Superfund Research Program

Toxicity and Liver Carcinogenicity of 1,4-Dioxane: Single Chemical and Mixtures Studies

Project Leader: Ying Chen
Grant Number: P42ES033815
Funding Period: 2022-2027

Project-Specific Links

Publications

2023

• Bellia GR, Bilott RA, Sun N, Thompson DC, Vasiliou V. 2023. Use of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity. Toxicol Mech Methods 33(5):378-387. doi:10.1080/15376516.2022.2150591 PMID:36446747 PMCID:PMC10625160

2022

• Chen Y, Wang Y, Charkoftaki G, Orlicky DJ, Davidson EA, Wan F, Ginsberg GL, Thompson DC, Vasiliou V. 2022. Oxidative stress and genotoxicity in 1,4-doxane liver toxicity as evidence in a mouse model of glutathione deficiency. Sci Total Environ 806(Pt2):150703. doi:10.1016/j.scitotenv.2021.150703 PMID:34600989 PMCID:PMC8633123
• Ginsberg GL, Chen Y, Vasiliou V. 2022. Mechanistic considerations in 1,4-dioxane cancer risk assessment. Current Opinion in Environmental Science & Health 30:100407. doi:10.1016/j.coesh.2022.100407 PMID:37091947
• Wang Y, Charkoftaki G, Davidson EA, Orlicky DJ, Tanguay RL, Thompson DC, Vasiliou V, Chen Y. 2022. Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models. Current Opinion in Environmental Science & Health 29:100389. doi:10.1016/j.coesh.2022.100389
• Zuccaro P, Thompson DC, de Boer J, Watterson A, Wang Q, Tang S, Shi X, Llompart M, Ratola N, Vasiliou V. 2022. Artificial turf and crumb rubber infill: an international policy review concerning the current state of regulations. Environ Chall 9:100620. doi:10.1016/j.envc.2022.100620 PMID:36644410 PMCID:PMC9838222

2021

• Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJ, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. 2021. Identification of dose-dependent DNA damage and repair responses from subchronic exposure to 1,4-dioxane in mice using a systems analysis approach. Toxicol Sci 183(2):338-351. doi:10.1093/toxsci/kfab030 PMID:33693819 PMCID:PMC8921626