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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of Louisville: Training Core

Superfund Research Program

Training Core

Project Leader: David W. Hein
Co-Investigator: Daniel J. Conklin
Grant Number: P42ES023716
Funding Period: 2017-2022

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Publications

2023

2022

  • Doll MA, Hein DW. 2022. 560G A (rs4986782) (R187Q) Single nucleotide polymorphism in arylamine N-acetyltransferase 1 increases affinity for the aromatic amine carcinogens 4-aminobiphenyl and N-hydroxy-4-aminobiphenyl: Implications for cancer risk assessment. Front Pharmacol doi:10.3389/fphar.2022.820082 PMID:35273499 PMCID:PMC8902414
  • Habil MR, Salazar-Gonzalez R, Doll MA, Hein DW. 2022. Differences in beta-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. Arch Toxicol doi:10.1007/s00204-022-03367-2 PMID:36040704
  • Hein DW, Doll MA, Habil MR. 2022. Human N-acetyltransferase 1 and 2 differ in affinity towards acetyl-coenzyme A cofactor and N-hydroxy-arylamine carcinogens. Front Pharmacol doi:10.3389/fphar.2022.821133 PMID:35281898 PMCID:PMC8914035
  • Wise JT, Salazar-Gonzalez R, Habil MR, Doll MA, Hein DW. 2022. Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells. Toxicol Appl Pharmacol 442:115993. doi:10.1016/j.taap.2022.115993 PMID:35353990
  • Wise JT, Salazar-Gonzalez R, Walls KM, Doll MA, Habil MR, Hein DW. 2022. Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and B-naphthylamine in immortalized human lung epithelial cells. Toxicol Appl Pharmacol 449:doi:10.1016/j.taap.2022.116095 PMID:35662664

2020

  • Hong KU, Doll MA, Lykoudi A, Salazar-Gonzalez R, Habil MR, Walls KM, Bakr AF, Ghare S, Barve S, Arteel GE, Hein DW. 2020. Acetylator genotype-dependent dyslipidemia in rats congenic for N-acetyltransferase 2. Toxicol Rep 7:1319-1330. doi:10.1016/j.toxrep.2020.09.011 PMID:33083237 PMCID:PMC7553889
  • Konkle S, Zierold K, Taylor KC, Riggs DW, Bhatnagar A. 2020. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res 182:10. doi:10.1016/j.envres.2019.108991 PMID:31835113
  • Leggett CS, Doll MA, States JC, Hein DW. 2020. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes. Arch Toxicol 95:doi:10.1007/s00204-020-02901-4 PMID:33136180
  • Riggs DW, Zafar N, Krishnasamy SS, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. 2020. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 180:doi:10.1016/j.envres.2019.108890 PMID:31718786 PMCID:PMC6899204
  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MH, Zafar N, Krishnasamy SS, DeFilippis A, Turner JR, Rai SN, Bhatnagar A. 2020. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 707:doi:10.1016/j.scitotenv.2019.135435 PMID:31865083

2019

  • Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. 2019. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut 247:1055-1063. doi:10.1016/j.envpol.2019.01.064 PMID:30823334 PMCID:PMC6404528
  • Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu S, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H. 2019. Myeloid-specific deletion of epsins 1 and 2 reduces atherosclerosis by preventing LRP-1 downregulation. Circ Res 124:e6-e19. doi:10.1161/circresaha.118.313028 PMID:30595089 PMCID:PMC6375743
  • Finch J, Riggs DW, O'Toole TE, Pope III C, Bhatnagar A, Conklin DJ. 2019. Acute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults. AIMS Environ Sci 6(4):265-276. doi:10.3934/environsci.2019.4.265
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant ML, Watson C, Prough RA, Cave MC. 2019. Hepatic signalling disruption by pollutant polychlorinated biphenyls in steatohepatitis. Cell Signal 53:132-139. doi:10.1016/j.cellsig.2018.10.004 PMID:30300668 PMCID:PMC6289731
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey D, Merchant ML, Watson C, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. 2019. Proteomic analysis reveals novel mechanisms by which polychlorinated biphenyls compromise the liver promoting diet-induced steatohepatitis. J Proteome Res 18(4):1582-1594. doi:10.1021/acs.jproteome.8b00886 PMID:30807179 PMCID:PMC7059562
  • Hein DW, Habil MR, Doll MA. 2019. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes. Pharmacogenet Genomics 30(3):doi:10.1097/fpc.0000000000000394 PMID:31895247 (ahead of print)
  • Salazar-Gonzalez R, Zhang X, Doll MA, Lykoudi A, Hein DW. 2019. Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline. Arch Toxicol 93(8):2237-2246. doi:10.1007/s00204-019-02516-4 PMID:31292670 PMCID:PMC6713601
  • Sibakoti T, Stinger C, Adhihetty P, Zamborini F, Nantz MH. 2019. Tunable aminooxy-functionalized monolayer-protected gold clusters for nonpolar and aqueous oximation reactions. Part Part Syst Charact 36:9. doi:10.1002/ppsc.201900093
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock GN, Cave MC. 2019. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutritional Examination Survey 2003-2004. Environ Sci Pollut Res Int 6(4):265-276. doi:10.1007/s11356-019-07066-x PMID:31873887
  • Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner K, Prough RA, Cave MC, Beier JI. 2019. Hepatic injury caused by the environmental toxicant vinyl chloride is sex-dependent in mice. Toxicol Sci 174(1):79-91. doi:10.1093/toxsci/kfz236 PMID:31774537 PMCID:PMC7043220
  • Wahlang B, Hardesty JE, Jin J, Falkner K, Cave MC. 2019. Polychlorinated biphenyls and nonalcoholic fatty liver disease. Curr Opin Toxicol 14:21-28. doi:10.1016/j.cotox.2019.06.001
  • Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. 2019. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol 129:64-76. doi:10.1016/j.fct.2019.04.007 PMID:31026535 PMCID:PMC6555661

2018

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