz MH. 2020. Effect of thiol molecular structure on the sensitivity of gold nanoparticle-based chemiresistors toward carbonyl compounds. Sensors (Basel) 20:doi:10.3390/s20247024 PMID:33302491 PMCID:PMC7763667
  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MH, Zafar N, Krishnasamy SS, DeFilippis A, Turner JR, Rai SN, Bhatnagar A. 2020. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 707:doi:10.1016/j.scitotenv.2019.135435 PMID:31865083

2019

  • Abplanalp WT, Wickramasinghe NS, Sithu S, Conklin D, Xie Z, Bhatnagar A, Srivastava S, O'Toole TE. 2019. Benzene exposure induces insulin resistance in mice. Toxicol Sci 167(2):426-437. doi:10.1093/toxsci/kfy252 PMID:30346588 PMCID:PMC6358255
  • Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. 2019. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut 247:1055-1063. doi:10.1016/j.envpol.2019.01.064 PMID:30823334 PMCID:PMC6404528
  • Bhattacharyya A, Rai SN. 2019. Adaptive Signature Design review of the biomarker guided adaptive phase III controlled design. Contemp Clin Trials 15:100378. doi:10.1016/j.conctc.2019.100378 PMID:31289760 PMCID:PMC6591770
  • Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu S, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H. 2019. Myeloid-specific deletion of epsins 1 and 2 reduces atherosclerosis by preventing LRP-1 downregulation. Circ Res 124:e6-e19. doi:10.1161/circresaha.118.313028 PMID:30595089 PMCID:PMC6375743
  • Conklin D, Guo Y, Nystoriak M, Jagatheesan G, Obal D, Kilfoil PJ, Hoetker JD, Guo L, Bolli R, Bhatnagar A. 2019. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 316:H889-H899. doi:10.1152/ajpheart.00106.2018 PMID:30735434 PMCID:PMC6483018
  • Conklin D, Schick SF, Blaha MJ, Carll AP, DeFilippis A, Ganz P, Hall MN, Hamburg NM, O'Toole TE, Reynolds LM, Srivastava S, Bhatnagar A. 2019. Cardiovascular injury induced by tobacco products: Assessment of risk factors and biomarkers of harm A Tobacco Center of Regulatory Science (TCORS) Compilation. Am J Physiol Heart Circ Physiol 316(4):H801-H827. doi:10.1152/ajpheart.00591.2018 PMID:30707616
  • Finch J, Riggs DW, O'Toole TE, Pope III C, Bhatnagar A, Conklin D. 2019. Acute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults. AIMS Environ Sci 6(4):265-276. doi:10.3934/environsci.2019.4.265
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant ML, Watson C, Prough RA, Cave MC. 2019. Hepatic signalling disruption by pollutant polychlorinated biphenyls in steatohepatitis. Cell Signal 53:132-139. doi:10.1016/j.cellsig.2018.10.004 PMID:30300668 PMCID:PMC6289731
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey D, Merchant ML, Watson C, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. 2019. Proteomic analysis reveals novel mechanisms by which polychlorinated biphenyls compromise the liver promoting diet-induced steatohepatitis. J Proteome Res 18(4):1582-1594. doi:10.1021/acs.jproteome.8b00886 PMID:30807179 PMCID:PMC7059562
  • Hein DW, Habil MR, Doll MA. 2019. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes. Pharmacogenet Genomics doi:10.1097/fpc.0000000000000394 PMID:31895247 (ahead of print)
  • Salazar-Gonzalez R, Zhang X, Doll MA, Lykoudi A, Hein DW. 2019. Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline. Arch Toxicol 93(8):2237-2246. doi:10.1007/s00204-019-02516-4 PMID:31292670 PMCID:PMC6713601
  • Shi H, Hardesty JE, Jin J, Head KZ, Cave MC, Prough RA. 2019. Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures. Xenobiotica 1-9. doi:10.1080/00498254.2019.1566582 PMID:30991879
  • Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam S, Chari ST, Cave MC. 2019. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 363:22-33. doi:10.1016/j.taap.2018.10.011 PMID:30312631
  • Sibakoti T, Stinger C, Adhihetty P, Zamborini F, Nantz MH. 2019. Tunable aminooxy-functionalized monolayer-protected gold clusters for nonpolar and aqueous oximation reactions. Part Part Syst Charact 36:9. doi:10.1002/ppsc.201900093
  • Srivastava S, Merchant ML, Rai A, Rai SN. 2019. Interactive web tool for standardizing proteomics workflow for liquid chromatography-mass spectrometry data. J Proteomics Bioinform 12:085-087. PMID:32148360 PMCID:PMC7059686
  • Srivastava S, Merchant ML, Rai A, Rai SN. 2019. Standardizing Proteomics Workflow for Liquid Chromatography-Mass Spectrometry: Technical and Statistical Considerations. J Proteomics Bioinform 12:048-055. doi:10.35248/0974-276x.19.12.496 PMID:32148359 PMCID:PMC7059694
  • Vatsalya V, Kong M, Gobejishvili L, Chen W, Srivastava S, Barve S, McClain CJ, Joshi-Barve S. 2019. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol 316(1):G115-G122. doi:10.1152/ajpgi.00209.2018 PMID:30234998
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock GN, Cave MC. 2019. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutritional Examination Survey 2003-2004. Environ Sci Pollut Res Int 6(4):265-276. doi:10.1007/s11356-019-07066-x PMID:31873887
  • Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner K, Prough RA, Cave MC, Beier JI. 2019. Hepatic injury caused by the environmental toxicant vinyl chloride is sex-dependent in mice. Toxicol Sci 174(1):79-91. doi:10.1093/toxsci/kfz236 PMID:31774537 PMCID:PMC7043220
  • Wahlang B, Hardesty JE, Jin J, Falkner K, Cave MC. 2019. Polychlorinated biphenyls and nonalcoholic fatty liver disease. Curr Opin Toxicol 14:21-28. doi:10.1016/j.cotox.2019.06.001
  • Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. 2019. Mechanisms of environmental contributions to fatty liver disease. Curr Environ Health Rep 6:80-94. doi:10.1007/s40572-019-00232-w PMID:31134516 PMCID:PMC6698418
  • Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. 2019. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol 129:64-76. doi:10.1016/j.fct.2019.04.007 PMID:31026535 PMCID:PMC6555661

2018

  • Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. 2018. Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures. Toxicol Sci 164:39-49. doi:10.1093/toxsci/kfy076 PMID:29684222 PMCID:PMC6016643
  • Conklin D, Ogunwale M, Chen Y, Theis W, Nantz MH, Fu X, Chen L, Riggs DW, Lorkiewicz P, Bhatnagar A, Srivastava S. 2018. Electronic cigarette-generated aldehydes: the contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure. Aerosol Science and Technology 52:1219-1232. doi:10.1080/02786826.2018.1500013
  • Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC. 2018. Epidermal growth factor receptor signaling disruption by endocrine and metabolic disrupting chemicals. Toxicol Sci 162:622-634. doi:10.1093/toxsci/kfy004 PMID:29329451 PMCID:PMC5888991
  • Hein DW, Fakis G, Boukouvala S. 2018. Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review. Pharmacogenet Genomics doi:10.1097/FPC.0000000000000350 PMID:30222709 PMCID:PMC6208141
  • Hein DW, Zhang X, Doll MA. 2018. Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation. Toxicol Lett 283:100-105. doi:10.1016/j.toxlet.2017.11.028 PMID:29180287 PMCID:PMC5745265
  • Lang AL, Beier JI. 2018. Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk. Biol Chem 399(11):1237-1248. doi:10.1515/hsz-2017-0324 PMID:29924722 PMCID:PMC6181143
  • Lang AL, Chen L, Poff GD, Ding WX, Barnett RA, Arteel GE, Beier JI. 2018. Vinyl chloride dysregulates metabolic homeostasis and enhances diet-induced liver injury in mice. Hepatol Commun 2(3):270-284. doi:10.1002/hep4.1151 PMID:29507902 PMCID:PMC5831023
  • Li M, Li Q, Nantz MH, Fu X. 2018. Analysis of carbonyl compounds in ambient air by a microreactor approach. ACS Omega 3:6764-6769. doi:10.1021/acsomega.8b00503 PMID:29978147 PMCID:PMC6026843
  • Liang Y, Lang AL, Zhang J, Chen J, Wang K, Chen L, Beier JI, Qian Y, Cai L. 2018. Exposure to vinyl chloride and its influence on western diet-induced cardiac remodeling. Chem Res Toxicol 31:482-493. doi:10.1021/acs.chemrestox.8b00043 PMID:29727174 PMCID:PMC6167925
  • Lorkiewicz P, Riggs DW, Keith RJ, Conklin D, Xie Z, Sutaria S, Lynch BJ, Srivastava S, Bhatnagar A. 2018. Comparison of urinary biomarkers of exposure in humans using electronic cigarettes, combustible cigarettes, and smokeless tobacco. Nicotine Tob Res doi:10.1093/ntr/nty089 PMID:29868926
  • Riggs DW, Yeager R, Bhatnagar A. 2018. Defining the human envirome: an omics approach for assessing the environmental risk of cardiovascular disease. Circ Res 122:1259-1275. doi:10.1161/circresaha.117.311230 PMID:29700071 PMCID:PMC6398443
  • Xie Z, Lorkiewicz P, Riggs DW, Bhatnagar A, Srivastava S. 2018. Comprehensive, robust, and sensitive UPLC-MS/MS analysis of free biogenic monoamines and their metabolites in urine. J Chromatogr B Analyt Technol Biomed Life Sci 1099:83-91. doi:10.1016/j.jchromb.2018.09.012 PMID:30248561 PMCID:PMC6398444
  • Xie Z, Ramakrishnam Raju MV, Stewart AC, Nantz MH, Fu X. 2018. Imparting sensitivity and selectivity to a gold nanoparticle chemiresistor through thiol monolayer functionalization for sensing aceton. RSC Adv 8:35618-35624. doi:10.1039/c8ra06137h PMID:30555687 PMCID:PMC6238108
  • Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin D, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. 2018. Association between residential greenness and cardiovascular disease risk. J Am Heart Assoc 7(24):e009117. doi:10.1161/JAHA.118.009117 PMID:30561265 PMCID:PMC6405613
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