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Your Environment. Your Health.

Project Publications: University of Alabama at Birmingham: Asthma in Children Exposed to Heavy Metals

Superfund Research Program

Asthma in Children Exposed to Heavy Metals

Project Leader: Jessy Deshane
Co-Investigators: Rui-Ming Liu, Diptiman Chanda
Grant Number: P42ES027723
Funding Period: 2020-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Cui H, Xie N, Banerjee S, Dey T, Liu R, Antony V, Sanders YY, Adams TS, Gomez JL, Thannickal V, Kaminski N. 2022. CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging. Am J Respir Crit Care Med 206(4):459-475. doi:10.1164/rccm.202109-2151OC PMID:35687485
  • Curtiss ML, Deshane J. 2022. Stick a Fork in Me; I'm Done: Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death. Am J Respir Cell Mol Biol 66(6):593-595. doi:10.1165/rcmb.2022-0023ED PMID:35377833 PMCID:PMC9163635
  • Goliwas KF, Kashyap M, Khan J, Sinha R, Weng Z, Oak AS, Jin L, Atigadda V, Lee MB, Elmets CA, Mukhtar MS, Raman C, Deshane J, Athar M. 2022. Ex vivo culture models of hidradenitis suppurativa for defining molecular pathogenesis and treatment efficacy of novel drugs. Inflammation 45(3):1388-1401. doi:10.1007/s10753-022-01629-w PMID:35301634 PMCID:PMC9940461
  • Goliwas KF, Wood AM, Simmons CS, Khan R, Khan SA, Wang Y, Berry JL, Athar M, Mobley JA, Kim Y, Thannickal V, Harrod KS, Donahue JM, Deshane J. 2022. Local SARS-CoV-2 peptide-specific immune responses in lungs of convalescent and uninfected human subjects. medRxiv doi:10.1101/2021.09.02.21263042 PMID:34518842 PMCID:PMC8437319
  • Li FJ, Surolia R, Singh P, Dsouza K, Stephens CT, Wang Z, Liu R, Bae S, Kim Y, Athar M, Dransfield MT, Antony V. 2022. Fibrinogen mediates cadmium-induced macrophage activation and serves as a predictor of cadmium exposure in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol doi:10.1152/ajplung.00475.2021 PMID:35200041
  • Rangarajan S, Locy ML, Chanda D, Kurundkar AR, Kurundkar D, Larson-Casey JL, Londono P, Bagchi RA, Deskin B, Elajaili H, Nozik ES, Deshane J, Zmijewski J, Eickelberg O, Thannickal V. 2022. Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis. Aging Cell 21(9):e13674. doi:10.1111/acel.13674 PMID:35934931 PMCID:PMC9470902
  • Srivastava RK, Wang Y, Khan J, Muzaffar S, Lee MB, Weng Z, Croutch C, Agarwal A, Deshane J, Athar M. 2022. Role of hair follicles in the pathogenesis of arsenical-induced cutaneous damage. Ann N Y Acad Sci 1515(1):168-183. doi:10.1111/nyas.14809 PMID:35678766 PMCID:PMC9531897
  • Wang H, Khattar V, Hensel JA, Ashton R, Lu Y, Sorace AG, Wang Y, Deshane J, Mieher JL, Deivanayagam C, Ponnazhagan S. 2022. Systemic checkpoint blockade by PD-L1 single-chain antibody confers potent antitumor immunity and long-term survival. Mol Cancer Ther 21(11):1710-1721. doi:10.1158/1535-7163.MCT-22-0010 PMID:36031328 PMCID:PMC963356


  • Chanda D, Rehan M, Smith S, Dsouza K, Bernard K, Memula V, Kojima K, Mobley JA, Benavides G, Darley-Usmar VM, Kim Y, Zmijewski J, Deshane J, De Langhe S, Thannickal V. 2021. Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells. Elife doi:10.7554/eLife.68049 PMID:34528872 PMCID:PMC8445616
  • Khan SA, Goliwas KF, Deshane J. 2021. Sphingolipids in lung pathology in the coronavirus disease era: a review of sphingolipid involvement in the pathogenesis of lung damage. Front Physiol 12:760638. doi:10.3389/fphys.2021.760638 PMID:34690821 PMCID:PMC8531546
  • Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AV, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal V, Carter AB, Antony V. 2021. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med 13(585):doi:10.1126/scitranslmed.aba2927 PMID:33731433
  • Rehan M, Kurundkar D, Kurundkar AR, Logsdon NJ, Smith S, Chanda D, Bernard K, Sanders YY, Deshane J, Dsouza K, Rangarajan S, Zmijewski J, Thannickal V. 2021. Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice. Nat Aging 1(2):205-217. doi:10.1038/s43587-021-00027-5 PMID:34386777 PMCID:PMC8357317



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