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Project Publications: Texas A&M University: Exposure Science Core

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Superfund Research Program

Exposure Science Core

Project Leader: Erin S. Baker (University of North Carolina-Chapel Hill)
Co-Investigator: Terry L. Wade
Grant Number: P42ES027704
Funding Period: 2017-2022

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Publications

2022

  • Bhandari S, Casillas GA, Aly NA, Zhu R, Newman G, Wright FA, Miller A, Adler G, Rusyn I, Chiu WA. 2022. Spatial and temporal analysis of impacts of Hurricane Florence on criteria air pollutants and air toxics in eastern North Carolina. Int J Environ Res Public Health 19(3):doi:10.3390/ijerph19031757 PMID:35162780 PMCID:PMC8835244
  • Bilbao A, Gibbons BC, Stow SM, Kyle AD, Bloodsworth KJ, Payne SH, Smith RD, Ibrahim YM, Baker ES, Fjeldsted JC. 2022. A preprocessing tool for enhanced ion mobility-mass spectrometry-based omics workflows. J Proteome Res 21:798-807. doi:10.1021/acs.jproteome.1c00425 PMID:34382401 PMCID:PMC8837709
  • Butler KE, Dodds J, Flick T, Campuzano ID, Baker ES. 2022. High-resolution demultiplexing (HRdm) ion mobility spectrometry-mass spectrometry for aspartic and isoaspartic acid determination and screening. Anal Chem doi:10.1021/acs.analchem.1c05533 PMID:35421308
  • Dodds J, Wang L, Patti GJ, Baker ES. 2022. Combining isotopologue workflows and simultaneous multidimensional separations to detect, identify, and validate metabolites in untargeted analyses. Anal Chem doi:10.1021/acs.analchem.1c04430 PMID:35089687 PMCID:PMC8934380
  • Foster MR, Rainey M, Watson C, Dodds J, Kirkwood KI, Fernandez FM, Baker ES. 2022. Uncovering PFAS and other xenobiotics in the dark metabolome using ion mobility spectrometry, mass defect analysis, and machine learning. Environ Sci Technol 56:doi:10.1021/acs.est.2c00201 PMID:35653285 PMCID:PMC9474714
  • Kirkwood KI, Fleming J, Nguyen H, Reif DM, Baker ES, Belcher SM. 2022. Utilizing pine needles to temporally and spatially profile per- and polyfluoroalkyl substances (PFAS). Environ Sci Technol 56:3441-3451. doi:10.1021/acs.est.1c06483 PMID:35175744
  • Kirkwood KI, Pratt BS, Shulman N, Tamura K, MacCoss MJ, MacLean BX, Baker ES. 2022. Utilizing Skyline to analyze lipidomics data containing liquid chromatography, ion mobility spectrometry and mass spectrometry dimensions. Nat Protoc doi:10.1038/s41596-022-00714-6 PMID:35831612
  • Odenkirk MT, Horman BM, Dodds J, Patisaul HB, Baker ES. 2022. Combining micropunch histology and multidimensional lipidomic measurements for in-depth tissue mapping. ACS Meas Sci Au 2(1):67-75. doi:10.1021/acsmeasuresciau.1c00035 PMID:35647605 PMCID:PMC9139744
  • Roman-Hubers AT, Cordova AC, Rohde A, Chiu WA, McDonald TJ, Wright FA, Dodds J, Baker ES, Rusyn I. 2022. Characterization of compositional variability in petroleum substances. Fuel 317:doi:10.1016/j.fuel.2022.123547 PMID:35250041 PMCID:PMC8896784
  • Sansom G, Fawkes L, Thompson C, Losa LM, McDonald TJ, Chiu WA. 2022. Cancer risk associated with soil distribution of polycyclic aromatic hydrocarbons within three environmental justice neighborhoods in Houston, Texas. Environ Geochem Health doi:10.1007/s10653-022-01245-5 PMID:35246781

2021

  • Aly NA, Dodds J, Luo Y, Grimm FA, Foster MR, Rusyn I, Baker ES. 2021. Utilizing ion mobility spectrometry-mass spectrometry for the characterization and detection of persistent organic pollutants and their metabolites. Anal Bioanal Chem 414(3):doi:10.1007/s00216-021-03686-w PMID:34668045 (ahead of print)
  • Butler KE, Takinami Y, Rainczuk A, Baker ES, Roberts BR. 2021. Utilizing ion mobility-mass spectrometry to investigate the unfolding pathway of Cu/Zn superoxide dismutase. Front Chem 9:614595. doi:10.3389/fchem.2021.614595 PMID:33634076 PMCID:PMC7900566
  • Casillas GA, Johnson N, Chiu WA, Ramirez J, McDonald TJ, Horney JA. 2021. Polycyclic aromatic hydrocarbons in Houston parks after Hurricane Harvey. Environ Justice 14(4):277-287. doi:10.1089/env.2020.0073 PMID:34484557 PMCID:PMC8404169
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2021. Quantitative characterization of population-wide tissue- and metabolite-specific variability in perchloroethylene toxicokinetics in male mice. Toxicol Sci 182(2):doi:10.1093/toxsci/kfab057 PMID:33988684 (ahead of print)
  • Dodds J, Alexander NL, Kirkwood KI, Foster MR, Hopkins ZR, Knappe D, Baker ES. 2021. From Pesticides to Per- and Polyfluoroalkyl Substances: An Evaluation of Recent Targeted and Untargeted Mass Spectrometry Methods for Xenobiotics. Anal Chem 93:641-656. doi:10.1021/acs.analchem.0c04359 PMID:33136371
  • Dodds J, Baker ES. 2021. Improving the speed and selectivity of newborn screening using ion mobility spectrometry-mass spectrometry. Anal Chem 93:17094-17102. doi:10.1021/acs.analchem.1c04267 PMID:34851605 PMCID:PMC8730783
  • Fantke P, Chiu WA, Aylward L, Judson RR, Huang L, Jang S, Gouin T, Rhomberg L, Aurisano N, McKone TE, Jolliet O. 2021. Exposure and toxicity characterization of chemical emissions and chemicals in products: Global recommendations and implementation in USEtox. Int J Life Cycle Assess 17:doi:10.1007/s11367-021-01889-y
  • Kirkwood KI, Christopher MW, Burgess JL, Littau S, Foster K, Richey K, Pratt BS, Shulman N, Tamura K, MacCoss MJ, MacLean BX, Baker ES. 2021. Development and application of multidimensional lipid libraries to investigate lipidomic dysregulation related to smoke inhalation injury severity. J Proteome Res doi:10.1021/acs.jproteome.1c00820 PMID:34874736 PMCID:PMC8741653
  • Kofeler HC, Ahrends R, Baker ES, Ekroos K, Han X, Hoffmann N, Holcapek M, Wenk MR, Liebisch G. 2021. Recommendations for good practice in MS-based lipidomics. J Lipid Res 62:doi:10.1016/j.jlr.2021.100138 PMID:34662536 PMCID:PMC8585648
  • Luo Y, Chen Z, Blanchette A, Zhou Y, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Food Chem Toxicol doi:10.1016/j.fct.2021.111979 PMID:33450301
  • Odenkirk MT, Reif DM, Baker ES. 2021. Multiomic big data analysis challenges: Increasing confidence in the interpretation of artificial intelligence assessments. Anal Chem 93(22):7763-7773. doi:10.1021/acs.analchem.0c04850 PMID:34029068
  • Roman-Hubers AT, Cordova AC, Aly NA, McDonald TJ, Lloyd D, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Data processing workflow to identify structurally related compounds in petroleum substances using ion mobility spectrometry-mass spectrometry. Energy Fuels 35:10529-10539. doi:10.1021/acs.energyfuels.1c00892 PMID:34366560 PMCID:PMC8341389
  • Roman-Hubers AT, McDonald TJ, Baker ES, Chiu WA, Rusyn I. 2021. A comparative analysis of analytical techniques for rapid oil spill identification. Environ Toxicol Chem 40(4):1034-1049. doi:10.1002/etc.4961 PMID:33315271 PMCID:PMC8104454
  • Sansom G, Kirsch KR, Casillas GA, Camargo K, Wade TL, Knap A, Baker ES, Horney JA. 2021. Spatial distribution of polycyclic aromatic hydrocarbon contaminants after Hurricane Harvey in a Houston neighborhood. J Health Pollut 11(29):doi:10.5696/2156-9614-11.29.210308 PMID:33815906 PMCID:PMC8009646
  • Valdiviezo A, Aly NA, Luo Y, Cordova AC, Casillas GA, Foster MR, Baker ES, Rusyn I. 2021. Analysis of per- and polyfluoroalkyl substances in Houston Ship Channel and Galveston Bay following a large-scale industrial fire using ion-mobility-spectrometry-mass spectrometry. J Environ Sci (China) 115:350-362. doi:10.1016/j.jes.2021.08.004 PMID:34969462 PMCID:PMC8724578
  • Zamith-Miranda D, Heyman HM, Burnet MC, Couvillion SP, Zheng X, Munoz N, Nelson WC, Kyle JE, Zink EM, Weitz KK, Bloodsworth KJ, Clair G, Zucker JD, Teuton JR, Payne SH, Kim Y, Gil MR, Baker ES, Bredeweg EL, Nosanchuk JD, Nakayasu ES. 2021. A histoplasma capsulatum lipid metabolic map identifies antifungal targets. MBio 12(6):e0297221. doi:10.1128/mBio.02972-21 PMID:34809453 PMCID:PMC8609360

2020

  • Aly NA, Luo Y, Liu Y, Casillas GA, McDonald TJ, Kaihatu JM, Jun M, Ellis N, Gossett S, Dodds J, Baker ES, Bhandari S, Chiu WA, Rusyn I. 2020. Temporal and spatial analysis of per and polyfluoroalkyl substances in surface waters of Houston ship channel following a large-scale industrial fire incident. Environ Pollut 265:115009. doi:10.1016/j.envpol.2020.115009 PMID:32574947 PMCID:PMC7857671
  • Bhandari S, Lewis PT, Craft ES, Marvel S, Reif DM, Chiu WA. 2020. HGBEnviroScreen: Enabling community action through data integration in the Houston-Galveston-Brazoria region. Int J Environ Res Public Health 17:doi:10.3390/ijerph17041130 PMID:32053902
  • Camargo K, Sericano JL, Bhandari S, Hoelscher C, McDonald TJ, Chiu WA, Wade TL, Dellapenna TM, Liu Y, Knap A. 2020. Polycyclic aromatic hydrocarbon status in post-hurricane Harvey sediments: considerations for environmental sampling in the Galveston Bay/Houston Ship Channel region. Mar Pollut Bull 162:111872. doi:10.1016/j.marpolbul.2020.111872 PMID:33256967 PMCID:PMC7867649
  • Dodds J, Hopkins ZR, Knappe D, Baker ES. 2020. Rapid characterization of per- and polyfluoroalkyl substances (PFAS) by ion mobility spectrometry-mass spectrometry (IMS-MS). Anal Chem 92:4427-4435. doi:10.1021/acs.analchem.9b05364 PMID:32011866 PMCID:PMC7173758
  • Ekelof M, Dodds J, Khodjaniyazova S, Garrard K, Baker ES, Muddiman DC. 2020. Coupling IR-MALDESI with Drift Tube Ion Mobility-Mass Spectrometry for High-Throughput Screening and Imaging Applications. J Am Soc Mass Spectrom 31:doi:10.1021/jasms.9b00081 PMID:31971795 PMCID:PMC7263366
  • Luo Y, Aly NA, McCord JP, Strynar M, Chiu WA, Dodds J, Baker ES, Rusyn I. 2020. Rapid characterization of emerging per- and polyfluoroalkyl substances in aqueous film-forming foams using ion mobility spectrometry-mass spectrometry. Environ Sci Technol 54(23):15024-15034. doi:10.1021/acs.est.0c04798 PMID:33176098 PMCID:PMC7719402
  • Luo Y, Ferguson K, Rusyn I, Chiu WA. 2020. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicol Sci doi:10.1093/toxsci/kfaa007 PMID:32040194
  • Odenkirk MT, Stratton KG, Bramer LM, Webb-Robertson B, Bloodsworth KJ, Monroe ME, Burnum-Johnson KE, Baker ES. 2020. From Prevention to Disease Perturbations: A Multi-Omic Assessment of Exercise and Myocardial Infarctions. Biomolecules 11(1):40. doi:10.3390/biom11010040 PMID:33396843 PMCID:PMC7824308
  • Odenkirk MT, Stratton KG, Gritsenko MA, Bramer LM, Webb-Robertson B, Bloodsworth KJ, Weitz KK, Lipton AK, Monroe ME, Ash J, Fourches D, Taylor BD, Burnum-Johnson KE, Baker ES. 2020. Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools. Mol Omics 16(6):doi:10.1039/d0mo00074d PMID:32966491 (ahead of print)
  • Odenkirk MT, Zin PK, Ash J, Reif DM, Fourches D, Baker ES. 2020. Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems. Analyst 145:7197-7209. doi:10.1039/d0an01638a PMID:33094747 PMCID:PMC769503
  • Rowe GT, Fernando H, Elferink CJ, Ansari G, Sullivan J, Heathman T, Quigg A, Croisant S, Wade TL, Santschi P. 2020. Polycyclic aromatic hydrocarbons (PAHs) cycling and fates in Galveston Bay, Texas, USA. PLoS One 15:e0243734. doi:10.1371/journal.pone.0243734 PMID:33370322 PMCID:PMC7769252
  • Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. 2020. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro 63:doi:10.1016/j.tiv.2019.104752 PMID:31857146
  • Soper-Hopper M, Vandegrift J, Baker ES, Fernandez FM. 2020. Metabolite collision cross section prediction without energy-minimized structures. Analyst 16:doi:10.1039/d0an00198h PMID:32583823 PMCID:PMC7423765
  • Wang M, Bera G, Mitra K, Wade TL, Knap A, Phillips TD. 2020. Tight sorption of arsenic, cadmium, mercury, and lead by edible activated carbon and acid-processed montmorillonite clay. Environ Sci Pollut Res Int 28(6):doi:10.1007/s11356-020-10973-z PMID:33009611 (ahead of print)

2019

  • Bera G, Camargo K, Sericano JL, Liu Y, Sweet S, Horney JA, Jun M, Chiu WA, Rusyn I, Wade TL, Knap A. 2019. Baseline data for distribution of contaminants by natural disasters: Results from a residential Houston neighborhood during Hurricane Harvey flooding. Heliyon 5:e02860. doi:10.1016/j.heliyon.2019.e02860 PMID:31763489 PMCID:PMC6861583
  • Burnum-Johnson KE, Zheng X, Dodds J, Ash J, Fourches D, Nicora CD, Wendler J, Metz TO, Waters KM, Jansson J, Smith RD, Baker ES. 2019. Ion mobility spectrometry and the omics: Distinguishing isomers, isobars, molecular classes and contaminant ions in complex samples. Trends in Analytical Chemistry 116:292-299. doi:10.1016/j.trac.2019.04.022 PMID:31798197 PMCID:PMC6887105
  • Dodds J, Baker ES. 2019. Ion mobility spectrometry: fundamental concepts, instrumentation, applications, and the road ahead. J Am Soc Mass Spectrom doi:10.1007/s13361-019-02288-2 PMID:31493234 PMCID:PMC6832852
  • Englehardt JD, Chiu WA. 2019. A general dose-response relationship for chronic chemical and other health stressors and mixtures based on an emergent illness severity model. PLoS One 14(2):e0211780. doi:10.1371/journal.pone.0211780 PMID:30768598 PMCID:PMC6377108
  • Kvasnicka J, Stylianou KS, Nguyen VK, Huang L, Chiu WA, Burton AG, Semrau J, Jolliet O. 2019. Human Health Benefits from Fish Consumption vs. Risks from Inhalation Exposures Associated with Contaminated Sediment Remediation: Dredging of the Hudson River. Environ Health Perspect 127:doi:10.1289/EHP5034 PMID:31834828
  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol 32(5):doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Monge ME, Dodds J, Baker ES, Edison AS, Fernandez FM. 2019. Challenges in Identifying the Dark Molecules of Life. Annu Rev Anal Chem 12:177-199. doi:10.1146/annurev-anchem-061318-114959 PMID:30883183 PMCID:PMC6716371
  • Plante P, Francovic-Fontaine E, May J, McLean JA, Baker ES, Laviolette F, Marchand M, Corbeil J. 2019. Predicting Ion Mobility Collision Cross-Sections Using a Deep Neural Network: DeepCCS. Anal Chem 91:5191-5199. doi:10.1021/acs.analchem.8b05821 PMID:30932474 PMCID:PMC6628689
  • Stermer A, Klein D, Wilson S, Dalaijamts C, Bai CY, Hall SJ, Madnick SJ, Bianchi E, Chiu WA, Boekelheide K. 2019. Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environ Toxicol Pharmacol 68:1-3. doi:10.1016/j.etap.2019.02.003 PMID:30836291 PMCID:PMC6594756
  • Zheng X, Smith FB, Aly NA, Cai J, Patterson A, Baker ES. 2019. Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry. Anal Bioanal Chem 411:4673-4682. doi:10.1007/s00216-019-01869-0 PMID:31098744 PMCID:PMC6612315

2018

  • Horney JA, Casillas GA, Baker ES, Stone KW, Kirsch KR, Camargo K, Wade TL, McDonald TJ. 2018. Comparing residential contamination in a Houston environmental justice neighborhood before and after Hurricane Harvey. PLoS One 13(2):e0192660. doi:10.1371/journal.pone.0192660 PMID:29420658 PMCID:PMC5805347
  • Hwang H, Fiala M, Wade TL, Park D. 2018. Review of pollutants in urban road dust: Part II. Organic contaminants from vehicles and road management. International Journal of Urban Sciences doi:10.1080/12265934.2018.1538811
  • MacLean BX, Prat BS, Egertson JD, MacCoss MJ, Smith RD, Baker ES. 2018. Using skyline to analyze data-containing liquid chromatography, ion mobility spectrometry, and mass spectrometry dimensions. J Am Soc Mass Spectrom 1-7. doi:10.1007/s13361-018-2028-5 PMID:30047074 PMCID:PMC6191345
  • Nicora CD, Burnum-Johnson KE, Nakayasu ES, Casey CP, White RA, Chowdhury TR, Kyle JE, Kim Y, Smith RD, Metz TO, Jansson J, Baker ES. 2018. The MPLEx protocol for multi-omic analyses of soil samples. J Vis Exp 135:e57343. doi:10.3791/57343 PMID:29912205 PMCID:PMC6101435
  • Orton DJ, Tfaily MM, Moore RJ, LaMarche BL, Zheng X, Fillmore TL, Chu RK, Weitz KK, Monroe ME, Kelly RT, Smith RD, Baker ES. 2018. A customizable flow injection system for automated, high throughput, and time sensitive ion mobility spectrometry and mass spectrometry measurements. Anal Chem 90(1):737-744. doi:10.1021/acs.analchem.7b02986 PMID:29161511 PMCID:PMC5764703
  • Zheng X, Dupuis KT, Aly NA, Zhou Y, Smith FB, Tang K, Smith RD, Baker ES. 2018. Utilizing ion mobility spectrometry and mass spectrometry for the analysis of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, polybrominated diphenyl ethers and their metabolites. Anal Chim Acta 1037:265-273. doi:10.1016/j.aca.2018.02.054 PMID:30292301 PMCID:PMC6223027
  • Zheng X, Smith RD, Baker ES. 2018. Recent advances in lipid separations and structural elucidation using mass spectrometry combined with ion mobility spectrometry, ion-molecule reactions and fragmentation approaches. Curr Opin Chem Biol 42:111-118. doi:10.1016/j.cbpa.2017.11.009 PMID:29223060 PMCID:PMC5828972

2017

  • Zheng X, Aly NA, Zhou Y, Dupuis KT, Bilbao A, Paurus VL, Orton DJ, Wilson R, Payne SH, Smith RD, Baker ES. 2017. A structural examination and collision cross section database for over 500 metabolites and xenobiotics using drift tube ion mobility spectrometry. Chem Sci 8(11):7724-7736. doi:10.1039/c7sc03464d PMID:29568436 PMCID:PMC5853271
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