Superfund Research Program

Heavy Metals Exacerbate Lower Respiratory Tract Infections

Project Leader: A. Brent Carter
Co-Investigator: Jennifer Casey
Grant Number: P42ES027723
Funding Period: 2020-2025

Project-Specific Links

Publications

2023

• Larson-Casey JL, Liu S, Pyles JM, Lapi SE, Saleem K, Antony V, Gonzalez ML, Crossman DK, Carter AB. 2023. Impaired PPARy activation by cadmium exacerbates infection-induced lung injury. JCI Insight 8(9):e166608. doi:10.1172/jci.insight.166608 PMID:36928191 PMCID:PMC10243824
• Larson-Casey JL, Saleem K, Surolia R, Pandey J, Mack M, Antony V, Bodduluri S, Bhatt S, Duncan SR, Carter AB. 2023. Myeloid heterogeneity mediates acute exacerbations of pulmonary fibrosis. J Immunol 211(11):1714-1724. doi:10.4049/jimmunol.2300053 PMID:37782053
• Pandey J, Larson-Casey JL, Patil MH, Joshi R, Jiang C, Zhou Y, He C, Carter AB. 2023. NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming. J Biol Chem 299(5):104695. doi:10.1016/j.jbc.2023.104695 PMID:37044213 PMCID:PMC10193017

2022

• He C, Carter AB. 2022. CRTH2 in pulmonary fibrosis: Friend or foe?. Am J Respir Cell Mol Biol 67(2):145-146. doi:10.1165/rcmb.2022-0232ED PMID:35675551 PMCID:PMC9348569
• Larson-Casey JL, Carter AB. 2022. Does UCP2 couple hyperoxia to lung injury?. Am J Respir Cell Mol Biol 66(3):250-251. doi:10.1165/rcmb.2021-0480ED PMID:34905723 PMCID:PMC8937246

2021

• Gu L, Surolia R, Larson-Casey JL, He C, Davis D, Kang J, Antony V, Carter AB. 2021. Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling. Cell Death Differ 29(1):doi:10.1038/s41418-021-00840-w PMID:34413485 (ahead of print)
• Larson-Casey JL, Gu L, Davis D, Cai G, Ding Q, He C, Carter AB. 2021. Post-translational regulation of PGC-1(alpha) modulates fibrotic repair. FASEB J 35:e21675. doi:10.1096/fj.202100339R PMID:34038004 PMCID:PMC8252570
• Larson-Casey JL, Gu L, Kang J, Dhyani A, Carter AB. 2021. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. J Biol Chem 297:12. doi:10.1016/j.jbc.2021.100810 PMID:34023385 PMCID:PMC8214193
• Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AV, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal V, Carter AB, Antony V. 2021. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med 13(585):doi:10.1126/scitranslmed.aba2927 PMID:33731433
• . 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1):1-382. doi:10.1080/15548627.2020.1797280 PMID:33634751 PMCID:PMC4835977

2020

• Larson-Casey JL, Gu L, Fiehn O, Carter AB. 2020. Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages. J Biol Chem 295:15754-15766. doi:10.1074/jbc.RA120.013632 PMID:32917723 PMCID:PMC7667973

2019

• Larson-Casey JL, Vaid M, Gu L, He C, Cai G, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini AF, Hanumanthu VS, Surolia R, Antony V, Carter AB. 2019. Increased flux through the mevalonate pathway mediates fibrotic repair without injury. J Clin Invest 129:4962-4978. doi:10.1172/JCI127959 PMID:31609245 PMCID:PMC6819144