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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Texas A&M University: Inter-Tissue and -Individual Variability in Responses to Mixtures

Superfund Research Program

Inter-Tissue and -Individual Variability in Responses to Mixtures

Project Leader: Ivan Rusyn
Grant Number: P42ES027704
Funding Period: 2022-2027
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2024

  • Ford L, Lin H, Tsai H, Zhou Y, Wright FA, Sedykh A, Shah R, Chiu WA, Rusyn I. 2024. Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types. Toxicology 503:153763. doi:10.1016/j.tox.2024.153763 PMID:38423244
  • Lin H, Rusyn I, Chiu WA. 2024. Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes. ALTEX 41(1):37-49. doi:10.14573/altex.2306231 PMID:37921411
  • Lu E, Ford L, Chen Z, Burnett SD, Rusyn I, Chiu WA. 2024. Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure. Regul Toxicol Pharmacol 148:105596. doi:10.1016/j.yrtph.2024.105596 PMID:38447894
  • Tsai H, Ford L, Chen Z, Dickey AN, Wright FA, Rusyn I. 2024. Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes. ALTEX doi:10.14573/altex.2311031 PMID:38429992
  • Vidal MS, Richardson L, Kumar Kammala A, Kim S, Lam P, Cherukuri R, Thomas T, Bettayeb M, Han A, Rusyn I, Menon R. 2024. Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies. Lab Chip doi:10.1039/d3lc00998j PMID:38334486

2023

  • Anderson MJ, Valdiviezo A, Conway MH, Farrell C, Andringa RK, Janik A, Chiu WA, Rusyn I, Hamer SA. 2023. Imidacloprid exposure is detectable in over one third of wild bird samples from diverse Texas ecoregions. Sci Total Environ 876:162723. doi:10.1016/j.scitotenv.2023.162723 PMID:36907393
  • Cordova AC, Dodds J, Tsai H, Lloyd D, Roman-Hubers AT, Wright FA, Chiu WA, McDonald TJ, Zhu R, Newman G, Rusyn I. 2023. Application of ion mobility spectrometry-mass spectrometry for compositional characterization and fingerprinting of a library of diverse crude oil samples. Environ Toxicol Chem doi:10.1002/etc.5727 PMID:37530422
  • Cordova AC, Ford L, Valdiviezo A, Roman-Hubers AT, McDonald TJ, Chiu WA, Rusyn I. 2023. Dosing methods to enable cell-based in vitro testing of complex substances: a case study with a PAH mixture. Toxics 11(1):19. doi:10.3390/toxics11010019 PMID:36668745 PMCID:PMC9866728
  • Cordova AC, Klaren WD, Ford L, Grimm FA, Baker ES, Zhou Y, Wright FA, Rusyn I. 2023. Integrative chemical-biological grouping of complex high production volume substances from lower olefin manufacturing streams. Toxics 11(7):586. doi:10.3390/toxics11070586 PMID:37505552 PMCID:PMC10385386
  • Cuomo D, Nitcher M, Barba E, Feinberg AP, Rusyn I, Chiu WA, Threadgill DW. 2023. Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population. Toxicol Sci doi:10.1093/toxsci/kfad054 PMID:37243727 PMCID:PMC10375319
  • Jang S, Shao K, Chiu WA. 2023. Beyond the cancer slope factor: Broad application of Bayesian and probabilistic approaches for cancer dose-response assessment. Environ Int 175:107959. doi:10.1016/j.envint.2023.107959 PMID:37182419
  • Lim AY, Kato Y, Sakolish C, Valdiviezo A, Han G, Bajaj P, Stanko JP, Ferguson SS, Villenave R, Hewitt P, Hardwick RN, Rusyn I. 2023. Reproducibility and robustness of a liver microphysiological system PhysioMimix LC12 under varying culture conditions and cell type combinations. Bioengineering 10(10):doi:10.3390/bioengineering10101195 PMID:37892925 PMCID:10603899
  • Lin H, Chiu WA. 2023. Development of physiologically-based gut absorption model for probabilistic prediction of environmental chemical bioavailability. ALTEX 40(3):471-484. doi:10.14573/altex.2210031 PMID:37158362
  • Lu E, Grimm FA, Rusyn I, Saeger SD, De Boevre M, Chiu WA. 2023. Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol. Environ Int 182:108326. doi:10.1016/j.envint.2023.108326 PMID:38000237
  • Lynch MT, Lay CR, Sokolinski S, Antezana A, Ghio C, Chiu WA, Rogers RD. 2023. Community-facing toxicokineticmodels to estimate PFAS serum levels based on life history and drinking water exposures. Environ Int 176:107974. doi:10.1016/j.envint.2023.107974 PMID:37245445
  • Oladeji O, Saitas M, Mustapha T, Johnson N, Chiu WA, Rusyn I, Robinson AL, Presto AA. 2023. Air pollutant patterns and human health risk following the East Palestine, Ohio, train derailment. Environ Sci Technol Lett 10(8):680-685. doi:10.1021/acs.estlett.3c00324 PMID:37577363 PMCID:PMC10413936
  • Rusyn I, Wright FA. 2023. Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations. Toxicol Sci doi:10.1093/toxsci/kfad134 PMID:38141214
  • Sakolish C, Moyer HL, Tsai H, Ford L, Dickey AN, Wright FA, Han G, Bajaj P, Baltazar MT, Carmichael PL, Stanko JP, Ferguson SS, Rusyn I. 2023. Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity. Toxicol Sci doi:10.1093/toxsci/kfad080 PMID:37555834
  • Tsai H, House JS, Wright FA, Chiu WA, Rusyn I. 2023. A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo. Toxicol Sci doi:10.1093/toxsci/kfad041 PMID:37079747 PMCID:PMC10230285

2022

  • Abrahamsson DP, Siddharth A, Robinson JF, Soshilov AA, Elmore S, Cogliano VJ, Ng CA, Khan EM, Ashton R, Chiu WA, Fung J, Zeise L, Woodruff TJ. 2022. Modeling the transplacental transfer of small molecules using machine learning: a case study on perand polyfluorinated substances (PFAS). J Expo Sci Environ Epidemiol 32(6):doi:10.1038/s41370-022-00481-2 PMID:36207486 PMCID:PMC9742309
  • Aeppli C, Mitchell DA, Keyes P, Beirne EC, McFarlin KM, Roman-Hubers AT, Rusyn I, Prince RC, Zhao L, Parkerton TF, Nedwed T. 2022. Oil irradiation experiments document changes in oil properties, molecular composition, and dispersant effectiveness associated with oil photo-oxidation. Environ Sci Technol 56:doi:10.1021/acs.est.1c06149 PMID:35605020
  • Chiu WA, Lynch MT, Lay CR, Antezana A, Malek P, Sokolinski S, Rogers RD. 2022. Bayesian estimation of human population toxicokinetics of PFOA, PFOS, PFHxS, and PFNA from studies of contaminated drinking water. Environ Health Perspect 130(12):127001. doi:10.1289/EHP10103 PMID:36454223 PMCID:PMC9714558
  • Ford L, Jang S, Chen Z, Zhou Y, Gallins P, Wright FA, Chiu WA, Rusyn I. 2022. A population-based human in vitro approach to quantify inter-individual variability in responses to chemical mixtures. Toxics 10(8):441. doi:10.3390/toxics10080441 PMID:36006120
  • Jang S, Ford L, Rusyn I, Chiu WA. 2022. Cumulative risk meets inter-individual variability: probabilistic concentration addition of complex mixture exposures in a population-based human in vitro model. Toxics 10(10):549. doi:10.3390/toxics10100549 PMID:36287830 PMCID:PMC9611413
  • Kato Y, Lim AY, Sakolish C, Valdiviezo A, Moyer HL, Hewitt P, Bajaj P, Han G, Rusyn I. 2022. Analysis of reproducibility and robustness of OrganoPlate 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs. Toxicol Vitro doi:10.1016/j.tiv.2022.105464 PMID:36057418 PMCID:PMC10015056
  • Kowalczewski A, Sakolish C, Hoang P, Liu X, Jacquir S, Rusyn I, Ma Z. 2022. Integrating nonlinear analysis and machine learning for human induced pluripotent stem cell-based drug cardiotoxicity testing. J Tissue Eng Regen Med doi:10.1002/term.3325 PMID:35621199
  • Roman-Hubers AT, Aeppli C, Dodds J, Baker ES, McFarlin KM, Letinski DJ, Zhao L, Mitchell DA, Parkerton TF, Prince RC, Nedwed T, Rusyn I. 2022. Temporal chemical composition changes in water below a crude oil slick irradiated with natural sunlight. Mar Pollut Bull 185:114360. doi:10.1016/j.marpolbul.2022.114360 PMID:36413931
  • Roman-Hubers AT, Cordova AC, Rohde A, Chiu WA, McDonald TJ, Wright FA, Dodds J, Baker ES, Rusyn I. 2022. Characterization of compositional variability in petroleum substances. Fuel 317:doi:10.1016/j.fuel.2022.123547 PMID:35250041 PMCID:PMC8896784
  • Rusyn I, Chiu WA. 2022. Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data. Toxicol Sci doi:10.1093/toxsci/kfac033 PMID:35404442
  • Rusyn I, Chiu WA, Wright FA. 2022. Model systems and organisms for addressing inter- and intra-species variability in risk assessment. Regul Toxicol Pharmacol 132:105197. doi:10.1016/j.yrtph.2022.105197 PMID:35636685
  • Sakolish C, Georgescu A, Huh DD, Rusyn I. 2022. A model of human small airway on a chip for studies of subacute effects of inhalation toxicants. Toxicol Sci 187(2):267-278. doi:10.1093/toxsci/kfac036 PMID:35357501
  • Shao K, Ji C, Chiu WA. 2022. Using prior toxicological data to support dose-response assessment-identifying plausible prior distributions for dichotomous dose-response models. Environ Sci Technol 56(22):16506-16516. doi:10.1021/acs.est.2c05872 PMID:36279400
  • Valdiviezo A, Brown GE, Michell AR, Trinconi CM, Bodke VV, Khetani SR, Luo Y, Chiu WA, Rusyn I. 2022. Reanalysis of trichloroethylene and tetrachloroethylene metabolism to glutathione conjugates using human, rat, and mouse liver in vitro models to improve precision in risk characterization. Environ Health Perspect 130(11):117009. doi:10.1289/EHP12006 PMID:36445294 PMCID:PMC9707501
  • Valdiviezo A, Kato Y, Baker ES, Chiu WA, Rusyn I. 2022. Evaluation of metabolism of a defined pesticide mixture through multiple in vitro liver models. Toxics 10(10):566. doi:10.3390/toxics10100566 PMID:36287846 PMCID:PMC9609317

2021

  • Valdiviezo A, Aly NA, Luo Y, Cordova AC, Casillas GA, Foster MR, Baker ES, Rusyn I. 2021. Analysis of per- and polyfluoroalkyl substances in Houston Ship Channel and Galveston Bay following a large-scale industrial fire using ion-mobility-spectrometry-mass spectrometry. J Environ Sci (China) 115:350-362. doi:10.1016/j.jes.2021.08.004 PMID:34969462 PMCID:PMC8724578
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