Superfund Research Program

Data Management and Analysis Core

Project Leader: Susan G. Hilsenbeck
Co-Investigator: Cristian Coarfa
Grant Number: P42ES027725
Funding Period: 2020-2025

Project-Specific Links

Publications

2024

• Adeniyi-Ipadeola GO, Hankins JD, Kambal A, Zeng X, Patil K, Poplaski V, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Stossi F, Crawford SE, Blutt SE, Speer A, Estes MK, Ramani S. 2024. Infant and adult human intestinal enteroids are morphologically and functionally distinct. MBio 15(8):e0131624. doi:10.1128/mbio.01316-24 PMID:38953637 PMCID:11323560
• Ahn S, Park J, Grimm SL, Piyarathna DW, Samanta T, Putluri V, Mezquita D, Fuqua SA, Putluri N, Coarfa C, Kaipparettu B. 2024. Metabolomic rewiring promotes endocrine therapy resistance in breast cancer. Cancer Res 84(2):291-304. doi:10.1158/0008-5472.Can-23-0184 PMID:37906431 PMCID:10842725
• Joshi C, Salazar A, Wang C, Ligon M, Chappidi R, Fashemi B, Felder P, Mora A, Grimm SL, Coarfa C, Mysorekar I. 2024. D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-18-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell 59(1):doi:10.1016/j.devcel.2023.11.017
• Napoli M, Deshpande A, Chakravarti D, Rajapakshe K, Gunaratne PH, Coarfa C, Flores ER. 2024. Genome-wide p63-target gene analyses reveal TAp63/NRF2-dependent oxidative stress responses. Cancer Res Commun doi:10.1158/2767-9764.Crc-23-0358 PMID:38165157 PMCID:10832605
• Padilla J, Osman N, Bissig-Choisat B, Grimm SL, Qin X, Major A, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig K, Moore DD, Fu L. 2024. Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model. J Hepatol 80(2):282-292. doi:10.1016/j.jhep.2023.10.018 PMID:37890720

2023

• Dasgupta A, Kurenbekova L, Patel TD, Rajapakshe K, Ghosal G, Nirala B, Coarfa C, Yustein JT. 2023. Modeling ewing sarcoma lung metastasis. Curr Protoc 3(2):e670. doi:10.1002/cpz1.670 PMID:36799651 PMCID:PMC9942121
• Grimm SL, Mendez EF, Stertz L, Meyer TD, Fries GR, Gandhi T, Kanchi R, Selvaraj S, Teixeira AL, Kosten TR, Gunaratne PH, Coarfa C, Walss-Bass C. 2023. MicroRNA-mRNA networks are dysregulated in opioid use disorder postmortem brain: Further evidence for opioid-induced neurovascular alterations. Front Psychiatry 13:1025346. doi:10.3389/fpsyt.2022.1025346 PMID:36713930 PMCID:PMC9878702
• Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K. 2023. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ 14(1):50. doi:10.1186/s13293-023-00535-6 PMID:37553579 PMCID:PMC10408139
• Grimm SL, Stading R, Robertson M, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B. 2023. Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation. Redox Biol 64:102790. doi:10.1016/j.redox.2023.102790 PMID:37348155 PMCID:PMC10271936
• Mendez EF, Grimm SL, Stertz L, Gorski D, Movva SV, Najera K, Moriel K, Meyer TD, Fries GR, Coarfa C, Walss-Bass C. 2023. A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons. Front Psychiatry 14:1070556. doi:10.3389/fpsyt.2023.1070556 PMID:36873219 PMCID:PMC9978009
• Poplaski V, Bomidi C, Kambal A, Nguyen-Phuc H, Di Rienzi SC, Danhof HA, Zeng X, Feagins LA, Deng N, Vilar E, McAllister F, Coarfa C, Min S, Kim HJ, Shukla R, Britton R, Estes MK, Blutt SE. 2023. Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation. J Clin Invest 133(21):e166884. doi:10.1172/JCI166884 PMID:37909332 PMCID:PMC10617781
• Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AH, Asmussen JK, Katsonis P, Meyers JN, Lai SY, Lu W, Stephan C, Powell R, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. 2023. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer 128(11):2013-2024. doi:10.1038/s41416-023-02253-7 PMID:37012319 PMCID:PMC10205814

2022

• Bobak C, Abhimanyu A, Natarajan H, Gandhi T, Grimm SL, Nishiguchi T, Koster K, Longlax SC, Dlamini Q, Kahari J, Mtetwa G, Cirillo JD, O'Malley J, Hill J, Coarfa C, DiNardo AR. 2022. Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis. Aging-US 14(5):2174-2193. doi:10.18632/aging.203936 PMID:35256539 PMCID:PMC8954968
• Chacon-Alberty L, Kanchi R, Ye S, Hochman-Mendez C, Daoud D, Coarfa C, Li M, Grimm SL, Baz M, Rosas I, Loor G. 2022. Plasma protein biomarkers for primary graft dysfunction after lung transplantation: a single-center cohort analysis. Sci Rep 12(1):16137. doi:10.1038/s41598-022-20085-y PMID:36167867 PMCID:PMC9515157
• DiNardo AR, Gandhi T, Heyckendorf J, Grimm SL, Rajapakshe K, Nishiguchi T, Reimann M, Kirchner HL, Kahari J, Dlamini Q, Lange C, Goldmann T, Marwitz S, Abhimanyu ., Cirillo JD, Kaufmann SH, Netea MG, Crevel Rv, Mandalakas AM, Coarfa C. 2022. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes. European Respiratory Journal 60(3):2102263. doi:10.1183/13993003.02263-2021 PMID:35169026 PMCID:PMC9474892
• Napoli M, Wu SJ, Gore BL, Abbas H, Lee K, Checker R, Dhar S, Rajapakshe K, Tan AC, Lee MG, Coarfa C, Flores ER. 2022. Np63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer. Nat Commun 13:doi:10.1038/s41467-022-28202-1 PMID:35105868 PMCID:PMC8807845
• Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W. 2022. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity 55:879-894. doi:10.1016/j.immuni.2022.03.018 PMID:35443157 PMCID:PMC9109419
• Saie AE, Fu C, Grimm SL, Robertson M, Hoffman K, Putluri V, Ambati CS, Putluri N, Shivanna B, Coarfa C, Pammi M. 2022. Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia. Pediatric Research 10:doi:10.1038/s41390-022-02002-1 PMID:35338351
• Thaiparambil J, Dong J, Grimm SL, Perera D, Ambati CS, Putluri V, Robertson M, Patel TD, Mistretta B, Gunaratne PH, Kim MP, Yustein JT, Putluri N, Coarfa C, El-Zein R. 2022. Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer. Cancer Med doi:10.1002/cam4.4933 PMID:35676822
• Thompson D, Fu C, Gandhi T, Fowler JC, Frueh BC, Weinstein BL, Petrosino J, Hadden JK, Carlson M, Coarfa C, Madan A. 2022. Differential co-expression networks of the gut microbiota are associated with depression and anxiety treatment resistance among psychiatric inpatients. Prog Neuropsychopharmacol Biol Psychiatry 120:110638. doi:10.1016/j.pnpbp.2022.110638 PMID:36122838

2021

• Anvari S, Watkin L, Rajapakshe K, Hassan O, Schuster K, Coarfa C, Davis CM. 2021. Memory and naive gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy. Clin Immunol 230:108820. doi:10.1016/j.clim.2021.108820 PMID:34365017 PMCID:PMC8607808
• Bomidi C, Robertson M, Coarfa C, Estes MK, Blutt SE. 2021. Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection. Proc Natl Acad Sci U S A 118(45):doi:10.1073/pnas.2112814118 PMID:34732579 PMCID:PMC8609316
• Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K. 2021. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight 6(13):e146863. doi:10.1172/jci.insight.146863 PMID:34061778 PMCID:PMC8410054
• Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Ruiz CB, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades N. 2021. Inhibition of GATA2 in prostate cancer by a clinically available small molecule. Endocr Relat Cancer 29(1):15-31. doi:10.1530/ERC-21-0085 PMID:34636746 PMCID:PMC8634153
• Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Pi X, Xie L. 2021. Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. Nat Commun 12:doi:10.1038/s41467-021-25673-6 PMID:34489478 PMCID:PMC8421392

2020

• Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim J, Dustin D, Lo H, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans W, Ando S, Fuqua SA. 2020. Hormonal modulation of ESR1 mutant metastasis. Oncogene 40(5):doi:10.1038/s41388-020-01563-x PMID:33323970 (ahead of print)
• Preidis GA, Soni KG, Suh J, Halder T, Kim K, Choi J, Li F, Devaraj S, Connor ME, Coarfa C, Jung SY, Moore DD. 2020. Coagulopathy in Malnourished Mice is Sexually Dimorphic and Regulated by Nutrient-sensing Nuclear Receptors. Hepatol Commun 4:1835-1850. doi:10.1002/hep4.1622 PMID:33305154 PMCID:PMC7706303