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Your Environment. Your Health.

Program Publications: University of Pennsylvania: Asbestos Fate, Exposure, Remediation, and Adverse Health Effects

Superfund Research Program

Asbestos Fate, Exposure, Remediation, and Adverse Health Effects

Center Director: Ian A. Blair
Grant Number: P42ES023720
Funding Period: 2014-2020
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

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Publications

2019

  • Chatterjee S, Pietrofesa RA, Park K, Tao J, Carabe-Fernandez A, Berman A, Koumenis C, Sielecki T, Christofidou-Solomidou M. 2019. LGM2605 reduces space radiation-induced NLRP3 inflammasome activation and damage in in vitro lung vascular networks. Int J Mol Sci 20(1):176. doi:10.3390/ijms20010176 PMID:30621290 PMCID:PMC6337675
  • Giacobbe C, Wright J, Dejoie C, Tafforeau P, Berruyer C, Vigliaturo R, Giere R, Gualtieri AF. 2019. Depicting the crystal structure of fibrous ferrierite from British Columbia using a combined synchrotron techniques approach. J Appl Crystallogr 52:1397-1408. doi:10.1107/S1600576719013980 PMID:31798362 PMCID:PMC6878881
  • Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K. 2019. Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. J Mol Cell Cardiol 127:232-245. doi:10.1016/j.yjmcc.2018.12.016 PMID:30611795 PMCID:PMC6359996
  • Vigliaturo R, Pollastri S, Giere R, Gualtieri AF, Drazic G. 2019. Experimental quantification of the Fe-valence state at amosite-asbestos boundaries using acSTEM dual-electron energy-loss spectroscopy. American Mineralogist 104:1820-1828. doi:10.2138/am-2019-7218
  • Weng L, Wang Q, Yu S, Yang X, Lynch DR, Mesaros C, Blair IA. 2019. Evaluation of antibodies for western blot analysis of frataxin protein isoforms. J Immunol Methods 474:doi:10.1016/j.jim.2019.07.001 PMID:31279523 PMCID:PMC6829029
  • Zhu B, Suzuki Y, DiSanto T, Rubin S, Penfil Z, Pietrofesa RA, Chatterjee S, Christofidou-Solomidou M, Cantu E. 2019. Applications of out of body lung perfusion. Acad Radiol 26(3):404-411. doi:10.1016/j.acra.2018.05.022 PMID:30054193 PMCID:PMC6345618

2018

  • Arletti R, Fantini R, Giacobbe C, Giere R, Vezzalini G, Vigliaturo R, Quartieri S. 2018. High-temperature behavior of natural ferrierite: In-situ synchrotron X-ray powder diffraction study. American Mineralogist 103:1741-1748. doi:10.2138/am-2018-6663
  • Chikara S, Mamidi S, Sreedasyam A, Pietrofesa RA, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM. 2018. Flaxseed consumption inhibits chemically induced lung tumorigenesis and modulates expression of phase II enzymes and inflammatory cytokines in A/J mice. Cancer Prev Res (Phila) 11(1):27-37. doi:10.1158/1940-6207.CAPR-17-0119 PMID:29074535 PMCID:PMC5754250
  • Ferdowsi B, Ortiz C, Jerolmack DJ. 2018. Glassy dynamics of landscape evolution. Proc Natl Acad Sci U S A 115(19):4827-4832. doi:10.1073/pnas.1715250115 PMID:29686102 PMCID:PMC5948954
  • Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD. 2018. Microbes vs. chemistry in the origin of the anaerobic gut lumen. Proc Natl Acad Sci U S A 4170-4175:115. doi:10.1073/pnas.1718635115 PMID:29610310 PMCID:PMC5910840
  • Goodwin TJ, Christofidou-Solomidou M. 2018. Oxidative stress and space biology: An organ-based approach. Int J Mol Sci 19(4):959. doi:10.3390/ijms19040959 PMID:29570635 PMCID:PMC5979446
  • Guo L, Wang Q, Weng L, Hauser LA, Strawser CJ, Mesaros C, Lynch DR, Blair IA. 2018. Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes. Sci Rep 8(1):17043. doi:10.1038/s41598-018-35346-y PMID:30451920 PMCID:PMC6242848
  • Guo L, Wang Q, Weng L, Hauser LA, Strawser CJ, Rocha AG, Dancis A, Mesaros C, Lynch DR, Blair IA. 2018. Liquid chromatography-high resolution mass spectrometry analysis of platelet frataxin as a protein biomarker for the rare disease Friedreich's ataxia. Anal Chem 90:2216-2223. doi:10.1021/acs.analchem.7b04590 PMID:29272104 PMCID:PMC5817373
  • Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C. 2018. Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res 59:564-575. doi:10.1194/jlr.D081414 PMID:29301865 PMCID:PMC5832923
  • Mishra OP, Popov AV, Pietrofesa RA, Andrake M, Nakamaru-Ogiso E, Christofidou-Solomidou M. 2018. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells. Biochim Biophys Acta 1862(6):1364-1375. doi:10.1016/j.bbagen.2018.03.003 PMID:29524540
  • Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper BB, Christofidou-Solomidou M, Willenbring JK. 2018. Siderophore-mediated iron removal from chrysotile: implications for asbestos toxicity reduction and bioremediation. J Hazard Mater 341:290-296. doi:10.1016/j.jhazmat.2017.07.033 PMID:28797944 PMCID:PMC5771417
  • Pietrofesa RA, Chatterjee S, Park K, Arguiri E, Albelda SM, Christofidou-Solomidou M. 2018. Synthetic lignan secoisolariciresinol diglucoside (LGM2605) reduces asbestos-induced inflammation and inflammasome activation in mice in an Nrf2-dependent and independent manner. Antioxidants (Basel) 7(3):38. doi:10.3390/antiox7030038 PMID:29498660 PMCID:PMC5874524
  • Ventura GD, Vigliaturo R, Giere R, Pollastri S, Gualtieri AF, Iezzi G. 2018. Infra red spectroscopy of the regulated asbestos amphiboles. Minerals 8(9):413. doi:10.3390/min8090413
  • Vigliaturo R, Ventura GD, Choi JK, Marengo A, Lucci F, O'Shea M, Perez-Rodriguez I, Giere R. 2018. Mineralogical characterization and dissolution experiments in Gamble's solution of Tremolitic Amphibole from Passo di Caldenno (Sondrio, Italy). Minerals 8:24. doi:10.3390/min8120557
  • Weng L, Guo L, Vachani A, Mesaros C, Blair IA. 2018. Quantification of serum high mobility group box 1 by liquid chromatography/high-resolution mass spectrometry: Implications for its role in immunity, inflammation, and cancer. Anal Chem 90:7552-7560. doi:10.1021/acs.analchem.8b01175 PMID:29791130
  • Xu R, Barg FK, Emmett EA, Wiebe D, Hwang W. 2018. Association between mesothelioma and non-occupational asbestos exposure: systematic review and meta-analysis. Environ Health 17(1):90. doi:10.1186/s12940-018-0431-9 PMID:30567579 PMCID:PMC6300000

2017

  • Blair IA, Wang Q, Guo L, Weng L, Salimatipour A, Hwang W, Lynch DR, Mesaros C. 2017. Systems pharmacology approach to the study of mitochondrial dysfunction. Abstr Pap Am Chem Soc 254:2.
  • Cheung M, Menges CW, Testa JR. 2017. Germline and Somatic Mutations in Human Mesothelioma and Lessons from Asbestos-Exposed Genetically Engineered Mouse Models. Chapter 8 in: Asbestos and Mesothelioma. Springer International Publishing, pp.175-195.
  • Cheung M, Testa JR. 2017. BAP1, a tumor suppressor gene driving malignant mesothelioma. Transl Lung Cancer Res 6(3):270-278. doi:10.21037/tlcr.2017.05.03 PMID:28713672 PMCID:PMC5504107
  • Chikara S, Lindsey K, Dhillon H, Mamidi S, Kittilson J, Christofidou-Solomidou M, Reindl KM. 2017. Enterolactone induces G1-phase cell cycle arrest in non-small cell lung cancer cells by down-regulating cyclins and cyclin-dependent kinases. Nutr Cancer 69(4):652-662. doi:10.1080/01635581.2017.1296169 PMID:28323486 PMCID:PMC5500210
  • Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Koumenis C, Segal R. 2017. Radiation mitigating properties of intranasally administered KL4 surfactant in a murine model of radiation-induced lung damage. Radiation Research 188(5):491-504. doi:10.1667/RR14686.1 PMID:28877030 PMCID:PMC5704933
  • Dietterich LH, Gonneau C, Casper BB. 2017. Arbuscular mycorrhizal colonization has little consequence for plant heavy metal uptake in contaminated field soils. Ecol Appl 27(6):1862-1875. doi:10.1002/eap.1573 PMID:28482132 PMCID:PMC5581990
  • Emmett EA, Cakouros B. 2017. Communities at High Risk in the Third Wave of Mesothelioma. Chapter 5 in: Asbestos and Mesothelioma. Springer International Publishing, pp.103-130.
  • Ferdowsi B, Ortiz C, Houssais M, Jerolmack DJ. 2017. River-bed armouring as a granular segregation phenomenon. Nat Commun 8(1):1363. doi:10.1038/s41467-017-01681-3 PMID:29118422 PMCID:PMC5678076
  • Gonneau C, Miller K, Mohanty SK, Xu R, Hwang W, Willenbring JK, Casper BB. 2017. Framework for assessment and phytoremediation of asbestos-contaminated sites. Environ Sci Pollut Res Int 24:25912-25922. doi:10.1007/s11356-017-0177-x PMID:28940054
  • Gonneau C, Mohanty SK, Dietterich LH, Hwang W, Willenbring JK, Casper BB. 2017. Differential elemental uptake in three pseudo-metallophyte C4 grasses in situ in the eastern USA. Plant Soil 416:149-163. doi:10.1007/s11104-017-3198-9 PMID:28845059 PMCID:PMC5568086
  • Hinderer C, Katz N, Louboutin J, Bell P, Tolar J, Orchard PJ, Lund TC, Nayal M, Weng L, Mesaros C, de Souza CF, Corte AD, Giugliani R, Wilson JM. 2017. Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis. Hum Mol Genet 26(19):3837-3849. doi:10.1093/hmg/ddx277 PMID:28934395 PMCID:PMC5886077
  • Huang J, Liu Y, Vitale S, Penning TM, Whitehead A, Blair IA, Vachani A, Clapper M, Muscat JE, Lazarus P, Scheet P, Moore JH, Chen Y. 2017. On meta- and mega-analyses for gene-environment interactions. Genet Epidemiol 41:876-886. doi:10.1002/gepi.22085 PMID:29110346
  • Mesaros C, Arroyo AD, Blair IA, Snyder NW. 2017. Coenzyme A thioester formation of 11-and 15-oxo-eicosatetraenoic acid. Prostaglandins Other Lipid Mediat 130:1-7. doi:10.1016/j.prostaglandins.2017.02.004 PMID:28238887 PMCID:PMC5446925
  • Mesaros C, Blair IA, Weng L. 2017. Biomarkers of response to asbestos exposure. Chapter 12 in: Asbestos and Mesothelioma. Springer International Publishing, pp.259-277.
  • Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan JC, Karagas MR, McAllister KA, Mechanic LM, Fallin MD, Ladd-Acosta C, Blair IA, Teitelbaum SL, Amos CI. 2017. Opportunities and challenges for environmental exposure assessment in population-based studies. Cancer Epidemiol Biomarkers Prev 26:1370-1380. doi:10.1158/1055-9965.epi-17-0459 PMID:28710076 PMCID:PMC5581729
  • Pietrofesa RA, Woodruff P, Hwang W, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M. 2017. The synthetic lignan secoisolariciresinol diglucoside prevents asbestos-induced NLRP3 inflammasome activation in murine macrophages. Oxid Med Cell Longev 2017:739523. doi:10.1155/2017/7395238 PMID:29075366 PMCID:PMC5615985
  • Testa JR. 2017. Malignant Mesothelioma: An Asbestos Legacy. Chapter 1 in: Asbestos and Mesothelioma. Springer International Publishing, pp.1-9.
  • Velalopoulou A, Chatterjee S, Pietrofesa RA, Koziol-White C, Panettieri RA, Lin L, Tuttle S, Berman A, Koumenis C, Christofidou-Solomidou M. 2017. Synthetic secoisolariciresinol diglucoside (LGM2605) protects human lung in an ex vivo model of proton radiation damage. Int J Mol Sci 18(12):E2525. doi:10.3390/ijms18122525 PMID:29186841 PMCID:PMC5751128
  • Wu L, Ortiz C, Jerolmack DJ. 2017. Aggregation of elongated colloids in water. Langmuir 33(2):622-629. doi:10.1021/acs.langmuir.6b03962 PMID:27931099 PMCID:PMC5283798
  • Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang W. 2017. Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure. Biomark Med 11:547-556. doi:10.2217/bmm-2017-0087 PMID:28534416 PMCID:PMC5619144

2016

  • Boschi V, Willenbring JK. 2016. The effect of pH, organic ligand chemistry and mineralogy on the sorption of beryllium over time. Environ Chem 13(4):711-722. doi:10.1071/EN15107
  • Clapp JT, Roberts JA, Dahlberg B, Berry LS, Jacobs LM, Emmett EA, Barg FK. 2016. Realities of environmental toxicity and their ramifications for community engagement. Soc Sci Med 170:143-151. doi:10.1016/j.socscimed.2016.10.019 PMID:27783970 PMCID:PMC5107345
  • Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros C, Blair IA, Vachani A, Snyder NW. 2016. Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry. Steroids 116:60-66. doi:10.1016/j.steroids.2016.10.003 PMID:27743906 PMCID:PMC5127713
  • Guo L, Worth AJ, Mesaros C, Snyder NW, Glickson JD, Blair IA. 2016. Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism. Rapid Commun Mass Spectrom 30(16):1835-1845. doi:10.1002/rcm.7667 PMID:27476658 PMCID:PMC4970762
  • Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. 2016. Bap1 is a bona fide tumor suppressor: genetic evidence from mouse models carrying heterozygous germline Bap1 mutations. Cancer Res 76(9):2836-2844. doi:10.1158/0008-5472.CAN-15-3371 PMID:26896281 PMCID:PMC4873414
  • Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR. 2016. Inflammation-related IL1β/IL1R signaling promotes the development of asbestos-induced malignant mesothelioma. Cancer Prev Res (Phila) 9(5):406-414. doi:10.1158/1940-6207.CAPR-15-0347 PMID:26935421 PMCID:PMC4854753
  • Mesaros C, Blair IA. 2016. Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteomics 13:20. doi:10.1186/s12014-016-9121-1 PMID:27713681 PMCID:PMC5050566
  • Mishra OP, Popov AV, Pietrofesa RA, Christofidou-Solomidou M. 2016. Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection. Biochim Biophys Acta 1860(9):1884-1897. doi:10.1016/j.bbagen.2016.05.037 PMID:27261092 PMCID:PMC5253237
  • Ohar J, Cheung M, Talarchek J, Howard S, Howard T, Hesdorffer M, Peng H, Rauscher FJ, Testa JR. 2016. Germline BAP1 mutational landscape of asbestos-exposed malignant mesothelioma patients with family history of cancer. Cancer Res 76(2):206-215. doi:10.1158/0008-5472.CAN-15-0295 PMID:26719535 PMCID:PMC4715907
  • Pietrofesa RA, Velalopoulou A, Albelda SM, Christofidou-Solomidou M. 2016. Asbestos induces oxidative stress and activation of Nrf2 signaling in murine macrophages: chemopreventive role of the synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). Int J Mol Sci 17(3):322. doi:10.3390/ijms17030322 PMID:26938529 PMCID:PMC4813184
  • Pietrofesa RA, Velalopoulou A, Arguiri E, Menges CW, Testa JR, Hwang W, Albelda SM, Christofidou-Solomidou M. 2016. Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice. Carcinogenesis 37(2):177-187. doi:10.1093/carcin/bgv174 PMID:26678224 PMCID:PMC4745643
  • Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M. 2016. Novel double-hit model of radiation and hyperoxia-induced oxidative cell damage relevant to space travel. Int J Mol Sci 17(6):953. doi:10.3390/ijms17060953 PMID:27322243 PMCID:PMC4926486
  • Salamatipour A, Mohanty SK, Pietrofesa RA, Vann D, Christofidou-Solomidou M, Willenbring JK. 2016. Asbestos fiber preparation methods affect fiber toxicity. Environ Sci Technol Lett 3(7):270-274. doi:10.1021/acs.estlett.6b00174 PMID:27540559 PMCID:PMC4985249
  • Sharkhuu A, Plante AF, Enkhmandal O, Gonneau C, Casper BB, Boldgiv B, Petraitis PS. 2016. Soil and ecosystem respiration responses to grazing, watering and experimental warming chamber treatments across topographical gradients in northern Mongolia. Geoderma 269:91-98. doi:10.1016/j.geoderma.2016.01.041 PMID:28239190 PMCID:PMC5325163
  • Vazquez-Medina J, Dodia C, Weng L, Mesaros C, Blair IA, Feinstein SI, Chatterjee S, Fisher AB. 2016. The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. FASEB J 30(8):2885-2898. doi:10.1096/fj.201500146R PMID:27178323 PMCID:PMC4970605

2015

  • Cheung M, Kadariya Y, Pei J, Talarchek J, Facciolo F, Visca P, Righi L, Cozzi I, Testa JR, Ascoli V. 2015. An asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutation. Cancer Genet 208(10):502-507. doi:10.1016/j.cancergen.2015.07.004 PMID:26364129 PMCID:PMC4608746
  • Cheung M, Kadariya Y, Talarchek J, Pei J, Ohar J, Kayaleh O, Testa JR. 2015. Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interaction. Cancer Lett 369(2):261-265. doi:10.1016/j.canlet.2015.09.011 PMID:26409435 PMCID:PMC4634709
  • Karla N, Zhang J, Thomas A, Xi L, Talarchek J, Burkett S, Tsokos MG, Chen Y, Raffeld M, Miettinen M, Pastan I, Testa JR, Hassan R, Cheung M. 2015. Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma. BMC Cancer 15:376. doi:10.1186/s12885-015-1362-2 PMID:25952750 PMCID:PMC4431029
  • Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA. 2015. Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Bioanalysis 7(9):1157-1173. doi:10.4155/bio.15.53 PMID:26039812 PMCID:PMC4487641
  • Snyder NW, Mesaros C, Blair IA. 2015. Translational metabolomics in cancer research. Biomark Med 9(9):821-834. doi:10.2217/bmm.15.52 PMID:26329905 PMCID:PMC4718447
  • Snyder NW, Tombline G, Worth AJ, Parry RC, Silvers JA, Gillespie KP, Basu SS, Millen J, Goldfarb DS, Blair IA. 2015. Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture. Anal Biochem 474:59-65. doi:10.1016/j.ab.2014.12.014 PMID:25572876 PMCID:PMC4413507
  • Velalopoulou A, Tyagi S, Pietrofesa RA, Arguiri E, Christofidou-Solomidou M. 2015. The flaxseed-derived lignan phenolic secoisolariciresinol diglucoside (SDG) protects non-malignant lung cells from radiation damage. Int J Mol Sci 17(1):doi:10.3390/ijms17010007 PMID:26703588 PMCID:PMC4730254
  • Wu L, Ortiz C, Xu Y, Willenbring JK, Jerolmack DJ. 2015. In situ liquid cell observations of asbestos fiber diffusion in water. Environ Sci Technol 49(22):13340-13349. doi:10.1021/acs.est.5b03839 PMID:26461183 PMCID:PMC4747642 (Completed with ARRA Funds)
  • Yabas M, Elliott H, Hoyne GF. 2015. The role of alternative splicing in the control of immune homeostasis and cellular differentiation. Int J Mol Sci 17(1):doi:10.3390/ijms17010003 PMID:26703587 PMCID:PMC4730250
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